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Clinical trials for Midazolam

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

  • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).


    The EU Clinical Trials Register currently displays   44346   clinical trials with a EudraCT protocol, of which   7374   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    140 result(s) found for: Midazolam. Displaying page 1 of 7.
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    EudraCT Number: 2014-003269-46 Sponsor Protocol Number: PedMicMida Start Date*: 2015-04-02
    Sponsor Name:Erasmus MC - Sophia
    Full Title: Pediatric microdosing midazolam: elucidating age-related changes in oral drug absorption
    Medical condition: Age-related changes in drug absorption and metabolism in children
    Disease:
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-003293-93 Sponsor Protocol Number: 14072011 Start Date*: 2011-09-23
    Sponsor Name:Sint Antonius Ziekenhuis
    Full Title: Cyp3A4 metabolism before and after surgery induced weight loss in morbidly obese patients, using midazolam as a model drug
    Medical condition: Morbid obesity
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-004958-34 Sponsor Protocol Number: UNOLE0457 Start Date*: 2015-01-30
    Sponsor Name:University of Leicester
    Full Title: Midazolam Measurement and Modelling using Matrix Samplers
    Medical condition: Not applicable
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2021-004789-36 Sponsor Protocol Number: 173-01 Start Date*: 2022-06-29
    Sponsor Name:Universität Heidelberg
    Full Title: Randomized, controlled trial of the use of intranasal midazolam for the treatment of terminal agitation in palliative care patients
    Medical condition: Terminal agitation in the final phase
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-000026-54 Sponsor Protocol Number: 18662008 Start Date*: 2018-09-12
    Sponsor Name:Medicinkliniken, Sjukhuset Lidköping
    Full Title: A comparison of sedatives used during gastroscopy, alfentanil vs midazolam
    Medical condition: Sedative effect during gastroscopy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-002242-20 Sponsor Protocol Number: ENT1 Start Date*: 2013-02-04
    Sponsor Name:Royal Bournemouth & Christchurch Hospitals NHS Foundation Trust
    Full Title: A single-centre, randomised controlled study of Entonox versus midazolam in upper GI endoscopy.
    Medical condition: Any patient with symptoms requiring investigation with a gastroscopy. There is no single condition to which this would apply.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2006-006031-50 Sponsor Protocol Number: 3005013 Start Date*: 2007-04-24
    Sponsor Name:Orion Corporation Orion Pharma
    Full Title: A PROSPECTIVE, MULTI-CENTRE, RANDOMISED, DOUBLE-BLIND COMPARISON OF INTRAVENOUS DEXMEDETOMIDINE WITH MIDAZOLAM FOR CONTINUOUS SEDATION OF VENTILATED PATIENTS IN INTENSIVE CARE UNIT
    Medical condition: Patients requiring mechanical ventilation and sedation in ICU.
    Disease: Version SOC Term Classification Code Term Level
    8.0 10039897 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) GB (Completed) BE (Completed) NL (Completed) DE (Completed) FR (Completed) EE (Completed)
    Trial results: View results
    EudraCT Number: 2012-005215-42 Sponsor Protocol Number: KloMid02 Start Date*: 2013-04-12
    Sponsor Name:Department of Anesthesiology and Intensive Care Medicine
    Full Title: Children's mood/anxiety, pain, nausea and behavioral changes after premedication with Clonidine versus Midazolam in ENT day surgery.
    Medical condition: Preanesthetic Medication at ear-nose-throat surgery
    Disease:
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-012808-11 Sponsor Protocol Number: MID001 Start Date*: Information not available in EudraCT
    Sponsor Name:Therakind Limited
    Full Title: An open label, single dose, pharmacokinetic study of oromucosal midazolam administered to children from 3 months to less than 18 years undergoing routine elective surgery
    Medical condition: In the context of the trial, the IMP is to be used as anaesthetic premedication in children undergoing elective routine surgery. (The medical condition for marketing is acute seizures in children ...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10058073 Anaesthetic premedication LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-004480-31 Sponsor Protocol Number: PSIKET_001CZE Start Date*: 2020-07-14
    Sponsor Name:Národní ústav duševního zdraví
    Full Title: Psilocybin versus ketamine – fast acting antidepressant strategies in treatment-resistant depression
    Medical condition: The study will include 60 patients with pharmaco-resistant depression (30 male, 30 female, aged 18–65). The basic inclusion criterion is the diagnosis of pharmaco-resistant moderate to severe depre...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2014-003582-24 Sponsor Protocol Number: CLON01 Start Date*: 2015-06-15
