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Clinical trials for Medication discontinuation

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    1,136 result(s) found for: Medication discontinuation. Displaying page 1 of 57.
    1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2018-002623-42 Sponsor Protocol Number: 66623 Start Date*: 2019-02-18
    Sponsor Name:Academic Medical Center
    Full Title: Vasospastic angina treatment by Endothelin Receptor Antagonism; a proof of concept study
    Medical condition: Vasospastic angina, i.e. epicardial vasospasm or microvascular coronary dysfunction.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10002383 Angina pectoris PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-004836-31 Sponsor Protocol Number: Tav01-13 Start Date*: 2014-04-07
    Sponsor Name:Montavit Ges.m.b.H.
    Full Title: Double-blind, randomised, placebo-controlled study evaluating the efficacy and safety of Tavipec capsules in acute Bronchitis A prsopective, multi-centre, parallel group, interventional clinical ph...
    Medical condition: acute bronchitis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2014-003834-21 Sponsor Protocol Number: 80-83600-98-10086 Start Date*: 2016-09-23
    Sponsor Name:Erasmus Medical Center Rotterdam
    Full Title: Effectiveness of penfluridol (oral long acting neuroleptic) as compared to second generation oral neuroleptics in psychotic disorder patients: an open label randomized controlled trial.
    Medical condition: Psychotic disorders
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2015-003957-16 Sponsor Protocol Number: ZonMw80-83600-98-3074 Start Date*: 2016-08-30
    Sponsor Name:University Medical Centre Groningen
    Full Title: A randomised controlled trial of oral S-ketamine as add-on medication for patients with treatment-resistant major depressive disorder
    Medical condition: Treatment resistant major depressive disorder
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-002406-12 Sponsor Protocol Number: NL6220204217 Start Date*: 2019-04-04
    Sponsor Name:University Medical Center Groningen
    Full Title: HAMLETT. Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment. A pragmatic single blind RCT of continuation versus discontinuation/ dose reduction of antipsychotic medicati...
    Medical condition: HAMLETT compares regular treatment guidelines for patients in remission after a first episode of psychosis, namely continuation with antipsychotic medication for at least one year, with early dose ...
    Disease:
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-000177-37 Sponsor Protocol Number: LITE Start Date*: 2017-09-21
    Sponsor Name:King's College London [...]
    1. King's College London
    2. King's College Hospital
    Full Title: Low-dose IL-2 to expand endogenous regulatory T cells and achieve tolerance in liver transplantation
    Medical condition: Discontinuation of immunosuppression in liver transplantation
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10024714 Liver transplant PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2013-002977-23 Sponsor Protocol Number: Tav02-13 Start Date*: 2013-12-13
    Sponsor Name:Montavit Ges.m.b.H.
    Full Title: Double-blind, randomised, placebo-controlled study evaluating the efficacy and Safety of Tavipec® capsules in acute Rhinosinusitis A prospective, multi-centre, parallel group, interventional clinic...
    Medical condition: Acute Rhinosinusitis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2014-002765-30 Sponsor Protocol Number: ABR49490 Start Date*: 2015-06-12
    Sponsor Name:EGRIS
    Full Title: European Long-acting Antipsychotics in Schizofrenia Trial EULAST
    Medical condition: Schizophrenia ICD-10 code F20
    Disease: Version SOC Term Classification Code Term Level
    19.0 10037175 - Psychiatric disorders 10039626 Schizophrenia PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Prematurely Ended) AT (Completed) IT (Completed) NO (Completed) BE (Completed) ES (Completed) DK (Completed) HU (Completed) RO (Suspended by CA) CZ (Completed) GR (Completed)
    Trial results: View results
    EudraCT Number: 2020-002979-35 Sponsor Protocol Number: 209348 Start Date*: 2020-12-22
    Sponsor Name:GlaxoSmithKline Research & Development Limited
    Full Title: A Phase IIb Multi-Center, Randomised, Open Label Study to Assess the Efficacy and Safety of Sequential Treatment with GSK3228836 followed by Pegylated Interferon Alpha 2a in Participants with Chron...
    Medical condition: Chronic Hepatitis B
    Disease: Version SOC Term Classification Code Term Level
    20.1 10021881 - Infections and infestations 10008910 Chronic hepatitis B PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA) PL (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2005-000350-69 Sponsor Protocol Number: FTY720A2302E01 Start Date*: Information not available in EudraCT
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A two-year extension to a one-year, multicenter, open-label, randomized study to evaluate the safety and efficacy of FTY720 combined with tacrolimus and steroids versus MMF (Cellcept) combined with...
    Medical condition: De novo kidney transplantation
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-005451-42 Sponsor Protocol Number: DISCAP Start Date*: 2009-01-13
    Sponsor Name:University Medical Center Groningen
    Full Title: Long-term use of antipsychotics for behavioral symptoms in patients with mental retardation; a controlled discontinuation study
    Medical condition: Mental retardation
    Disease:
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2010-019765-28 Sponsor Protocol Number: SP0993 Start Date*: 2011-02-08
    Sponsor Name:UCB BIOSCIENCES GmbH
    Full Title: A MULTICENTER, DOUBLE BLIND, DOUBLE DUMMY, RANDOMIZED, POSITIVE CONTROLLED STUDY COMPARING THE EFFICACY AND SAFETY OF LACOSAMIDE (200 TO 600MG/DAY) TO CONTROLLED RELEASE CARBAMAZEPINE (400 TO 1200M...
