Flag of the European Union EU Clinical Trials Register Help

Clinical trials for Osteoarthritis, Knee AND Pain

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44341   clinical trials with a EudraCT protocol, of which   7370   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
    How to search [pdf]
    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
    Advanced Search: Search tools
     
    228 result(s) found for: Osteoarthritis, Knee AND Pain. Displaying page 5 of 12.
    « Previous 1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2009-010008-27 Sponsor Protocol Number: F1J-MC-HMGP Start Date*: 2009-06-17
    Sponsor Name:Eli Lilly and Company
    Full Title: Duloxetine 60 mg once daily versus Placebo in the Treatment of Patients with Osteoarthritis Knee Pain
    Medical condition: Osteoarthritis Knee Pain
    Disease: Version SOC Term Classification Code Term Level
    9.1 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) DE (Completed) ES (Completed) GR (Completed)
    Trial results: View results
    EudraCT Number: 2007-001197-93 Sponsor Protocol Number: CG100649-2-01 Start Date*: 2007-09-21
    Sponsor Name:CrystalGenomics, Inc.
    Full Title: Double-blind, placebo controlled Phase II repeat dose study of the safety and efficacy of three parallel loading and maintenance dose regimens of CG100649 versus placebo for the treatment of primar...
    Medical condition: Primary osteoarthritis (OA) of the knee or hip
    Disease: Version SOC Term Classification Code Term Level
    9.1 10020108 Hips osteoarthritis LLT
    9.1 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: HU (Completed) DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-003826-28 Sponsor Protocol Number: Z7190L01 Start Date*: 2012-10-03
    Sponsor Name:ZAMBON S.p.A.
    Full Title: Evaluation of efficacy and safety of Ibuprofen Arginine 600 mg tid vs. Ibuprofen 600 mg tid in the treatment of pain and inflammation in Osteoarthritis (OA) patients with hypertension pharmacologic...
    Medical condition: Osteoarthritis of the knee or hip that requires taking NSAIDs for at least 14 days and hypertension stabilized with drugs.
    Disease: Version SOC Term Classification Code Term Level
    15.0 10028395 - Musculoskeletal and connective tissue disorders 10023476 Knee osteoarthritis LLT
    15.0 10028395 - Musculoskeletal and connective tissue disorders 10029875 OA hip LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-003360-26 Sponsor Protocol Number: KF0151Y/07 & amendment (A)1.0 Start Date*: 2006-02-14
    Sponsor Name:Grünenthal GmbH
    Full Title: A randomized, multi-centre, double blind, parallel-group study assessing the analgesic efficacy and safety of different dosages of GRT0151Y bid compared to active comparator bid and placebo bid in ...
    Medical condition: Osteoarthritis of the knee
    Disease: Version SOC Term Classification Code Term Level
    8.0 10023476 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2017-001702-15 Sponsor Protocol Number: R475-OA-1688 Start Date*: 2018-03-05
    Sponsor Name:Regeneron Pharmaceuticals, Inc.
