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Clinical trials for Esophageal dysphagia

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    39 result(s) found for: Esophageal dysphagia. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2012-001502-26 Sponsor Protocol Number: TRIAMRAD001 Start Date*: 2012-09-07
    Sponsor Name:Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E.
    Full Title: Intralesional steroid injection in radiation-induced esophageal strictures
    Medical condition: Radiation induced esophageal strictures
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10048900 Radiation esophagitis LLT
    14.1 10017947 - Gastrointestinal disorders 10030195 Oesophageal stenosis acquired LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2009-013259-31 Sponsor Protocol Number: 6232 Start Date*: 2009-12-29
    Sponsor Name:UMC Utrecht
    Full Title: A multicenter double blind placebo-controlled randomised trial for benign esophageal anastomotic strictures: Savary dilation vs savary dilation with Triamcinolon
    Medical condition: Patients with first time dysphagia (grade 2-4) due to a benign anastomotic esophageal stricture
    Disease: Version SOC Term Classification Code Term Level
    9.1 10015449 Esophageal stricture LLT
    9.1 10030199 Oesophageal stricture LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-000603-16 Sponsor Protocol Number: HYPOXIC Start Date*: 2013-09-12
    Sponsor Name:University Medical Center Utrecht
    Full Title: HYPerbaric OXygen therapy for benign anastomotIC esophageal strictures: a pilot study
    Medical condition: Patients with benign recurrent and refractory esophageal anastomotic strictures.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-021390-36 Sponsor Protocol Number: buspar2010 Start Date*: 2010-09-07
    Sponsor Name:uzleuven
    Full Title: The Effect of Acute Intake of Oral Buspirone Hydrochloride on Esophageal Motility, Bolus Transit and Symptoms of Dysphagia, in Patients with Ineffective Esophageal Motility: A Pilot, Open-label, Si...
    Medical condition: Ineffective Esophageal Motility
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2004-003116-33 Sponsor Protocol Number: 20030185 Start Date*: 2005-04-11
    Sponsor Name:Swedish Orphan Biovitrum (Sobi) AB (publ)
    Full Title: A Phase 2 Study to Evaluate the Efficacy and Safety of Palifermin (Recombinant Human Keratinocyte Growth Factor) in the Reduction of Dysphagia in Patients Receiving Concurrent Chemoradiotherapy fo...
    Medical condition: Dysphasia
    Disease: Version SOC Term Classification Code Term Level
    14.1 10017947 - Gastrointestinal disorders 10013950 Dysphagia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2016-001853-41 Sponsor Protocol Number: 57698 Start Date*: 2018-09-19
    Sponsor Name:Academic Medical Center
    Full Title: Intensive endoscopic therapy versus conventional treatment for untreated benign anastomotic strictures after esophagectomy: a pilot and randomized controlled trial
    Medical condition: Benign esophagogastric anastomotic strictures after esophagectomy
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10030199 Oesophageal stricture LLT
    20.0 100000004856 10015449 Esophageal stricture LLT
    20.0 10042613 - Surgical and medical procedures 10030215 Oesophagectomy PT
    20.0 10042613 - Surgical and medical procedures 10015460 Esophagectomy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-005856-33 Sponsor Protocol Number: AT10008 Start Date*: 2007-02-13
    Sponsor Name:The Department of Molecular Medicin and Surgery, P9:03, Karolinska Institutet
    Full Title: Local Glucocorticoid Injektion in the Treatment of Benign Oesophageal Strictures, a Randomized Clinical Study
    Medical condition: Patients with benign oesophageal strictures and symptoms where dilatation of the stricture is planned.
    Disease: Version SOC Term Classification Code Term Level
    8.1 10030199 Oesophageal stricture LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-005246-59 Sponsor Protocol Number: EO1115 Start Date*: 2016-03-23
    Sponsor Name:Michael Patrick Achiam
    Full Title: Endoscopic electroporation in esophageal cancer
    Medical condition: Esophageal cancer
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004864 10056267 Gastroesophageal cancer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-004336-16 Sponsor Protocol Number: CC-93538-EE-001 Start Date*: 2021-09-29
    Sponsor Name:Celgene International II Sàrl
    Full Title: A Phase 3, Multi-Center, Multi-National, Randomized, Double-Blind, Placebo-Controlled Induction and Maintenance Study to Evaluate the Efficacy and Safety of CC-93538 in Adult and Adolescent Subject...
