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Clinical trials for Risk of mortality

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44344   clinical trials with a EudraCT protocol, of which   7373   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    681 result(s) found for: Risk of mortality. Displaying page 1 of 35.
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    EudraCT Number: 2015-004896-60 Sponsor Protocol Number: LUMC2015-02 Start Date*: 2015-11-26
    Sponsor Name:Leiden University Medical Center
    Full Title: Decitabine-cytarabine chemotherapy in elderly AML and high risk MDS patients (> 65 years) with high early mortality risk
    Medical condition: Acute myeloid leukemia and high risk myelodysplasia
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-001099-21 Sponsor Protocol Number: 2010-04-23 Start Date*: 2011-05-19
    Sponsor Name:Population Health Research Institute
    Full Title: SIRS Steroids In caRdiac Surgery Trial
    Medical condition: From available evidence, corticosteroids attenuate the inflammatory response to CPB which is felt to contribute to morbidity and mortality in cardiac surgery patients. The meta-analysis of the lite...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2009-011817-26 Sponsor Protocol Number: BHS-UCB2009 Start Date*: 2010-10-21
    Sponsor Name:UZ Brussel VUB
    Full Title: A pilot study to assess the feasibility of unrelated umbilical cord blood transplantation with coinfusion of third-party mesenchymal stem cells after myeloablative or nonmyeloablative conditioning ...
    Medical condition: Adult patients with hematological malignancies
    Disease:
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-000591-34 Sponsor Protocol Number: 123456 Start Date*: 2011-05-06
    Sponsor Name:Mater University Hospital
    Full Title: SIRS Steroids In caRdiac Surgery Trial
    Medical condition: Study Objective(s) To determine whether high-risk patients undergoing cardiac surgery requiring CPB derive benefit from perioperative steroids. Study Design Multicentre, International, random...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-001479-22 Sponsor Protocol Number: NCT03021525 Start Date*: 2017-08-04
    Sponsor Name:University Medical Center Hamburg-Eppendorf, Germany
    Full Title: Individualized perioperative hemodynamic goal-directed therapy in major abdominal surgery (iPEGASUS-trial)
    Medical condition: - Hemodynamic Instability - Cardiac Output - High Peroperative Complication
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-003088-76 Sponsor Protocol Number: 11-170 Start Date*: 2014-07-14
    Sponsor Name:Clinical Evaluation Research Unit (CERU)
    Full Title: SodiUm SeleniTe Adminstration IN Cardiac Surgery surgery (SUSTAIN CSX®-trial) - A randomized controlled trial of high dose sodium-selenite administration in high risk cardiac surgical patients
    Medical condition: Selenium is a key component of a number of selenoproteins which protect against oxidative stress and is well recognised for its prominent role in immune defence. Selenoproteins have the potential t...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-005570-56 Sponsor Protocol Number: GLINT Start Date*: 2014-01-28
    Sponsor Name:Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
    Full Title: Glucose Lowering In Non-diabetic hyperglycaemia Trial (GLINT) - a randomised controlled trial to establish the effectiveness and cost-effectiveness of metformin in preventing cardiovascular events ...
    Medical condition: Non-diabetic hyperglycaemia (elevated blood glucose levels below the diagnostic threshold for diabetes) and high risk of cardiovascular disease (>20% risk over 10 years)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-007593-31 Sponsor Protocol Number: prot 122 Start Date*: 2008-11-21
    Sponsor Name:FONDAZIONE RICERCA TRAPIANTO DI MIDOLLO OSSEO
    Full Title: Thiotepa dose finding study for allogeneic SCT in adult patients with high risk haematological malignancies
    Medical condition: bone marrow transplantation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-000316-31 Sponsor Protocol Number: HIDR-0721/COV Start Date*: 2021-07-15
    Sponsor Name:FAES FARMA S.A.
