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Clinical trials for Bone turnover

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    204 result(s) found for: Bone turnover. Displaying page 1 of 11.
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    EudraCT Number: 2019-003771-19 Sponsor Protocol Number: 2019-100 Start Date*: 2019-11-19
    Sponsor Name:Aarhus Universitetshospital
    Full Title: The effect of improved insulin sensitivity on bone turnover markers and bone biomechanical properties in persons with type 2 diabetes mellitus
    Medical condition: Type 2 diabetes mellitus Diabetic bone disease
    Disease: Version SOC Term Classification Code Term Level
    21.1 10027433 - Metabolism and nutrition disorders 10067585 Type 2 diabetes mellitus PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-004513-15 Sponsor Protocol Number: Start Date*: 2005-11-28
    Sponsor Name:Univ. Prof. Dr. Christoph Zielinski
    Full Title: ASSESSMENT OF BIOCHEMICAL MARKERS OF BONE TURNOVER IN PATIENTS WITH METASTATIC BREAST CANCER SWITCHED FROM INTRAVENOUS ZOLEDRONIC ACID THERAPY TO ORAL IBANDRONATE
    Medical condition: Metastatic bone disease due to breast cancer
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-005040-35 Sponsor Protocol Number: 0120 Start Date*: 2021-01-28
    Sponsor Name:Aarhus University Hospital
    Full Title: The effect of effervescent and buffered alendronate on bone turnover compared to conventional alendronate: A randomized non-inferiority trial
    Medical condition: Osteopenia, i.e. bone mineral density T-score < -1
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004848 10005991 Bone mass decreased LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2005-004316-73 Sponsor Protocol Number: 3189 Start Date*: 2006-08-23
    Sponsor Name:Royal Liverpool University hospital
    Full Title: The effects of growth hormone, strontium ranelate and phosphate on PTH circadian rhythm, PTH target organ sensitivity, bone turnover markers, phospho-calcium metabolism and bone mineral density. A ...
    Medical condition: Osteoporosis and Reduced Bone mineral density (T scores< -1.0 on DEXA scan), Adult growth hormone deficiency ( GH levels,9mU/l on Insulin stress test) with reduced BMD (T scores< -1.0 on DEXA scan)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2007-001041-17 Sponsor Protocol Number: 20060289 Start Date*: 2007-09-11
    Sponsor Name:Amgen Inc.
    Full Title: An Open Label, Single Arm, Extension Study to Evaluate the Long Term Safety and Sustained Efficacy of Denosumab (AMG162) in the Treatment of Postmenopausal Osteoporosis
    Medical condition: Treatment of postmenopausal osteoporosis
    Disease: Version SOC Term Classification Code Term Level
    17.0 10028395 - Musculoskeletal and connective tissue disorders 10031285 Osteoporosis postmenopausal PT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: DK (Completed) SE (Completed) EE (Completed) DE (Completed) LV (Completed) GB (Completed) LT (Completed) HU (Completed) AT (Completed) FI (Completed) BE (Completed) MT (Completed) CZ (Completed) FR (Completed) ES (Completed) GR (Completed) IT (Completed) BG (Completed) SK (Completed)
    Trial results: View results
    EudraCT Number: 2016-001253-41 Sponsor Protocol Number: GOIM16002-CABONESTUDY Start Date*: 2018-03-12
    Sponsor Name:GRUPPO ONCOLOGICO DELL'ITALIA MERIDIONALE
    Full Title: Impact of cabazitaxel on metastatic bone disease in patients with castration resistant prostate cancer previously treated with docetaxel
    Medical condition: 1. Histologically or cytologically confirmed adenocarcinoma of prostate that is resistant to hormone therapy and previously treated with a docetaxel containing regimen.
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004864 10001198 Adenocarcinoma of the prostate metastatic LLT
    Population Age: Elderly Gender: Male
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-002975-17 Sponsor Protocol Number: EMS/2004/017-04/33 Start Date*: 2005-01-31
    Sponsor Name:Epsom & St Helier University Hospitals NHS Trust
    Full Title: A pilot study to examine the effect of vitamin C on bone turnover and antioxidant levels in postmenopausal women with low bone density
    Medical condition: low bone density / osteoporosis postmenopausal women
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-004942-15 Sponsor Protocol Number: CZOL446EIT14 Start Date*: 2005-12-15
    Sponsor Name:NOVARTIS FARMA
    Full Title: A prospective, randomized, multi-center comparative 2-arm trial on efficacy and safety of zoledronic acid every 3-months vs. every 4 weeks beyond approximately 1 year of treatment with zoledronic...
    Medical condition: bone metastasis in patients with breast cancer
    Disease: Version SOC Term Classification Code Term Level
    6.1 10027452 PT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2008-005667-34 Sponsor Protocol Number: G0701625 Start Date*: 2009-01-16
    Sponsor Name:University of Edinburgh [...]
    1. University of Edinburgh
    2. NHS Lothian
    Full Title: Randomised Trial of Genetic Testing and Targeted Zoledronic acid therapy to Prevent SQSTM1 Mediated Paget's Disease (Zoledronate in the Prevention of Paget's).
