Flag of the European Union EU Clinical Trials Register Help

Clinical trials for Gastrointestinal perforation

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
    How to search [pdf]
    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
    Advanced Search: Search tools
     
    42 result(s) found for: Gastrointestinal perforation. Displaying page 1 of 3.
    1  2  3  Next»
    EudraCT Number: 2007-002121-80 Sponsor Protocol Number: 47/2007/O/Sper Start Date*: 2007-09-25
    Sponsor Name:AZIENDA OSPEDALIERA DI BOLOGNA POLICLINICO S. ORSOLA M. MALPIGHI
    Full Title: A prospective, double-blind, multi center, randomized clinical study to compare the efficacy and safety of Ertapenem 3 days versus Ampicillin- Sulbactam 3 days in the treatment of localized communi...
    Medical condition: localized community acquired intra-abdominal infection (IAI)
    Disease: Version SOC Term Classification Code Term Level
    6.1 10017967 HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-006056-37 Sponsor Protocol Number: 1160.143 Start Date*: 2013-09-05
    Sponsor Name:Hamilton Health Sciences Corporation
    Full Title: A large, international, randomized, placebo-controlled trial to assess the impact of dabigatran (a direct thrombin inhibitor) and omeprazole (a proton-pump inhibitor) in patients suffering myocardi...
    Medical condition: MINS (myocardial injury after noncardiac surgery)
    Disease: Version SOC Term Classification Code Term Level
    20.1 10022117 - Injury, poisoning and procedural complications 10066592 Post procedural myocardial infarction PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed) IT (Completed) PT (Completed) ES (Completed) GB (Completed) AT (Completed) DE (Prematurely Ended) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2007-003006-98 Sponsor Protocol Number: PROT-TISSUCOL-001 Start Date*: 2007-07-16
    Sponsor Name:Cirugía General II. Hospital General Universitario “Gregorio Marañón”
    Full Title: ESTUDIO FASE IV, UNICENTRICO, ALEATORIZADO, SIMPLE CIEGO, CONTROLADO, COMPARATIVO DE DOS GRUPOS PARALELOS PARA EVALUAR LA EFICACIA DE TISSUCOL DUO (ADHESIVO BIOLOGICO A BASE DE FIBRINA) EN LA PREVE...
    Medical condition: Defectos de cicatrización (fístulas, dehiscencias y fugas subclínicas) en la(s) anastomosis(s) de tubo digestivo de alto riesgo: Las anastomosis consideradas de alto riesgo son: 1. Anastomosis rect...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10058066 Perforation of anastomosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-022548-19 Sponsor Protocol Number: TP-434-P2-cIAI-1 Start Date*: 2011-05-09
    Sponsor Name:Tetraphase Pharmaceuticals, Inc.
    Full Title: A Phase 2, Randomized, Double-Blind, Double-Dummy, Multicenter, Prospective Study to Assess the Efficacy, Safety and Pharmacokinetics of 2 Dose Regimens of TP-434 Compared with Ertapenem in Adult...
    Medical condition: Community-acquired complicated intra-abdominal infection
    Disease: Version SOC Term Classification Code Term Level
    14.1 10021881 - Infections and infestations 10056570 Intra-abdominal infection LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: LT (Completed) BG (Completed) LV (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-002348-26 Sponsor Protocol Number: HUS-PERFECT Start Date*: 2020-02-18
    Sponsor Name:Helsinki University Hospital
    Full Title: Role of delay and antibiotics on PERForation rate while waiting appendECTomy – Randomized non-inferiority trial (PERFECT)
    Medical condition: Acute appendicitis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-003339-39 Sponsor Protocol Number: EHDA-01 Start Date*: 2017-05-03
    Sponsor Name:JOSÉ MARÍA PALAZÓN AZORÍN
    Full Title: A randomized, controlled and double-blind trial of intravenous azithromycin versus intravenous erythromycin as a single dose prior to endoscopy in upper gastrointestinal bleeding
    Medical condition: Upper gastrointestinal haemorrhage
    Disease: Version SOC Term Classification Code Term Level
    19.1 10017947 - Gastrointestinal disorders 10046274 Upper gastrointestinal haemorrhage PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-000448-99 Sponsor Protocol Number: 3074A1-315-WW Start Date*: 2005-12-12
    Sponsor Name:Wyeth Pharmaceuticals, Inc., Global Medical Affairs
    Full Title: A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection.
