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Clinical trials for Antiarrhythmic drugs

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    17 result(s) found for: Antiarrhythmic drugs. Displaying page 1 of 1.
    EudraCT Number: 2014-004954-33 Sponsor Protocol Number: 7U/2014 Start Date*: 2014-11-27
    Sponsor Name:Central Finland Hospital District
    Full Title: Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in ischemic Ventricular Tachyarrhythmias. A prospective, randomized multicentre study MANTRA-VT
    Medical condition: Ventricular tachyarrhtyhmias in patients with prior myocardial infarction and implantable cardioverter defibrillator
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004849 10007518 Cardiac arrhythmia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2018-001518-13 Sponsor Protocol Number: 10407 Start Date*: 2018-11-12
    Sponsor Name:Maatschap Cardiologie Zwolle
    Full Title: Comparison between treatment with catheter ablation or anti-arrhythmic drugs (sotalol or combination of verapamil and flecainide) of patients with benign ventricular premature beats and ventricular...
    Medical condition: Premature ventricular beats, ventricular ectopy, ventricle tachycardia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2017-004202-18 Sponsor Protocol Number: CRAFT Start Date*: 2018-01-30
    Sponsor Name:Fundación Interhospitalaria para la Investigación Cardiovascular
    Full Title: CRioablation vs Antiarrhythmic Drugs for Persistent Atrial Fibrillation Trial (CRAFT)
    Medical condition: Recurrent Persistent Atrial Fibrillation
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10071667 Persistent atrial fibrillation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2008-001384-11 Sponsor Protocol Number: captaf Start Date*: 2008-04-03
    Sponsor Name:
    Full Title: Catheter Ablation compared with Pharmacological Therapy for Atrial Fibrillation – the CAPTAF trial
    Medical condition: To study the effect of catheter ablation (using CE marked products) on the quality of life an in patients with atrial fibrillation depsite treatment with conevntional antiarrhythmic medical therapy...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10066664 Recurrent symptomatic atrial fibrillation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-004456-38 Sponsor Protocol Number: XEN-D0103-CL-05 Start Date*: 2014-04-11
    Sponsor Name:Xention Limited
    Full Title: A double blind, randomised, placebo-controlled, crossover study assessing the use of XEN D0103 in patients with paroxysmal atrial fibrillation and implanted pacemakers allowing continuous beat-to-b...
    Medical condition: Paroxysmal atrial fibrillation
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004849 10034039 Paroxysmal atrial fibrillation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2018-002103-33 Sponsor Protocol Number: 1080719 Start Date*: 2019-02-26
    Sponsor Name: AZ Sint-Jan Brugge-Oostende AV
    Full Title: Pulmonary vein isolation with versus without continued antiarrhythmic drug treatment in subjects with persistent atrial fibrillation: a prospective multi-centre randomized controlled clinical study...
    Medical condition: Symptomatic persistent atrial fibrillation: atrial fibrillation, that lasts longer than 7 days, including episodes that are terminated by cardioversion, either with drugs or by direct current cardi...
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10071667 Persistent atrial fibrillation LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Ongoing) DK (Completed) ES (Ongoing) FR (Ongoing)
    Trial results: View results
    EudraCT Number: 2021-006614-37 Sponsor Protocol Number: CryoStopPersAF Start Date*: 2022-05-11
    Sponsor Name:Region Örebro
    Full Title: First-line cryoablation for early treatment of Persistent Atrial Fibrillation – a randomized study comparing early trigger isolation using the Cryoballoon versus antiarrhythmic medication.
