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Clinical trials for Pharmacokinetics

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

  • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).


    The EU Clinical Trials Register currently displays   43873   clinical trials with a EudraCT protocol, of which   7293   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    5,809 result(s) found for: Pharmacokinetics. Displaying page 1 of 291.
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    EudraCT Number: 2012-000737-40 Sponsor Protocol Number: BAY12-8039/11826 Start Date*: 2012-02-20
    Sponsor Name:Bayer HealthCare Pharmaceuticals
    Full Title: Safety, Tolerability and Pharmacokinetics of Single Dose Intravenous Moxifloxacin in Pediatric Patients
    Medical condition: No medical condition specified as the purpose of this study is to describe the pharmacokinetics of moxifloxacin in children for future antibiotic treatment.
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2016-003785-77 Sponsor Protocol Number: 59244 Start Date*: 2017-03-16
    Sponsor Name:
    Full Title: Microdosing as a tool to individualize docetaxel dosing: development of a limited sampling model
    Medical condition: Patients with breast-, prostate or non-small cell lung cancer (NSCLC), who are eligible for treatment with docetaxel.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2015-002230-41 Sponsor Protocol Number: PPH-LYF02 Start Date*: 2015-06-29
    Sponsor Name:Landspitali University Hospital
    Full Title: Pharmacokinetics of Proton Pump Inhibitors in a random Icelandic Population.
    Medical condition: Gastro Oesophageal Reflux Disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: IS (Completed)
    Trial results: View results
    EudraCT Number: 2005-002996-34 Sponsor Protocol Number: PK 2005 xx Start Date*: 2006-04-27
    Sponsor Name:University Hospitals of Leicester NHS Trust
    Full Title: Pharmacokinetics of actinomycin D in children with cancer
    Medical condition: Any children's cancer where this drug is administered as part of the treatment regimen
    Disease:
    Population Age: Newborns, Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2016-001894-34 Sponsor Protocol Number: E7389-A001-113 Start Date*: 2016-11-16
    Sponsor Name:Eisai Inc.
    Full Title: A Phase 1 Study of Eribulin Mesylate (E7389, IND #116,292), a Novel Microtubule Targeting Chemotherapeutic Agent in Children with Refractory or Recurrent Solid Tumors (Excluding CNS), Including Lym...
    Medical condition: Solid Tumors including Lymphomas
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2015-004442-25 Sponsor Protocol Number: CFAM810B2304 Start Date*: 2016-04-12
    Sponsor Name:Novartis Pharmaceuticals
    Full Title: A multicenter, open-label, single-arm, two-step study to evaluate the safety and single-dose pharmacokinetics of famciclovir and multiple-dose safety after administration of famciclovir oral pediat...
    Medical condition: Chickenpox Herpes Zoster
    Disease:
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2012-000406-29 Sponsor Protocol Number: Lisette-3 Start Date*: 2012-07-03
    Sponsor Name:
    Full Title: The influence of morning versus evening administration on tamoxifen pharmacokinetics
    Medical condition: Breast cancer
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10070575 Estrogen receptor positive breast cancer LLT
    Population Age: Adults Gender: Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-002026-39 Sponsor Protocol Number: N15LDC Start Date*: 2015-09-10
    Sponsor Name:NKI-AVL
    Full Title: The Effect of Prehydration on the Pharmacokinetics of Low-dose Cisplatin
    Medical condition: Tumor
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-004488-30 Sponsor Protocol Number: TAPAS-PK-2014 Start Date*: 2014-01-31
    Sponsor Name:Haga Hospital
    Full Title: Targeting Antibiotics to Pseudomonas Aeruginosa in Small airways (TAPAS) study in patients with cystic fibrosis: pharmacokinetics (PK)
    Medical condition: Cystic fibrosis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-007647-14 Sponsor Protocol Number: Nabu1A2 Start Date*: 2009-01-07
    Sponsor Name:Turku University Hospital
    Full Title: The effect of fluvoxamine and ciprofloxacin on the pharmacokinetics and pharmacodynamics of nabumetone: A three-phase double-blind placebo-controlled cross-over study.
    Medical condition: Pharmacokinetics and pharmacodynamics, healthy volunteer trial
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-000131-13 Sponsor Protocol Number: DDD17CRCCXB1 Start Date*: 2017-05-11
