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Clinical trials for Plasminogen

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    73 result(s) found for: Plasminogen. Displaying page 1 of 4.
    1  2  3  4  Next»
    EudraCT Number: 2008-003371-53 Sponsor Protocol Number: STROKE-FNUSA-01 Start Date*: 2008-08-08
    Sponsor Name:Fakultní nemocnice u svaté Anny
    Full Title: Acute Stroke Study of Optimized tPA Dosing in Correlation with Artery Status
    Medical condition: Patients with acute ischemic stroke with proven occlusion of major brain arteries demonstrated by transcranial ultrasound.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10059620 Plasminogen activator inhibitor LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-005490-20 Sponsor Protocol Number: 2002C011G Start Date*: 2016-06-29
    Sponsor Name:ProMetic BioTherapeutics Inc.
    Full Title: A Phase 2/3, Open-Label, Repeat-Dose Study of the Pharmacokinetics, Efficacy, and Safety of ProMetic Plasminogen Intravenous Infusion in Subjects with Hypoplasminogenemia
    Medical condition: Hypoplasminogenemia
    Disease: Version SOC Term Classification Code Term Level
    18.1 10022891 - Investigations 10035493 Plasminogen decreased PT
    Population Age: Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: View results
    EudraCT Number: 2012-001340-21 Sponsor Protocol Number: KB046 Start Date*: 2013-01-15
    Sponsor Name:KEDRION
    Full Title: A Historically-Controlled Phase II/III study to Evaluate Efficacy and Safety of Kedrion Human Plasminogen Eye Drop Preparation in Patients Diagnosed with Ligneous Conjunctivitis
    Medical condition: Ligneous Conjunctivitis ( MedDRA Code vers. 15.0: 10071570 LLT - no present in OsSC database) associated with Type I Plasminogen Deficiency
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2016-004782-11 Sponsor Protocol Number: 2002C014G Start Date*: 2017-12-05
    Sponsor Name:Prometic Biotherapeutics Ltd
    Full Title: A Phase 1/2A Prospective, Dose-Escalation, Open-Label Study of the Safety, Feasibility, and Initial Efficacy of Subcutaneous Plasminogen (Human) 10 for the Treatment of Diabetic Foot Ulcer
    Medical condition: Diabetic foot ulcer (DFU)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000014568 10012664 Diabetic foot ulcer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2017-002927-68 Sponsor Protocol Number: 2002C015G Start Date*: 2017-11-08
    Sponsor Name:Prometic Biotherapeutics Ltd
    Full Title: A Phase 1/2A, Dose Escalation, Randomized, Placebo Controlled Study of the Safety, Feasibility, and Efficacy of Subcutaneous Plasminogen (Human) 10 for the Treatment of Chronic Tympanic Membrane Pe...
    Medical condition: Tympanic Membrane Perforation
    Disease: Version SOC Term Classification Code Term Level
    20.0 10013993 - Ear and labyrinth disorders 10045210 Tympanic membrane perforation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2004-000919-26 Sponsor Protocol Number: IVH05 Start Date*: 2005-07-29
    Sponsor Name:Newcastle upon Tyne Hospitals NHS Trust [...]
    1. Newcastle upon Tyne Hospitals NHS Trust
    2. Johns Hopkins University
    Full Title: Phase II, randomized, pharmokinetic, dose finding, and dose frequency determination using rt-PA in intraventricular hemorrhage
    Medical condition: Intracerebral haemorrhage with intraventricular extension
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) FI (Completed)
    Trial results: View results
    EudraCT Number: 2012-003289-42 Sponsor Protocol Number: 41399 Start Date*: 2012-12-21
    Sponsor Name:Academic Medical Center Amsterdam
    Full Title: Randomized Controlled Trial Investigating the Efficacy and Safety of Nebulized Heparin versus Placebo in Burn Patients with Inhalation Trauma
    Medical condition: Burn-associated inhalation trauma requiring intubation and mechanical ventilation.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2020-001640-26 Sponsor Protocol Number: 132151 Start Date*: 2020-04-17
    Sponsor Name:University College London
    Full Title: A pilot, open label, phase II clinical trial of nebulised recombinant tissue-Plasminogen Activator (rtPA)in patients with COVID-19 ARDS: The Plasminogen Activator COVID-19 ARDS (PACA) trial
    Medical condition: Acute respiratory distress syndrome (ARDS) caused by COVID-19
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2014-000377-40 Sponsor Protocol Number: MST-188-07 Start Date*: 2014-11-13
    Sponsor Name:Mast Therapeutics, Inc.
    Full Title: Evaluation of MST-188 in Acute Lower Limb Ischemia: A Phase 2 Randomized Double-Blind, Placebo-Controlled, Multi-Center Clinical Trial Evaluating the Safety and Efficacy Of MST-188 in Subjects with...