    Medical condition: Epilepsy, partial onset or generalised tonic-clonic seizures.
    Disease: Version SOC Term Classification Code Term Level
    18.1 10029205 - Nervous system disorders 10015037 Epilepsy PT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) BE (Completed) CZ (Completed) FI (Completed) SE (Completed) HU (Completed) ES (Completed) PT (Completed) PL (Completed) SK (Completed) GB (Completed) GR (Completed) IT (Completed) LV (Completed) LT (Completed) BG (Completed) Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2018-003063-64 Sponsor Protocol Number: 3005031 Start Date*: 2018-10-05
    Sponsor Name:Orion Corporation, Orion Pharma
    Full Title: Open clinical trial to evaluate safety, tolerability, and efficacy of Dexdor for sedation in paediatric patients in intensive care settings. Multi-centre trial in Russia for marketing registratio...
    Medical condition: male and female patients aged 12 to 17 years with spontaneous or artificial ventilation and clinical need for prolonged (>24h) light to moderate sedation.
    Disease:
    Population Age: Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2010-023911-32 Sponsor Protocol Number: BAY86-5028 / 13363 Start Date*: 2011-05-04
    Sponsor Name:Bayer HealthCare AG
    Full Title: Multicenter, open-label, randomized, controlled parallel-group study to assess discontinuation rates, bleeding patterns, user satisfaction and adverse event profile of LCS12 in comparison to etonog...
    Medical condition: The aim of the present study is to examine the discontinuation rates in women (ages 18-35, inclusive) using LCS12 compared with the discontinuation rates in women using the ENG subdermal contracept...
    Disease: Version SOC Term Classification Code Term Level
    14.0 10042613 - Surgical and medical procedures 10010808 Contraception PT
    Population Age: Adults Gender: Female
    Trial protocol: SE (Completed) FI (Completed) GB (Completed) NO (Completed)
    Trial results: View results
    EudraCT Number: 2004-004377-28 Sponsor Protocol Number: CFTY720A0124E1 Start Date*: 2005-02-03
    Sponsor Name:Novartis Pharma AG
    Full Title: A two-year extension to a one-year, multicenter, partially blinded, double-dummy, randomized study to evaluate the efficacy and safety of FTY720 combined with reduced-dose or full-dose Neoral and c...
    Medical condition: Prophylaxis of kidney allograft rejection in de novo adult renal transplant recipients
    Disease: Version SOC Term Classification Code Term Level
    7.0 10023439 LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2013-003582-34 Sponsor Protocol Number: MK8835-002 Start Date*: 2014-05-29
    Sponsor Name:Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
    Full Title: A Phase III, Multicenter, Randomized, Double-Blind, Active-Comparator-Controlled Clinical Trial to Study the Safety and Efficacy of the Addition of Ertugliflozin (MK-8835/PF-04971729) Compared With...
    Medical condition: Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metaformin
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004861 10063624 Type II diabetes mellitus inadequate control LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) LT (Completed) HU (Completed) SK (Completed) RO (Completed)
    Trial results: View results
    EudraCT Number: 2013-003698-82 Sponsor Protocol Number: MK8835-005 Start Date*: 2014-07-09
    Sponsor Name:Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
    Full Title: A Phase III, Randomized, Double-Blind, Multicenter Study to Evaluate the Efficacy and Safety of the Combination of Ertugliflozin (MK-8835/PF-04971729) with Sitagliptin Compared with Ertugliflozin A...
    Medical condition: Treatment of type 2 diabetes mellitus (T2DM) and inadequate glycemic control on treatment with metformin.
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004861 10063624 Type II diabetes mellitus inadequate control LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) CZ (Completed) IT (Completed) GB (Completed) FI (Completed) SK (Completed) BG (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2004-000587-26 Sponsor Protocol Number: CFTY720A2218E1 Start Date*: 2005-02-01
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A 24-month Extension to a one-year, multicentre, double-blinded, double-dummy, randomized study to evaluate the safety and efficacy of two doses of FTY720 combined with full-dose Neoral and steroid...
    Medical condition: Prophylaxis of kidney allograft rejection in de novo adult renal transplant recipients
    Disease: Version SOC Term Classification Code Term Level
    7.0 10023439 LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: HU (Completed) DE (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2021-006108-34 Sponsor Protocol Number: 10140021910006 Start Date*: 2022-09-29
    Sponsor Name:AmsterdamUMC (location VUmc)
    Full Title: Trial Examining Methods for Antidepressant Discontinuation
    Medical condition: Major Depressive Disorder
    Disease: Version SOC Term Classification Code Term Level
    21.1 10037175 - Psychiatric disorders 10025464 Major depressive disorder, single episode in full remission LLT
    21.1 10037175 - Psychiatric disorders 10025455 Major depressive disorder, recurrent episode, in full remission LLT
    20.0 10037175 - Psychiatric disorders 10025465 Major depressive disorder, single episode, in partial or unspecified remission LLT
    20.0 10037175 - Psychiatric disorders 10025456 Major depressive disorder, recurrent episode, in partial or unspecified remission LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2019-002607-18 Sponsor Protocol Number: AmiloridNS-01 Start Date*: 2020-02-11
    Sponsor Name:University Hospital Tuebingen
    Full Title: Randomized, controlled interventional trial to investigate the efficacy of amiloride for the treatment of edema in human nephrotic syndrome
    Medical condition: Nephrotic syndrome
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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