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Clinical trials for Exacerbation

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44339   clinical trials with a EudraCT protocol, of which   7369   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    766 result(s) found for: Exacerbation. Displaying page 1 of 39.
    1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2017-004872-76 Sponsor Protocol Number: RECUT-Trial Start Date*: 2020-05-07
    Sponsor Name:Medizinische Universtitätsklinik, Kantonsspital Baselland
    Full Title: Reduction of corticosteroid use in outpatient treatment of exacerbated COPD – a randomized, double-blind, non-inferiority study (The “RECUT”-Trial)
    Medical condition: acute exacerbation of COPD; acute exacerbation (defined solely by clinical parameters according to the Anthonisen criteria, meaning ≥2 of the following: change of baseline dyspnea, change of cough,...
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004855 10010953 COPD exacerbation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-004178-24 Sponsor Protocol Number: 1704 Start Date*: 2020-06-13
    Sponsor Name:Amphia
    Full Title: Defining long-term macrolide maintenance therapy in COPD: a single center randomized controlled trial:
    Medical condition: Chronic obstructive pulmonary disease COPD
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004855 10010952 COPD LLT
    21.1 100000004855 10010953 COPD exacerbation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-004048-21 Sponsor Protocol Number: 7171L01 Start Date*: 2006-12-29
    Sponsor Name:ZAMBON GROUP
    Full Title: A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, PARALLEL GROUPS STUDY ON EFFICACY AND SAFETY OF NAC 600 MG DAILY AND NAC 1200 MG DAILY AS MUCOLYTIC AGENT IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PUL...
    Medical condition: Chronic Obstructive Pulmonary Bronchitis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10029978 Obstructive chronic bronchitis with acute exacerbation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2017-001074-42 Sponsor Protocol Number: 200879 Start Date*: 2017-12-01
    Sponsor Name:GlaxoSmithKline Research and Development Ltd.
    Full Title: A Phase IIb, Randomized (Stratified), Double-Blind (Sponsor Open), Parallel-Group, Placebo-Controlled, Dose-Finding Study of Nemiralisib (GSK2269557) Added to Standard of Care (SoC) Versus SoC Alon...
    Medical condition: Chronic Obstructive Pulmonary Disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10009033 Chronic obstructive pulmonary disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended) SE (Prematurely Ended) GB (Prematurely Ended) PL (Prematurely Ended) DE (Prematurely Ended) ES (Prematurely Ended) IT (Prematurely Ended) RO (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-007275-16 Sponsor Protocol Number: InfQ-001 Start Date*: 2008-12-18
    Sponsor Name:Department of Infetious Diseases, Odense University Hospital
    Full Title: Antibiotic treatment in patients hospitalized with an acute exacerbation in chronic obstructive pulmonary disease. Effect of one day of antibiotic treatment compared t0 6 days of antibiotic treatme...
    Medical condition: Acute exacerbation of chronic ostructive pulmonary disease in hospitalized patients. All patients receive "standard of care", and 1 day of intravenous antibiotics. In addition patients are randomiz...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10056971 Infective exacerbation of chronic obstructive airways disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-004986-99 Sponsor Protocol Number: NBTCS02 Start Date*: 2017-01-11
    Sponsor Name:NovaBiotics, Ltd
    Full Title: A Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study Investigating the Optimal Dose Regimen, Efficacy, and Safety of Adding Oral Cysteamine in Adult Patients with Cystic Fibrosis (C...
    Medical condition: exacerbation of Cystic Fibrosis
    Disease: Version SOC Term Classification Code Term Level
    19.0 10021881 - Infections and infestations 10070608 Infective pulmonary exacerbation of cystic fibrosis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Ongoing) GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-005660-13 Sponsor Protocol Number: He-08-01 Start Date*: 2008-12-11
    Sponsor Name:BOC Ltd.