    Medical condition: Acute Lower Limb Ischemia
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004866 10066920 Leg ischemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Prematurely Ended) CZ (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-007643-27 Sponsor Protocol Number: V10153-2S-01 Start Date*: 2008-03-28
    Sponsor Name:Vernalis (R & D) Limited
    Full Title: A Phase IIa, Multi-Centre Study to Evaluate the Safety and Efficacy of V10153 in Acute Ischaemic Stroke
    Medical condition: Acute Ischaemic Stroke
    Disease: Version SOC Term Classification Code Term Level
    9.1 10061256 Ischaemic stroke PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended) CZ (Completed) HU (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2012-002478-30 Sponsor Protocol Number: FLUSH Start Date*: 2013-06-05
    Sponsor Name:Leiden University Medical Center
    Full Title: Arterial perfusion with t-PA in donation after cardiac death (DCD) to reduce the incidence of non-anastomotic biliary strictures after orthotopic liver transplantation
    Medical condition: Biliary strictures after orthotopic liver transplantation caused by microthrombi in the donorliver during procurement
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-024377-40 Sponsor Protocol Number: TPA-ALI Start Date*: 2011-06-29
    Sponsor Name:Medizinische Universität Wien, UniKlinik für Klinische Pharmakologie
    Full Title: A randomized phase II pilot - trial, examining the safety, pharmacokinetics, pharmacodynamics, and clinical efficacy of escalating doses of alteplase in patients with acute lung injury / acute resp...
    Medical condition: acute lung injury, acute respiratory distress syndrom, severe pneumonia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2010-018637-21 Sponsor Protocol Number: 1 Start Date*: 2013-11-20
    Sponsor Name:Universitätsklinikum Schleswig-Holstein UKSH
    Full Title: Intravitreal Injection of Lucentis (Ranibizumab) after Pars Plana Vitrectomy and Subretinal Application of Recombinant Tissue Plasminogen Activator (rtPA) in Patients with Acute Submacular Hemorrha...
    Medical condition: exsudative age-related macular degeneration with acut submacular hemorrhage
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004853 10055305 Macula lutea hemorrhage LLT
    16.1 100000004853 10067791 Wet macular degeneration LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2013-005473-52 Sponsor Protocol Number: 40964 Start Date*: 2014-04-24
    Sponsor Name:Hospital of South West Jutland
    Full Title: Prevention of bleeding and edema in bi-maxillary orthognathic surgery; the effectiveness of tranexamic acid on intraoperative bleeding in orthognathic surgery
    Medical condition: Surgical bleeding during bi-maxillary orthognathic surgery
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004863 10051536 Intraoperative bleeding LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2006-000614-21 Sponsor Protocol Number: 7168K01 Start Date*: 2007-08-09
    Sponsor Name:Zambon Group S.p.A
    Full Title: A multicentre, open-label study to evaluate the efficacy and safety of 5-MTHF administration, added on to the individual established therapy, on plasma homocysteine levels in patients with congenit...
    Medical condition: homocystinuria
    Disease: Version SOC Term Classification Code Term Level
    8.1 10020365 pref
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: AT (Completed) SK (Completed) HU (Completed) GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2021-000444-22 Sponsor Protocol Number: NL75930.078.20 Start Date*: 2021-04-07
    Sponsor Name:Erasmus MC
    Full Title: Differences in coagulation between fresh frozen plasma and Solventdetergent plasma in pediatric congenital heart surgery
    Medical condition: coagulation in pediatric cardiac surgery
    Disease:
    Population Age: Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2015-001946-26 Sponsor Protocol Number: AMITNED Start Date*: 2016-01-19
    Sponsor Name:Aarhus University Hospital
    Full Title: Amilorid treatment of nephrotic edema
    Medical condition: Childhood idiopathic nephrotic syndrome (NS)
    Disease:
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-001070-27 Sponsor Protocol Number: EP-PAE Metalyse Start Date*: 2005-07-07
    Sponsor Name:Division of Angiology Graz
    Full Title: Open, randomised, monosite pilot trial for comparison of thrombolytic efficacy of tenecteplase and alteplase in patients with acute pulmonary embolism
    Medical condition: Patients with acute pulmonary embolism and indication for thrombolytic therapy are included in the study
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2010-019760-36 Sponsor Protocol Number: T05018-2004 Start Date*: 2010-11-22
    Sponsor Name:Grifols Therapeutics, Incorporated
    Full Title: A Phase 2, Randomized, Open-label (with Blinded Plasminogen Activator and Placebo Control Groups) Study to Evaluate the Effects of Different Intra-thrombus Infusion Regimens of Plasmin (Human) Comp...
    Medical condition: acute peripheral arterial occlusion
    Disease: Version SOC Term Classification Code Term Level
    14.0 10047065 - Vascular disorders 10057525 Peripheral artery occlusion LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SK (Completed) HU (Prematurely Ended) DE (Prematurely Ended) BE (Completed) ES (Prematurely Ended) CZ (Completed) BG (Completed)
    Trial results: View results
    EudraCT Number: 2017-002760-41 Sponsor Protocol Number: CL2-RTCCAR-001 Start Date*: 2017-09-18
    Sponsor Name:institute de Recherches Internacionales Servier (promotor internacional)
    Full Title: Assessment of Active Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa) plasma kinetics in Patients at acute stage of Ischemic Stroke: Prospective, Multicentre, Open, Non-randomised, Biomarker Study
    Medical condition: Acute Ischemic Stroke
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000013700 10055221 Ischemic stroke LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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