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Clinical trials for Threshold dose

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    297 result(s) found for: Threshold dose. Displaying page 1 of 15.
    1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2005-002159-41 Sponsor Protocol Number: Mo_top_Sb_100505 Start Date*: 2005-10-03
    Sponsor Name:Department of Anaesthesia & General Intensive Care Medicine
    Full Title: Investigation of the antihyperalgesic effect of topical buprenorphine in an UV-B induced inflammatory skin pain model in healthy volunteers
    Medical condition: Volunteer study with healthy volunteers using the UV-B-model as model of hyperalgesia.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2015-003610-25 Sponsor Protocol Number: CT-MT001-2-2015-1 Start Date*: 2015-12-09
    Sponsor Name:Myelo Therapeutics GmbH
    Full Title: A randomised, double-blind, placebo-controlled, parallel-design, multi-centre study to investigate the efficacy to reduce chemotherapy-induced neutropenia (CIN), effects on the haematopoietic syste...
    Medical condition: Chemotherapy-induced neutropenia (CIN)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10072806 Chemotherapy toxicity attenuation PT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2010-020042-94 Sponsor Protocol Number: LS07-040 Start Date*: 2010-09-02
    Sponsor Name:Medizinische Universität Wien, Universitätsklinik für Anästhesie, Allgemeine Intensivmedizin
    Full Title: The Effect of High-dose Remifentanil on the Reversal of Neuropathic Pain in Postherpetic Patients
    Medical condition: Post herpetic hyperalgesia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2015-001863-38 Sponsor Protocol Number: iFAAM-PPIwalnut Start Date*: 2015-09-24
    Sponsor Name:Fundación para la investigación biomedica del hospital clinico san carlos de madrid
    Full Title: The impact of proton-pump inhibitors (antacids) on threshold dose distributions
    Medical condition: walnut allergic patients
    Disease: Version SOC Term Classification Code Term Level
    18.0 10021428 - Immune system disorders 10016946 Food allergy PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2011-000631-92 Sponsor Protocol Number: CQGE031A2208 Start Date*: 2011-12-07
    Sponsor Name:Novartis Pharma AG
    Full Title: A phase II, randomized, double-blind, placebo controlled, parallel design, dose ranging, multi-center trial of four levels of exposure of QGE031 s.c. for 16 weeks in subjects aged 18 years and olde...
    Medical condition: Peanut allergy
    Disease: Version SOC Term Classification Code Term Level
    14.0 10021428 - Immune system disorders 10034202 Peanut allergy LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Prematurely Ended) GB (Prematurely Ended) GR (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2018-004427-37 Sponsor Protocol Number: 5421234 Start Date*: 2019-02-20
    Sponsor Name:Odense Research Centre for Anaphylaxis (ORCA)
    Full Title: Treatment with Omalizumab in food allergic children
    Medical condition: Food Allergy with Anaphylaxis
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004870 10064075 Seafood allergy LLT
    20.0 100000004870 10014315 Egg allergy LLT
    20.0 100000004870 10016709 Fish allergy LLT
    20.0 100000004870 10040539 Shellfish allergy LLT
    20.0 100000004870 10001745 Allergy to cow's milk LLT
    20.1 100000004870 10034202 Peanut allergy LLT
    20.0 100000004870 10011240 Cow's milk allergy LLT
    20.1 100000004870 10054957 Allergy to grains LLT
    20.1 100000004870 10054959 Allergy to nuts LLT
    20.0 100000004870 10076438 Milk protein allergy LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-002602-36 Sponsor Protocol Number: KKSH-127 Start Date*: 2016-06-21
    Sponsor Name:Martin-Luther-Universität Halle-Wittenberg
    Full Title: Efficacy and safety of high dose glucocorticosteroid treatment for idiopathic sudden sensorineural hearing loss (HODOKORT)
    Medical condition: Idiopathic sudden sensorineural hearing loss
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-015780-14 Sponsor Protocol Number: High-Dose-RemiSun Start Date*: 2009-12-28
    Sponsor Name:Abteilung für Anästhesie und Intensivmedizin, Medizinische Universität Wien
    Full Title: The effect of high dose remifentanil on the reversal of established sunburn-induced hyperalgesia in human volunteers
    Medical condition: Volunteer study with 24 healthy volunteers to perform pain research and to study the reversal of hyperalgesia by IMP
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2015-001431-20 Sponsor Protocol Number: CHDR1417 Start Date*: 2015-08-17
    Sponsor Name:Centre for Human Drug Research
    Full Title: A randomized, double blind, double-dummy placebo controlled, 3-way cross-over study to determine the test-retest reliability of, and the effect of oral retigabine and riluzole on, peripheral motor ...
    Medical condition: Amytrophic Lateral Sclerosis
    Disease: Version SOC Term Classification Code Term Level
    18.1 10029205 - Nervous system disorders 10002026 Amyotrophic lateral sclerosis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2017-002443-15 Sponsor Protocol Number: ICAF-BETA Start Date*: 2017-09-20
    Sponsor Name:York Teaching Hospitals NHS Foundation Trust
    Full Title: Improving cardiac function in high-risk surgical patients: exercise testing, biomarkers and beta-blockade
    Medical condition: Impaired VE/CO2 on cardio pulmonary exercise testing
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004849 10007648 Cardiovascular disease, unspecified LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2022-002169-14 Sponsor Protocol Number: TAK-573-2001 Start Date*: 2023-03-10
    Sponsor Name:Takeda Development Center Americas, Inc.
