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Clinical trials for Eplerenone

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44351   clinical trials with a EudraCT protocol, of which   7378   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    40 result(s) found for: Eplerenone. Displaying page 2 of 2.
    « Previous 1  2 
    EudraCT Number: 2015-002519-14 Sponsor Protocol Number: 2015-775 Start Date*: 2015-08-25
    Sponsor Name:Herlev Hospital
    Full Title: The MIRAD study - Mineralocorticoid Receptor Antagonists in Type 2 Diabetes. A randomised, double-blind, placebo-controlled study of the effect of Mineralocorticoid Receptor Antagonists in Type 2 D...
    Medical condition: diabetes (type 2)
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004861 10012594 Diabetes LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2011-002518-35 Sponsor Protocol Number: 2011-402 Start Date*: 2012-02-22
    Sponsor Name:Karl Emil Kristensen
    Full Title: The effect of aldosterone on the development of chronic allograft nephropathy after kidney transplantation
    Medical condition: Chronic allograft nephropathy in kidney transplants, defined as tubular atrophy and interstitial fibrosis in graft biopsy (Banff criteria)
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10063209 Chronic allograft nephropathy PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2005-003351-12 Sponsor Protocol Number: A6141079 Start Date*: 2005-10-27
    Sponsor Name:Pfizer Ltd
    Full Title: The effect of eplerenone versus placebo on cardiovascular mortality and heart failure hospitalization in subjects with NYHA Class II Chronic Systolic Heart Failure
    Medical condition: Chronic systolic heart failure
    Disease: Version SOC Term Classification Code Term Level
    8.0 10008908 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) IE (Completed) SK (Completed) SE (Completed) GB (Completed) ES (Completed) HU (Completed) BE (Completed) PT (Completed) GR (Completed) IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2010-019844-38 Sponsor Protocol Number: A6141116 Start Date*: 2010-08-12
    Sponsor Name:Pfizer, S.A
    Full Title: A double-blind, randomized, placebo-controlled trial evaluating the safety and efficacy of early the treatment with Eplerenone in patients with acute myocardial infarction. Estudio doble ciego, al...
    Medical condition: Infarto agudo de miocardio
    Disease: Version SOC Term Classification Code Term Level
    13 10000891 Infarto agudo de miocardio LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) SK (Completed) CZ (Completed) HU (Completed) GB (Completed) DE (Completed) NL (Completed) GR (Completed)
    Trial results: View results
    EudraCT Number: 2021-001327-41 Sponsor Protocol Number: IMIB-RMV-2021-02 Start Date*: 2021-07-12
    Sponsor Name:Fundación para la formación e investigación sanitarias de la Región de Murcia
    Full Title: Withdrawal of pharmacological treatment in patients responding to cardiac resynchronization therapy: Open and randomized study
    Medical condition: Heart failure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-003555-35 Sponsor Protocol Number: PAT-DEU-402 Start Date*: 2017-11-17
    Sponsor Name:Fresenius Medical Care Nephrologica Deutschland GmbH
    Full Title: A Multicentre, Randomised, Open-label, Parallel-Group Pilot Study to Evaluate the Efficacy of Patiromer in Optimising Mineralocorticoid Receptor Antagonist Therapy in Heart Failure Subjects with Hy...
    Medical condition: Heart Failure with reduced ejection fraction (HFrEF) subjects with hyperkalaemia
    Disease: Version SOC Term Classification Code Term Level
    20.1 10027433 - Metabolism and nutrition disorders 10020646 Hyperkalaemia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2009-011291-29 Sponsor Protocol Number: RACE 3 Start Date*: 2011-08-16
    Sponsor Name:Interuniversity Cardiology Institute of the Netherlands (ICIN)
    Full Title: Routine versus Aggressive Upstream Rhythm Control for Prevention of Early Atrial Fibrillation in Heart Failure: RACE 3
    Medical condition: atrial fibrillation
    Disease: Version SOC Term Classification Code Term Level
    14.0 10007541 - Cardiac disorders 10003661 Atrial fibrillation paroxysmal LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA) NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-000773-23 Sponsor Protocol Number: I4M-MC-MRAC Start Date*: 2012-04-23
    Sponsor Name:Eli Lilly and Company
    Full Title: Study of the Safety and Efficacy of LY2623091 in Chronic Kidney Disease Patients
    Medical condition: Chronic kidney disease
    Disease: Version SOC Term Classification Code Term Level
    14.1 10038359 - Renal and urinary disorders 10064848 Chronic kidney disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BG (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-003139-19 Sponsor Protocol Number: CLCI699A2201 Start Date*: 2008-09-12
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A multi-center, randomized, double-blind, placebo and active controlled, parallel group, dose finding study to evaluate the efficacy and safety of LCI699 compared to placebo after 8 weeks treatment...
