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Clinical trials for Dryness

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44349   clinical trials with a EudraCT protocol, of which   7376   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    122 result(s) found for: Dryness. Displaying page 1 of 7.
    1  2  3  4  5  6  7  Next»
    EudraCT Number: 2016-002199-28 Sponsor Protocol Number: VFCr-12/2015 Start Date*: 2016-10-11
    Sponsor Name:Dr. August Wolff GmbH & Co. KG Arzneimittel
    Full Title: Prospective, open-label, multicenter, multinational, randomized trial to investigate the non-inferiority of treatment with Vagisan® Moisturising Cream in comparison to an Estriol containing cream i...
    Medical condition: postmenopausal women suffering from symptoms of vulvovaginal dryness
    Disease: Version SOC Term Classification Code Term Level
    19.0 10038604 - Reproductive system and breast disorders 10047791 Vulvovaginal dryness PT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2021-001801-56 Sponsor Protocol Number: VagDry001 Start Date*: 2021-09-29
    Sponsor Name:Gynial GmbH
    Full Title: Efficacy and Safety of a hyaluronic and lactic acid containing vaginal gel “HydroSanta® Vaginalgel” for the treatment of vaginal dryness symptoms – a multicenter randomized two-arm study
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004872 10047782 Vulvovaginal atrophy LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2018-000348-24 Sponsor Protocol Number: CVB2018-1 Start Date*: 2018-06-11
    Sponsor Name:Department of Otorhinolaryngology, Head and Neck Surgery
    Full Title: Mesenchymal stem cells for radiation-induced hyposalivation and xerostomia in previous head and neck cancer patients (MESRIX-II)
    Medical condition: The trial will include participants with Xerostomia (International Classification of Diseases-10: DQ 838A) who have been treated with raditherapy for a head and neck cancer prevoiusly.
    Disease: Version SOC Term Classification Code Term Level
    20.1 10017947 - Gastrointestinal disorders 10013781 Dry mouth PT
    20.0 10017947 - Gastrointestinal disorders 10048223 Xerostomia LLT
    20.0 100000004865 10039420 Salivary gland therapeutic procedures HLT
    20.0 10017947 - Gastrointestinal disorders 10039404 Salivary gland conditions HLGT
    21.1 10017947 - Gastrointestinal disorders 10039390 Salivary gland atrophy PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2005-006017-41 Sponsor Protocol Number: XER-002 Start Date*: 2006-03-28
    Sponsor Name:Calabar AB
    Full Title: A single-centre, placebo-controlled, cross-over, double blind study of the effects on salivation by increasing doses of physostigmine applied to the labial mucosa of subjects with chronic dry mouth...
    Medical condition: Chronic dry mouth
    Disease: Version SOC Term Classification Code Term Level
    7.0 10013781 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-016668-35 Sponsor Protocol Number: HBO-CPH1 Start Date*: 2009-12-22
    Sponsor Name:Copenhagen University Hospital
    Full Title: Hyperbaric Oxygen - a new treatment modality in patients with salivary gland radiation injury
    Medical condition: Late radiation tissue injury to salivary glands
    Disease: Version SOC Term Classification Code Term Level
    12.0 10013781 Dry mouth LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-017378-19 Sponsor Protocol Number: RDT-NTBo-01 Start Date*: 2011-09-27
    Sponsor Name:Dr. Antonio Mari Roig
    Full Title: Estudio prospectivo controlado sobre el efecto protector de la toxina botulínica tipo a en la sialoadenitis radioinducida
    Medical condition: Con este estudio se pretende valorar el posible efecto de radioprotección glandular de la inyección de toxina botulínica previa al inicio del tratamiento con radioterapia debido a la disminución en...
