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Clinical trials for Hypothalamus

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43881   clinical trials with a EudraCT protocol, of which   7295   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    22 result(s) found for: Hypothalamus. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2021-000146-18 Sponsor Protocol Number: TM008 Start Date*: 2022-02-09
    Sponsor Name:Saniona A/S
    Full Title: A Phase 2b, Double-blind, Randomized, Placebo-controlled, Dose finding, Multi-center, 36-week Safety and Efficacy Study with Open-label Extension Period of Tesomet in Subjects with Hypothalamic Obe...
    Medical condition: Hypothalamic Obesity
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004860 10013367 Disorders of the pituitary gland and its hypothalamic control LLT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-000871-17 Sponsor Protocol Number: GLP1 Start Date*: 2014-08-21
    Sponsor Name:Eva Marie Erfurth [...]
    1. Eva Marie Erfurth
    2. Lund University
    3. Lund University
    Full Title: Effects of Exenatid on Weigth during diet and Caloric Restriction in patients with Craniopharyngioma and Hypothalamic obesity
    Medical condition: Operated craniopharyngioma with hypothalamic involvement, Craniopharyngioma is a pituitary tumor that often affects the hypothalamus. These patients suffer from an intractable weight gain. This is ...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-010357-12 Sponsor Protocol Number: 43/2009 Start Date*: 2009-03-16
    Sponsor Name:POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI
    Full Title: Hypothalamus-Pituitary-Adrenal Axis function in the topical management with clobetasol propionate of oral lichen planus (OLP
    Medical condition: oral lichen planus
    Disease: Version SOC Term Classification Code Term Level
    9.1 10030983 Oral lichen planus LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-001584-23 Sponsor Protocol Number: 7605 Start Date*: 2018-10-30
    Sponsor Name:University Hospital of Montpellier
    Full Title: "Microglial Activation in Narcolepsy Type 1: Positron Emission Tomography (PET) Study in [18F] DPA-714"
    Medical condition: To study in vivo microglial activation by PET [18F] DPA-714 in NT1 patients with recent evolution (appearance of the first symptoms - somnolence and cataplexy-less than 2 years ago) compared with c...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-000082-72 Sponsor Protocol Number: RC-P0054 Start Date*: 2019-01-03
    Sponsor Name:Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL)
    Full Title: Study of the communication of the hypothalamus with the periphery: impact of metformin on leptin transport in the cerebrospinal fluid of obese patients. A monocentric prospective study
    Medical condition: OBESITY (BMI > 30)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10027433 - Metabolism and nutrition disorders 10029883 Obesity PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2005-005613-38 Sponsor Protocol Number: 44648368 Start Date*: 2006-05-31
    Sponsor Name:Dr. Chris Thompson
    Full Title: Assessment of platelet function in the hypopituitary population. Does hormone replacement therapy alter thrombotic risk?
    Medical condition: Hypopituitarism refers to decreased secretion of pituitary hormones, which can result from diseases of the pituitary gland or from diseases of the hypothalamus, which cause diminished secretion of ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-005404-17 Sponsor Protocol Number: TAO-EX-2012 Start Date*: 2013-01-16
    Sponsor Name:Center for Neuropsychiatric Schizophrenia Research
    Full Title: Treatment of antipsychotic associated obesity with a GLP-1 Analogue: the TAO study
    Medical condition: Obesity
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2022-000161-40 Sponsor Protocol Number: AdrenalClock Start Date*: 2022-07-18
    Sponsor Name:Medical University of Vienna, Division of Endocrinology
    Full Title: Investigating cardiometabolic risk factors and changes in chronobiology patterns in patients with autonomous adrenal cortisol secretion
    Medical condition: Autonomous cortisol secretion in patients with adrenal adenoma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-004954-27 Sponsor Protocol Number: Start Date*: 2012-12-07
    Sponsor Name:Clinical Trials and Research Governance, University of Oxford
    Full Title: A single centre open-label randomised controlled trial of long term pituitary down-regulation before in vitro fertilisation for women with endometriosis: a pilot study
    Medical condition: Sub-infertility due to endometriosis
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004872 10016402 Female infertility of pituitary-hypothalamic origin LLT
    Population Age: Adults Gender: Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-002392-28 Sponsor Protocol Number: RM-493-Supplementation-Therapy Start Date*: 2014-11-28
    Sponsor Name:Charité Univeritaetsmedizin Berlin
    Full Title: Setmelanotide (RM-493) Treatment Trial in Patients with rare genetic disorders of obesity
    Medical condition: Body weight is regulated within the hypothalamus. In rare cases mutations in genes, which are embedded in the signaling cascades of the hypothalamus lead to early onset severe obesity. POMC is one ...
    Disease:
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2018-003672-12 Sponsor Protocol Number: TM005 Start Date*: 2019-01-29
    Sponsor Name:Saniona A/S
    Full Title: A 24-week phase 2, double-blind, randomized, placebo-controlled, single-centre safety and efficacy study to evaluate overall safety and tolerability of co-administration of tesofensine and metoprol...
