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Clinical trials for TNF-α

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44339   clinical trials with a EudraCT protocol, of which   7369   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    221 result(s) found for: TNF-α. Displaying page 1 of 12.
    1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2013-001212-30 Sponsor Protocol Number: GW/MB/42964 Start Date*: 2013-07-04
    Sponsor Name:
    Full Title: Modulation of immune function by parenteral fish oil in patients with Crohn’s disease and high inherent Tumor Necrosis Factor-alfa production, a randomized, single blinded, cross-over study
    Medical condition: Crohn's disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-002126-36 Sponsor Protocol Number: BP39261 Start Date*: 2017-03-01
    Sponsor Name:F. Hoffmann-La Roche Ltd
    Full Title: A randomized, double-blind, placebo-controlled, multi-center, three-part phase II study to evaluate the safety and efficacy of RO7123520 as adjunct treatment in patients with moderately to severely...
    Medical condition: Rheumatoid Arthritis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10039073 Rheumatoid arthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended) DE (Prematurely Ended) ES (Prematurely Ended) IT (Completed)
    Trial results: View results
    EudraCT Number: 2008-004699-34 Sponsor Protocol Number: D4260C00008 Start Date*: 2008-10-28
    Sponsor Name:AstraZeneca AB
    Full Title: A Randomised, Double-Blind, Placebo-Controlled, Parallel Group, Phase II study to Assess the efficacy of 28 Day Oral Administration of AZD1236 in Adult Patients with Cystic Fibrosis.
    Medical condition: Cystic Fibrosis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10011763 Cystic fibrosis lung LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended) ES (Completed)
    Trial results: View results
    EudraCT Number: 2006-005330-20 Sponsor Protocol Number: WA20495 Start Date*: 2007-06-07
    Sponsor Name:F. Hoffmann-La Roche Ltd
    Full Title: A randomized, double-blind, parallel group, international study to evaluate the safety and efficacy of ocrelizumab compared to placebo in patients with active rheumatoid arthritis who have an in...
    Medical condition: Rheumatoid arthritis
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10028395 Musculoskeletal and connective tissue disorders SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) DE (Completed) FR (Completed) HU (Completed) ES (Temporarily Halted) CZ (Completed) NL (Completed) SI (Completed) SE (Completed) IT (Completed) SK (Completed)
    Trial results: View results
    EudraCT Number: 2007-002951-18 Sponsor Protocol Number: GEN411/OFA110634 Start Date*: 2007-12-10
    Sponsor Name:Genmab A/S
    Full Title: A double-blind, randomized, placebo controlled, parallel group, multi-center, phase III trial of ofatumumab investigating clinical efficacy in adult patients with active rheumatoid arthritis who ha...
    Medical condition: Rheumatoid Arthritis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10039073 Rheumatoid arthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended) IT (Completed) ES (Completed) GB (Completed) FR (Completed) SE (Completed) DK (Prematurely Ended) DE (Completed)
    Trial results: View results
    EudraCT Number: 2020-001177-78 Sponsor Protocol Number: APHP191008 Start Date*: 2021-02-25
    Sponsor Name:University of Utah
    Full Title: Certolizumab to Prevent Pregnancy Complications in High-Risk Patients with APS or SLE
    Medical condition: Pregnant women with Antiphospholipid Syndrom (APS) and Lupus Antocoagulant (LAC)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10005329 - Blood and lymphatic system disorders 10002817 Antiphospholipid syndrome PT
    20.1 100000004848 10058347 Lupus anticoagulant positive LLT
    20.0 100000004848 10058355 Lupus anticoagulant LLT
    Population Age: Adults Gender: Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-017622-39 Sponsor Protocol Number: ERNLPT01 Start Date*: 2010-04-21
    Sponsor Name:Clinical Center Ljubljana
    Full Title: A double blind, randomized study to compare influence of niacin/laropiprant on functional and morphological characteristics of arterial wall and parameters of inflammation in subjects with CHD alre...
    Medical condition: To evaluate the influence of 12 weeks of ER niacin/laropiprant therapy on endothelial dependent dilatation of the arterial wall in CHD patients already treated with a statin compared to placebo as...
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: SI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-003325-22 Sponsor Protocol Number: 2022-15944 Start Date*: 2023-01-25
    Sponsor Name:RadboudUMC
    Full Title: The immunomodulatory effect of sugammadex after total hip replacement surgery under neuraxial anaesthesia: a pilot study
    Medical condition: Hip osteoarthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-021020-94 Sponsor Protocol Number: ACT11575 Start Date*: 2011-03-10
    Sponsor Name:Sanofi-aventis Recherche & Développement
    Full Title: A randomized, double-blind, parallel-group, placebo- and active calibrator-controlled study assessing the clinical benefit of SAR153191 subcutaneous (SC) on top of methotrexate (MTX) in patients wi...