    Disease: Version SOC Term Classification Code Term Level
    13.1 10017947 - Gastrointestinal disorders 10048223 Xerostomia LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-002384-27 Sponsor Protocol Number: KKSH-037 Start Date*: 2008-03-20
    Sponsor Name:Martin-Luther-Universität Halle Wittenberg
    Full Title: Hyperbarer Sauerstoff (HBO) in der Behandlung der radiogenen Xerostomie - Eine randomisierte, prospektive Multizenter-Studie
    Medical condition: Mundtrockenheit (Xerostomie) nach strahlentherapeutischer Behandlung von Kopf-Hals-Tumoren
    Disease: Version SOC Term Classification Code Term Level
    9.1 10048223 Xerostomia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2018-001720-19 Sponsor Protocol Number: XRS-ITRT-2018 Start Date*: 2018-12-12
    Sponsor Name:Institut de Terapia Regenerativa Tissular S.L. (ITRT)
    Full Title: Phase II clinical trial to evaluate the effect and safety of MSV * in Xerostomia * adult autologous bone marrow mesenchymal stem cells, expanded under GMP of IBGM
    Medical condition: Xerostomia post radiotherapy
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10048223 Xerostomia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-005787-42 Sponsor Protocol Number: ITFE-2092-C1 Start Date*: 2016-08-10
    Sponsor Name:ITF Research Pharma SLU
    Full Title: A Phase 2, Dose-ranging, 12-week, Randomized, Double-blind, Placebo-controlled, Parallel-group Study Evaluating the Efficacy and Safety of Three Formulations of Ultra-low Dose Estriol Vaginal Gel (...
    Medical condition: Vulvovaginal atrophy in postmenopausal women
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000024113 10047782 Vulvovaginal atrophy LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: SE (Completed) CZ (Completed) HU (Completed) ES (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2011-000978-53 Sponsor Protocol Number: DX10008 Start Date*: 2011-06-07
    Sponsor Name:Acacia Pharma Ltd
    Full Title: Randomised, double-blind, placebo-controlled Phase II proof-of-concept study of APD515 solution for oromucosal and oral administration for relief of xerostomia in patients with cancer
    Medical condition: Xerostomia
    Disease: Version SOC Term Classification Code Term Level
    14.0 10017947 - Gastrointestinal disorders 10048223 Xerostomia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DK (Completed)
    Trial results: View results
    EudraCT Number: 2006-001468-21 Sponsor Protocol Number: KIIOIW001 Start Date*: 2006-08-24
    Sponsor Name:Karolinska Institutet
    Full Title: Sympthomatic and prophylactic treatment of drug induced oral dryness in elderly patients with high drug consumption.
    Medical condition: Oral dryness is a common problem with serious consquences, especially among elderly individuals. The most common reason for oral dryness is drug consumption. Research has shown that an individual w...
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2022-002158-15 Sponsor Protocol Number: SYL1001_V Start Date*: 2022-11-17
    Sponsor Name:Sylentis SAU
    Full Title: Tivanisiran for Dry Eye in Subjects with Sjögren’s Syndrome
    Medical condition: Dry Eye Disease
    Disease: Version SOC Term Classification Code Term Level
    21.1 10015919 - Eye disorders 10013774 Dry eye PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-004349-29 Sponsor Protocol Number: 01-10-2014 Start Date*: 2015-04-01
    Sponsor Name:Rigshospitalet
    Full Title: Mesenchymal stem cells for radiation-induced xerostomia (MESRIX) in previous HPV-positive oropharyngeal head and neck cancer patients
    Medical condition: The study will include participants with xerostomi (International Classification of Diseases-10: DQ 838A) and oropharyngeal cancer (DC 10).
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004864 10031103 Oropharyngeal cancer stage unspecified LLT
    17.1 100000004856 10048223 Xerostomia LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2019-004119-30 Sponsor Protocol Number: IP-AVV2019 Start Date*: 2020-01-08
    Sponsor Name:Instituto Palacios
    Full Title: EVALUATION OF THE ACCEPTABILITY AND EFFICACY OF 10 MICROGRAMS OF ESTRADIOL VAGINAL TABLETS VS PROMESTRIENE VAGINAL CREAM
    Medical condition: VULVOVAGINAL ATROPHY
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-001708-19 Sponsor Protocol Number: SVS20-EUR-06-01 Start Date*: 2008-02-21
    Sponsor Name:TRB CHEMEDICA INTERNATIONAL SA
    Full Title: A 3-month study of the efficacy and safety of SVS20 in patients with bilateral moderate dry eye syndrome : A prospective, double-masked, randomised, controlled, parallel-group, 3-arm, multicentre, ...
