Flag of the European Union EU Clinical Trials Register Help

Clinical trials for Tear film

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44346   clinical trials with a EudraCT protocol, of which   7374   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
    How to search [pdf]
    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
    Advanced Search: Search tools
     
    35 result(s) found for: Tear film. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2020-004978-22 Sponsor Protocol Number: OPHT-300920 Start Date*: 2021-01-21
    Sponsor Name:Medical University of Vienna, Department of Clinical Pharmacology
    Full Title: Detection of acetylsalicylic acid and omega-3 fatty acids in Schirmers’ test strips using mass spectrometry and correlations with tear film and blood flow parameters in healthy adults: an open-labe...
    Medical condition: Healthy subjects
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2015-002508-94 Sponsor Protocol Number: OPHT-030815 Start Date*: 2015-10-06
    Sponsor Name:Medical University of Vienna
    Full Title: Effect of topical azithromycin on tear film thickness in patients with meibomian gland dysfunction – comparison to oral treatment with doxycycline
    Medical condition: Meibomian gland dysfunction Dry eye syndrome
    Disease: Version SOC Term Classification Code Term Level
    20.0 10015919 - Eye disorders 10065062 Meibomian gland dysfunction PT
    20.0 100000014904 10013777 Dry eye syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-001647-46 Sponsor Protocol Number: IIBSP-END-2018-96 Start Date*: 2020-01-20
    Sponsor Name:Institut de Recerca H. de la Santa Creu i Sant Pau
    Full Title: Evaluation of the regenerative efficacy of Endoret® (PRGF-Plasm Rich in Growth Factors) on the ocular surface of glaucoma patients treated chronically with ocular hypotensive drugs
    Medical condition: Glaucoma
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-002578-37 Sponsor Protocol Number: OPHT-240518 Start Date*: 2019-04-25
    Sponsor Name:Medical University of Vienna, Department of Clinical Pharmacology
    Full Title: The effect of antibiotic eye drops on the nasal microbiome in healthy subjects
    Medical condition: healthy volunteers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-002507-28 Sponsor Protocol Number: OPHT-280515 Start Date*: 2015-07-20
    Sponsor Name:Medical University of Vienna
    Full Title: Effect of benzalkonium chloride containing eye drops on the conjunctival bacterial flora of dry eye patients.
    Medical condition: conjunctival bacterial flora in patients with dry eye syndrome
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004853 10013777 Dry eye syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-005379-10 Sponsor Protocol Number: HUS_MON_2014-01 Start Date*: 2015-05-18
    Sponsor Name:Emiliano Hernández Galilea
    Full Title: Study of tear osmolarity and Quality of Life on patients treated with unpreserved latanoprost 0.005%
    Medical condition: Chronic open angle glaucoma and ocular hypertension
    Disease: Version SOC Term Classification Code Term Level
    17.1 10015919 - Eye disorders 10018307 Glaucoma and ocular hypertension HLGT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-004012-37 Sponsor Protocol Number: HOM1-2015 Start Date*: 2015-12-18
    Sponsor Name:Ordination Dr. Hommer
    Full Title: An open, non-randomized study on the effect of changing from preserved prostaglandin formulations to preservative free tafluprost (Saflutan® Augentropfen) in patients with ocular hypertension or pr...
    Medical condition: Glaucoma / Ocular Hypertension
    Disease: Version SOC Term Classification Code Term Level
    18.1 10015919 - Eye disorders 10018307 Glaucoma and ocular hypertension HLGT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2012-001556-19 Sponsor Protocol Number: COL_SCU_2011 Start Date*: 2012-11-08
    Sponsor Name:FUNDACION IMABIS
    Full Title: A Prospective, Randomized, Doubled-masked, Single Center, Clinical Comparison of Autologous Serum, Heterologous Serum and Umbilical Cord Serum Eye Drops in the Management of Dry Eye Syndrome
    Medical condition: Ocular surface disturbances.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-004271-12 Sponsor Protocol Number: NGF0213 Start Date*: 2014-01-17
    Sponsor Name:Dompé s.p.a
    Full Title: An open-label study evaluating safety and efficacy of recombinant human nerve growth factor (rhNGF) eye drops at different doses in patients with Dry Eye
    Medical condition: Dry Eye syndrome is caused by either decreased tear production or increased tear film evaporation. Dry eye is a chronic inflammatory condition of the ocular surface with severe symptoms and visual ...
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004853 10013777 Dry eye syndrome LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2019-000747-27 Sponsor Protocol Number: 049/SI Start Date*: 2020-09-09
    Sponsor Name:SOCIETÀ INDUSTRIA FARMACEUTICA ITALIANA (SIFI) SPA
    Full Title: A Multicenter, Randomized, Double-Masked, Placebo-Controlled Phase II Study to evaluate the Safety and Efficacy of Pro-ocular™ 0.5% and 1% in Patients with Dry Eye Syndrome
    Medical condition: Dry Eye is a multifactorial disease of the ocular surface characterized by a loss of homeostasis of the tear film and accompanied by ocular symptoms, in which tear film instability, hyperosmolarity...
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004853 10013777 Dry eye syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-002183-63 Sponsor Protocol Number: IOBA-CERLab-003-2013 Start Date*: 2013-11-12
    Sponsor Name:IOBA
    Full Title: Unicenter, double masked, crossover clinical trial to assess the efficacy of FML (0.1% Fluorometolone) in dry eye patients
