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Clinical trials for Nanobody

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
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    10 result(s) found for: Nanobody. Displaying page 1 of 1.
    EudraCT Number: 2010-019375-30 Sponsor Protocol Number: ALX-0681-2.1/10 Start Date*: 2010-09-07
    Sponsor Name:Ablynx
    Full Title: A Phase II single blind, randomized, placebo controlled trial to study the efficacy and safety of anti-von Willebrand factor Nanobody administered as adjunctive treatment to patients with acquired ...
    Medical condition: Acquired thrombotic thrombocytopenic purpura (TTP)
    Disease: Version SOC Term Classification Code Term Level
    16.0 10005329 - Blood and lymphatic system disorders 10043648 Thrombotic thrombocytopenic purpura PT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Prematurely Ended) AT (Completed) GB (Completed) DE (Completed) IT (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2016-001651-49 Sponsor Protocol Number: ALX0171-C201 Start Date*: 2016-11-07
    Sponsor Name:Ablynx NV
    Full Title: A randomized, double-blind, placebo-controlled, multicenter dose ranging study of ALX-0171 in infants and young children hospitalized for respiratory syncytial virus lower respiratory tract infection
    Medical condition: RSV lower respiratory tract infection
    Disease: Version SOC Term Classification Code Term Level
    20.1 10021881 - Infections and infestations 10061603 Respiratory syncytial virus infection PT
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed) LV (Completed) HU (Completed) ES (Completed) EE (Completed) LT (Completed) SK (Completed) BE (Completed) BG (Completed) CZ (Completed) Outside EU/EEA PL (Completed) HR (Completed)
    Trial results: View results
    EudraCT Number: 2010-022865-81 Sponsor Protocol Number: ALX-0061-1.1/10 Start Date*: 2011-03-02
    Sponsor Name:Ablynx NV
    Full Title: A phase I/II, multi-center, randomized, double-blind, placebo controlled study, with a single ascending dose part followed by a multiple ascending dose part, evaluating the safety, pharmacokinetics...
    Medical condition: Rheumatoid arthritis
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10039073 Rheumatoid arthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) HU (Completed)
    Trial results: View results
    EudraCT Number: 2021-005575-40 Sponsor Protocol Number: UZB-VHH2-4 Start Date*: 2023-02-15
    Sponsor Name:UZ Brussel
    Full Title: A phase II study to evaluate the imaging potential of 68GaNOTA-Anti-MMR VHH2 for in vivo imaging of MMR-expressing Macrophages by means of Positron Emission Tomography (PET) in patients with non-s...
    Medical condition: Patients diagnosed with non-small cell lung cancer (NSCLC), planned for standard-of-care (SOC) surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2014-002841-23 Sponsor Protocol Number: ALX0171-C104 Start Date*: 2014-09-22
    Sponsor Name:Ablynx NV
    Full Title: A Phase I/IIa Multicentre Study in Otherwise Healthy Infants and Toddlers Hospitalised For and Diagnosed With Respiratory Syncytial Virus Lower Respiratory Tract Infection, Consisting of an Open-la...
    Medical condition: Respiratory Syncytial Virus Lower Respiratory Tract Infection
    Disease: Version SOC Term Classification Code Term Level
    18.0 10021881 - Infections and infestations 10061603 Respiratory syncytial virus infection PT
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: GB (Completed) HU (Completed) SK (Completed) BE (Completed) ES (Completed) EE (Prematurely Ended) LV (Prematurely Ended) BG (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2022-001177-31 Sponsor Protocol Number: EFC16521 Start Date*: 2022-08-29
    Sponsor Name:Sanofi-Aventis Recherche & Développement
    Full Title: An open-label, single-arm, multicenter study to evaluate the efficacy and safety of caplacizumab and immunosuppressive therapy without first line therapeutic plasma exchange in adults with immune-m...
