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Clinical trials for NSAIDs

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44339   clinical trials with a EudraCT protocol, of which   7369   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    525 result(s) found for: NSAIDs. Displaying page 1 of 27.
    1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2015-001669-16 Sponsor Protocol Number: 80-83600-98-3143 Start Date*: 2015-12-21
    Sponsor Name:Erasmus MC
    Full Title: Duloxetine for chronic osteoarthritis pain; an important alternative?
    Medical condition: osteoarthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-003407-34 Sponsor Protocol Number: pre-CIN Start Date*: 2021-06-01
    Sponsor Name:Oslo University Hospital
    Full Title: A randomized clinical three-arm trial comparing inflammation and cystoid macular edema for the medication regimens preoperative and postoperative topical NSAIDs to only postoperative topical NSAIDs...
    Medical condition: Cataract surgery, and the medical treatment is anti-inflammatory eye drops to treat (and prevent) intraocular inflammation and development og cystoid macular edema.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-000431-14 Sponsor Protocol Number: M16-098 Start Date*: 2017-11-13
    Sponsor Name:AbbVie Deutschland GmbH & Co. KG
    Full Title: A Multicenter, Randomized, Double-Blind, Placebo Controlled Study Evaluating the Safety and Efficacy of Upadacitinib in Subjects with Active Ankylosing Spondylitis
    Medical condition: Active Ankylosing Spondylitis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10002556 Ankylosing spondylitis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) DK (Completed) DE (Completed) FI (Completed) CZ (Completed) GB (GB - no longer in EU/EEA) ES (Completed) PT (Completed) NL (Completed) BE (Completed) HU (Completed) PL (Completed) SE (Completed) HR (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2009-016374-32 Sponsor Protocol Number: MK-0462-082 Start Date*: 2010-02-15
    Sponsor Name:Merck & Co., Inc.
    Full Title: A Worldwide, Randomized, Double Blind, Placebo-Controlled, Parallel Group Clinical Trial to Evaluate the Safety and Efficacy of Rizatriptan for the Acute Treatment of Migraine in Children and Adole...
    Medical condition: Acute treatment of migraine, with or without aura, in children and adolescents, ages 6 to 17 years, who do not have a satisfactory response to prior treatment with nonsteroidal anti-inflammatory dr...
    Disease: Version SOC Term Classification Code Term Level
    12.0 10066635 Acute migraine LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Completed) DE (Completed) FI (Completed) BE (Completed) ES (Completed) EE (Completed) LV (Completed) SE (Completed) FR (Completed) DK (Completed) GB (Completed) IT (Completed) Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2018-002735-26 Sponsor Protocol Number: CC-10004-PSA-013 Start Date*: 2019-04-16
    Sponsor Name:Amgen Inc.
    Full Title: A PHASE 4, MULTICENTER, RANDOMIZED, DOUBLEBLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF APREMILAST (CC-10004) IN SUBJECTS WITH EARLY, OLIGOARTICULAR PSORIAT...
    Medical condition: EARLY, OLIGOARTICULAR PSORIATIC ARTHRITIS
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004859 10037160 Psoriatic arthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Restarted) FR (Prematurely Ended) ES (Ongoing) BE (Completed) NL (Completed) GB (GB - no longer in EU/EEA) IT (Completed)
    Trial results: View results
    EudraCT Number: 2015-004020-65 Sponsor Protocol Number: MK-8259-038 Start Date*: 2017-07-20
    Sponsor Name:Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
    Full Title: A Phase-IV, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial to Evaluate the Efficacy and Safety of Golimumab (MK-8259 [SCH 900259]) After Treatment Withdrawal, Compared With Cont...
    Medical condition: Treatment of non-radiographic axial spondyloarthritis (nr-axSpA)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10076297 Non-radiographic axial spondyloarthritis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed) ES (Completed) NL (Completed) PL (Completed) RO (Completed)
    Trial results: View results
    EudraCT Number: 2009-015515-40 Sponsor Protocol Number: vumc-09-206 Start Date*: 2009-11-20
    Sponsor Name:Wyeth Pharmaceuticals B.V.