    Medical condition: Dry eye syndrome (DES)
    Disease: Version SOC Term Classification Code Term Level
    16.0 10015919 - Eye disorders 10013777 Dry eye syndrome LLT
    16.0 10015919 - Eye disorders 10013774 Dry eye PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-005468-14 Sponsor Protocol Number: OPHT-081214 Start Date*: 2015-02-24
    Sponsor Name:Medical University of Vienna, Department of Clinical Pharmacology
    Full Title: Latanoprost preserved versus unpreserved: effect on tear film thickness as measured with OCT
    Medical condition: glaucoma and ocular hypertension
    Disease: Version SOC Term Classification Code Term Level
    19.1 10015919 - Eye disorders 10018307 Glaucoma and ocular hypertension HLGT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2017-003285-27 Sponsor Protocol Number: T1565-PIV-0117 Start Date*: 2017-09-26
    Sponsor Name:Laboratoires Thea
    Full Title: Clinical efficacy of topical hydrocortisone 0.335% (Softacort®) in patients with chronic dry eye disease and associated ocular surface inflammation
    Medical condition: Dry Eye Disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004853 10013777 Dry eye syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-001642-18 Sponsor Protocol Number: WP3 Start Date*: 2019-12-05
    Sponsor Name:Department of Ophthalmology, Rigshospitalet-Glostrup
    Full Title: Effect on the ocular surface when treating glaucoma with eye drops: an investigation of the conjunctival goblet cells
    Medical condition: Open angular glaucoma and ocular hypertension
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-001022-34 Sponsor Protocol Number: AVX012-CT-001 Start Date*: 2016-10-06
    Sponsor Name:AVIZOREX PHARMA, S.L.
    Full Title: A phase I/II, double-blind, placebo-controlled study assessing the safety and efficacy of AVX-012 ophthalmic solution in subjects with mild-to-moderate dry eye syndrome
    Medical condition: Dry eye syndrome
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004853 10013777 Dry eye syndrome LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-005405-36 Sponsor Protocol Number: LT1580-301 Start Date*: 2016-05-10
    Sponsor Name:Laboratoires Théa
    Full Title: EFFICACY AND SAFETY ASSESSMENT OF T1580 VERSUS VEHICLE IN DRY EYE DISEASE TREATMENT
    Medical condition: Dry Eye
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000014904 10013778 Dry eyes LLT
    20.0 100000014904 10013777 Dry eye syndrome LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: BE (Completed) HU (Prematurely Ended) LV (Prematurely Ended) AT (Prematurely Ended) GB (Prematurely Ended) LT (Prematurely Ended) GR (Prematurely Ended) CZ (Prematurely Ended) BG (Prematurely Ended) PL (Prematurely Ended) HR (Prematurely Ended) ES (Prematurely Ended) IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2011-000608-16 Sponsor Protocol Number: 5466 Start Date*: 2011-12-21
    Sponsor Name:The Newcastle upon Tyne Hospitals NHS Foundation Trust [...]
    1. The Newcastle upon Tyne Hospitals NHS Foundation Trust
    2. The Newcastle upon Tyne Hospitals NHS Foundation Trust
    Full Title: To evaluate the safety and effectiveness of human ex vivo expanded autologous limbal stem cells for the treatment of unilateral total limbal stem cell deficiency
    Medical condition: unilateral total limbal stem cell deficiency
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2020-001720-33 Sponsor Protocol Number: CSA_2020 Start Date*: 2020-09-08
    Sponsor Name:UNIVERSITÀ CAMPUS BIO-MEDICO DI ROMA
    Full Title: Cyclosporine 0.1% Eye Drops as Prophylactic Treatment in Post Surgical Ocular Surface System Failure Within The Age
    Medical condition: High-risk patients, i.e. elder patients, who show dry eye syndrome after insult.
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004853 10013777 Dry eye syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000937-54 Sponsor Protocol Number: MC2-03-C1 Start Date*: 2015-08-03
    Sponsor Name:DRUG DELIVERY SOLUTIONS ApS (PART OF MC2 BIOTEK GROUP)
    Full Title: A phase II, multicenter, randomized, double-masked, 4 parallel arms, controlled 6-month trial designed to evaluate the safety and efficacy of PAD ciclosporin (CsA 0.06% and 0.03%) ophthalmic disper...
    Medical condition: ocular dryness (Dry Eye Disease - DED)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000014904 10013778 Dry eyes LLT
    20.0 100000014904 10013777 Dry eye syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DK (Completed) NO (Completed) AT (Completed) ES (Completed) PT (Completed) FR (Completed) SK (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2017-005160-18 Sponsor Protocol Number: RP101-200 Start Date*: 2018-12-18
    Sponsor Name:Redwood Pharma AB
    Full Title: A Phase II, multicentre, randomised, placebo-controlled, double-masked trial of RP101 ophthalmic formulation versus vehicle in post-menopausal women with moderate to severe dry eye syndrome
    Medical condition: moderate or severe dry eye syndrome
    Disease: Version SOC Term Classification Code Term Level
    20.0 10015919 - Eye disorders 10013774 Dry eye PT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: AT (Completed) HU (Completed) DE (Completed)
    Trial results: View results
    Download Options:
    Number of Trials to download:
    Download Content:
    Download Format:
    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
    1  2  Next»
    Query did not match any studies.
    For support, Contact us.
    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

    European Medicines Agency © 1995-Mon Jun 30 15:57:25 CEST 2025 | Domenico Scarlattilaan 6, 1083 HS Amsterdam, The Netherlands
    EMA HMA