    Medical condition: treatment on bilateral moderate dry eye syndrome due to Sjögren's syndrome or diagnosed as a primary syndrome
    Disease: Version SOC Term Classification Code Term Level
    9.1 10013774 Dry eye LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-006287-50 Sponsor Protocol Number: EMAOS Start Date*: 2015-04-01
    Sponsor Name:Clínica Universidad de Navarra/Universidad de Navarra
    Full Title: Phase III comparative clinical trial to evaluate the efficacy of amniotic membrane extract for the treatment of severe dry eye disease, in comparison with autologous serum eyedrops.
    Medical condition: Severe Dry Eye Disease
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004853 10013778 Dry eyes LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-002325-30 Sponsor Protocol Number: VMP-03/2018 Start Date*: 2019-09-18
    Sponsor Name:Dr. August Wolff GmbH & Co. KG Arzneimittel
    Full Title: Prospective, open-label, monocenter, trial to investigate the efficacy and tolerability of Vagisan® a lactic acid containing vaginal suppository, in a panel of post-menopausal women suffering from...
    Medical condition: vulvovaginal atrophy
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004872 10047782 Vulvovaginal atrophy LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2011-000160-97 Sponsor Protocol Number: NVG10E117 Start Date*: 2011-04-08
    Sponsor Name:NOVAGALI Pharma S.A.
    Full Title: A MULTICENTER, RANDOMIZED, DOUBLE-MASKED, 2 PARALLEL ARM, VEHICLE CONTROLLED, 6-MONTH PHASE III TRIAL WITH A 6 MONTH OPEN LABEL TREATMENT SAFETY FOLLOW-UP PERIOD TO EVALUATE THE EFFICACY AND SAFETY...
    Medical condition: Severe Dry Eye Disease
    Disease: Version SOC Term Classification Code Term Level
    13.1 10015919 - Eye disorders 10013774 Dry eye PT
    13.1 10015919 - Eye disorders 10013777 Dry eye syndrome LLT
    13.1 10015919 - Eye disorders 10023350 Keratoconjunctivitis sicca PT
    13.1 10015919 - Eye disorders 10013778 Dry eyes LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) BE (Completed) DE (Completed) IT (Ongoing) AT (Completed) GB (Completed) CZ (Completed) ES (Ongoing)
    Trial results: View results
    EudraCT Number: 2012-002066-12 Sponsor Protocol Number: NVG12D122 Start Date*: 2012-12-13
    Sponsor Name:NOVAGALI Pharma S.A.S
    Full Title: A Multicenter, Open Label, Interventional, Prospective, Non Randomized, One Cohort Extension Study To Assess the Sustainability of the Effect of NOVA22007 Following Treatment Discontinuation in Imp...
    Medical condition: Severe Dry Eye Disease
    Disease: Version SOC Term Classification Code Term Level
    14.1 10015919 - Eye disorders 10023350 Keratoconjunctivitis sicca LLT
    14.1 10015919 - Eye disorders 10013778 Dry eyes LLT
    14.1 10015919 - Eye disorders 10013777 Dry eye syndrome LLT
    14.1 10015919 - Eye disorders 10013774 Dry eye PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) BE (Completed) AT (Completed) DE (Completed) GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-021430-64 Sponsor Protocol Number: RR10/9389 Start Date*: 2010-12-03
    Sponsor Name:University of Leeds
    Full Title: A randomised double blind placebo controlled clinical trial of anti B-cell therapy in patients with primary Sjögren’s syndrome.
    Medical condition: Primary Sjögren’s syndrome (PSS).
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10040767 Sjogren's syndrome PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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