    Medical condition: Complicated Intra-Abdominal Infection
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) GB (Completed) ES (Completed) FI (Completed) DK (Completed) GR (Completed) PT (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2007-005891-15 Sponsor Protocol Number: CG104 Start Date*: 2008-05-19
    Sponsor Name:Cogentus Pharmaceuticals, Inc.
    Full Title: A Randomized, Double-Blind, Double-Dummy, Parallel Group, Phase 3 Efficacy and Safety Study of CGT-2168 Compared with Clopidogrel to Reduce Upper Gastrointestinal Events including Bleeding and Symp...
    Medical condition: Gastrointestinal events including bleeding in patients receiving dual anti-platelet therapy (clopidogrel and aspirin)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10018012 Gastrointestinal signs and symptoms HLGT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Prematurely Ended) DE (Temporarily Halted) CZ (Prematurely Ended) SK (Completed) IT (Prematurely Ended) BG (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2020-002586-34 Sponsor Protocol Number: STEROID_MC_1 Start Date*: 2020-11-12
    Sponsor Name:Department of Anesthesiology, Copenhagen University Hospital Hvidovre, Capital Region of Denmark
    Full Title: The effects of preoperative high-dose Dexamethasone on inflammatory response and recovery after emergency laparotomy, a randomized, double-blind, placebo-controlled clinical trial - AHA STEROID ...
    Medical condition: Patients undergoing emergency laparotomy due to either Intestinal obstruction or perforated abdominal viscus.
    Disease: Version SOC Term Classification Code Term Level
    21.1 10042613 - Surgical and medical procedures 10053361 Explorative laparotomy PT
    20.1 10018065 - General disorders and administration site conditions 10051379 Systemic inflammatory response syndrome PT
    22.0 10017947 - Gastrointestinal disorders 10021328 Ileus PT
    20.0 10017947 - Gastrointestinal disorders 10034406 Perforation bowel LLT
    20.0 10017947 - Gastrointestinal disorders 10034430 Perforation stomach LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-001913-34 Sponsor Protocol Number: TP-434-008 Start Date*: 2013-08-16
    Sponsor Name:Tetraphase Pharmaceuticals, Inc.
    Full Title: A Phase 3, Randomized, Double-Blind, Double-Dummy, Multicenter, Prospective Study to Assess the Efficacy and Safety of Eravacycline Compared with Ertapenem in Complicated Intra-abdominal Infections
    Medical condition: Complicated Intra-abdominal Infections
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004862 10056570 Intra-abdominal infection LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: LV (Completed) CZ (Completed) EE (Completed) LT (Completed) DE (Completed) BG (Completed)
    Trial results: View results
    EudraCT Number: 2005-002634-35 Sponsor Protocol Number: MHH-MW-01 Start Date*: 2005-08-25
    Sponsor Name:Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Medizinische Hochschule Hannover
    Full Title: Single centre, prospective, comparative, open-label, randomised study to evaluate the efficacy and tolerability of the combination of Moxifloxacin plus Metronidazole versus Piperacillin/Tazobactam ...
    Medical condition: The patients to be treated present with intra-abdominal abscesses (clinical or radiological or sonomorphological diagnosis)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2018-004121-80 Sponsor Protocol Number: Start Date*: 2019-02-05
    Sponsor Name:The Christie Hospital NHS Foundation Trust
    Full Title: A proof of concept, window trial of the IMmunological effects of AveLumab and Aspirin in Triple-Negative Breast Cancer.
    Medical condition: Breast Cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10006187 Breast cancer PT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2009-014845-95 Sponsor Protocol Number: NRL0706-01/2009 (VOM) Start Date*: 2010-02-22
    Sponsor Name:Norgine Ltd.
    Full Title: Open study to assess the tolerability, safety and efficacy of an adapted 2 litre gut cleansing solution (NRL0706) in routine colon cleansing prior to colonoscopies for colon tumour screening
    Medical condition: Subjects without relevant clinical symptoms for gastrointestinal disorders will undergo a complete selective colonoscopy for colon cancer screening.
    Disease: Version SOC Term Classification Code Term Level
    12.0 10010007 Colonoscopy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2018-000213-20 Sponsor Protocol Number: D961WC00001 Start Date*: 2023-06-06
    Sponsor Name:Astrazeneca K.K.
    Full Title: An Open Label, Parallel Group, Multi-centre, Phase III Study to Assess the Efficacy and Safety of D961H for the Maintenance Therapy Following Initial Treatment in Japanese Paediatric Patients with ...