    Medical condition: Hypothalmic injury-induced obesity (HIO)
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004860 10013367 Disorders of the pituitary gland and its hypothalamic control LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2017-004973-15 Sponsor Protocol Number: TETRO Start Date*: 2018-04-09
    Sponsor Name:Leiden University Medical Center
    Full Title: Reversal through TRH of opioid-induced respiratory depression (OIRD) in healthy volunteers
    Medical condition: opioid-induced respiratory depression
    Disease: Version SOC Term Classification Code Term Level
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10038678 Respiratory depression PT
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10038680 Respiratory depression postoper LLT
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10078059 Central respiratory depression LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-000492-16 Sponsor Protocol Number: CCR2739 Start Date*: 2006-07-20
    Sponsor Name:Royal Marsden Foundation Hospital
    Full Title: A Phase II, Single-Centre, Randomised, Controlled, Open-Label Clinical Trial to Compare the Efficacy and Safety of Three Therapeutic Interventions on the Treatment of Hypothalamic Obesity due to Ch...
    Medical condition: Hypothalamic Obesity due to Childhood Cancer with Cranial Insults
    Disease: Version SOC Term Classification Code Term Level
    8.1 10021111 LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2020-004115-27 Sponsor Protocol Number: IIBSP-OXI-2020-102 Start Date*: 2021-05-10
    Sponsor Name:Institut de Recerca Hospital de la Santa Creu i Sant Pau - IIB Sant Pau
    Full Title: Identification and clinical relevance of oxytocin deficient status: randomized, crossover, placebo-controlled pathophysiological pilot study: GLP1 study
    Medical condition: Hypopituitarism
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2022-004107-32 Sponsor Protocol Number: RM-493-030 Start Date*: 2023-01-23
    Sponsor Name:Rhythm Pharmaceuticals, Inc.
    Full Title: A Phase 2, Open-Label 20-Week Study to Evaluate the Safety and Efficacy of Setmelanotide in Subjects with Hypothalamic Obesity
    Medical condition: Hypothalamic Obesity
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2011-001699-20 Sponsor Protocol Number: 042011 Start Date*: 2012-05-18
    Sponsor Name:St. Anna Kinderkrebsforschung, GmbH
    Full Title: LCH-IV International Collaborative Treatment Protocol for Children and Adolescents with LANGERHANS CELL HISTIOCYTOSIS
    Medical condition: Langerhans cell histiocytosis
    Disease:
    Population Age: Newborns, Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: AT (Ongoing) BE (Ongoing) NL (Ongoing) DK (Ongoing) NO (Ongoing) IE (Ongoing) IT (Ongoing) SE (Ongoing) CZ (Ongoing) ES (Ongoing) PL (Ongoing) GR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-001750-28 Sponsor Protocol Number: 35456235 Start Date*: 2007-02-08
    Sponsor Name:Rigshospitalet, Psykiatrisk Klinik
    Full Title: Associationer mellem genpolymorfier, endofænotyper for depression og antidepressiv behandling
    Medical condition: Forsøget fortages på raske personer med disposition til affektiv lidelse.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012378 Depression LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-003336-12 Sponsor Protocol Number: FatherTrials2015 Start Date*: 2016-03-23
    Sponsor Name:Universiteit Leiden
    Full Title: Father Trials: Hormonal Experiments on Prenatal and Postnatal Parenting
    Medical condition: There are no medical conditions or diseases under investigation
    Disease: Version SOC Term Classification Code Term Level
    18.1 10022891 - Investigations 10047146 Vasopressin LLT
    18.1 10022891 - Investigations 10033329 Oxytocin PT
    Population Age: Adults Gender: Male
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-003370-27 Sponsor Protocol Number: DMFMRI201303 Start Date*: 2014-09-25
    Sponsor Name:Rainer Rupprecht, Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg am Bezirksklinikum
    Full Title: Functional MRI (fMRI) after challenge and treatment with antidepressants and their relation to the clinical course, to the Hypothalamus-Hypophysis-Adrenocortical Axis and the colon microbiome
    Medical condition: Major Depressive Disorder is a chronic stress related disorder characterized by depressed mood and by vegetative and cognitive symptoms. Moreover, genetic, neuroendocrine and neurochemical biomarke...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-003275-34 Sponsor Protocol Number: UHFRT Start Date*: 2021-11-08
    Sponsor Name:IRCCS-A.O.U. SAN MARTINO-IST
    Full Title: TEMOZOLOMIDE + ULTRA-HYPER-FRACTIONATED RADIOTHERAPY VS TEMOZOLOMIDE ALONE FOR THE MAINTENANCE TREATMENT OF GLIOBLASTOMA PATIENTS - PILOT STUDY
    Medical condition: histologically confirmed glioblastoma according to WHO criteria (grade IV).
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10018336 Glioblastoma PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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