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Clinical trials for One Health

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44339   clinical trials with a EudraCT protocol, of which   7369   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
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    6,667 result(s) found for: One Health. Displaying page 1 of 334.
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    EudraCT Number: 2005-003129-23 Sponsor Protocol Number: 04/MR/111 Start Date*: 2006-04-18
    Sponsor Name:Belfast Health and Social Care Trust, Musgrave Park Hospital
    Full Title: Prevention and Treatment of Steroid-Induced Osteopenia in children and adolescents with rheumatic diseases
    Medical condition: Children and adolescents with Juvenile Idiopathic arthritis (JIA), Juvenile dermatomyositis (JDMS) Juvenile systemic lupus erythematosis (JSLE) Vasculitis
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-001954-88 Sponsor Protocol Number: IdIx Start Date*: 2015-12-03
    Sponsor Name:Helsinki University Centrel Hospital
    Full Title: Immune response to intradermally administrated Ixiaro in healthy adults: a randomized study
    Medical condition: 18-64 years old volunteers with general good health
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2020-001678-31 Sponsor Protocol Number: APHP200462 Start Date*: 2020-04-28
    Sponsor Name:Assistance Publique Hopitaux de Paris
    Full Title: Randomized controlled trial evaluating the efficacy of vaccination with Bacillus Calmette and Guérin (BCG) in the Prevention of COVID-19 via the strengthening of innate immunity in Health Care Work...
    Medical condition: COVID 19 Health care workers (medical or non-medical) in French hospitals in direct contact with COVID-19 patients, including nurses, medical doctors and other personnel working in wards in charge...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-005082-34 Sponsor Protocol Number: A2620383 Start Date*: 2007-12-14
    Sponsor Name:GlaxoSmithKline Consumer Healthcare
    Full Title: A Proof of Principle Study to Investigate the Efficacy of a Medical Device and Topical Analgesic Combination for the Treatment of Pain and Performance Related Function in Osteoarthritis
    Medical condition: To compare the efficacy of 72 hours (hrs) treatment of topical diclofenac plus a heat patch with 72 hrs treatment of topical diclofenac plus a placebo patch on the primary endpoint of mobility in p...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2017-002532-16 Sponsor Protocol Number: 02 Start Date*: 2017-12-05
    Sponsor Name:Cliniques Universitaires Saint-Luc
    Full Title: Adjunctive systemic antimicrobial therapy in the surgical treatment of peri-implantitis. A prospective randomized clinical study
    Medical condition: To treat patients with chronic infection of dental implants. One group with antibiotics and one group without.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-005010-37 Sponsor Protocol Number: 62 Start Date*: 2005-08-16
    Sponsor Name:Suffolk Mental Health Partnerships Trust
    Full Title: Enhancing cognition in bipolar disorder
    Medical condition: Bipolar affective disorder, currently in remission
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-012275-98 Sponsor Protocol Number: HELENA Start Date*: 2010-09-08
    Sponsor Name:Free state of Bavaria
    Full Title: HEXVIX® VERUS WHITE LIGHT GUIDED TURB FOR EORTC SCORE INTERMEDIATE RISK NON-MUSCLE INVASIVE BLADDER CANCER FOLLOWED BY ATTENUATED INTRAVESICAL ADJUVANT CHEMOTHERAPY.
    Medical condition: NON-MUSCLE INVASIVE BLADDER CANCER
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) AT (Ongoing)
    Trial results: View results
    EudraCT Number: 2014-005309-18 Sponsor Protocol Number: V66_05 Start Date*: 2014-12-10
    Sponsor Name:Novartis Vaccines and Diagnostics
    Full Title: A Ph III, Single Arm, Multi-Center, Open-Label Study to Assess the Immunogenicity, Safety and Tolerability of a Fully Liquid Pentavalent Vaccine Quinvaxem® (DTwP-Hib-HepB Vaccine) when Administered...
    Medical condition: Prophilaxis against diphtheria, tetanus, pertussis, hepatitis B and invasive Haemophilus influenzae type b disease.
    Disease:
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2021-001624-17 Sponsor Protocol Number: 210321 Start Date*: 2021-07-21
    Sponsor Name:Karolinska University Hospital
    Full Title: Safety of oral micronized progesterone versus norethisterone acetate in continuous combination with oral estrogen as menopausal hormone therapy – a double-blind randomized study- PROBES study (Prog...
    Medical condition: Climacteric symptoms
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2006-001061-42 Sponsor Protocol Number: 0881A3-405 Start Date*: 2006-07-31
    Sponsor Name:Wyeth Pharmaceuticals France, Wyeth Research Division
    Full Title: An open-label, multicentre, supplementary and extension study of Etanercept in subjects with Ankylosing Spondylitis (AS)
    Medical condition: Ankylosing spondylitis (AS).