    Sponsor Name:KU Leuven
    Full Title: Pharmacokinetics of Celebrex for the prevention/treatment of colorectal cancer: Systemic pharmacokinetics and elimination of Celebrex in healthy volunteers
    Medical condition: Colorectal cancer
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2012-003386-18 Sponsor Protocol Number: ETB Start Date*: 2013-01-10
    Sponsor Name:UMCG
    Full Title: PHARMACOKINETICS AND PHARMACODYNAMICS OF ERTAPENEM IN PATIENTS WITH TUBERCULOSIS
    Medical condition: Tuberculosis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-007972-70 Sponsor Protocol Number: 11/2008 FDB Start Date*: 2009-01-22
    Sponsor Name:University Hospital Leuven
    Full Title: Transplacentar pharmacokinetics of remifentanil
    Medical condition: Transplacentar pharmacokinetics of Remifentanil
    Disease:
    Population Age: In utero, Under 18 Gender: Female
    Trial protocol: BE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-003132-12 Sponsor Protocol Number: s57150 Start Date*: 2015-11-20
    Sponsor Name:UZLeuven
    Full Title: apixaban in end -stage renal disease
    Medical condition: the pharmacokinetics profile of Apixaban allows safe use in patients with end-stage renal disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2007-003114-34 Sponsor Protocol Number: CUR001 Start Date*: 2007-11-29
    Sponsor Name:Department of Nephrology and Renal Transplantation, University Hospitals Leuven
    Full Title: The impact of oral curcumin (Curcuma longa) on mycophenolic acid and metabolite pharmacokinetics in stable renal allograft recipients: exploratory investigation of the role of intestinal uridine-di...
    Medical condition: Stable renal allograft recipients
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-004207-22 Sponsor Protocol Number: CLCZ696B2319 Start Date*: 2017-04-06
    Sponsor Name:Novartis Pharma Services AG
    Full Title: Multicenter, open-label, study to evaluate safety, tolerability, pharmacokinetics and, pharmacodynamics of LCZ696 followed by a 52-week randomized, double-blind, parallel group, active-controlled s...
    Medical condition: Pediatric heart failure 1 month to <18 years old
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10019279 Heart failure LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DE (Completed) FI (Completed) NL (Ongoing) SE (Completed) NO (Completed) ES (Completed) GB (GB - no longer in EU/EEA) CZ (Completed) IT (Completed) FR (Completed) BG (Completed) PL (Completed) HU (Completed) HR (Completed) AT (Completed) PT (Completed) RO (Completed)
    Trial results: View results
    EudraCT Number: 2015-004443-40 Sponsor Protocol Number: CFAM810B2305 Start Date*: 2016-04-12
    Sponsor Name:Novartis Pharmaceuticals
    Full Title: A Multicenter, Open-label, Single-arm Study to Evaluate the Safety and Pharmacokinetics of Famciclovir Single 1500 mg Dose in Adolescents With Recurrent Herpes Labialis
    Medical condition: Herpes Labialis
    Disease:
    Population Age: Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2022-000291-19 Sponsor Protocol Number: COL-ECMO2022 Start Date*: 2022-06-21
    Sponsor Name:Fakultní nemocnice u sv. Anny v Brně
    Full Title: Pharmacokinetics of colistin in critically ill patients with extracorporeal membrane oxygenation
    Medical condition: Pharmacokinetics in critically ill
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2015-001172-21 Sponsor Protocol Number: CLO05908 Start Date*: 2015-05-18
    Sponsor Name:Genzyme Japan K.K.
    Full Title: A Phase 1, Open-label, Multi-center Study of Clofarabine in Japanese Pediatric Patients with Relapsed or Refractory Acute Lymphoblastic Leukemia
    Medical condition: Acute Lymphoblastic Leukemia
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004864 10000845 Acute lymphoblastic leukemia LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2012-001632-64 Sponsor Protocol Number: CLCZ696B2225 Start Date*: 2012-08-08
    Sponsor Name:Novartis Pharma Services AG
    Full Title: An open label, three-period, single sequence study to evaluate the pharmacokinetic drug-drug interaction between LCZ696 and sildenafil in subjects with mild to moderate hypertension
    Medical condition: mild to moderate hypertension
    Disease: Version SOC Term Classification Code Term Level
    14.1 10047065 - Vascular disorders 10020772 Hypertension PT
    Population Age: Adults Gender: Male
    Trial protocol: DE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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