    Medical condition: EOSINOPHILIC ESOPHAGITIS
    Disease: Version SOC Term Classification Code Term Level
    20.1 10017947 - Gastrointestinal disorders 10064220 Eosinophilic esophagitis LLT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) AT (Completed) PT (Completed) BE (Completed) PL (Completed) IT (Completed) ES (Ongoing)
    Trial results: View results
    EudraCT Number: 2019-002187-26 Sponsor Protocol Number: neostigmine2019 Start Date*: 2019-08-28
    Sponsor Name:KU Leuven - TARGID
    Full Title: A Prospective evaluation of the effect of a single dose of neostigmine in patients with patients with weak or absent esophageal peristalsis
    Medical condition: Patients with complaints of dysphagia and poor esophageal motility
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2020-004723-17 Sponsor Protocol Number: UZBSK001 Start Date*: 2021-02-26
    Sponsor Name:UZ Brussel
    Full Title: Clinical usefulness and influence on oesophageal motility of pyridostigmine for dysphagia in systemic sclerosis.
    Medical condition: Dysphagia by patients suffering from systemic sclerosis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2019-002182-35 Sponsor Protocol Number: buspirone2019 Start Date*: 2019-09-10
    Sponsor Name:KU Leuven - TARGID
    Full Title: The effect of oral buspirone hydrochloride on esophageal motility, bolus transit and symptoms of dysphagia, in patients with poor esophageal motility: A randomized, double-blind, placebo controlle...
    Medical condition: Patients with complaints of dysphagia and poor esophageal motility
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2020-002878-27 Sponsor Protocol Number: EECT2020 Start Date*: 2021-03-04
    Sponsor Name:Michael Patrick
    Full Title: Endoscopic electrochemotherapy in esophageal cancer – a phase II clinical trial
    Medical condition: Esophageal cancer
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004864 10015362 Esophageal cancer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2022-001786-12 Sponsor Protocol Number: CDX0159-08 Start Date*: 2023-03-31
    Sponsor Name:Celldex Therapeutics, Inc.
    Full Title: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Barzolvolimab (CDX-0159) in Adults with Active Eosinophilic Esophagitis (The "EvolvE" Study)
    Medical condition: Eosinophilic esophagitis (EoE)
    Disease: Version SOC Term Classification Code Term Level
    20.1 10017947 - Gastrointestinal disorders 10064220 Eosinophilic esophagitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Trial now transitioned) IT (Trial now transitioned) PL (Trial now transitioned) ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-005787-58 Sponsor Protocol Number: eCaEP2021 Start Date*: 2021-05-12
    Sponsor Name:Michael Patrick
    Full Title: Endoscopic assisted Calcium electroporation in esophageal cancer – a safety study
    Medical condition: Esophageal cancer
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004864 10015362 Esophageal cancer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2020-003226-23 Sponsor Protocol Number: APD334-206 Start Date*: 2021-02-02
    Sponsor Name:Arena Pharmaceuticals Inc.
    Full Title: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of Etrasimod in Adult Subjects with Eosinophilic Esophagitis
    Medical condition: Eosinophilic Esophagitis (EoE)
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004856 10064220 Eosinophilic esophagitis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed) NL (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2019-001202-14 Sponsor Protocol Number: CiPA001 Start Date*: 2019-06-05
    Sponsor Name:Amsterdam UMC
    Full Title: CiPA Trial: Effect of Citalopram on chest pain in patients with achalasia
    Medical condition: Achalasia is a motility disorder of the esophagus. Disappearance of myenteric neurons in the esophageal wall leads to failure of relaxation of the lower esophageal sphincter (LES) and impaired peri...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2022-003287-25 Sponsor Protocol Number: 2018-002863-24,2022-003287-25 Start Date*: 2023-04-10
    Sponsor Name:Erasmus University Medical Center - Sophia Childrens Hospital
    Full Title: Intralesional steroid injections to prevent refractory strictures in patients with esophageal atresia - a randomized controlled trial
    Medical condition: Recurrent anastomotic strictures in the esophagus following surgical repair with primary anastomosis of esophageal atresia in neonates.
    Disease:
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2019-002871-32 Sponsor Protocol Number: D3255C00001 Start Date*: 2020-02-05
    Sponsor Name:AstraZeneca AB
    Full Title: A Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study to Investigate the Use of Benralizumab for Eosinophilic Esophagitis (MESSINA)
    Medical condition: Eosinophilic Esophagitis (EoE)
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004856 10064220 Eosinophilic esophagitis LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: ES (Prematurely Ended) NL (Prematurely Ended) PL (Prematurely Ended) DE (Prematurely Ended) GB (GB - no longer in EU/EEA) FR (Prematurely Ended) IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-000082-16 Sponsor Protocol Number: ACESO Start Date*: 2021-01-21
    Sponsor Name:EsoCap AG
    Full Title: A randomized, placebo-controlled, double-blind trial evaluating the efficacy, tolerability and safety of ESO-101 in adult patients with active eosinophilic esophagitis
    Medical condition: Active eosinophilic esophagitis
    Disease: Version SOC Term Classification Code Term Level
    20.1 10017947 - Gastrointestinal disorders 10064212 Eosinophilic oesophagitis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) NL (Completed) PL (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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