    Full Title: COPD exacerbation - Heliox Therapy - Assessment Heliox vs. Medical Air in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Pilot Randomised Controlled Trial
    Medical condition: Chronic Obstructive Pulmonary Disease
    Disease: Version SOC Term Classification Code Term Level
    9.1 10010953 COPD exacerbation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-003944-42 Sponsor Protocol Number: REP-FAR-005 Start Date*: 2006-12-22
    Sponsor Name:REPLIDYNE, INC.
    Full Title: Prospective, Randomized, Double-Blind Trial to Evaluate the Efficacy and Safety of Faropenem Medoxomil 600 mg PO, BID for 5 Days Versus Placebo Versus Telithromycin In the Treatment of Acute Exacer...
    Medical condition: Acute Exacerbation of Chronic Bronchitis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10006458 Bronchitis chronic LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Prematurely Ended) LV (Completed) BG (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-002498-80 Sponsor Protocol Number: 06062019 Start Date*: 2019-09-24
    Sponsor Name:Mikkel Brabrand
    Full Title: Will titrated oxygen flow to a peripheral oxygen saturation of 88-92% compared with oxygen flow to a saturation >94% reduce mortality in Chronic Obstructive Pulmonary Disease patients with acute ex...
    Medical condition: Acute COPD Exacerbation
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004855 10010953 COPD exacerbation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-000006-67 Sponsor Protocol Number: PIRRI/CT/001 Start Date*: 2007-10-29
    Sponsor Name:LALLEMAND PHARMA INTERNATIONAL
    Full Title: Sub-lingual administration of a Polyvalent Mechanical Bacterial Lysate (PMBL) in patients with Moderate or Severe and very Severe Chronic Obstructive Pulmonary Disease (COPD) according to GOLD clas...
    Medical condition: Patients with documented moderate, severe and very severe COPD.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10029978 Obstructive chronic bronchitis with acute exacerbation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-004558-13 Sponsor Protocol Number: Z7224L02 Start Date*: 2017-05-30
    Sponsor Name:Zambon S.p.A.
    Full Title: A double-blind, placebo controlled, multicentre, clinical trial to investigate the efficacy and safety of 12 months of therapy with inhaled Promixin® (colistimethate sodium) in the treatment of sub...
    Medical condition: Non-cystic fibrosis bronchiectasis chronically infected with Pseudomonas aeruginosa
    Disease: Version SOC Term Classification Code Term Level
    19.1 10038738 - Respiratory, thoracic and mediastinal disorders 10006445 Bronchiectasis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) PL (Completed) DE (Completed) PT (Completed) GR (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2008-004807-67 Sponsor Protocol Number: APOTEL01 Start Date*: 2009-01-15
    Sponsor Name:University of Athens, Medical School
    Full Title: AN OPEN-LABEL, NON-RANDOMIZED PHASE IV CLINICAL TRIAL OF THE EFFICACY OF INTRAVENOUSLY ADMINISTERED 1000MG PARACETAMOL AS ANTIPYRETIC AND ANALGESIC MEDICATION
    Medical condition: Fever and pain
    Disease: Version SOC Term Classification Code Term Level
    9.1 10010264 Condition aggravated LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GR (Completed)
    Trial results: View results
    EudraCT Number: 2014-002275-28 Sponsor Protocol Number: 1237.19 Start Date*: 2014-11-18
    Sponsor Name:Boehringer Ingelheim Finland Ky
    Full Title: A randomised, double-blind, active-controlled parallel group study to evaluate the effect of 52 weeks of once daily treatment of orally inhaled tiotropium + olodaterol fixed dose combination compar...
    Medical condition: chronic obstructive pulmonary disease
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004855 10010952 COPD LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) IT (Completed) SE (Completed) PT (Completed) DK (Completed) BE (Completed) NL (Completed) HU (Completed) GB (Completed) ES (Completed) AT (Completed) IE (Completed) LT (Completed) CZ (Completed) LV (Completed) SK (Completed) DE (Completed) SI (Completed) GR (Completed) BG (Completed) HR (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2006-003886-15 Sponsor Protocol Number: TELIT L 01747 Start Date*: 2006-09-12
    Sponsor Name:SANOFI-AVENTIS S.P.A
    Full Title: Steady state telithromycin pharmacokinetics and pharmacodynamic in adult patients with mild-moderate acute exacerbation of chronic obstructive pulmonary disease treated with a standard oral dos...
