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Clinical trials for Chronic Pain

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

  • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).


    The EU Clinical Trials Register currently displays   44341   clinical trials with a EudraCT protocol, of which   7370   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    1,162 result(s) found for: Chronic Pain. Displaying page 7 of 59.
    EudraCT Number: 2011-000506-21 Sponsor Protocol Number: Chumbley1 Start Date*: 2011-06-21
    Sponsor Name:Imperial College Healthcare NHS Trust
    Full Title: A double-blind, randomised placebo-controlled trial to determine whether low-dose intravenous ketamine peri-operatively can prevent chronic post-surgical pain, in patients undergoing thoracotomy or...
    Medical condition: Chronic post-surgical pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2005-002691-15 Sponsor Protocol Number: Jointcare/Fe/1/DK Start Date*: 2006-02-16
    Sponsor Name:Ferrosan A/S
    Full Title: Ginger, ginger-avokado-soy, glucosamine sulfate and ginger-ibuprofen in relation to chronic low back pain - a randomised double-blind, placebo-controlled clinical trial with parallel groups for 3 m...
    Medical condition: Chronic low back pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-010427-12 Sponsor Protocol Number: KF5503/44 Start Date*: 2009-10-14
    Sponsor Name:Grünenthal GmbH
    Full Title: An evaluation of the effectiveness and tolerability of tapentadol hydrochloride prolonged release, and tapentadol hydrochloride immediate release on demand, in subjects with uncontrolled severe chr...
    Medical condition: Low back Pain
    Disease: Version SOC Term Classification Code Term Level
    9.1 10024891 Low back pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) FR (Completed) AT (Completed) DE (Completed) IT (Completed) PL (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2020-001068-27 Sponsor Protocol Number: 2020-001068-27 Start Date*: 2020-12-01
    Sponsor Name:Leiden University Medical Center
    Full Title: Pamidronate for pain in adult chronic nonbacterial osteitis (PAM-CNO): a randomized, double-blind, placebo-controlled trial
    Medical condition: Chronic nonbacterial osteitis (CNO) in adults
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2009-009856-19 Sponsor Protocol Number: 42160443PAI2004AmINT-2 Start Date*: 2009-12-17
    Sponsor Name:Janssen-Cilag International NV
    Full Title: A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42160443 as Adjunctive Therapy in Subjects With Moderate to Severe Knee ...
    Medical condition: moderate to severe, chronic, knee or hip pain from osteoarthritis (OA) that is not adequately controlled by standard pain therapy
    Disease: Version SOC Term Classification Code Term Level
    14.0 10028395 - Musculoskeletal and connective tissue disorders 10023477 Knee pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2018-000818-37 Sponsor Protocol Number: MTX-071-P03 Start Date*: 2018-06-28
    Sponsor Name:Grünenthal GmbH
    Full Title: A randomized, double-blind, placebo-controlled, single dose phase IIb exploratory study to document the clinical effects and safety of intra-articular injections of Lopain (MTX-071) in patients wit...
    Medical condition: chronic osteoarthritic knee joint pain
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10023476 Knee osteoarthritis LLT
    20.0 100000004859 10003244 Arthritic pains LLT
    20.0 100000004859 10064238 Gonalgia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) SK (Completed) HR (Completed)
    Trial results: View results
    EudraCT Number: 2012-001420-35 Sponsor Protocol Number: LBP_Caps_v1 Start Date*: 2012-06-05
    Sponsor Name:Abteilung für Anästhesie, Intensiv- und Schmerzmedizin, Wilhelminenspital der Stadt Wien
    Full Title: The effect of a single skin treatment with Capsaicine 8% in low back pain
    Medical condition: chronic low back pain with neuropathic pain component or unclear neuropathic pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2015-002563-41 Sponsor Protocol Number: RFCLAI004 Start Date*: 2016-02-09
    Sponsor Name:Jorge Orduna Valls
    Full Title: Prospective, randomized cohort study to evaluate the efficacy of two techniques against chronic knee pain: echo-guided radiofrequency over sensitive nerves of the knee, compared to intraarticular i...
    Medical condition: Chronic knee pain (more than 3 months), in patients either non eligible for knee surgery, or with pain after three months of knee surgery.
    Disease: Version SOC Term Classification Code Term Level
    18.1 10029205 - Nervous system disorders 10064332 Complex regional pain syndrome PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-005334-22 Sponsor Protocol Number: 347PUNCIOHEMODIALISIS Start Date*: 2016-05-31
    Sponsor Name:HOSPITAL DE PALAMÓS
    Full Title: CLINICAL TRIAL FOR THE TREATMENT OF PAIN IN HEMODIALYSIS PUNCTURE WITH LIDOCAINE / PRILOCAINE, VERSUS CHLOROETHYL, CROSSOVER RANDOMIZED STUDY
    Medical condition: Hemodialysis is the most commonly used therapy for renal replacement being the arteriovenous fistula used for vascular access . Venipuncture in patients causes stress, pain and anxiety.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-004471-37 Sponsor Protocol Number: 1824/DEV Start Date*: 2012-02-14