    Full Title: PREVENTION OF THE PROGRESSION OF VERY EARLY SYMPTOMS INTO ANKYLOSING SPONDYLITIS: A PLACEBO CONTROLLED TRIAL WITH ETANERCEPT
    Medical condition: The diagnosis of Ankylosing Spondylitis (AS) requires radiographically proven sacroiliitis.Inflammation on MRI is a prognostic factor for the development of AS. The aim is the decrease of inflammat...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-005402-65 Sponsor Protocol Number: IIBSP-ANA-2013-163 Start Date*: 2015-01-19
    Sponsor Name:Institut de Recerca HSCSP
    Full Title: Efficacy and safety of anakinra (antagonist of the interleukin-1 receptor) in the treatment of periarticular inflammation in patients refractory to NSAID and / or steroids
    Medical condition: Inflammation in periarticular structures in patients refractory to NSAIDs and / or corticosteroids.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2013-003187-31 Sponsor Protocol Number: GN09CA403 Start Date*: 2015-03-19
    Sponsor Name:NHS Greater Glasgow & Clyde
    Full Title: Misoprostol for the Healing of Small Bowel Ulceration in Patients with Obscure Blood Loss while Taking Low-Dose Aspirin or Non-Steroidal Anti-inflammatory Drugs [MASTERS Trial]
    Medical condition: Small bowel ulcers associated with iron deficiency anaemia or obscure blood loss in patients using aspirin or non-steroidal anti-inflammatory drugs
    Disease: Version SOC Term Classification Code Term Level
    20.0 10005329 - Blood and lymphatic system disorders 10066761 Acute anaemia LLT
    20.0 10005329 - Blood and lymphatic system disorders 10057220 Acute post haemorrhagic anaemia LLT
    20.0 10005329 - Blood and lymphatic system disorders 10002034 Anaemia PT
    20.0 10005329 - Blood and lymphatic system disorders 10002034 Anaemia PT
    20.1 10005329 - Blood and lymphatic system disorders 10002083 Anaemia- Hypochromic microcytic picture LLT
    20.0 10005329 - Blood and lymphatic system disorders 10002062 Anaemia iron deficiency LLT
    20.0 10022891 - Investigations 10014816 Endoscopy small intestine PT
    20.0 10022891 - Investigations 10014816 Endoscopy small intestine PT
    20.1 10022891 - Investigations 10014817 Endoscopy small intestine abnormal PT
    20.1 10022891 - Investigations 10014818 Endoscopy small intestine normal PT
    20.1 10017947 - Gastrointestinal disorders 10041133 Small intestine ulcer PT
    20.1 10017947 - Gastrointestinal disorders 10041133 Small intestine ulcer PT
    20.1 10017947 - Gastrointestinal disorders 10041134 Small intestine ulcer haemorrhagic LLT
    20.1 10017947 - Gastrointestinal disorders 10055339 Small intestine ulcer hemorrhagic LLT
    20.0 10017947 - Gastrointestinal disorders 10045335 Ulcer small intestine LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2004-001239-42 Sponsor Protocol Number: RE&D VÚFB 8/2004/Tol-4 Start Date*: 2005-07-27
    Sponsor Name:RE&D VÚFB, s.r.o.
    Full Title: Evaluation of tolerance of preparation KETOPROFEN HBF GEL 2.5% (Herbacos-bofarma) and its comparison with preparation PROFENID GEL (Laboratoires Aventis) in patients with benign joint injury.
    Medical condition: treatment of bruised or sprained joints
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-003238-29 Sponsor Protocol Number: BRN-C-2015-03 Start Date*: 2016-04-06
    Sponsor Name:Fundación Sociedad Española de Médicos de Atención Primaria (SEMERGEN)
    Full Title: Pilot phase II clinical trial, randomized, double-blind, controlled, single-center study to evaluate the efficacy and safety of Solanum malacoxylon 9CH in patients with calcific tendinitis of shoulder
    Medical condition: Calcific tendinitis of shoulder
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2007-004973-25 Sponsor Protocol Number: PIAS005/06 Start Date*: 2008-05-28
    Sponsor Name:Laboratoire Expanscience
    Full Title: Prospective multicentric open clinical study comparing the efficacy and safety of piascledine 300 plus standard treatment versus standard treatment only in patients with osteoarthritis of the knee
    Medical condition: Osteoarthritis of the knee
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: View results
    EudraCT Number: 2013-000098-65 Sponsor Protocol Number: 09012313 Start Date*: 2013-09-13
    Sponsor Name:University of Tromsø
    Full Title: Treatment of Axial Spondyloarthritis with reduced doses of NSAIDs: Application of pharmacotherapeutic conditioning in clinical practice.