    Medical condition: Essential Hypertension
    Disease: Version SOC Term Classification Code Term Level
    9.1 10015488 Essential hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) SE (Completed) NL (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2008-001192-29 Sponsor Protocol Number: cv-08/025 Start Date*: 2008-06-03
    Sponsor Name:Fundación Investigación y Desarrollo en el Area Cardiovascular
    Full Title: “Evaluación mediante proteómica de biomarcadores proteicos asociados con el tratamiento con Eplerenona versus espironolactona en pacientes post-infarto agudo de miocardio, diabéticos con hipertensi...
    Medical condition: Disfunción ventricular leve-moderada post-infarto agudo de miocardio en pacientes diabéticos con hipertensión arterial no controlada. Low-moderate ventricular dysfunction in post-acute coronary sy...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-007338-23 Sponsor Protocol Number: CLCI699A2216 Start Date*: 2009-02-18
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A phase II, randomized, double-blind, placebo and active controlled, parallel group, multi-center, dose ranging study to evaluate the efficacy and safety of LCI699 compared to placebo after 8 weeks...
    Medical condition: resistant hypertension
    Disease: Version SOC Term Classification Code Term Level
    9.1 10020772 Hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IS (Completed)
    Trial results: View results
    EudraCT Number: 2009-012445-35 Sponsor Protocol Number: ALBLOCK-2 Start Date*: 2009-11-26
    Sponsor Name:Herlev Hospital
    Full Title: Aldosterone receptor blockade in patients with chronic kidney disease. Influence on arterial stiffness and kidney function.
    Medical condition: Chronic kidney disease, stages 3 and 4.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10064848 Chronic kidney disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2011-001264-22 Sponsor Protocol Number: SILK/Eplerenone1 Start Date*: 2012-11-08
    Sponsor Name:Region Skåne
    Full Title: Eplerenone and spironolactone in male patients with ascites due to liver cirrhosis. A Swedish prospective randomized multicenter study of efficacy and endocrinologic side effects.
    Medical condition: Ascites complicating liver cirrhosis in males
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004871 10024667 Liver cirrhosis LLT
    14.1 100000004861 10021038 Hyponatremia LLT
    14.1 10038604 - Reproductive system and breast disorders 10018800 Gynaecomastia PT
    14.1 100000004848 10003146 Arterial blood pressure decreased LLT
    14.1 100000004848 10040409 Serum testosterone LLT
    15.1 10038604 - Reproductive system and breast disorders 10025522 Male sexual dysfunction NEC LLT
    14.1 10038604 - Reproductive system and breast disorders 10025503 Male erectile disorder LLT
    14.1 100000004871 10064704 Decompensated cirrhosis LLT
    14.1 100000004857 10023422 Kidney function abnormal LLT
    14.1 100000004861 10020647 Hyperkalemia LLT
    14.1 10017947 - Gastrointestinal disorders 10003445 Ascites PT
    Population Age: Elderly Gender: Male
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-005176-35 Sponsor Protocol Number: ESR-19-20262 Start Date*: 2021-01-14
    Sponsor Name:Sahlgrenska University Hospital
    Full Title: OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosili-cate in Heart Failure (OPRA-HF)
    Medical condition: Heart failure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2011-000414-20 Sponsor Protocol Number: CHANCE-HF Start Date*: 2011-08-02
    Sponsor Name:Consorcio de Apoyo a la Investigacion Biomedica en Red (CAIBER)
    Full Title: Ensayo aleatorizado controlado sobre la terapia guiada por el antígeno carbohidrato 125 en los pacientes dados de alta por insuficiencia cardiaca aguda: efecto sobre la mortalidad a 1 año.
