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Clinical trials for Eye Diseases AND Treatment of Dry Eye Disease

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    48 result(s) found for: Eye Diseases AND Treatment of Dry Eye Disease. Displaying page 1 of 3.
    1  2  3  Next»
    EudraCT Number: 2015-005405-36 Sponsor Protocol Number: LT1580-301 Start Date*: 2016-05-10
    Sponsor Name:Laboratoires Théa
    Full Title: EFFICACY AND SAFETY ASSESSMENT OF T1580 VERSUS VEHICLE IN DRY EYE DISEASE TREATMENT
    Medical condition: Dry Eye
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000014904 10013778 Dry eyes LLT
    20.0 100000014904 10013777 Dry eye syndrome LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: BE (Completed) HU (Prematurely Ended) LV (Prematurely Ended) AT (Prematurely Ended) GB (Prematurely Ended) LT (Prematurely Ended) GR (Prematurely Ended) CZ (Prematurely Ended) BG (Prematurely Ended) PL (Prematurely Ended) HR (Prematurely Ended) ES (Prematurely Ended) IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2011-000160-97 Sponsor Protocol Number: NVG10E117 Start Date*: 2011-04-08
    Sponsor Name:NOVAGALI Pharma S.A.
    Full Title: A MULTICENTER, RANDOMIZED, DOUBLE-MASKED, 2 PARALLEL ARM, VEHICLE CONTROLLED, 6-MONTH PHASE III TRIAL WITH A 6 MONTH OPEN LABEL TREATMENT SAFETY FOLLOW-UP PERIOD TO EVALUATE THE EFFICACY AND SAFETY...
    Medical condition: Severe Dry Eye Disease
    Disease: Version SOC Term Classification Code Term Level
    13.1 10015919 - Eye disorders 10013774 Dry eye PT
    13.1 10015919 - Eye disorders 10013777 Dry eye syndrome LLT
    13.1 10015919 - Eye disorders 10023350 Keratoconjunctivitis sicca PT
    13.1 10015919 - Eye disorders 10013778 Dry eyes LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) BE (Completed) DE (Completed) IT (Ongoing) AT (Completed) GB (Completed) CZ (Completed) ES (Ongoing)
    Trial results: View results
    EudraCT Number: 2013-002183-63 Sponsor Protocol Number: IOBA-CERLab-003-2013 Start Date*: 2013-11-12
    Sponsor Name:IOBA
    Full Title: Unicenter, double masked, crossover clinical trial to assess the efficacy of FML (0.1% Fluorometolone) in dry eye patients
    Medical condition: Dry eye syndrome (DES)
    Disease: Version SOC Term Classification Code Term Level
    16.0 10015919 - Eye disorders 10013777 Dry eye syndrome LLT
    16.0 10015919 - Eye disorders 10013774 Dry eye PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2022-002158-15 Sponsor Protocol Number: SYL1001_V Start Date*: 2022-11-17
    Sponsor Name:Sylentis SAU
    Full Title: Tivanisiran for Dry Eye in Subjects with Sjögren’s Syndrome
    Medical condition: Dry Eye Disease
    Disease: Version SOC Term Classification Code Term Level
    21.1 10015919 - Eye disorders 10013774 Dry eye PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-002066-12 Sponsor Protocol Number: NVG12D122 Start Date*: 2012-12-13
    Sponsor Name:NOVAGALI Pharma S.A.S
    Full Title: A Multicenter, Open Label, Interventional, Prospective, Non Randomized, One Cohort Extension Study To Assess the Sustainability of the Effect of NOVA22007 Following Treatment Discontinuation in Imp...
    Medical condition: Severe Dry Eye Disease
    Disease: Version SOC Term Classification Code Term Level
    14.1 10015919 - Eye disorders 10023350 Keratoconjunctivitis sicca LLT
    14.1 10015919 - Eye disorders 10013778 Dry eyes LLT
    14.1 10015919 - Eye disorders 10013777 Dry eye syndrome LLT
    14.1 10015919 - Eye disorders 10013774 Dry eye PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) BE (Completed) AT (Completed) DE (Completed) GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-006287-50 Sponsor Protocol Number: EMAOS Start Date*: 2015-04-01
    Sponsor Name:Clínica Universidad de Navarra/Universidad de Navarra
    Full Title: Phase III comparative clinical trial to evaluate the efficacy of amniotic membrane extract for the treatment of severe dry eye disease, in comparison with autologous serum eyedrops.