    Medical condition: active rheumatoid arthritis
    Disease: Version SOC Term Classification Code Term Level
    13.1 10028395 - Musculoskeletal and connective tissue disorders 10039073 Rheumatoid arthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) IT (Prematurely Ended) HU (Completed) CZ (Prematurely Ended) ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-002104-18 Sponsor Protocol Number: GID25 Start Date*: 2007-08-27
    Sponsor Name:Sanofi Pasteur SA
    Full Title: Evaluation of the Cellular, Humoral and Mucosal Immune Response in Adults and Elderly Subjects Vaccinated either with an Inactivated Influenza Vaccine Administered via the Intradermal Route or an I...
    Medical condition: Vaccination of adult subjects aged 18 to 40 years and elderly subjects aged 60 to 85 years with an inactivated, split-virion influenza vaccine administered via the intradermal route using Vaxigrip®...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2009-010191-19 Sponsor Protocol Number: ALS-002-2009 Start Date*: 2010-03-19
    Sponsor Name:Alloksys Life Sciences BV
    Full Title: A randomized, double-blind, placebo-controlled phase IIIa study on bIAP, an anti-inflammatory moiety, in patients undergoing combined aortic valve replacement and coronary artery bypass grafting.
    Medical condition: Patients undergoing invasive cardiac surgery with prolonged perfusion time. This often is associated with potentially life-threatening inflammatory complications due to ischemic periods during surg...
    Disease: Version SOC Term Classification Code Term Level
    12.0 10057944 Combined valvular disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-005687-97 Sponsor Protocol Number: NoSIRS Start Date*: 2013-06-20
    Sponsor Name:Medtronic Inc.
    Full Title: Effects of Transvenous Vagus Nerve Stimulation on Immune Response: a pilot study
    Medical condition: Possible future indications: inflammatory conditions in general
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-014348-12 Sponsor Protocol Number: ASIM (IMM 08-0061) Start Date*: 2009-10-13
    Sponsor Name:Mikkel Østergaard
    Full Title: Helkrops MR, MR af sacroiliacaled og columna totalis og cirkulerende biomarkører hos patienter med spondylartritis i behandling med adalimumab (ASIM)
    Medical condition: Spondyloartritis
    Disease: Version SOC Term Classification Code Term Level
    12.1 10051265 Spondyloarthropathy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2013-001558-87 Sponsor Protocol Number: UBS-HG Start Date*: 2014-02-24
    Sponsor Name:Karolinska University Hospital
    Full Title: Safety of normalising slightly elevated plasma glucose by Exenatide in acute ischemic stroke patients treated with intravenous thrombolysis: a pilot study
    Medical condition: Patients with acute ischemic stroke, treated with intravenous thrombolysis treatment according to the European regulatory criteria
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2015-005308-27 Sponsor Protocol Number: CL04041025 Start Date*: 2016-06-07
    Sponsor Name:R-Pharm International LLC
    Full Title: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multicenter Phase III Study of the Efficacy and Safety of Olokizumab in Subjects with Moderately to Severely Active Rheumatoid Arthri...
    Medical condition: Moderately to Severely Active Rheumatoid Arthritis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Completed) HU (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2012-004938-42 Sponsor Protocol Number: EHRVI Start Date*: 2013-03-01
    Sponsor Name:Radboud University Nijmegen Medical Centre
    Full Title: Experimental Human Rhinovirus Infection, a randomized placebo-controlled pilot study
    Medical condition: Viral infections in general, and the "common cold" induced by HRV-16 in particular.
    Disease: Version SOC Term Classification Code Term Level
    14.1 10021881 - Infections and infestations 10061494 Rhinovirus infection PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2015-002202-37 Sponsor Protocol Number: 2015-115 Start Date*: 2016-01-06
    Sponsor Name:radboudumc
    Full Title: Pilot study: Is concomitant administration of lidocaine during oxaliplatin infusion able to prevent pain as a result of oxaliplatin induced acute neuropathy?
    Medical condition: Acute oxaliplatin induced neuropathy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-002174-22 Sponsor Protocol Number: Avifibro Start Date*: 2006-11-08
    Sponsor Name:Mondobiotech Laboratories Anstalt
    Full Title: Influence of inhaled Aviptadil on CCL18 serum concentrations in patients with pulmonary fibrosis
    Medical condition: Pulmonary Fibrosis categorized as UIP or NSIP
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-003601-10 Sponsor Protocol Number: NL69300 Start Date*: 2020-09-18
    Sponsor Name:Amsterdam University Medical Centers
    Full Title: Treatment of Skin Severity in Ichthyosis with Hyperbaric Oxygen Therapy
    Medical condition: ichthyosis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10010331 - Congenital, familial and genetic disorders 10021198 Ichthyosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-003539-56 Sponsor Protocol Number: 1.01 Start Date*: 2006-11-10
    Sponsor Name:Medical University of Vienna, Department of Internal Medicine IV
    Full Title: Simvastatin in patients with septic shock
    Medical condition: Septic shock
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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