    Medical condition: Persistent symptomatic atrial fibrillation
    Disease: Version SOC Term Classification Code Term Level
    25.1 100000004865 10081865 Cardiac catheter ablation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2011-002532-12 Sponsor Protocol Number: IDE:G050233 Start Date*: 2011-10-27
    Sponsor Name:MAYO CLINIC
    Full Title: Catheter Ablation Versus Antiarrhythmic Drug Therapy for Atrial Fibrillation Trial (CABANA)
    Medical condition: Atrial fibrillation
    Disease: Version SOC Term Classification Code Term Level
    14.1 10007541 - Cardiac disorders 10003658 Atrial fibrillation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed) DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-011291-29 Sponsor Protocol Number: RACE 3 Start Date*: 2011-08-16
    Sponsor Name:Interuniversity Cardiology Institute of the Netherlands (ICIN)
    Full Title: Routine versus Aggressive Upstream Rhythm Control for Prevention of Early Atrial Fibrillation in Heart Failure: RACE 3
    Medical condition: atrial fibrillation
    Disease: Version SOC Term Classification Code Term Level
    14.0 10007541 - Cardiac disorders 10003661 Atrial fibrillation paroxysmal LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA) NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-000530-29 Sponsor Protocol Number: CONVERT-AF Start Date*: 2014-08-19
    Sponsor Name:University Hospital Basel
    Full Title: Canakinumab for the Prevention of Recurrences After Electrical Cardioversion in Patients With Persistent Atrial Fibrillation (CONVERT-AF) Trial - A Randomized Double Blind Placebo Controlled Study
    Medical condition: Atrial Fibrillation
    Disease: Version SOC Term Classification Code Term Level
    16.1 10007541 - Cardiac disorders 10003658 Atrial fibrillation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2011-000695-34 Sponsor Protocol Number: Verna-Ibu-AF_1.0 Start Date*: 2011-07-22
    Sponsor Name:Medizinische Universität Wien, Univ.-Klinik für Notfallmedizin
    Full Title: Vernakalant Versus Ibutilide In Recent-Onset Atrial Fibrillation
    Medical condition: recent-onset atrial fibrillation
    Disease: Version SOC Term Classification Code Term Level
    13.1 10007541 - Cardiac disorders 10034039 Paroxysmal atrial fibrillation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2018-002541-11 Sponsor Protocol Number: P170912J Start Date*: 2019-06-06
    Sponsor Name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
    Full Title: Prevention of post-operative Atrial Fibrillation by BOTulinum toxin injections into epicardial fat pads around pulmonary veins in patients undergoing cardiac surgery
    Medical condition: Adult patients with indication for conventional cardiac surgery (CABG, aortic replacement, or ascending aorta surgery) will be eligible
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004865 10067824 Prophylaxis against atrial fibrillation LLT
    Population Age: Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2018-001936-23 Sponsor Protocol Number: BRAKE-AF Start Date*: 2018-09-21
    Sponsor Name:Dr. Adolfo Fontenla Cerezuela
    Full Title: A multicenter, randomized, open-label, phase III clinical trial to compare the efficacy and safety of Ivabradine versus Digoxine in the chronic control of heart rate in patients with permanent atri...
    Medical condition: Heart rate control in patients with chronic atrial fibrillation.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10071668 Permanent atrial fibrillation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2014-000042-30 Sponsor Protocol Number: GS-US-372-1234 Start Date*: 2015-05-18
    Sponsor Name:Gilead Sciences, Inc.
    Full Title: A Phase 3, Single-Blind Study to Evaluate the Effect of Eleclazine (GS-6615) on Shortening of the QT Interval, Safety, and Tolerability in Subjects with Long QT-3 Syndrome
    Medical condition: Subjects with an established diagnosis of LQT3.
    Disease: Version SOC Term Classification Code Term Level
    18.1 10007541 - Cardiac disorders 10024803 Long QT syndrome PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) DE (Prematurely Ended) NL (Prematurely Ended) ES (Prematurely Ended) FI (Prematurely Ended) IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2021-002487-46 Sponsor Protocol Number: APHP180618 Start Date*: 2023-03-14
    Sponsor Name:Assistance Publique - Hôpitaux de Paris
    Full Title: Prophylactic frequent premature ventricular complexeS sUPPression on left ventriculaR function impairmEnt in aSymptomatic patientS SUPPRESS
    Medical condition: Premature ventricular contractions (PVCs)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10036614 Premature ventricular contractions LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2015-003077-15 Sponsor Protocol Number: EIG-LNF-002 Start Date*: 2015-11-23
    Sponsor Name:Eiger BioPharmaceuticals
    Full Title: A Phase 2, Open-Label Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Activity of Titrating-Dose Lonafarnib in Combination with Ritonavir in Patients Chronically Infected w...
    Medical condition: Chronic Hepatitis D Virus (HDV) Infection.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2015-005098-19 Sponsor Protocol Number: 1414-ROG-GUCG Start Date*: 2017-09-28
    Sponsor Name:European Organisation for Research and Treatment of Cancer (EORTC)
    Full Title: Phase IIIb randomized trial comparing irradiation plus long term adjuvant androgen deprivation with GnRH antagonist versus GnRH agonist plus flare protection in patients with very high risk localiz...
    Medical condition: very high risk localized or locally advanced prostate cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10060862 Prostate cancer PT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: BE (Trial now transitioned) ES (Restarted) FR (Completed) AT (Completed) DE (Trial now transitioned) GB (GB - no longer in EU/EEA) DK (Completed) IT (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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