    Medical condition: Severe Dry Eye Disease
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004853 10013778 Dry eyes LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-000937-54 Sponsor Protocol Number: MC2-03-C1 Start Date*: 2015-08-03
    Sponsor Name:DRUG DELIVERY SOLUTIONS ApS (PART OF MC2 BIOTEK GROUP)
    Full Title: A phase II, multicenter, randomized, double-masked, 4 parallel arms, controlled 6-month trial designed to evaluate the safety and efficacy of PAD ciclosporin (CsA 0.06% and 0.03%) ophthalmic disper...
    Medical condition: ocular dryness (Dry Eye Disease - DED)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000014904 10013778 Dry eyes LLT
    20.0 100000014904 10013777 Dry eye syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DK (Completed) NO (Completed) AT (Completed) ES (Completed) PT (Completed) FR (Completed) SK (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2016-003903-79 Sponsor Protocol Number: SYL1001_IV Start Date*: 2017-07-24
    Sponsor Name:Sylentis SAU - PharmaMar Group
    Full Title: A double-masked study of SYL1001 in patients with moderate to severe dry eye disease (DED)
    Medical condition: Moderate to severe dry eye disease (DED)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10015919 - Eye disorders 10013774 Dry eye PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) ES (Completed) PT (Completed) EE (Completed) SK (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2013-004271-12 Sponsor Protocol Number: NGF0213 Start Date*: 2014-01-17
    Sponsor Name:Dompé s.p.a
    Full Title: An open-label study evaluating safety and efficacy of recombinant human nerve growth factor (rhNGF) eye drops at different doses in patients with Dry Eye
    Medical condition: Dry Eye syndrome is caused by either decreased tear production or increased tear film evaporation. Dry eye is a chronic inflammatory condition of the ocular surface with severe symptoms and visual ...
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004853 10013777 Dry eye syndrome LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2010-024254-11 Sponsor Protocol Number: CF101-301KCS Start Date*: 2011-03-30
    Sponsor Name:Can-Fite BioPharma, Ltd
    Full Title: A Phase 3, Randomized, Double-Masked, Placebo-Controlled, Dose-Finding, Parallel-Group Study of the Safety and Efficacy of Daily CF101 Administered Orally in Patients with Moderate-to-Severe Dry Ey...
    Medical condition: Moderate-to-severe Dry Eye disease
    Disease: Version SOC Term Classification Code Term Level
    14.1 10015919 - Eye disorders 10013774 Dry eye PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BG (Completed)
    Trial results: View results
    EudraCT Number: 2021-006801-31 Sponsor Protocol Number: 01-INSULINAOJOSECO-2021 Start Date*: 2022-07-04
    Sponsor Name:Barbara Burgos-Blasco
    Full Title: RANDOMIZED PARALLEL CLINICAL TRIAL TO DETERMINE THE EFFECTIVENESS AND SAFETY OF TOPICAL INSULIN IN THE TREATMENT OF DRY EYE IN PATIENTS WITH DRY EYE
    Medical condition: Dry eye disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-002508-94 Sponsor Protocol Number: OPHT-030815 Start Date*: 2015-10-06
    Sponsor Name:Medical University of Vienna
    Full Title: Effect of topical azithromycin on tear film thickness in patients with meibomian gland dysfunction – comparison to oral treatment with doxycycline
    Medical condition: Meibomian gland dysfunction Dry eye syndrome
    Disease: Version SOC Term Classification Code Term Level
    20.0 10015919 - Eye disorders 10065062 Meibomian gland dysfunction PT
    20.0 100000014904 10013777 Dry eye syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-004605-27 Sponsor Protocol Number: Occhuiosecco Start Date*: 2012-11-05
    Sponsor Name:AZIENDA OSPEDALIERA ARCISPEDALE S. MARIA NUOVA
