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Clinical trials for Anal sphincter

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

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    39 result(s) found for: Anal sphincter. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2005-003759-11 Sponsor Protocol Number: FI 1 Start Date*: 2007-03-09
    Sponsor Name:BKH Schwaz
    Full Title: Autologous myoblasts for treatment of anal incontinence due to anal sphincter defects
    Medical condition: Fecal (anal) inconinence caused by ruptures/ traumas of the external anal sphincter
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-004114-13 Sponsor Protocol Number: 956 Start Date*: 2008-01-07
    Sponsor Name:POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI
    Full Title: TOPIC LEVETIRACETAM IN ANAL FISSURE. A PILOT STUDY ABOUT EFFECTIVENESS AND TOLERABLENESS
    Medical condition: Anal fissure
    Disease: Version SOC Term Classification Code Term Level
    9.1 10002153 Anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2019-000853-30 Sponsor Protocol Number: DRGT119C01 Start Date*: 2019-05-31
    Sponsor Name:Druggability Technologies Holdings Ltd
    Full Title: A Randomized, Double-Blind, Adaptive Trial with an Open-Label Treatment Extension to Determine the Efficacy and Safety of Topical DRGT-119 0.1% and 0.2% Gels in Patients with Chronic Anal Fissure
    Medical condition: chronic anal fissure
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10071195 Chronic anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2017-001216-11 Sponsor Protocol Number: FISAN-BOT-2017-01 Start Date*: 2017-04-25
    Sponsor Name:Dra. A. Teresa Calderón Duque
    Full Title: Usefulness of botulinum toxin type A in the treatment of chronic anal fissure
    Medical condition: Chronic anal fissure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-002335-27 Sponsor Protocol Number: IGG-VIJA-001 Start Date*: 2005-09-01
    Sponsor Name:ISTITUTO GIANNINA GASLINI
    Full Title: Botulin Toxin injection for the treatment of Internal Anal Sphincter Achalasia
    Medical condition: Treatment of internal anal sphincter achalasia
    Disease: Version SOC Term Classification Code Term Level
    6.1 10042613 SOC
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-003351-65 Sponsor Protocol Number: RDD110 Start Date*: 2016-03-16
    Sponsor Name:RDD Pharma Ltd.
    Full Title: The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients with Anal Fissure
    Medical condition: Anal Fissure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BG (Completed) PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-002819-60 Sponsor Protocol Number: FAC-BOTOX Start Date*: 2021-08-19
    Sponsor Name:Hospital Universitario de Burgos
    Full Title: Treatment of chronic anal fissure with ultrasound-guided intersphincteric infiltration of botulinum toxin A.
    Medical condition: Chronic anal fissure
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-002882-19 Sponsor Protocol Number: MCHT001 Start Date*: 2004-12-10
    Sponsor Name:Mid Cheshire Hospitals NHS Trust
    Full Title: A controlled trial into the benefit of topical perianal glyceryl trinitrate (GTN) as a sphincter relaxant, pre-insertion of ultrasound probe for trans rectal ultrasound (TRUS) guided biopsy of the ...
    Medical condition: Prostate Cancer Diagnosis – Pain relief during biopsy
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-003627-54 Sponsor Protocol Number: 150601 Start Date*: 2016-05-11
    Sponsor Name:Tecnimede, Sociedade Técnico-Medicinal, S.A.
    Full Title: Randomized, multicenter, placebo-controlled, double blind study to assess the efficacy and tolerability of 2% diltiazem hydrochloride in the treatment of chronic anal fissure and a 24 week follow-u...
    Medical condition: Cronic Anal fissure (CAF) The underlying pathogenesis of chronic anal fissure involves initial local trauma (generally caused by hard stools), resulting in a wound, internal anal sphincter spasm an...
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000016260 10071195 Chronic anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2005-005675-15 Sponsor Protocol Number: DIL-UBI-DEX-CLOII/2003/003/PT Start Date*: 2008-10-08
    Sponsor Name:Tecnimede, Sociedade Técnico-Medicinal S.A.
    Full Title: Randomized, multicenter, placebo-controlled, single blind study to assess the efficacy and tolerability of a combination of a cream containing ubidecarenone, dexpanthenol and chlorohexidine and a p...
    Medical condition: Cronic Anal fissure (CAF) The underlying pathogenesis of chronic anal fissure involves initial local trauma (generally caused by hard stools), resulting in a wound, internal anal sphincter spasm an...
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004856 10071195 Chronic anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PT (Completed) CZ (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2005-004139-23 Sponsor Protocol Number: 62202-677 Start Date*: 2006-08-18
    Sponsor Name:University of Cologne
    Full Title: An open-label, non-randomized phase I/II trial of neoadjuvant radio-immunochemotherapy with cetuximab and 5-FU for advanced rectal cancer
    Medical condition: advanced adenocarcinoma of the rectum
    Disease:
    Population Age: Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-001384-12 Sponsor Protocol Number: PancolonicPressurization Start Date*: 2014-07-16
    Sponsor Name:KULEUVEN
    Full Title: IS THE ABSENCE OF PAN-COLONIC PRESSURIZATIONS A RELEVANT PATHOPHYSIOLOGICAL MECHANISM IN A SUBGROUP OF PATIENTS WITH CHRONIC IDIOPHATIC CONSTIPATION?