    Medical condition: Thrombotic Thrombocytopenic Purpura
    Disease: Version SOC Term Classification Code Term Level
    20.0 10005329 - Blood and lymphatic system disorders 10043648 Thrombotic thrombocytopenic purpura PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned) DE (Trial now transitioned) AT (Trial now transitioned) BE (Trial now transitioned) NL (Trial now transitioned) ES (Ongoing) CZ (Trial now transitioned) IT (Trial now transitioned) GR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-001503-23 Sponsor Protocol Number: ALX0681-C302 Start Date*: 2016-08-16
    Sponsor Name:Ablynx NV
    Full Title: Prospective Follow-up Study for Patients who Completed Study ALX0681-C301 (HERCULES) to Evaluate Long-term Safety and Efficacy of Caplacizumab (Post-HERCULES)
    Medical condition: Acquired thrombotic thrombocytopenic purpura (TTP)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10005329 - Blood and lymphatic system disorders 10043648 Thrombotic thrombocytopenic purpura PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) ES (Completed) HU (Completed) GB (Completed) CZ (Completed) BE (Completed) FR (Completed) DE (Completed) NL (Prematurely Ended) IT (Completed)
    Trial results: View results
    EudraCT Number: 2015-000372-95 Sponsor Protocol Number: ALX0061-C204 Start Date*: 2015-08-20
    Sponsor Name:Ablynx N.V.
    Full Title: A Phase II Multicenter, Randomized, Double-blind, Placebo controlled, Dose-range Finding Study to Evaluate the Safety and Efficacy of ALX 0061 Administered Subcutaneously in Subjects with Moderate ...
    Medical condition: Moderate to Severe Active Systemic Lupus Erythematosus
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000017968 10025139 Lupus erythematosus systemic LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Completed) DE (Completed) PT (Completed) HU (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2015-001098-42 Sponsor Protocol Number: ALX0681-C301 Start Date*: 2015-08-27
    Sponsor Name:Ablynx NV
    Full Title: A Phase III double-blind, randomized, parallel group, multicenter placebo-controlled trial to study the efficacy and safety of caplacizumab in patients with acquired thrombotic thrombocytopenic pur...
    Medical condition: Acquired Thrombotic thrombocytopenic purpura
    Disease: Version SOC Term Classification Code Term Level
    18.0 10005329 - Blood and lymphatic system disorders 10043648 Thrombotic thrombocytopenic purpura PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) CZ (Completed) ES (Completed) AT (Completed) DE (Completed) HU (Completed) NL (Completed) Outside EU/EEA IT (Completed)
    Trial results: View results
    EudraCT Number: 2009-012206-39 Sponsor Protocol Number: ALX-0081-2.1/09 Start Date*: 2009-08-14
    Sponsor Name:Ablynx
    Full Title: A phase II randomized, open label clinical trial in high risk percutaneous coronary intervention (PCI) patients receiving standard antithrombotic treatment plus either ALX-0081 or GPIIb/IIIa inhibi...
    Medical condition: Thrombotic events associated with percutaneous coronary intervention (PCI) in patients with unstable angina or Non ST-Segment Elevation Myocardial Infarction (NSTEMI), or stable angina with at leas...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10011076 Coronary artery atherosclerosis LLT
    9.1 10011078 Coronary artery disease LLT
    9.1 10013210 Disorder coronary artery LLT
    9.1 10063933 Coronary stent thrombosis LLT
    9.1 10065608 Percutaneous coronary intervention LLT
    9.1 10003211 Arteriosclerosis coronary artery LLT
    9.1 10011067 Coronary angiogram abnormal LLT
    9.1 10011093 Coronary atherosclerosis LLT
    9.1 10011099 Coronary disease LLT
    9.1 10051592 Acute coronary syndrome LLT
    9.1 10011076 Coronary artery atherosclerosis LLT
    9.1 10011093 Coronary atherosclerosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) DE (Completed) CZ (Completed) AT (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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