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Clinical trials for Senescence

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
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    28 result(s) found for: Senescence. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2012-003987-34 Sponsor Protocol Number: S54555 Start Date*: 2013-03-19
    Sponsor Name:UZ Leuven
    Full Title: “Therapeutic interventions on senescence markers after human kidney transplantation, does metformine meets his expectations?”
    Medical condition: Kidney transplant patients 3 months after TX, with a stable kidney function, no signs of graft failure. No other conditions like heart failure, diabetes, ....
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004863 10069030 Graft failure LLT
    14.1 10022891 - Investigations 10004782 Biopsy kidney PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-004835-26 Sponsor Protocol Number: D169AL00005 Start Date*: 2021-05-24
    Sponsor Name:IRCCS-A.O.U. SAN MARTINO-IST
    Full Title: Single-center, randomized, controlled study to evaluate the effects of a six-month treatment with renal glucose transport inhibitor (SGLT2i) drugs on markers of senescence, inflammation and tubuloi...
    Medical condition: Chronic Kidney Deseas
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004857 10050441 Chronic renal insufficiency LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-002894-36 Sponsor Protocol Number: IXIARO-booster-senescence Start Date*: 2017-12-22
    Sponsor Name:Medical University of Vienna (MUW)
    Full Title: "An open, monocentric, uncontrolled phase 4 trial to characterise cellular and humoral immune responses following the first booster immunisation with the inactivated, purified Japanese Encephalitis...
    Medical condition: The condition under investigation is the naturally aging immune system. The aim of this study is to investigate the immune responses following a booster immunisation with the Japanese Encephalitis ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-004970-24 Sponsor Protocol Number: 2012-004970-24 Start Date*: 2013-04-19
    Sponsor Name:Fundació Clinic per a la Recerca Biomèdica
    Full Title: Virological and immunological safety of a dose reduction strategy antiretroviral regimen with efavirenz / tenofovir / emtricitabine
    Medical condition: HIV -1 infection
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004862 10068341 HIV-1 infection LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-002722-36 Sponsor Protocol Number: RAGTIME Start Date*: 2017-03-29
    Sponsor Name:FUNDACIÓ LLUITA CONTRA LA SIDA
    Full Title: Randomized, double-blind, placebo-controlled clinical trial to evaluate the effect of Raltegravir intensification (1.200 mg QD) on the gut microbiota of chronically HIV-1 infected subject over time...
    Medical condition: HIV-1
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004862 10068341 HIV-1 infection LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-022882-80 Sponsor Protocol Number: 2010.621 Start Date*: 2010-09-17
    Sponsor Name:Hospices Civils de Lyon
    Full Title: EXPAND ID. Analyse de la réponse immunitaire à la vaccination anti-grippe chez les sujets âgés de 65 ans et plus.
    Medical condition: Sujets de 65 ans et plus, ayant été vaccinés contre la grippe saisonnière
    Disease: Version SOC Term Classification Code Term Level
    12.1 10014348 Elderly LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-001288-26 Sponsor Protocol Number: DASAHIVCURE Start Date*: 2022-08-18
    Sponsor Name:IDIBAPS
    Full Title: Safety, tolerance and antiretroviral activity of dasatinib: a pilot clinical trial in patients with recent HIV-1 infection
    Medical condition: Recent HIV-1 infection
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004862 10058427 Primary HIV infection LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-004430-96 Sponsor Protocol Number: 201600107 Start Date*: 2017-12-11
    Sponsor Name:University Medical Center Groningen
    Full Title: Short-term Testosterone replacement in testicular cancer survivors to treat overweight and improve cardiometabolic risk
    Medical condition: Testicular cancer
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-005682-13 Sponsor Protocol Number: 76061 Start Date*: 2021-04-22
    Sponsor Name:Radboudumc
    Full Title: Exploratory study into age-related immunological differences related to immunogenicity in influenza vaccination and herpes zoster vaccination
    Medical condition: Influenza Herpes Zoster
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2016-004039-19 Sponsor Protocol Number: GEIS-51 Start Date*: 2017-03-23
    Sponsor Name:Grupo Español de Investigación en Sarcomas (GEIS)
    Full Title: Phase II multicenter trial of palbociclib in second line of advanced sarcomas with CDK4 overexpression.