    Full Title: A Phase 1/2a Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of Modakafusp Alfa in Combination With Daratumumab Subcutaneous in Patients With...
    Medical condition: Multiple Myeloma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Prematurely Ended) ES (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2019-003644-68 Sponsor Protocol Number: V114-033 Start Date*: 2021-12-07
    Sponsor Name:Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
    Full Title: A Phase 3, Multicenter, Randomized, Double-blind, Active-Comparatorcontrolled Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 in Healthy Japanese Infants
    Medical condition: Prevention of pneumococcal disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10061353 Pneumococcal infection PT
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2021-006686-37 Sponsor Protocol Number: SH600009 Start Date*: 2022-02-18
    Sponsor Name:Sanofi Pasteur
    Full Title: Immunogenicity and Safety of a DTwP-HepB-Hib-IPV (SHAN6™) Vaccine when Administered Concomitantly with Routine Pediatric Vaccines in Healthy Infants and Toddlers in Thailand
    Medical condition: Diphtheria, Tetanus, Pertussis, Hepatitis-B, invasive Haemophilus influenzae type b and Poliomyelitis diseases
    Disease: Version SOC Term Classification Code Term Level
    21.1 10042613 - Surgical and medical procedures 10069577 Pertussis immunisation PT
    21.1 10042613 - Surgical and medical procedures 10054129 Diphtheria immunisation PT
    21.1 10042613 - Surgical and medical procedures 10054175 Polio immunisation PT
    21.1 10042613 - Surgical and medical procedures 10054181 Hepatitis B immunization LLT
    21.1 10042613 - Surgical and medical procedures 10069533 Haemophilus influenzae type b immunisation PT
    21.1 10042613 - Surgical and medical procedures 10054131 Tetanus immunisation PT
    21.1 10042613 - Surgical and medical procedures 10076886 Rotavirus immunisation PT
    21.1 10042613 - Surgical and medical procedures 10069578 Pneumococcal immunisation PT
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2005-001639-30 Sponsor Protocol Number: TramaPara8405 Start Date*: 2006-10-02
    Sponsor Name:Department of Anaesthesia&Intensive Care B, Vienna Medical University
    Full Title: Investigation of the antihyperalgesic effect of a combination of tramadol and paracetamol on primary and secondary hyperalgesia in an UV-B induced inflammatory skin pain model in healthy volunteers.
    Medical condition: This is a volunteer study in healthy volunteers.
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2018-003787-31 Sponsor Protocol Number: V114-025 Start Date*: 2019-08-23
    Sponsor Name:Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
    Full Title: A Phase 3, Multicenter, Randomized, Double-blind, Active -comparator-controlled Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 in Healthy Infants (PNEU-PED-EU-1)
    Medical condition: Pneumococcal disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10061353 Pneumococcal infection PT
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: DE (Completed) EE (Completed) BE (Completed) CZ (Completed) ES (Completed) PL (Completed) GR (Completed) Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2011-002174-23 Sponsor Protocol Number: SMART_5 Start Date*: 2011-11-21
    Sponsor Name:Lofarma S.p.A.
    Full Title: A dose Finding Study of the Efficacy of LAIS Grass tablets in patients suffering from grass pollen-induced allergic rhinoconjunctivitis
    Medical condition: allergic rhinoconjunctivitis
    Disease: Version SOC Term Classification Code Term Level
    14.0 10015919 - Eye disorders 10001728 Allergic rhinoconjunctivitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2016-004295-22 Sponsor Protocol Number: NL59645.098.16 Start Date*: 2017-04-10
    Sponsor Name:Hagaziekenhuis
    Full Title: Treatment of thromBocytopenia with EltRombopag or Intravenous Immune Globulin (IVIG) Before and DurING Invasive Procedures in Patients with Immune ThrombocytoPenia.
    Medical condition: Immune thrombocytopenia patients with low platelets and in need of surgery.
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004851 10023095 ITP LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-003923-23 Sponsor Protocol Number: 1.1 Start Date*: 2015-10-12
    Sponsor Name:Imperial College London
    Full Title: GLP-1 Receptor Agonist interVentIon for poor responders afTer bariAtric Surgery: The GRAVITAS trial
    Medical condition: TYPE 2 DIABETES MELLITUS
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2017-004793-34 Sponsor Protocol Number: P171103J Start Date*: 2018-07-10
    Sponsor Name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
    Full Title: 68Ga-DOTATATE PET-CTA imaging for the early detection of progressing coronary atherosclerosis
    Medical condition: Patients with coronary atherosclerosis without significant myocardial ischemia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-000083-29 Sponsor Protocol Number: P21.xxx Start Date*: 2021-07-13
    Sponsor Name:Leiden University Medical Center
    Full Title: Influence of ∆9-tetrahydrocannabinol (THC) on oxycodone induced ventilatory depression in healthy volunteers
    Medical condition: healthy volunteers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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