    Medical condition: Acute exacerbation of chronic-obstructive pulmonary disease.
    Disease: Version SOC Term Classification Code Term Level
    6.1 10029978 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-002724-33 Sponsor Protocol Number: RECHMPL19-0069 Start Date*: 2019-11-15
    Sponsor Name:University Hospital of Montpellier
    Full Title: Eosinophil-driven corticotherapy for patients hospitalized for COPD exacerbation: a double-blind, randomized, controlled trial
    Medical condition: The study population corresponds to patients hospitalized for COPD exacerbation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-017051-10 Sponsor Protocol Number: 09-313 Start Date*: 2010-07-13
    Sponsor Name:UMC Utrecht
    Full Title: Metabolic adverse events before and after glucocorticoid pulse therapy in rheumatoid arthritis
    Medical condition: Patients with rheumatoid arthritis, who suffer from a exacerbation of disease can be included in this study. Exacerbation is defined as a Disease Activity Score of 5.1 or higher. Patients will be e...
    Disease: Version SOC Term Classification Code Term Level
    12.0 10060732 Rheumatoid arthritis flare up LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-006096-37 Sponsor Protocol Number: BAY 12-8039/11980 Start Date*: 2008-05-09
    Sponsor Name:Bayer HealthCare AG, Leverkusen, Germany
    Full Title: A prospective, multinational, multicenter, randomized, double-blind, double-dummy, controlled study comparing the efficacy and safety of moxifloxacin to that of amoxicillin-clavulanic acid for the ...
    Medical condition: acute exacerbation of chronic bronchitis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10000743 Acute exacerbation of chronic bronchitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) GB (Completed) IE (Completed) BE (Completed) DE (Completed) ES (Completed) PT (Completed) GR (Completed) LT (Completed) LV (Completed) IT (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2011-004351-39 Sponsor Protocol Number: FARM8MXYFL Start Date*: 2011-10-28
    Sponsor Name:AZIENDA UNIVERSITARIA POLICLINICO UMBERTO I DI ROMA
    Full Title: Phase II, randomized, double arm, multi-center study evaluating the efficacy and safety of azithromycin for the long term prophylactic treatment of COPD in primary antibody deficiency patients with...
    Medical condition: primary immunodefciency patients with COPD and frequent exacerbations
    Disease: Version SOC Term Classification Code Term Level
    14.1 10021881 - Infections and infestations 10029978 Obstructive chronic bronchitis with acute exacerbation LLT
    14.1 10021428 - Immune system disorders 10013289 Disorders involving the immune mechanism LLT
    14.1 10038738 - Respiratory, thoracic and mediastinal disorders 10003554 Asthma aggravated LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-002826-58 Sponsor Protocol Number: 1 Start Date*: 2020-02-05
    Sponsor Name:Rijnstate Hospital, Arnhem
    Full Title: The effects of enoximone in acute exacerbation COPD: a pilot study
    Medical condition: Acute exacerbation of COPD
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004855 10010953 COPD exacerbation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-003842-27 Sponsor Protocol Number: Studio-flourochinoloni-in-BPCO. Start Date*: 2008-10-14
    Sponsor Name:CENTRO STUDI FADOI
    Full Title: Randomized, single-blind, parallel groups, controlled study to compare levofloxacin and prulifloxacin in patients with exacerbations of COPD previously treated with different antibiotics and admitt...
    Medical condition: - Patients with acute exacerbation of COPD of possible infectious origin, previously treated with antibiotic therapy (no quinolones), without clinical improvement, and hospitalized in Internal Medi...
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
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