    Medical condition: Axial Spondyloarthritis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-000872-18 Sponsor Protocol Number: WA18221 Start Date*: 2008-04-15
    Sponsor Name:F. Hoffmann-La Roche Ltd.
    Full Title: A 12-week randomized, double blind, placebo-controlled, parallel group, 2-arm study to evaluate the efficacy and safety of tocilizumab in patients with active systemic juvenile idiopathic arthritis...
    Medical condition: Systemic Juvenile Idiopathic Arthritis (sJIA)
    Disease: Version SOC Term Classification Code Term Level
    13.1 10028395 - Musculoskeletal and connective tissue disorders 10059176 Juvenile idiopathic arthritis LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: BE (Completed) SE (Completed) DE (Completed) NO (Ongoing) CZ (Completed) ES (Completed) DK (Completed) NL (Completed) GR (Completed) SK (Completed) IT (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-004666-61 Sponsor Protocol Number: CACZ885H2255 Start Date*: 2008-10-09
    Sponsor Name:Novartis Pharma Services AG
    Full Title: An adaptive dose-ranging, multi-center, single-blind, double-dummy, active-controlled trial to determine the target dose of canakinumab (ACZ885) in the treatment of acute flares in gout patients wh...
    Medical condition: Acute gout (patients who are refractory or contraindicated to NSAIDs and/or colchicine)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10018628 Gout acute LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) DE (Completed) GB (Completed) FI (Prematurely Ended) FR (Completed)
    Trial results: View results
    EudraCT Number: 2010-018543-34 Sponsor Protocol Number: 12153599 Start Date*: 2010-06-11
    Sponsor Name:Orthopaedic Syrgery Unit Northern Jytland
    Full Title: NSAIDs INFLUENCE ON HEAL OF COLLES FRACTURE
    Medical condition: Ivestigations hypotheses: 1. NSAIDs provide a significant postoperative pain relief that can make mobilization / rehabilitation faster and easier oedema prophylaxis. 2. NSAIDs do not affect bone he...
    Disease: Version SOC Term Classification Code Term Level
    12.1 10009924 Colles' fracture LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2008-003596-46 Sponsor Protocol Number: 942/08 Start Date*: 2009-02-25
    Sponsor Name:POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI
    Full Title: Multicenter, not-for-profit clinical study, in a open, controlled, randomized fashion to compare tolerability, safety and efficacy of two different treatment strategies for non malignant, persisten...
    Medical condition: non neoplastic cronic pain
    Disease: Version SOC Term Classification Code Term Level
    9.1 10033371 Pain PT
    9.1 10050819 Musculoskeletal chest pain PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2018-002225-26 Sponsor Protocol Number: 280789 Start Date*: 2019-10-22
    Sponsor Name:HOSPITAL UNIVERSITARIO FUNDACION ALCORCON
    Full Title: EVALUATION OF THE COFACTORS IN THE MAINTENANCE PHASE REACTIONS AFTER MILK AND EGG ORAL IMMUNOTHERAPY
    Medical condition: Investigate the role of the drug in the possible allergic reactions as a cofactor
    Disease:
    Population Age: Adolescents, Under 18 Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-004088-34 Sponsor Protocol Number: APHP180571 Start Date*: 2020-02-04
    Sponsor Name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ( AP-HP)
    Full Title: Effect of two injections of synchronized methotrexate with the first injection of Adalimumab to prevent anti-adalimumab immunization in spondyloarthritis
    Medical condition: adult patients with Axial Spondyloarthritis who have an indication for anti-TNF therapy
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10028395 Musculoskeletal and connective tissue disorders SOC
    21.1 10028395 - Musculoskeletal and connective tissue disorders 10071400 Axial spondyloarthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-003679-48 Sponsor Protocol Number: CNTO1275AKS3001 Start Date*: 2015-12-09
    Sponsor Name:Janssen-Cilag International N.V.
    Full Title: A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Ustekinumab in the Treatment of Anti-TNF alpha Naive Subjects With Active Radiograph...
    Medical condition: Axial Spondyloarthritis
    Disease: Version SOC Term Classification Code Term Level
    19.0 10028395 - Musculoskeletal and connective tissue disorders 10071400 Axial spondyloarthritis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Prematurely Ended) PL (Completed)
    Trial results: View results
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