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Clinical trials for Laxatives

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44349   clinical trials with a EudraCT protocol, of which   7376   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    57 result(s) found for: Laxatives. Displaying page 1 of 3.
    1  2  3  Next»
    EudraCT Number: 2013-002948-91 Sponsor Protocol Number: 1315V9232 Start Date*: Information not available in EudraCT
    Sponsor Name:Shionogi Inc.
    Full Title: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Naldemedine in the Treatment of Opioid-induced Constipation in Subjects with Non-malignant Chronic Pain Receiving Opioid Therapy
    Medical condition: Opioid-induced Constipation in Subjects with Non-malignant Chronic Pain Receiving Opioid Therapy
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed) AT (Completed) ES (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2021-000239-29 Sponsor Protocol Number: PEC19156 Start Date*: 2021-07-09
    Sponsor Name:BIOGAIA PHARMA
    Full Title: A randomized placebo-controlled study to assess safety and preliminary efficacy of BGP345A in patients with constipation due to the use of opioid-based medications for the management of chronic non...
    Medical condition: Opioid induced constipation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2012-005601-46 Sponsor Protocol Number: 000081 Start Date*: 2013-05-15
    Sponsor Name:Ferring International Pharmascience Center US, Inc.
    Full Title: A Multicenter, Open-label, Safety and Tolerability Extension Trial of 5 mg and 10 mg Elobixibat Daily in the Treatment of Chronic Idiopathic Constipation
    Medical condition: Chronic idiopathic constipation
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004856 10072118 Chronic idiopathic constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) SE (Completed) SK (Completed) HU (Completed) CZ (Completed) GB (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2008-005692-10 Sponsor Protocol Number: 3200K1-4006-WW Start Date*: 2009-03-25
    Sponsor Name:Wyeth Research Division of Wyeth Pharmaceuticals Inc.
    Full Title: A Randomized, Double-blind, Placebo-Controlled Trial Evaluating the Safety and Efficacy of Subcutaneous Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Subjects With Cancer-Rel...
    Medical condition: Opioid-induced constipation in subjects with cancer-related pain Estreñimiento inducido por opiáceos en pacientes con dolor de origen tumoral
    Disease: Version SOC Term Classification Code Term Level
    9.1 10010774 Constipation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2009-011853-42 Sponsor Protocol Number: NALCOL 01 Start Date*: 2009-12-22
    Sponsor Name:Norfolk and Norwich University Hospital NHS Trust
    Full Title: NALOXONE HYDROCHLORIDE SR GASTRO-RESISTANT SUSTAINED RELEASE CAPSULES AS A TREATMENT FOR FUNCTIONAL CONSTIPATION: A RANDOMISED, DOUBLE BLIND CONTROLLED TRIAL IN SECONDARY CARE
    Medical condition: Functional constipation
    Disease: Version SOC Term Classification Code Term Level
    11 10010774 Constipation LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-000927-38 Sponsor Protocol Number: PLATONEv1.0.2020 Start Date*: 2021-07-27
    Sponsor Name:AIGO - Associazione Italiana Gastroenterologi ed Endoscopisti DIgestivi Ospedalieri
    Full Title: Bowel preparation with either novel 1L PEG+Asc or 2L PEG+Asc solution: a multicenter, randomized study in elderly outpatients: the PLATONE Study.
    Medical condition: Bowel preparation for diagnostic / operative colonscopy in outpatient
    Disease: Version SOC Term Classification Code Term Level
    21.0 10022891 - Investigations 10010011 Colonoscopy normal PT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-000408-36 Sponsor Protocol Number: 08440012010002 Start Date*: 2022-10-25
    Sponsor Name:ZonMw
    Full Title: OMAMA-study – prevention of opioid-induced constipation in patients with advanced cancer
    Medical condition: Opioid-induced constipation in patients with advanced cancer, starting with opioids for pain
    Disease: Version SOC Term Classification Code Term Level
    24.0 10017947 - Gastrointestinal disorders 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2013-002241-11 Sponsor Protocol Number: 1314V9231 Start Date*: 2014-03-10
    Sponsor Name:Shionogi Inc.
    Full Title: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Naldemedine in the Treatment of Opioid-induced Constipation in Subjects with Non-malignant Chronic Pain Receiving Opioid Therapy
    Medical condition: Opioid-induced Constipation in Subjects with Non-malignant Chronic Pain Receiving Opioid Therapy
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) AT (Completed) CZ (Completed) GB (Completed) ES (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2013-000180-81 Sponsor Protocol Number: SLT4501 Start Date*: 2013-09-20
    Sponsor Name:Mundipharma Research GmbH & Co. KG
    Full Title: A single-arm, open-label, multicentre, non-randomised, study to assess the effect and tolerability of standardised laxative therapy (SLT) for the reversal of opioid-induced constipation (OIC) in s...
    Medical condition: Assess the effect and tolerability of standardised laxative therapy (SLT) for the reversal of opioid-induced constipation (OIC) in subjects suffering from malignant or non-malignant pain that requi...
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) SE (Completed)
    Trial results: View results
    EudraCT Number: 2012-004311-31 Sponsor Protocol Number: 0177/DEV Start Date*: 2013-03-20
    Sponsor Name:Develco Pharma Schweiz AG
    Full Title: Randomised, double-blind, placebo-controlled, parallel-group design, multi-centre, dose-escalation phase III trial to investigate the efficacy, safety, and tolerability of Naloxone HCl PR tablets a...
    Medical condition: Opioid-induced bowel dysfunction (OBD) involves not only constipation, but also a constellation of symptoms including incomplete evacuation, bloating, abdominal distension, and increased gastric re...