    Medical condition: Paget's disease of the bone (PDB)
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004859 10033363 Paget's disease of bone LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA) BE (Completed) IT (Completed) IE (Completed) ES (Ongoing)
    Trial results: View results
    EudraCT Number: 2021-000275-36 Sponsor Protocol Number: CSUB0202 Start Date*: 2021-04-23
    Sponsor Name:Sahlgrenska University Hospital
    Full Title: Prevention of Glucocorticoid induced impairment of bone metabolism – A Randomized, Placebo-Controlled, Single Centre Clinical Trial
    Medical condition: Oral glucocorticoid (GC) therapy leads to a rapid and profound effects on bone metabolism.The gut microbiota is involved in regulating bone metabolism.Lactobacillus reuteri (LR) has been shown to h...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2022-000178-24 Sponsor Protocol Number: W2021.040 Start Date*: 2023-10-20
    Sponsor Name:
    Full Title: Active vitamin D for secondary hyperparathyroidism after bariatric surgery: a multicenter randomized controlled trial.
    Medical condition: patients with secondary hyperparathyroidism after Roux-en-Y gastric bypass surgery (RYGB).
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2019-003570-11 Sponsor Protocol Number: BC-6072 Start Date*: 2019-10-21
    Sponsor Name:Ghent University Hospital
    Full Title: The use of buffered soluble alendronate 70 mg (Steovess/Binosto) after denosumab discontinuation to prevent increase in bone turnover.
    Medical condition: erosive osteoarthritis of the interphalangeal finger joints
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10016686 Finger osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2009-016523-61 Sponsor Protocol Number: PJMR0062105 Start Date*: 2009-12-07
    Sponsor Name:King’s College London [...]
    1. King’s College London
    2. Guy's & St Thomas NHS Trust
    Full Title: 18F-fluoride PET for Early Non-invasive Assessment of Cortical Bone Formation
    Medical condition: Osteopenia Please note this is not a study to investigate the use of the IMP for the treatment of osteopenia but rather to validate a non-invasive imaging technique for measuring early changes in b...
    Disease: Version SOC Term Classification Code Term Level
    12 10049088 Osteopenia LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-002370-23 Sponsor Protocol Number: CL2-12911-039 Start Date*: 2011-11-30
    Sponsor Name:INSTITUT DE RECHERCHES INTERNATIONALES SERVIER
    Full Title: A double-blind, multicenter, international randomised study to assess the effects of 4 month-oral administration of 2g per day of strontium ranelate versus placebo on the bone quality and remodelli...
    Medical condition: Dental implantation in osteoporotic patients or in patients at risk of osteoporotic fracture.
    Disease: Version SOC Term Classification Code Term Level
    14.1 10042613 - Surgical and medical procedures 10042613 Surgical and medical procedures SOC
    14.1 10042613 - Surgical and medical procedures 10064143 Dental implantation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended) DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-001481-18 Sponsor Protocol Number: 6925 Start Date*: 2011-10-07
    Sponsor Name:Uppsala University Hospital
    Full Title: Uncemented total hip implant and subcutaneous injection of Denosumab for patients with osteoarthritis of the hip. A randomised double blind placebo controlled study on the effects on bone evaluated...
    Medical condition: Patients with osteoarthritis of the hip treated with an uncemented total hip arthroplasty. This procedure is accompanied with an increased risk for loss of bone adjacent to the implants
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2018-003162-13 Sponsor Protocol Number: WI232128 Start Date*: 2019-01-23
    Sponsor Name:AZIENDA OSPEDALIERA UNIVERSITARIA INTEGRATA VERONA
    Full Title: A Study to investigate Bone turnover Markers in patients planned to receive tofacitinib
    Medical condition: Rheumatoid arthritis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10039073 Rheumatoid arthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-002692-42 Sponsor Protocol Number: 1.1_2011 Start Date*: 2012-06-20
    Sponsor Name:MUW-Medical University of Vienna,Medizinische Universität Wien
    Full Title: Characterization of myeloma bone lesions - before and during anti-cancer therapy - using 18F-FDG-, 18F-fluoride PET/CT and MRI- a pilot study
    Medical condition: The primary aim of this study is the characterization of WB MRI detected untreated MM bone lesions in consideration of the mineralization status and tumor activity using 18F-fluorid-PET/CT and 18F ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2014-002720-27 Sponsor Protocol Number: 2014-002720-27 Start Date*: 2014-12-04
    Sponsor Name:Fundació Clínic per a la Recerca Biomèdica
    Full Title: Simplification from Tenofovir plus Lamivudine or Emtricitabine plus Ritonavir-Boosted-Protease Inhibitor to Ritonavir-Boosted-Atazanavir plus Lamivudine in Virologically-Suppressed-HIV-Infected Adu...
    Medical condition: Chronic HIV infection.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-003888-56 Sponsor Protocol Number: 20192022 Start Date*: 2021-01-30
    Sponsor Name:Department of Nephrology, Herlev & Gentofte Hospital, Herlev Hospital
    Full Title: Treatment of adynamic bone disorder with parathyroid hormone in patients with chronic kidney disease
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004859 10060881 Adynamic bone disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2005-003076-37 Sponsor Protocol Number: SB205 Start Date*: 2005-09-02
    Sponsor Name:Sanos Bioscience A/S
    Full Title: GLP-2 and Bone Resorption. A double-blind, randomized, placebo-controlled, dose ranging, safety, tolerability and pharmacokinetic/dynamic efficacy study with multiple subcutaneous injections of GL...
    Medical condition: postmenopausal women with osteopenia (BMD T-score -2.5 < T ≤ -1.0) at one or more of the regions: the lumbar spine, femoral neck or total hip.
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: DK (Completed) CZ (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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