    Medical condition: acute heart failure
    Disease: Version SOC Term Classification Code Term Level
    14.1 10007541 - Cardiac disorders 10007556 Cardiac failure acute PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-002605-53 Sponsor Protocol Number: EVEDES Start Date*: 2008-05-20
    Sponsor Name:Fundació Institut de Recerca de l'Hospital de la Santa Creu i de Sant Pau
    Full Title: Antagonistas aldosterónicos en el tratamiento de pacientes con ventrículo derecho sistémico: ensayo clínico aleatorizado.
    Medical condition: Transposición de grandes vasos tratada mediante la técnica de redirección auricular (técnicas de Senning o Mustard).
    Disease: Version SOC Term Classification Code Term Level
    9.1 10010143 Complete transposition of great vessels LLT
    9.1 10044443 Transposition of the great vessels LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-005351-27 Sponsor Protocol Number: 2015CD007B Start Date*: 2016-02-17
    Sponsor Name:Royal Brompton & Harefield NHS Foundation Trust
    Full Title: A randomised controlled pilot trial of the feasibility and safety of therapy withdrawal in asymptomatic patients with a prior diagnosis of dilated cardiomyopathy & recovered cardiac function.
    Medical condition: Dilated Cardiomyopathy with recovered cardiac function
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10007636 Cardiomyopathy PT
    20.0 10007541 - Cardiac disorders 10007636 Cardiomyopathy PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2020-003312-27 Sponsor Protocol Number: D9480C00018 Start Date*: 2021-03-02
    Sponsor Name:AstraZeneca AB
    Full Title: Phase IV, Double-Blind, Placebo-Controlled, Randomized-Withdrawal Trial Evaluating Sodium Zirconium Cyclosilicate (SZC) for the Management of Hyperkalaemia in Patients with Symptomatic Heart Failur...
    Medical condition: Hyperkalemia in Patients with Symptomatic Heart Failure.
    Disease: Version SOC Term Classification Code Term Level
    21.1 10027433 - Metabolism and nutrition disorders 10020646 Hyperkalaemia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) ES (Ongoing)
    Trial results: View results
    EudraCT Number: 2007-000490-40 Sponsor Protocol Number: S320.2.003 Start Date*: 2007-06-20
    Sponsor Name:Solvay Pharmaceuticals GmbH
    Full Title: Randomised, Double-Blind, Placebo-Controlled, Multi-Center, Sequential Cohort Study to Evaluate the Effect of SLV320 in Addition to Chronic Furosemide Treatment on Renal Function in Subjects with C...
    Medical condition: Renal Function in Subjects with Congestive Heart Failure and Impaired Renal Function who are on Chronic Furosemide Treatment
    Disease: Version SOC Term Classification Code Term Level
    9.1 10010684 Congestive heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) CZ (Prematurely Ended) ES (Ongoing) DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2018-005030-38 Sponsor Protocol Number: PAT-CR-302 Start Date*: 2019-08-10
    Sponsor Name:Vifor Pharma, Inc.
    Full Title: A Multicenter, Double-blind, Placebo-controlled, Randomized Withdrawal, Parallel Group Study of Patiromer for the Management of Hyperkalemia in Subjects Receiving Renin-Angiotensin-Aldosterone Syst...
    Medical condition: Management of hyperkalemia due to renin-angiotension-aldosterone system medications in patients treated for heart failure.
    Disease: Version SOC Term Classification Code Term Level
    21.0 10022891 - Investigations 10005725 Blood potassium increased PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Completed) CZ (Completed) NL (Completed) ES (Ongoing) HU (Completed) DE (Completed) BG (Completed) GB (GB - no longer in EU/EEA) BE (Completed) IT (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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