    Full Title: A Phase 3 Randomized, Double-Blind, Multi-Dose, Placebo And NSAID-Controlled Study To Evaluate The Efficacy And Safety Of Fasinumab In Patients With Pain Due To Osteoarthritis Of The Knee Or Hip
    Medical condition: Pain due to osteoarthritis of the knee or hip
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10023476 Knee osteoarthritis LLT
    20.0 100000004859 10020108 Hips osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended) DE (Completed) EE (Completed) GB (GB - no longer in EU/EEA) RO (Completed)
    Trial results: View results
    EudraCT Number: 2014-005329-11 Sponsor Protocol Number: FX006-2014-008 Start Date*: 2015-02-26
    Sponsor Name:Flexion Therapeutics
    Full Title: A Double-Blind, Randomized, Single-Dose Study to Assess the Safety and Efficacy of FX006 for the Treatment of Pain in Patients with Osteoarthritis of the Knee
    Medical condition: Osteoarthritis of the knee
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed) LT (Completed) EE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-000692-14 Sponsor Protocol Number: HKO-22112010 Start Date*: 2011-11-03
    Sponsor Name:Hannu Kokki
    Full Title:
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    14.0 10028395 - Musculoskeletal and connective tissue disorders 10067624 Knee arthritis LLT
    14.0 10022117 - Injury, poisoning and procedural complications 10036284 Post-operative hip pain LLT
    14.0 10042613 - Surgical and medical procedures 10023479 Knee total replacement LLT
    14.0 10028395 - Musculoskeletal and connective tissue disorders 10065955 Hip arthrosis LLT
    14.0 10042613 - Surgical and medical procedures 10003397 Arthroplasty of hip LLT
    14.0 10028395 - Musculoskeletal and connective tissue disorders 10031174 Osteoarthrosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-001701-85 Sponsor Protocol Number: AKT-001 Start Date*: 2013-10-18
    Sponsor Name:Akron Molecules GmbH
    Full Title: A placebo controlled, double blind, randomised, 8-week phase IIa proof of concept study to assess the efficacy and safety of AKR 202 in patients with osteoarthritis pain.
    Medical condition: Moderate to severe osteoarthritis pain in the index knee
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) CZ (Completed) DE (Completed)
    Trial results: Removed from public view
    EudraCT Number: 2018-003094-10 Sponsor Protocol Number: CNTX-4975i-OA-303 Start Date*: 2018-11-27
    Sponsor Name:Centrexion Therapeutics Corp
    Full Title: An Open-label, 8-Week Study to Compare the Comfort and Ease of Use of Five Different Treatment Regimens for CNTX-4975-05 Intra-articular Injection in Subjects with Chronic, Moderate-to-Severe Osteo...
    Medical condition: The index knee must show evidence of chronic OA with a K-L grade of 1, 2, 3 or 4. Subjects who were screen failures for the United States (US) CNTX-4975i-OA-301 or CNTX-4975i-OA-304 trials may be c...
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2015-003783-36 Sponsor Protocol Number: R475-PN-1523 Start Date*: 2016-05-19
    Sponsor Name:Regeneron Pharmaceuticals, Inc.
    Full Title: A Phase 3 Randomized, Double-Blind, Multi-Dose, Placebo-Controlled Study to Evaluate the Long-Term Safety and the Efficacy of Fasinumab in Patients with Pain Due to Osteoarthritis of the Knee or Hip
    Medical condition: Pain due to osteoarthritis of the knee or hip
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10023476 Knee osteoarthritis LLT
    21.1 100000004859 10020108 Hips osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BG (Completed) DK (Completed) SE (Completed) DE (Completed) LT (Completed) GB (GB - no longer in EU/EEA) PL (Completed) ES (Completed) HU (Completed) RO (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2017-003003-22 Sponsor Protocol Number: N-20170060 Start Date*: 2017-11-27
    Sponsor Name:Aalborg University Hospital, Department of Orthopedics [...]
    1. Aalborg University Hospital, Department of Orthopedics
    2. Mogens Brouw Jørgensen
    Full Title: postoperative effect of optimal multimodal pain management supplemented with systemic single dose of Dexamethason in the first week after UKA. Low dose (8mg) or mean dose
    Medical condition: knee osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10031165 Osteoarthritis knee LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2018-002081-39 Sponsor Protocol Number: CLI/22 Start Date*: 2019-03-14
    Sponsor Name:Abiogen Pharma S.p.A.
    Full Title: A randomised, double-blind, parallel-group, multicenter, placebo-controlled, dose-ranging study, to evaluate the efficacy and safety of clodronate ampoules at different dosages, after intra-articul...