    Sponsor Name:Develco Pharma Schweiz AG
    Full Title: Randomised, double-blind, cross-over Phase III study to investigate the efficacy and safety of hydromorphone after once daily administration of Hydromorphone HCl PR tablets XL in comparison to twic...
    Medical condition: Chronic severe cancer or non-cancer pain
    Disease: Version SOC Term Classification Code Term Level
    14.1 10018065 - General disorders and administration site conditions 10049475 Chronic pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) SI (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2010-020977-18 Sponsor Protocol Number: 214868-002 Start Date*: 2010-10-06
    Sponsor Name:Allergan Ltd
    Full Title: A Multicenter, Double-blind, Randomized, Placebo-controlled, Repeat Treatment (two cycle) Study of the Safety and Efficacy of AGN-214868 in Patients with Postherpetic Neuralgia
    Medical condition: Phase II study to investigate the safety and efficacy of AGN-214868 compared to placebo in the treatment of postherpetic neuralgia The study will look at patients with postherpetic neuralgia (PHN...
    Disease: Version SOC Term Classification Code Term Level
    14.0 10029205 - Nervous system disorders 10054095 Neuropathic pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2016-000048-32 Sponsor Protocol Number: 15-062 Start Date*: 2018-03-01
    Sponsor Name:RWTH Aachen University/CTC-A
    Full Title: Evaluation of the Therapeutic Effects of Testosterone on Pain Perception in case of Chronic Pain Disorder
    Medical condition: Patient with persistent somatoform pain disorder (F45.40 or F45.41) should be included into the study.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2013-000201-23 Sponsor Protocol Number: reflect01 Start Date*: 2013-08-30
    Sponsor Name:St. Antonius Ziekenhuis
    Full Title: A randomised clinical trial evaluating the effect of remifentanil vs fentanyl during cardiac surgery on the incidence of chronic thoracic pain.
    Medical condition: chronic thoracic pain after cardiac surgery via sternotomy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-002198-32 Sponsor Protocol Number: 11394 Start Date*: 2008-01-14
    Sponsor Name:Biomet NL
    Full Title: Prospective randomized study of the effect of autologous concentrated thrombocytes versus corticosteroid injections in lateral epicondylitis.
    Medical condition: Tenniselbow, also known as lateral epicondylitis.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-004505-14 Sponsor Protocol Number: Modic02 Start Date*: 2015-03-04
    Sponsor Name:Oslo University Hospital HF, Ullevål Hospital, FORMI-Formidlingsenheten for muskel- og skjelettlidelser
    Full Title: Antibiotic treatment in patients with chronic low back pain and Modic Changes: a double-blind randomized placebo-controlled trial
    Medical condition: A recent Danish study published during spring 2013 advances a remarkable cause and treatment with Amoxicillin for a selected sub-group of low back pain patients.The study was based upon a hypothesi...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: View results
    EudraCT Number: 2007-003638-40 Sponsor Protocol Number: XTL B07-001 Start Date*: 2008-01-08
    Sponsor Name:XTL Development Inc.
    Full Title: A Double-blind, Randomized, Placebo-controlled, Parallel, Multicenter Study of the Safety and Efficacy of Two Dosages of Bicifadine SR in Adult Outpatients with Chronic Neuropathic Pain Associated ...
    Medical condition: Chronic neuropathic pain in patients with diabetic peripheral neuropathy
    Disease: Version SOC Term Classification Code Term Level
    9.1 10054095 Neuropathic pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-005996-32 Sponsor Protocol Number: LDH0230 Start Date*: 2008-06-25
    Sponsor Name:Luton & Dunstable Hospital NHS Foundation Trust
    Full Title: To determine the pre-emptive effect of Gabapentin on acute and chronic post-operative pain after spinal surgery
    Medical condition: Acute and chronic back pain after surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2016-000864-41 Sponsor Protocol Number: CHUB-patch-lidocaine Start Date*: 2016-06-02
    Sponsor Name:Centre Hospitalier Universitaire Brugmann
    Full Title: A randomized controlled trial of lidocaine patch for lower limb amputation pain.
    Medical condition: Lower limb amputation pain: phantom limb pain and primary/secondary scar hyperalgesia.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2021-003690-65 Sponsor Protocol Number: 78304 Start Date*: 2021-11-10
    Sponsor Name:St Antonius Hospital
    Full Title: Peppermint Oil for the treatment of Irritable Bowel Syndrome or Functional Abdominal Pain in Children: the MINT study
    Medical condition: Irritable Bowel syndrome Functional Abdominal Pain Not otherwise specified
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-001195-21 Sponsor Protocol Number: SFK3 Start Date*: 2015-10-19
    Sponsor Name:Sørlandet Hospital
    Full Title: NoTOPain Novel Treatment Option for neuropathic Pain A randomized, cross-over, placebo-controlled, double-blind, single-center, phase II study of cetuximab in patients with treatment-refracto...
    Medical condition: Neuropathic pain conditions, i.e. radiculopathy or Complex regional pain syndrome
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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