    Medical condition: Patients with advanced soft tissue sarcomas and osteosarcomas
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2023-000061-14 Sponsor Protocol Number: BCN04-DASA Start Date*: 2023-05-26
    Sponsor Name:Institut de Recerca Germans Trias i Pujol
    Full Title: Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People with HIV under Antiretroviral Treatment
    Medical condition: Human immunodeficiency virus (HIV)
    Disease: Version SOC Term Classification Code Term Level
    20.1 10021881 - Infections and infestations 10020161 HIV infection PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-000879-24 Sponsor Protocol Number: IJB-BC-NEORHEA-2016 Start Date*: 2017-03-23
    Sponsor Name:Institut Jules Bordet
    Full Title: Neoadjuvant Biomarker ResearcH Study of Palbociclib Combined with Endocrine Therapy in Estrogen Receptor Positive/ HER2 Negative Breast CAncer
    Medical condition: Primary breast cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004864 10006192 Breast cancer NOS LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2019-004074-25 Sponsor Protocol Number: ABc2 Start Date*: 2020-08-12
    Sponsor Name:AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
    Full Title: A Phase II Open-Label Randomized COntrolled Pre-Surgical Feasibility Study of Antibiotic COmbinations in Early Breast Cancer
    Medical condition: We investigated, in a population of patients with breast cancer, the combined effect of azithrocyn, docyciclin and vitamin C on biomarkers associated with cell proliferation
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004865 10079328 Breast tumor excision LLT
    Population Age: Adults Gender: Female
    Trial protocol: IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2018-004557-24 Sponsor Protocol Number: UKM17_0056 Start Date*: 2019-07-29
    Sponsor Name:Westfälische Wilhelms-Universität Münster c/o Universitätsklinikum Münster, Geschäftsbereich Recht u. Drittmittel
    Full Title: Clarifying the mechanism of action of cladribine in relapsing multiple sclerosis
    Medical condition: Multiple Sclerosis
    Disease: Version SOC Term Classification Code Term Level
    20.1 10029205 - Nervous system disorders 10028245 Multiple sclerosis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-014096-46 Sponsor Protocol Number: P090402 Start Date*: 2009-10-12
    Sponsor Name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
    Full Title: Essai thérapeutique de phase IIa ouvert, multicentrique, évaluant l'intérêt du Pazopanib dans les dermatofibrosarcomes de Darier-ferrand (DFSP) inopérables ou localement avancés (intervention mutil...
    Medical condition: Dermatofibrosarcome protubérant (DFSP) ou sarcome de Darrier-Ferrand.
    Disease: Version SOC Term Classification Code Term Level
    8.1 10057070 Dermatofibrosarcome protubérant PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-002635-15 Sponsor Protocol Number: 15-06 Start Date*: 2016-07-28
    Sponsor Name:VU Medical Center
    Full Title: Study to Identify Factors associated with Resilience to Clinical Dementia at Old Age
    Medical condition: The protective factors of Alzheimer's disease in subjects aged 90 years and older
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2018-000650-21 Sponsor Protocol Number: PHARMADIPOAGE Start Date*: 2018-10-31
    Sponsor Name:Universidad Autónoma de Madrid
    Full Title: CLINICAL TRIAL FOR EVALUATION OF THE ADIPOQUINAS: NEW PHARMACOLOGICAL TARGETS TO PREVENT VASCULAR AGING
    Medical condition: PREDIABETES
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004861 10065542 Prediabetes LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-002560-33 Sponsor Protocol Number: UC-0140/1404_CARMINA04 Start Date*: 2014-12-15
    Sponsor Name:UNICANCER
    Full Title: Open-label, randomized, multicenter, international, parallel exploratory phase II study, comparing 3 FEC-3 Docetaxel chemotherapy to letrozole + palbociclib combination as neoadjuvant treatment of ...
    Medical condition: Post-menopausal patients with localized, stage II-IIIA, PAM50 ROR (Prosigna™)- defined Luminal A and Node-positive or Luminal B (ER+ and HER2-) operable breast cancer, candidate for chemotherapy bu...
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004864 10006190 Breast cancer invasive NOS LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: FR (Completed) BE (Completed)
    Trial results: View results
    EudraCT Number: 2011-000092-13 Sponsor Protocol Number: INF-001 Start Date*: 2011-05-16
    Sponsor Name:
    Full Title: A trial aimed at enhancing immunity to Influenza in elderly individuals through reversal of immune senescence mediated by herpes virus infection.
    Medical condition: The trial is aimed to improve the efficiency of the seasonal influenza vaccine. Healthy volunteers who are positive for cytomegalovirus (CMV) will be recruited and given anti-viral treatment. We h...
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2018-004400-19 Sponsor Protocol Number: 1707-FIVI-084-MV Start Date*: 2019-05-30
    Sponsor Name:IVIRMA MADRID
    Full Title: Study of the effects of telomerase reactivation with Danazol on ovarian function. A Pilot Study.
    Medical condition: low ovarian reserve
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004872 10036602 Premature ovarian failure LLT
    Population Age: Adults Gender: Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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