    Full Title: Multicenter, double-blind, randomized clinical trial to evaluate the efficacy of calcifediol soft capsules versus placebo in reducing hospital admissions in patients with a positive diagnostic test...
    Medical condition: SARS-CoV-2 coronavirus infection (COVID-19).
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-005569-58 Sponsor Protocol Number: BAY59-7939/17454 Start Date*: 2015-09-23
    Sponsor Name:Bayer AG
    Full Title: An international, multicenter, randomized, double-blind, placebo-controlled phase 3 trial investigating the efficacy and safety of Rivaroxaban to reduce the risk of major thrombotic vascular event...
    Medical condition: Peripheral artery disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004865 10053375 Peripheral revascularization LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) AT (Completed) ES (Completed) HU (Completed) GB (Completed) FR (Completed) PT (Completed) SE (Completed) BE (Completed) BG (Completed) DK (Completed) DE (Completed) NL (Completed) PL (Completed) SK (Completed) LT (Completed) LV (Completed) RO (Completed) EE (Completed) FI (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2020-001250-21 Sponsor Protocol Number: 2020/3078 Start Date*: 2020-04-03
    Sponsor Name:GUSTAVE ROUSSY
    Full Title: COVID-19 - Epidemiology of SARS-CoV-2 and Mortality to Covid19 Disease upon Hydroxychloroquine and Azithromycin Therapy in French Cancer patients
    Medical condition: Patients eligible for, or under, or recently treated by chemotherapy (CT) and/or immune-checkpoint blockade (ICB) for the treatment of solid tumors or hematological malignancies.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-000758-28 Sponsor Protocol Number: 19767 Start Date*: 2022-11-23
    Sponsor Name:Bayer AG
    Full Title: A multicenter, international, randomized, active comparator-controlled, double-blind, double-dummy, parallel-group, 2-arm, Phase 3 study to compare the efficacy and safety of the oral FXIa inhibito...
    Medical condition: Prevention of stroke or systemic embolism in atrial fibrillation
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10049165 Cerebrovascular accident prophylaxis PT
    21.1 10042613 - Surgical and medical procedures 10049910 Thromboembolism prophylaxis LLT
    20.0 10007541 - Cardiac disorders 10003658 Atrial fibrillation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned) DE (Trial now transitioned) BE (Trial now transitioned) FI (Trial now transitioned) AT (Trial now transitioned) ES (Trial now transitioned) SE (Trial now transitioned) HU (Trial now transitioned) NO (Trial now transitioned) SK (Trial now transitioned) LT (Trial now transitioned) CZ (Trial now transitioned) NL (Trial now transitioned) GR (Trial now transitioned) IT (Trial now transitioned) LV (Trial now transitioned) PT (Trial now transitioned) PL (Trial now transitioned) RO (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-002644-32 Sponsor Protocol Number: EFC14875 Start Date*: 2017-11-14
    Sponsor Name:SANOFI-AVENTIS RECHERCHE ET DEVELOPPEMENT
    Full Title: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Demonstrate the Effects of Sotagliflozin on Cardiovascular and Renal Events in Patients with Type 2 Diabetes, Ca...