    Medical condition: COLONIC MOTILITY WILL BE STUDIED BOTH IN HEALTHY SUBJECTS AND IN PATIENTS WITH CHRONIC CONSTIPATION
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2010-021463-32 Sponsor Protocol Number: IC-01-02-02-007 Start Date*: 2011-02-24
    Sponsor Name:Innovacell Biotechnologie AG
    Full Title: Skeletal muscle-derived cell implantation for the treatment of fecal incontinence: a multicenter, randomized, double-blind, placebocontrolled, parallel-group, dose-finding clinical study
    Medical condition: Fecal incontinence in female and male patients with external anal sphincter weakness or sphincter damage.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000167639 10016296 Fecal incontinence LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended) DE (Prematurely Ended) SE (Prematurely Ended) CZ (Prematurely Ended) GB (Prematurely Ended) SI (Prematurely Ended) BG (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-005839-76 Sponsor Protocol Number: PDE5I-UPR-AAR-01 Start Date*: 2021-02-15
    Sponsor Name:University hospital Bispebjerg and Frederiksberg, Department of Clinical Pharmacology
    Full Title: Effects of single dose tadalafil on urethral and anal closure function and on urinary flow in healthy females: A randomised, controlled, double-blinded, two-period cross-over study
    Medical condition: Urinary stress incontinence and fecal incontinence
    Disease: Version SOC Term Classification Code Term Level
    22.0 10022891 - Investigations 10022891 Investigations SOC
    Population Age: Adults Gender: Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2021-000593-29 Sponsor Protocol Number: CHUBX2020/64 Start Date*: 2021-06-17
    Sponsor Name:CHU DE BORDEAUX
    Full Title: A Prospective Pilot Study to assess the efficacy of BOTOX-A in patients with Low Anterior Resection syndrome (LARS>20) and refractory medical treatment after rectal resection
    Medical condition: Low Anterior Resection syndrome (LARS>20) and refractory medical treatment after rectal resection
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-000392-37 Sponsor Protocol Number: Protocol_version_1_09-02-2021 Start Date*: 2021-11-02
    Sponsor Name:Oslo University Hospital
    Full Title: A double-blind randomized placebo-controlled four-arm trial to assess the efficacy of oral bicarbonate and intravenous butylscopolamine bromide to facilitate spontaneous (non-operative) delivery in...
    Medical condition: Nulliparous women with induction of labor at term and a singleton fetus in vertex position
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NO (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2018-002717-35 Sponsor Protocol Number: P170920J Start Date*: 2018-12-13
    Sponsor Name:ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS (AP-HP)
    Full Title: Non inferiority multicenter phase III randomized trial comparing preoperative chemotherapy only to chemoradiotherapy for locally advanced resectable rectal cancer (intergroup FRENCH-GRECCAR- PRODIGE)
    Medical condition: Adults ≥ 18 years with middle or low locally advanced resectable rectal carcinoma
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10038038 Rectal cancer PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-003582-10 Sponsor Protocol Number: AVANA Start Date*: 2019-01-17
    Sponsor Name:G.O.N.O. - GRUPPO ONCOLOGICO DEL NORD OVEST
    Full Title: PHASE II STUDY OF PREOPERATIVE CHEMORADIOTHERAPY PLUS AVELUMAB IN PATIENTS WITH LOCALLY ADVANCED RECTAL CANCER
    Medical condition: Locally advanced rectal cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10038038 Rectal cancer PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-000649-20 Sponsor Protocol Number: STAR-03 Start Date*: 2012-06-11
    Sponsor Name:FONDAZIONE DELL'ISTITUTO TOSCANO TUMORI
    Full Title: Phase II study of pre-operative treatment with external radiotherapy plus panitumumab in operable locally advanced rectal cancer (favourable and intermediate prognostic group) (RaP Study/STAR-03)
    Medical condition: Operable locally advanced rectal cancer
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10038019 Rectal adenocarcinoma LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-002325-18 Sponsor Protocol Number: CATARTIC Start Date*: 2021-09-28
    Sponsor Name:FONDAZIONE IRCCS "ISTITUTO NAZIONALE DEI TUMORI"
    Full Title: Multicenter phase II study of preoperative chemoradiotherapy with CApecitabine plus Temozolomide in patients with MGMT silenced and microsatellite stable locally Advanced RecTal Cancer: the CATARTI...
    Medical condition: Localy advanced low-risk rectal cancer, placed at less then 15 cm form the anal verge and staged as cT = 2 and cN0 or cT1-3 cN1 (TNM classification 8th edition), without evidence of distant metasta...
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004864 10010023 Colorectal neoplasms malignant HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Trial now transitioned)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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