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) SE (Completed) FI (Completed) DK (Completed)
    Trial results: View results
    EudraCT Number: 2014-005059-25 Sponsor Protocol Number: V59P6E1 Start Date*: 2014-11-25
    Sponsor Name:Novartis Vaccines &Diagnostics, Inc.
    Full Title: A Phase 2b, Open-Label, Multi-Center Study to Evaluate the Persistence of Antibody Response and to Assess the Immune Response to a Booster Dose of MenACWY Conjugate Vaccine in Subjects Previously V...
    Medical condition: Novartis Meningococcal ACWY Conjugate Vaccine is intended for prevention of meningitis and septicemia caused by Neisseria meningitidis A, C, W-135 and Y.
    Disease:
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2016-003052-70 Sponsor Protocol Number: APAC2016 Start Date*: 2016-11-10
    Sponsor Name:Academic Medical Center of Amsterdam
    Full Title: Initial non-operative treatment strategy versus appendectomy treatment strategy for simple appendicitis in children aged 7-17 years old. APAC study
    Medical condition: Acute uncomplicated (simple) appendicitis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10003011 Appendicitis PT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-000599-25 Sponsor Protocol Number: 3010 Start Date*: 2008-05-09
    Sponsor Name:TweeSteden Hospital
    Full Title: Iron and Folic acid v.s. Iron solely in the treatment of post partum anaemia, effects on haemoglobin and health status
    Medical condition: post partum anemia is generally treated by ferrous fumarate. It is unclear whether the addition of folic acid to ferrous fumarate in the treatment of anaemia could accelerate the increase of haemog...
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2009-013134-24 Sponsor Protocol Number: RGHT000675 Start Date*: 2009-07-31
    Sponsor Name:Belfast Health & Social Care Trust
    Full Title: Comparison of fascia iliaca compartment block or femoral nerve block using levobupivacaine for postoperative analgesia after operative repair of femoral neck fracture: a dose response study
    Medical condition: Postoperative Analgesia in patients undergoing operative repair of fractured neck of femur
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-004424-65 Sponsor Protocol Number: 15085MS-AS Start Date*: 2016-05-09
    Sponsor Name:Belfast Health and Social Care Trust
    Full Title: Prevention of post-operative complications by using HMG-CoA Reductase Inhibitor in patients undergoing oesophagectomy - A multicentre, randomised, double blind, placebo controlled trial
    Medical condition: Post-operative complications - Post-operative Pulmonary complication, Acute Respiratory Distress Syndrome and Myocardial Infarction
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2010-024271-10 Sponsor Protocol Number: V00162GL203 Start Date*: 2011-07-06
    Sponsor Name:PIERRE FABRE MEDICAMENT
    Full Title: Urodynamic effect of one single vaginal application of 2 mL of V0162 gel (0.8%) in post-menopausal women with overactive bladder
    Medical condition: Overactive Bladder symptoms.
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: PL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-000872-89 Sponsor Protocol Number: MK001 Start Date*: 2015-10-29
    Sponsor Name:University of Oxford
    Full Title: ANODE: a randomised controlled trial of prophylactic ANtibiotics to investigate the prevention of infection following Operative vaginal DElivery.
    Medical condition: Maternal infection in the first six weeks after operative vaginal delivery.
    Disease:
    Population Age: Adolescents, Under 18, Adults Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2015-000682-30 Sponsor Protocol Number: 01-09.02.15. Start Date*: 2015-04-27
    Sponsor Name:Tartu University Hospital
    Full Title: Botulinum neurotoxin type A treatment for sialorrhea in central nervous system diseases
    Medical condition: Hypersalivation
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004856 10020746 Hypersalivation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: EE (Completed)
    Trial results: View results
    EudraCT Number: 2004-000905-24 Sponsor Protocol Number: 25052004 Start Date*: 2005-02-08
    Sponsor Name:University of York
    Full Title: Cryotherapy versus salicylic acid for the treatment of verrucae: a randomised controlled trial.
    Medical condition: Verrucae
    Disease:
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) IE (Completed)
    Trial results: View results
    EudraCT Number: 2015-000617-43 Sponsor Protocol Number: CLEE011F2301 Start Date*: 2015-05-27
    Sponsor Name:Novartis Pharma Services AG
    Full Title: MONALEESA-3: A randomized double-blind, placebo-controlled study of ribociclib in combination with fulvestrant for the treatment of men and postmenopausal women with hormone receptor positive, HER2...
    Medical condition: men and postmenopausal women with HR+, HER2-negative advanced (loco regionally recurrent not amenable to curative therapy or metastatic) breast cancer
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004864 10072737 Advanced breast cancer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) DE (Completed) AT (Completed) ES (Completed) CZ (Completed) DK (Completed) NL (Completed) HU (Completed) BE (Completed) BG (Completed) FR (Completed) PT (Completed) IT (Completed)
    Trial results: View results
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    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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