Flag of the European Union EU Clinical Trials Register Help

Clinical trials for Proof of concept

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44338   clinical trials with a EudraCT protocol, of which   7368   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
    How to search [pdf]
    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
    Advanced Search: Search tools
     
    645 result(s) found for: Proof of concept. Displaying page 1 of 33.
    1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2017-002183-41 Sponsor Protocol Number: METc2017.174 Start Date*: 2020-08-27
    Sponsor Name:UMCG
    Full Title: PET for Registration of Inflammation in the Vascular wall of Intracranial Aneurysms
    Medical condition: intracranial aneurysm
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-000133-39 Sponsor Protocol Number: 2019-02-07 Start Date*: 2019-05-08
    Sponsor Name:Academic Medical Center
    Full Title: A proof-of-concept study to evaluate 99mTechnetium radiolabeled Fucoidan as a diagnostic modality for thrombosis
    Medical condition: Deep vein thrombosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-000155-12 Sponsor Protocol Number: 2018_49 Start Date*: 2020-05-12
    Sponsor Name:InBrain Pharma SAS
    Full Title: A new concept of continuous dopaminergic stimulation by cerebroventricular administration of A-dopamine (dopamine stored in anaerobia) for severe motor fluctuations in Parkinson’s disease?
    Medical condition: Proof of concept study: prospective, monocentric, controlled randomized study according a cross over design with 2 groups: cerebroventricular administration of A-dopamine versus optimized oral trea...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2021-004032-28 Sponsor Protocol Number: 112415 Start Date*: 2021-11-24
    Sponsor Name:Radboud University Medical Center
    Full Title: Pharmacokinetic boosting of olaparib to improve exposure, tolerance and cost-effectiveness (PROACTIVE-study)
    Medical condition: Ovarian cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10033128 Ovarian cancer PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2020-005717-40 Sponsor Protocol Number: 2001-FIVI-002-IC Start Date*: 2021-05-05
    Sponsor Name:IVI Foundation
    Full Title: Umbilical cord plasma for treating endometrial pathologies (thin endometrium / Ash erman’s syndrome/ endometria atrophy)
    Medical condition: Endometrial pathologies (Thin endometrium/ Asherman's syndrome/ Endometrial atrophy)
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-003698-25 Sponsor Protocol Number: RHMMED1063 Start Date*: 2013-02-26
    Sponsor Name:University Hospital Southampton NHS Foundation Trust
    Full Title: Proof of concept clinical trial examining the effect of clopidogrel on allergen challenge in asthma
    Medical condition: asthma
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004855 10001705 Allergic asthma LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2018-001137-41 Sponsor Protocol Number: 666 Start Date*: 2018-06-26
    Sponsor Name:Hvidovre Hospital. Dep of Respiratory Medicine
    Full Title: Use of Omalizumab will increase the pregnancy rate, proof of concept study, where women with asthma and infertility will be treated three times with weight and IgE balanced dosis at the sixth day o...
    Medical condition: infertility within female asthma patients as a result of systemic inflamation.
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-022976-29 Sponsor Protocol Number: FX005-2010-001 Start Date*: 2011-01-11
    Sponsor Name:Flexion Therapeutics, Inc.
    Full Title: A Double-Blind, Randomised, Placebo-Controlled, Two-Phase Study (a Single Ascending Dose Phase Followed by a Proof of Concept Phase) to Assess the Safety, Efficacy and Pharmacokinetics of FX005 (50...
    Medical condition: Treatment of Pain in osteoarthritis of the knee
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) AT (Completed)
    Trial results: View results
    EudraCT Number: 2016-000506-11 Sponsor Protocol Number: Lx-Gf01 Start Date*: 2017-06-06
    Sponsor Name:Limoxifen BV
    Full Title: Proof-of-concept study on treating cognitive side-effects of Tamoxifen with guanfacine in postmenopausal women with E2/Pg receptor-positive breast cancer.
    Medical condition: Memory loss, attention deficit
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-004297-34 Sponsor Protocol Number: 236252 Start Date*: 2018-03-31
    Sponsor Name:Aston University
    Full Title: A placebo controlled double blind randomised controlled proof of concept study of zolpidem for the treatment of motor and cognitive deficits in late-stage Parkinson’s
    Medical condition: Parkinson's Disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029205 - Nervous system disorders 10061536 Parkinson's disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2018-001176-38 Sponsor Protocol Number: CNTO1959HDS2001 Start Date*: 2018-10-29