    Full Title: Study Prospective Randomized Controlled Double-Blind: Comparison of tear substitute (Siccafluid) and Autologous Serum in Dry Eye Disease
    Medical condition: Dry eye disease
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004853 10018728 Gritty eyes LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2017-003285-27 Sponsor Protocol Number: T1565-PIV-0117 Start Date*: 2017-09-26
    Sponsor Name:Laboratoires Thea
    Full Title: Clinical efficacy of topical hydrocortisone 0.335% (Softacort®) in patients with chronic dry eye disease and associated ocular surface inflammation
    Medical condition: Dry Eye Disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004853 10013777 Dry eye syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-002434-13 Sponsor Protocol Number: 01-INSULINAGLAUCOMA-2022 Start Date*: 2023-01-18
    Sponsor Name:Barbara Burgos-Blasco
    Full Title: RANDOMIZED CLINICAL TRIAL DOUBLE BLIND (WITH BLIND EVALUATOR) TO DETERMINE THE EFFECTIVENESS AND SAFETY OF TOPICAL INSULIN IN THE TREATMENT OF DRY EYE IN PATIENTS WITH TOPICAL HYPOTENSIVE DRUGS
    Medical condition: Dry eye disease in glaucoma
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-001720-33 Sponsor Protocol Number: CSA_2020 Start Date*: 2020-09-08
    Sponsor Name:UNIVERSITÀ CAMPUS BIO-MEDICO DI ROMA
    Full Title: Cyclosporine 0.1% Eye Drops as Prophylactic Treatment in Post Surgical Ocular Surface System Failure Within The Age
    Medical condition: High-risk patients, i.e. elder patients, who show dry eye syndrome after insult.
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004853 10013777 Dry eye syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-001022-34 Sponsor Protocol Number: AVX012-CT-001 Start Date*: 2016-10-06
    Sponsor Name:AVIZOREX PHARMA, S.L.
    Full Title: A phase I/II, double-blind, placebo-controlled study assessing the safety and efficacy of AVX-012 ophthalmic solution in subjects with mild-to-moderate dry eye syndrome
    Medical condition: Dry eye syndrome
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004853 10013777 Dry eye syndrome LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-000747-27 Sponsor Protocol Number: 049/SI Start Date*: 2020-09-09
    Sponsor Name:SOCIETÀ INDUSTRIA FARMACEUTICA ITALIANA (SIFI) SPA
    Full Title: A Multicenter, Randomized, Double-Masked, Placebo-Controlled Phase II Study to evaluate the Safety and Efficacy of Pro-ocular™ 0.5% and 1% in Patients with Dry Eye Syndrome
    Medical condition: Dry Eye is a multifactorial disease of the ocular surface characterized by a loss of homeostasis of the tear film and accompanied by ocular symptoms, in which tear film instability, hyperosmolarity...
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004853 10013777 Dry eye syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-001662-35 Sponsor Protocol Number: BTIIMD-02-EC/22/GLAUCOMA Start Date*: 2022-08-18
    Sponsor Name:BTI I MAS D S.L.
    Full Title: Randomized, double-blind, parallel group clinical trial to evaluate the efficacy and safety of PRGF eye drops as a treatment for dry eye disease in patients with glaucoma
    Medical condition: Dry eye disease in patients with glaucoma
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-003469-36 Sponsor Protocol Number: THEA_HLF_1/21 Start Date*: 2021-09-17
    Sponsor Name:Laboratorios Théa, S.A.
    Full Title: “Prospective evaluation of the efficacy and safety of topical hydrocortisone treatment on clinical signs and symptoms of dry eye disease associated with moderate meibomian gland dysfunction”
    Medical condition: Dry Eye (DE) and Meibomian gland dysfunction (MGD)
    Disease: Version SOC Term Classification Code Term Level
    21.1 10015919 - Eye disorders 10013774 Dry eye PT
    20.1 10015919 - Eye disorders 10065062 Meibomian gland dysfunction PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
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