    Medical condition: Type 2 diabetes mellitus Chronic kidney disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 10027433 - Metabolism and nutrition disorders 10067585 Type 2 diabetes mellitus PT
    20.0 10038359 - Renal and urinary disorders 10064848 Chronic kidney disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Prematurely Ended) LV (Completed) GB (Completed) HU (Completed) SE (Completed) NO (Completed) FR (Completed) NL (Completed) DK (Completed) ES (Prematurely Ended) LT (Completed) EE (Completed) PT (Completed) BE (Completed) GR (Completed) BG (Completed) IT (Completed) RO (Completed)
    Trial results: View results
    EudraCT Number: 2011-001495-18 Sponsor Protocol Number: 2010-04-23 Start Date*: 2011-08-23
    Sponsor Name:Population health Research Institute
    Full Title: Steroids in Cardiac Surgery (SIRS) trial
    Medical condition: cardiac surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2007-002010-19 Sponsor Protocol Number: TASC07 Start Date*: 2007-10-15
    Sponsor Name:University of Dundee
    Full Title: The TASCFORCE Project: Tayside Screening For risk of Cardiac Events and the effect of statin on risk reduction (as evidenced by change in LV mass)
    Medical condition: The aim of this study is to validate MRI as a screening tool for detection of early signs of heart disease. Those thought to be at the highest risk of developing cardiovascular disease will be rand...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2010-023093-39 Sponsor Protocol Number: SIRS Start Date*: 2011-09-08
    Sponsor Name:AZIENDA OSPEDALIERA OSPEDALE POLICLINICO CONSORZIALE
    Full Title: Steroids In caRdiac Surgery Trial
    Medical condition: Require CPB for any cardiac surgical procedure
    Disease: Version SOC Term Classification Code Term Level
    13.1 10007541 - Cardiac disorders 10007541 Cardiac disorders SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed) CZ (Completed) ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-001067-27 Sponsor Protocol Number: 20604 Start Date*: 2022-11-10
    Sponsor Name:Bayer AG
    Full Title: A multicenter, international, randomized, placebo controlled, double-blind, parallel group and event driven Phase 3 study of the oral FXIa inhibitor asundexian (BAY 2433334) for the prevention of i...
    Medical condition: Prevention of ischemic stroke in patients post acute non-cardioembolic ischemic stroke or high-risk transient ischemic attack
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10049165 Cerebrovascular accident prophylaxis PT
    22.1 100000004852 10055221 Ischemic stroke LLT
    20.1 100000004852 10072760 Transient ischemic attack LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned) FI (Trial now transitioned) SE (Trial now transitioned) NO (Trial now transitioned) LT (Trial now transitioned) HU (Trial now transitioned) ES (Trial now transitioned) AT (Trial now transitioned) FR (Trial now transitioned) IT (Trial now transitioned) BE (Trial now transitioned) GR (Trial now transitioned) CZ (Trial now transitioned) NL (Trial now transitioned) PL (Trial now transitioned) LV (Trial now transitioned) PT (Trial now transitioned) BG (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-003902-14 Sponsor Protocol Number: 16-118 Start Date*: 2017-07-06
    Sponsor Name:RWTH Aachen University, represented by the Clinical Trial Center (CTC-A)
    Full Title: Intravenous Fish Oil based Lipid Emulsion as Pharmaconutrient Strategy in High-Risk Cardiac Surgery Patients: a Phase II Dosing Study
    Medical condition: Given the recently meta-analyzed data from previous RCTs about fish oil , we hypothesize that the provision of intravenous (i.v.) FO (0.20 g/kg and 0.50 g/kg) to cardiac surgery patients may reduc...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2017-001735-39 Sponsor Protocol Number: CMX001-999 Start Date*: Information not available in EudraCT
    Sponsor Name:Chimerix, Inc
    Full Title: An Open-label, Randomized, Multi-center, Parallel Group, Two-arm Study to Assess the Safety, Overall Tolerability, and Antiviral Activity of Brincidofovir versus Standard of Care for Treatment of A...
    Medical condition: Treatment of adenovirus infections in high-risk pediatric allogeneic hematopoietic cell transplant recipients
    Disease: Version SOC Term Classification Code Term Level
    20.1 10021881 - Infections and infestations 10060931 Adenovirus infection PT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IE (Completed) DE (Prematurely Ended) ES (Prematurely Ended) IT (Prematurely Ended) FR (Completed) NL (Prematurely Ended) GB (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2014-005439-15 Sponsor Protocol Number: CAP Start Date*: Information not available in EudraCT
    Sponsor Name:Akershus University Hospital
    Full Title: Apixaban for treatment of venous thrombosis in patients with cancer.
    Medical condition: Venous thrombosis in patients with cancer
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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