    Sponsor Name:Janssen-Cilag International NV
    Full Title: A Phase 2, Multicenter, Randomized, Placebo-Controlled, Double-Blind, Proof-of-Concept Study to Evaluate Guselkumab for the Treatment of Subjects with Moderate to Severe Hidradenitis Suppurativa
    Medical condition: Moderate to Severe Hidradenitis Suppurativa
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004858 10076650 Acne inversa LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) DE (Completed) NL (Completed) DK (Completed)
    Trial results: View results
    EudraCT Number: 2005-001827-12 Sponsor Protocol Number: D-IIS-BP-01 Start Date*: 2005-12-29
    Sponsor Name:Georg-August-Universität Göttingen, Bereich Humanmedizin
    Full Title: Myfortic ® zur Therapie des Bullösen Pemphigoids. Eine offene monozentrische proof-of-concept Studie
    Medical condition: Bullous Pemphigoid
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2019-003812-30 Sponsor Protocol Number: NL70495.078.19 Start Date*: 2020-10-21
    Sponsor Name:Erasmus MC
    Full Title: Primovist CT: proof of concept
    Medical condition: Hepatocellular adenoma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-000042-34 Sponsor Protocol Number: C20-109-07 Start Date*: 2020-09-24
    Sponsor Name:
    Full Title: PROOF OF CONCEPT STUDY ON LTX-109 AS TREATMENT FOR HIDRADENITIS SUPPURATIVA
    Medical condition: Hidradenitis suppurativa, Hurley stage I-III
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: View results
    EudraCT Number: 2005-001587-31 Sponsor Protocol Number: A001-2PX Start Date*: 2005-06-07
    Sponsor Name:SantoSolve AS
    Full Title:
    Medical condition: Patients with fibromyalgia diagnosed according to ACR classification (1990) and with chronic pain at defined symmetrical body areas.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-005601-22 Sponsor Protocol Number: poc1doxy Start Date*: 2008-03-27
    Sponsor Name:
    Full Title: Proof–of–concept study 1 (POC1): Evaluation of effect of doxycycline versus placebo on retinal function and posterior segment neovascularization in patients with severe non-proliferative or early ...
    Medical condition: Diabetic retinopathy
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012689 Diabetic retinopathy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-003089-14 Sponsor Protocol Number: CCTU0218 Start Date*: 2019-12-03
    Sponsor Name:Cambridge University Hospitals NHS Foundation Trust and University of Cambridge
    Full Title: Azathioprine Immunosuppression and Disease Modification in Parkinson’s Disease (AZA-PD): a randomised double-blind placebo-controlled phase II trial
    Medical condition: Parkinson's disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029205 - Nervous system disorders 10061536 Parkinson's disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2004-003986-34 Sponsor Protocol Number: 502.469 Start Date*: 2005-03-30
    Sponsor Name:Boehringer Ingelheim Danmark A/S
    Full Title: A randomised, double-blind, placebo-controlled, parallel group, 16-week MICARDIS® (160 mg) tablets, proof-of-concept study, evaluating insulin sensitivity in overweight or obese, non-diabetic, norm...
    Medical condition: Overweight or obese, non-diabetic, normotensive subjects
    Disease: Version SOC Term Classification Code Term Level
    7.1 10052066 PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed) DE (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2015-002672-25 Sponsor Protocol Number: STR001-201 Start Date*: 2015-11-18
    Sponsor Name:Strekin AG
    Full Title: A Phase II multicenter, placebo-controlled, proof-of-concept study evaluating the safety, and efficacy of intratympanic STR001 thermogel to preserve residual hearing in adults undergoing cochlear ...
    Medical condition: Prevention of Hearing Loss after Cochlear Implant Surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) ES (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2008-002795-96 Sponsor Protocol Number: CBFH772A2201 Start Date*: 2008-12-11
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A single center, phase I, partially blinded, placebo-controlled, first-in-man study to evaluate the safety, tolerability and Proof of Mechanism (PoM) of a single administration of BFH772 in healthy...
    Medical condition: Plaque psoriasis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10037153 Psoriasis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    Download Options:
    Number of Trials to download:
    Download Content:
    Download Format:
    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
    1  2  3  4  5  6  7  8  9  Next» Last»»
    Query did not match any studies.
    For support, Contact us.
    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

    European Medicines Agency © 1995-Sat May 24 09:15:21 CEST 2025 | Domenico Scarlattilaan 6, 1083 HS Amsterdam, The Netherlands
    EMA HMA