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Clinical trials for Spontaneous breathing trial

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44341   clinical trials with a EudraCT protocol, of which   7370   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    25 result(s) found for: Spontaneous breathing trial. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2005-003612-30 Sponsor Protocol Number: 0904HELIOX Start Date*: 2005-11-23
    Sponsor Name:Barts and the London NHS Trust
    Full Title: A comparison of Helium-oxygen mixture (Heliox) with an oxygen-air mixture in reducing the work of breathing during weaning from mechanical ventilation.
    Medical condition: Patients admitted to the intensive care unit who are in the recovery phase of their illness and are weaning from mechanical ventilation.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2018-001650-98 Sponsor Protocol Number: AC1802 Start Date*: 2018-12-10
    Sponsor Name:University of Edinburgh and NHS Lothian [...]
    1. University of Edinburgh and NHS Lothian
    2. NHS Lothian
    Full Title: Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): A randomised, parallel-group, allocation concealed, controlled, open, phase 3 pragmatic clinical and cost...
    Medical condition: Any patient requiring intensive care treatment due to critical illness.
    Disease: Version SOC Term Classification Code Term Level
    20.1 10029205 - Nervous system disorders 10033305 Oversedation LLT
    20.0 10029205 - Nervous system disorders 10039897 Sedation PT
    21.1 100000004865 10049124 Sedation during medical procedure LLT
    20.1 10029205 - Nervous system disorders 10039898 Sedation excessive LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2013-002078-30 Sponsor Protocol Number: REDNES06052013 Start Date*: 2013-08-08
    Sponsor Name:Onze-Lieve-Vrouw Ziekenhuis
    Full Title: Acceleromyography and diaphragm electromyographic activity during neostigmine or sugammadex enhanced recovery from moderate residual neuromuscular blockade after rocuronium 0.6 mg kg-1: a double bl...
    Medical condition: We will compare usual care (neostigmine) with sugammadex for reversal of a moderate rocuronium-induced neuromuscular blockade and assess the effect on diaphragmatic EMG activity of sugammadex versu...
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-003415-29 Sponsor Protocol Number: 2.0 Start Date*: 2023-04-03
    Sponsor Name:Leiden University Medical Centre
    Full Title: The effect of antenatal acetaminophen administration on breathing effort of premature infants at birth: a pilot study
    Medical condition: Pregnant women expected to deliver between 24 and 30 weeks' gestation
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004848 10033762 Paracetamol LLT
    Population Age: In utero, Preterm newborn infants, Newborns, Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-002147-18 Sponsor Protocol Number: ABR49503 Start Date*: 2015-07-02
    Sponsor Name:Academic Medical Center
    Full Title: A randomized controlled double-blinded trial comparing the effect of on Demand ROcuronium boluses vs continuous infusion on rating of surgical and anesthesia conditions and need for reversal in Pat...
    Medical condition: oesophageal carcinoma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-012449-48 Sponsor Protocol Number: ALS-8-09-A-101 Start Date*: 2009-11-09
    Sponsor Name:Air Liquide Santé International
    Full Title: „Sympathetic neural outflow during Xenon anesthesia in humans“
    Medical condition: We would like to frame the thesis, that a general, inhalative Xenon anesthesia (1 MAC) does not effect the sympathetic outflow and the sympathetic baroreflex reagibility under spontaneous breathing...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2019-002411-26 Sponsor Protocol Number: GO-SLEEP Start Date*: 2019-10-09
    Sponsor Name:CHU de Poitiers
    Full Title: Impact of Gamma-OH on sleep in ICU patients difficult to wean from mechanical ventilation
    Medical condition: Patients difficult to wean from mechanical ventilation in the ICU
    Disease: Version SOC Term Classification Code Term Level
    21.1 10042613 - Surgical and medical procedures 10067221 Mechanical ventilation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2021-005922-82 Sponsor Protocol Number: IVIO1.3 Start Date*: 2022-01-13
    Sponsor Name:Prehospital Emergency Medical Services, Central Denmark Region
    Full Title: Intravenous vs. Intraosseous Vascular Access During Out-of-Hospital Cardiac Arrest - A Randomized Clinical Trial
    Medical condition: Out-of-hospital cardiac arrest (OHCA)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10007517 Cardiac arrest transient LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2013-001926-25 Sponsor Protocol Number: B300201316844 Start Date*: 2013-09-23
    Sponsor Name:Universitair Ziekenhuis Antwerpen
    Full Title: Sugammadex and the diaphragm: recovery of diaphragmatic function and neuromuscular blockade
    Medical condition: Residual neuromuscular blockade and diphragm fatigue
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-004551-67 Sponsor Protocol Number: SED001 Start Date*: 2017-04-18
    Sponsor Name:Sedana Medical AB
    Full Title: A randomised, controlled, open-label study to confirm the efficacy and safety of sedation with isoflurane in invasively ventilated ICU patients using the AnaConDa administration system
    Medical condition: Adult subjects admitted to the ICU clinically indicated to require sedation with propofol and invasive ventilation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) SI (Completed)
    Trial results: View results
    EudraCT Number: 2018-001169-18 Sponsor Protocol Number: UoL001360 Start Date*: 2018-10-15
    Sponsor Name:University Of Liverpool
    Full Title: The efficacy and mechanism of surfactant therapy for critically ill infants with bronchiolitis: The Bronchiolitis Endotracheal Surfactant Study.