    Sponsor Name:Universitätsklinikum Erlangen
    Full Title: A double blind, randomised, multicentre, active controlled, parallel-group, phase III trial to evaluate the efficacy, safety and pharmacokinetics of intravenous clonidine (hydrochloride) compared t...
    Medical condition: sedation in intensive care
    Disease: Version SOC Term Classification Code Term Level
    18.1 10029205 - Nervous system disorders 10039897 Sedation PT
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Completed) DE (Prematurely Ended) SE (Completed) IT (Prematurely Ended) CZ (Completed) EE (Prematurely Ended) ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2013-002428-17 Sponsor Protocol Number: 2013052044 Start Date*: 2013-10-04
    Sponsor Name:Gastroenheden D, Herlev Hospital
    Full Title: Nurse Administered Propofol Sedation vs combined sedation with midazolam/fentanil for colonoscopy in patients with IBD. A randomised controlled trial of satisfaction and adhearence to treatment pro...
    Medical condition: Satisfaction with sedation during colonoscopy in patients with inflammatory bowel disease
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004865 10049683 Monitored anesthesia care sedation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2016-004555-79 Sponsor Protocol Number: 16-115 Start Date*: 2017-08-08
    Sponsor Name:RWTH Aachen University represented by the Rector himself, represented by the Dean of the Medical Faculty
    Full Title: Impact of preoperative midazolam on outcome of elderly patients: a multicenter randomised controlled trial
    Medical condition: Under investigation are elderly patients (≥65 years of age) undergoing each kind of surgery with planned general or combined regional and general anaesthesia. Primary, we will investigate the posto...
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2022-003381-21 Sponsor Protocol Number: RAFAEL Start Date*: 2023-09-11
    Sponsor Name:Psyon, s.r.o.
    Full Title: Regression of atherosclerosis induced by life changing experience with psilocybin
    Medical condition: Ischemic Heart Disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2011-003216-23 Sponsor Protocol Number: UF8736 Start Date*: Information not available in EudraCT
    Sponsor Name:CHRU MONTPELLIER
    Full Title: Intranasal Midazolam versus intranasal Ketamine to sedate newborns for intubation in delivery room
    Medical condition: Maladie des membranes hyalines du nouveau-né (Code CIM : P22.OX-001)
    Disease:
    Population Age: Preterm newborn infants, Under 18 Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-004890-26 Sponsor Protocol Number: R0115 Start Date*: 2005-01-07
    Sponsor Name:HULL AND EAST YORKSHIRE NHS TRUST
    Full Title: RANDOMISED CONTROLLED TRIAL OF SEDATION FOR COLONOSCOPY-ENTONOX VERSUS MIDAZOLAM/ FENTANYL
    Medical condition: COLONOSCOPY
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-002106-19 Sponsor Protocol Number: Start Date*: 2008-07-10
    Sponsor Name:Chelsea & Westminster NHS Foundation Trust
    Full Title: Remifentanil sedation for outpatient endoscopic procedures
    Medical condition: We are investigating the use of remifentanil for sedation in outpatient endoscopic procedures. It will be compared to 'current practice' sedation with midazolam and fentanyl. Patient who are due to...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-001814-34 Sponsor Protocol Number: OPI 04/006 Start Date*: 2006-09-12
    Sponsor Name:The Norwegian University of Science and Technology
    Full Title: Effects of hypothermia on the disposition of morphine, fentanyl, midazolam and propofol in intensive care unit patients
    Medical condition: Patients treated with therapeutic hypothermia (33-34 °C) and a control group of normothermic patients matched on sex, age and duration of morphine infusion.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: View results
    EudraCT Number: 2005-002782-37 Sponsor Protocol Number: ENT05 Start Date*: 2005-11-17
    Sponsor Name:Heart of England NHS Foundation Trust
    Full Title: A Randomised Trial of Inhaled Entonox Plus Local Anaesthesia Versus Intravenous Midazolam Plus Local Anaesthesia To Improve Pain Control During Bone Marrow Biopsy
    Medical condition: This study will involve a group of patients requiring diagnostic bone marrow aspiration and biopsy. The reasons for these will include haematological abnormalities of the blood count , which may be...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-003307-20 Sponsor Protocol Number: SPICEIII Start Date*: 2014-11-06
    Sponsor Name:ANZIC RESEARCH CENTRE
    Full Title: "Sedation Practices in Intensive Care Evaluation: SPICE III – A Prospective Multicentre Randomised Controlled Trial of Early Goal Direct Sedation vs. Standard Care Sedation”
    Medical condition: adult patients hospitalized in intensive therapy unit undergoing continuous and immediate sedation for at least 24 hours
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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