    Medical condition: Reflux esophagitis in Japanese paediatric patients Past gastric ulcer or duodenal ulcer in Japanese paediatric patients
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10038262 Reflux esophagitis LLT
    21.1 100000004865 10036904 Prophylaxis of NSAID gastric ulceration LLT
    20.0 100000004856 10013858 Duodenal ulcer, unspecified as acute or chronic, without mention of haemorrhage or perforation LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2010-018771-23 Sponsor Protocol Number: 2010-0128771-23 Start Date*: 2010-03-03
    Sponsor Name:AZIENDA OSPEDALIERA "S. CROCE E CARLE"
    Full Title: Therapy of patency of ductus arteriosus (PDA) in very low birth weight (VLBW)preterm infants: oral ibuprofen versus intravenous ibuprofen
    Medical condition: treatment on pharmacological closure of patent ductus arteriosus (PDA)in preterm very low birthweight infants.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10028920 HLGT
    Population Age: Preterm newborn infants, Under 18 Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-003177-14 Sponsor Protocol Number: IBUPAR-Trial Start Date*: 2016-04-06
    Sponsor Name:
    Full Title: Paracetamol versus ibuprofen in preterm infants with a hemodynamically significant patent ductus arteriosus: a randomized clinical trial.
    Medical condition: Persistent ductus arteriosus haemodynamically significant
    Disease:
    Population Age: Preterm newborn infants, Under 18 Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-005491-28 Sponsor Protocol Number: MO29594 Start Date*: 2015-06-19
    Sponsor Name:Roche Farma, S.A en nombre de F. Hoffmann-La Roche Ltd
    Full Title: A MULTICENTRE OPEN-LABEL SINGLE-ARM PHASE II STUDY EVALUATING THE SAFETY AND EFFICACY OF BEVACIZUMAB IN COMBINATION WITH CARBOPLATIN AND PACLITAXEL IN PATIENTS WITH METASTATIC, RECURRENT OR PERSIST...
    Medical condition: Metastatic, Recurrent or Persistent Cervical Cancer
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004864 10008236 Cervical cancer stage IV LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: ES (Completed) PT (Completed) PL (Completed) GR (Completed) FR (Completed) BG (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2006-000874-56 Sponsor Protocol Number: BAY12-8039/11976 Start Date*: 2006-06-12
    Sponsor Name:Bayer HealthCare AG
    Full Title: A prospective, randomized, double dummy, double blind, multi-center trial comparing the safety and efficacy of moxifloxacin 400 mg IV QD 24 hours to that of ertapenem 1.0 g IV QD 24 hours for 5 to ...
    Medical condition: Complicated intra-abdominal Infections
    Disease: Version SOC Term Classification Code Term Level
    8.1 10056570 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: LT (Completed) BE (Completed) EE (Completed) DE (Completed) ES (Completed) LV (Completed) GR (Completed)
    Trial results: View results
    EudraCT Number: 2013-003883-30 Sponsor Protocol Number: 044CF13273 Start Date*: 2014-01-30
    Sponsor Name:Aziende Chimiche Riunite Angelini Francesco ACRAF S.p.A
    Full Title: Efficacy and safety of paracetamol in comparison to ibuprofen for patent ductus arteriosus treatment in preterm infants. A randomized, open label, comparator-controlled, prospective study.
    Medical condition: Patent ductus arteriosus
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004865 10034190 PDA Repair patent ductus arteriosus LLT
    Population Age: Preterm newborn infants, Under 18 Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2020-001541-39 Sponsor Protocol Number: BEVACOR Start Date*: 2020-04-24
    Sponsor Name:Fundación para la Investigación Biomédica de Córdoba
    Full Title: Pilot study of single-dose bevacizumab as a treatment for acute respiratory distress syndrome in patients with COVID-19
    Medical condition: Acute respiratory distress syndrome in patients with COVID-19
    Disease: Version SOC Term Classification Code Term Level
    21.1 10038738 - Respiratory, thoracic and mediastinal disorders 10001052 Acute respiratory distress syndrome PT
    23.0 10021881 - Infections and infestations 10051905 Coronavirus infection PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
    Download Options:
    Number of Trials to download:
    Download Content:
    Download Format:
    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
    1  2  3  Next»
    Query did not match any studies.
    For support, Contact us.
    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

    European Medicines Agency © 1995-Fri May 09 07:53:43 CEST 2025 | Domenico Scarlattilaan 6, 1083 HS Amsterdam, The Netherlands
    EMA HMA