    Medical condition: Critical Illness due to Bronchiolitis of infancy requiring conventional invasive Mechanical Ventilation (MV) Diagnosis of bronchiolitis per clinical criteria defined in national guidance NICE-NG9.
    Disease: Version SOC Term Classification Code Term Level
    20.1 10021881 - Infections and infestations 10038718 Respiratory syncytial virus bronchiolitis PT
    20.1 10021881 - Infections and infestations 10065188 Lower respiratory tract infection viral PT
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2008-006173-33 Sponsor Protocol Number: ALMED-07-C3-009 Start Date*: 2009-10-09
    Sponsor Name:Air Liquide
    Full Title: An international phase III randomised trial comparing in severe Exacerbations of Chronic obstructive pulmonary disease the efficacy of Helium/Oxygen versus Air/Oxygen administered during spontaneo...
    Medical condition: Patients eligible for this study are critically ill patients with COPD admitted in ICU for an exacerbation of their chronic disease with hypercapnic acute respiratory failure.
    Disease: Version SOC Term Classification Code Term Level
    12.0 10009033 Chronic obstructive pulmonary disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) BE (Prematurely Ended) DE (Completed) IT (Ongoing) GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-002475-29 Sponsor Protocol Number: GS-US-218-1502 Start Date*: 2015-02-10
    Sponsor Name:Gilead Sciences, Inc.
    Full Title: A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Multi-Center Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of GS-5806 in Hematopoietic Cell Transplant (HCT...
    Medical condition: Respiratory Syncytial Virus (RSV) Infection of the lower respiratory tract.
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004862 10039247 RSV infection LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2020-004118-37 Sponsor Protocol Number: CNS7056-026 Start Date*: 2021-08-31
    Sponsor Name:PAION UK Ltd [...]
    1. PAION UK Ltd
    2. Acacia Pharma Ltd.
    Full Title: A Phase 2/3, prospective, open-label trial evaluating the efficacy, safety, and pharmacokinetics of remimazolam for intravenous sedation in paediatric patients undergoing diagnostic and/or therapeu...
    Medical condition: Paediatric procedural sedation
    Disease: Version SOC Term Classification Code Term Level
    23.0 100000004865 10083924 Sedation procedure LLT
    Population Age: Newborns, Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-001054-17 Sponsor Protocol Number: PHRN15-SE/AMIKINHAL Start Date*: 2017-01-27
    Sponsor Name:CHRU de Tours
    Full Title: Double-blinded multicenter randomized controlled trial comparing inhaled amikacin versus placebo to prevent ventilator associated pneumonia
    Medical condition: Patient with mechanical ventilation through an endotracheal tube
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004862 10065153 Ventilator associated pneumonia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-001227-31 Sponsor Protocol Number: NISCI Start Date*: 2019-06-19
    Sponsor Name:University Zurich, University Hospital Balgrist, Spinal Cord Injury Center
    Full Title: Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury
    Medical condition: spinal cord injury
    Disease: Version SOC Term Classification Code Term Level
    20.1 10022117 - Injury, poisoning and procedural complications 10041554 Spinal cord injury cervical PT
    20.1 10022117 - Injury, poisoning and procedural complications 10041552 Spinal cord injury PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2015-004143-39 Sponsor Protocol Number: SHIP002 Start Date*: 2016-08-09
    Sponsor Name:Erasmus MC
    Full Title: A Phase 3 randomised, double-blind, controlled trial of inhaled 7% hypertonic saline versus 0.9% isotonic saline for 48 weeks in patients with Cystic Fibrosis at 3-6 years of age in parallel with t...
    Medical condition: Cystic Fibrosis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10010331 - Congenital, familial and genetic disorders 10011763 Cystic fibrosis lung PT
    20.0 10010331 - Congenital, familial and genetic disorders 10011762 Cystic fibrosis PT
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Completed) BE (Completed) DK (Completed) FR (Completed) ES (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2013-005572-17 Sponsor Protocol Number: 20132312 Start Date*: 2014-05-21
    Sponsor Name:Erasmus Medical Center
    Full Title: Optimizing propofol dosing for (preterm) newborn infants that need endotracheal intubation
    Medical condition: Sedation for endotracheal intubation in newborns of different ages at the neonatal intensive care unit
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004869 10029392 Newborn LLT
    Population Age: Preterm newborn infants, Newborns, Under 18 Gender: Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-001239-19 Sponsor Protocol Number: PHRN14-PFD-CAPE_COD Start Date*: 2015-08-14
    Sponsor Name:CHRU de TOURS
    Full Title: Effects of low-dose corticosteroids on survival of severe Community-Acquired Pneumonia
    Medical condition: Severe community-acquired pneumonia
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004862 10010120 Community acquired pneumonia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-000202-35 Sponsor Protocol Number: I13018 Start Date*: 2015-01-30
    Sponsor Name:CHU de LIMOGES
    Full Title: Prevention of early ventilator-associated pneumonia with antibiotic therapy in patients treated with mild therapeutic hypothermia after cardiac arrest. Randomized, multicenter double-blind placeb...
    Medical condition: Pneumonia
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004855 10047263 Ventilation pneumonitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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