    Medical condition: knee osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Prematurely Ended) CZ (Prematurely Ended) IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-000395-32 Sponsor Protocol Number: 2006001 Start Date*: 2006-03-29
    Sponsor Name:King's College London
    Full Title: The effect of COX-2 Inhibition on Reducing Central Sensitisation of Pain in Osteoarthritis
    Medical condition: Osteoarthritis of the knee
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2019-003591-40 Sponsor Protocol Number: 131082019 Start Date*: 2020-06-16
    Sponsor Name:Medizinische Universität Wien, Universitätsklinik für Anästhesie, Allgemeine Intensivmedizin und Schmerztherapie
    Full Title: Efficacy of Cannabidiol in Treatment of Pain due to symptomatic Osteoarthritis of the Knee: A randomized, double-blind, placebo-controlled
    Medical condition: Painful osteoarthritis of the knee
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2018-001618-13 Sponsor Protocol Number: R475-OA-1816 Start Date*: 2018-11-28
    Sponsor Name:Regeneron Pharmaceuticals, Inc.
    Full Title: Study to Evaluate Arthroplasty Specimens in the Phase 3 Fasinumab Program for Osteoarthritis of the Knee and Hip
    Medical condition: Pain due to osteoarthritis of the knee or hip
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10023476 Knee osteoarthritis LLT
    20.0 100000004859 10020108 Hips osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) PL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2021-006540-28 Sponsor Protocol Number: LEVI-04-21-02 Start Date*: 2022-07-21
    Sponsor Name:Levicept Ltd.
    Full Title: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Trial of the Efficacy and Safety of LEVI-04 in Patients with Osteoarthritis of the Knee
    Medical condition: Osteoarthritis of the knee
    Disease: Version SOC Term Classification Code Term Level
    21.1 10028395 - Musculoskeletal and connective tissue disorders 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-003982-32 Sponsor Protocol Number: UCA-01-EC/13/ART Start Date*: 2013-12-26
    Sponsor Name:Arthroscopic Surgery Unit
    Full Title: Pilot study to evaluate combination of intraosseous with intra-articular infiltrations of plasma rich in growth factors (PRGF®-Endoret®) in the treatment of knee osteoarthritis.
    Medical condition: Knee osteoarthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-001943-12 Sponsor Protocol Number: R475-PN-1612 Start Date*: 2018-05-22
    Sponsor Name:Regeneron Pharmaceuticals, Inc.
    Full Title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Fasinumab in Patients with Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hi...
    Medical condition: Pain due to osteoarthritis and chronic lower back pain
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10023476 Knee osteoarthritis LLT
    20.0 100000004859 10020108 Hips osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) HU (Prematurely Ended) ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2004-005261-38 Sponsor Protocol Number: AVS00103 Start Date*: 2005-10-04
    Sponsor Name:Genzyme Europe BV
    Full Title: A Multicenter, Parallel, Double-Blind, Blinded Evaluator, Randomized Comparison of the Efficacy and Safety of an Alternate Viscosupplement (AVS-beta) to Methylprednisolone Acetate in Patients with ...
    Medical condition: Osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    8.1 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-004996-22 Sponsor Protocol Number: 7962-CL-0022 Start Date*: 2016-02-01
    Sponsor Name:Astellas Pharma Europe B.V.
    Full Title: A Phase 2a, Randomized, Double-blind, Placebo- and Naproxen-controlled, Parallel-group Study to Assess the Analgesic Efficacy of ASP7962 in Patients with Pain Due to Osteoarthritis of the Knee
    Medical condition: Osteoarthritis of the knee
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004859 10031165 Osteoarthritis knee LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) HU (Completed) GB (Completed) CZ (Completed) ES (Completed)
    Trial results: View results
    Download Options:
    Number of Trials to download:
    Download Content:
    Download Format:
    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
    « Previous 1  2  3  4  5  6  7  8  9  Next» Last»»
    Query did not match any studies.
    For support, Contact us.
    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

    European Medicines Agency © 1995-Wed Jun 04 14:26:49 CEST 2025 | Domenico Scarlattilaan 6, 1083 HS Amsterdam, The Netherlands
    EMA HMA