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) AT (Completed) CZ (Completed) DE (Completed) GB (Completed) SK (Completed) ES (Completed) IT (Completed) PL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-003218-14 Sponsor Protocol Number: 0176/DEV Start Date*: 2013-01-22
    Sponsor Name:Develco Pharma Schweiz AG
    Full Title: Randomised, double-blind, placebo-controlled, parallel-group design, multi-centre, dose-escalation phase III trial to investigate the efficacy, safety, and tolerability of Naloxone HCl PR tablets a...
    Medical condition: Opioid-induced bowel dysfunction (OBD) involves not only constipation, but also a constellation of symptoms including incomplete evacuation, bloating, abdominal distension, and increased gastric re...
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) HU (Completed) CZ (Completed) SK (Completed) ES (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2011-001986-41 Sponsor Protocol Number: D3820C00005 Start Date*: 2012-02-21
    Sponsor Name:AstraZeneca AB
    Full Title: A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of NKTR-118 in Patients with Non-Cancer-Related Pain and Opioid-Induced Constipation (OIC)
    Medical condition: Opioid-induced constipation (OIC)
    Disease: Version SOC Term Classification Code Term Level
    14.1 10017947 - Gastrointestinal disorders 10010774 Constipation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) HU (Completed) CZ (Completed) BE (Completed) ES (Completed) SE (Completed)
    Trial results: View results
    EudraCT Number: 2011-001987-24 Sponsor Protocol Number: D3820C00004 Start Date*: 2011-08-22
    Sponsor Name:AstraZeneca AB
    Full Title: A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of NKTR-118 in Patients with Non-Cancer-Related Pain and Opioid-Induced Constipation (OIC)
    Medical condition: Opioid-induced constipation (OIC)
    Disease: Version SOC Term Classification Code Term Level
    14.1 10017947 - Gastrointestinal disorders 10010774 Constipation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) SK (Completed)
    Trial results: View results
    EudraCT Number: 2010-021879-85 Sponsor Protocol Number: 10050 Start Date*: 2010-09-08
    Sponsor Name:University of Nottingham
    Full Title: Mode of action of Moviprep:impact on distribution of intestinal fluid and colonic microbiota
    Medical condition: for bowel cleansing prior to any clinical procedure requiring a clean bowel, e.g, bowel endoscopy, lower gastrointestinal tract radiology or digestive tract surgery.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2012-004367-44 Sponsor Protocol Number: picopru Start Date*: 2013-05-28
    Sponsor Name:KU LEUVEN
    Full Title: A RANDOMISED, PLACEBO-CONTROLLED, CROSSOVER STUDY TO COMPARE THE EFFECT OF SODIUM PICOSULFATE AND PRUCALOPRIDE ON COLONIC SENSORY AND MOTOR RESPONSE TO DISTENSION IN HEALTHY SUBJECTS
    Medical condition: SENSORY AND MOTOR RESPONSE OF DESCENDING COLON TO DISTENSION WILL BE STUDIED IN HEALTHY SUBJECTS
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2019-003850-10 Sponsor Protocol Number: Laxatives26092019 Start Date*: 2020-02-10
    Sponsor Name:Hospital Pharmacy Funen, Research Department, Odense University Hospital
    Full Title: Oral laxatives after hip fracture surgery: A randomised controlled trial.
    Medical condition: The aim is to investigate which constipation therapy is the most optimal choice for postoperative treatment in older patients after hip fracture surgery.
    Disease: Version SOC Term Classification Code Term Level
    23.0 10022117 - Injury, poisoning and procedural complications 10020100 Hip fracture PT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2005-001723-10 Sponsor Protocol Number: 767905/012 Start Date*: 2005-08-26
    Sponsor Name:GlaxoSmithKline R & D Limited
    Full Title: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Efficacy and Safety of Alvimopan 0.5mg Once Daily and 0.5mg Twice Daily for 12 Weeks for the Treatment of O...
    Medical condition: Opioid-induced bowel dysfunction
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed) FI (Completed) GB (Completed) DE (Completed) DK (Completed) EE (Completed) AT (Completed)
    Trial results: View results
    EudraCT Number: 2007-005421-30 Sponsor Protocol Number: 07-IN-NX003 Start Date*: 2008-04-17
    Sponsor Name:Nektar Therapeutics
    Full Title: A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Multiple-Dose, Dose Escalation Study to Evaluate the Efficacy, Safety and Tolerability of NKTR-118 in Patients with Opioid-Induced Constipat...
    Medical condition: Opioid induced constipation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-022991-29 Sponsor Protocol Number: SMR/0211OBD-1033 Start Date*: 2011-02-01
    Sponsor Name:Sucampo Pharma Americas, Inc.
    Full Title: A Multicenter, Randomized, Placebo-controlled, Double-blinded Study of the Efficacy and Safety of Lubiprostone in Patients with Opioid-induced Bowel Dysfunction
    Medical condition: Opioid-induced Bowel Dysfunction
    Disease: Version SOC Term Classification Code Term Level
    14.0 10017947 - Gastrointestinal disorders 10061247 Intestinal functional disorder PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed) BE (Completed) SE (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2005-001725-28 Sponsor Protocol Number: 767905/014 Start Date*: 2005-08-26
    Sponsor Name:GlaxoSmithKline R & D Limited
    Full Title: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Long-Term Safety of Alvimopan 0.5mg Twice Daily for 12 Months for the Treatment of Opioid-Induced Bowel Dys...
    Medical condition: Opioid-induced bowel dysfunction
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed) FI (Completed) SE (Completed) GB (Completed) HU (Completed) AT (Completed) DK (Completed) PT (Completed) ES (Completed)
    Trial results: View results
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