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Clinical trials

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44380   clinical trials with a EudraCT protocol, of which   7392   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
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    44,380 result(s) found. Displaying page 342 of 2,219.
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    EudraCT Number: 2013-000241-39 Sponsor Protocol Number: BAY86-9766/16728 Start Date*: 2013-07-26
    Sponsor Name:Bayer HealthCare AG
    Full Title: A prospective, single-arm, multicenter, uncontrolled, open-label Phase II trial of refametinib (BAY 86-9766) in combination with sorafenib as first line treatment in patients with RAS mutant Hepato...
    Medical condition: KRAS or NRAS mutant unresectable or metastatic Hepatocellular carcinoma (HCC)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) CZ (Completed) GB (Completed) DE (Completed) BE (Completed) IT (Completed) HU (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2013-002521-27 Sponsor Protocol Number: 8477-CL-0020 Start Date*: 2014-05-08
    Sponsor Name:Astellas Pharma Europe B.V. (APEB)
    Full Title: A Phase 2a Enriched Enrollment Randomized Withdrawal Study to Assess Analgesic Efficacy and Safety of ASP8477 in Subjects with Peripheral Neuropathic Pain
    Medical condition: Peripheral Neuropathic Pain
    Disease: Version SOC Term Classification Code Term Level
    17.1 10029205 - Nervous system disorders 10036376 Post herpetic neuralgia PT
    17.1 10029205 - Nervous system disorders 10012683 Diabetic peripheral neuropathy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-002535-24 Sponsor Protocol Number: BIOS-13-005 Start Date*: 2013-09-20
    Sponsor Name:Ethicon Inc., a Johnson & Johnson Co.
    Full Title: A Phase III Randomized, Controlled, Superiority Study Evaluating EVARREST™ Fibrin Sealant Patch Versus Standard of Care Treatment in Controlling Parenchymal Bleeding During Hepatic Surgery
    Medical condition: Subjects undergoing elective, open, hepatic surgery during which a resection plane is created and wherein an appropriate Target Bleeding Site is identified
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-003493-27 Sponsor Protocol Number: CQAL964B2201 Start Date*: 2014-04-08
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A randomized, double-blind, placebo-controlled study to investigate the safety, tolerability and efficacy of orally administered QAL964 in patients with active rheumatoid arthritis on stable dos...
    Medical condition: Rheumatoid Arthritis
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004870 10039075 Rheumatoid arthritis and associated conditions HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Prematurely Ended) GR (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2013-003501-25 Sponsor Protocol Number: ECM2013 Start Date*: 2014-02-20
    Sponsor Name:Mesoestetic Pharma group S.L.
    Full Title: Efficacy and safety of a 4% hydroquinone cream (Melanoderm 4%) for the treatment of melasma: a randomized controlled split-face study.
    Medical condition: Facial melasma
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004858 10027161 Melasma LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-003503-19 Sponsor Protocol Number: MGN1703-C03 Start Date*: 2014-01-28
    Sponsor Name:Mologen AG
    Full Title: Randomized Clinical Trial of Maintenance Therapy with Immunomodulator MGN1703 in Patients with Extensive Disease Small Cell Lung Cancer after Platinum-Based First-Line Therapy
    Medical condition: Small Cell Lung Cancer
    Disease: Version SOC Term Classification Code Term Level
    18.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10041068 Small cell lung cancer extensive stage PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) AT (Completed) DE (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2012-002316-12 Sponsor Protocol Number: SR052012 Start Date*: 2012-08-14
    Sponsor Name:University Hospitals of the KU Leuven
    Full Title: The safety and feasibility of administering xenon to patients undergoing off-pump coronary artery bypass graft surgery: a pilot study XOPCAB – Xenon in Off-Pump Coronary Artery Bypass Grafting
    Medical condition: Xenon anesthesia in cardiac surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2012-002323-15 Sponsor Protocol Number: I4V-MC-JADW Start Date*: 2012-12-18
    Sponsor Name:ELI LILLY AND COMPANY
    Full Title: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Evaluating the Efficacy and Safety of Baricitinib (LY3009104) in Patients with Moderately to Severely Active Rheumatoid Arthritis Who...
    Medical condition: Moderately to severely active rheumatoid arthritis
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10028395 Musculoskeletal and connective tissue disorders SOC
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10039073 Rheumatoid arthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed) PL (Completed) BE (Completed) GB (Completed) AT (Completed) DK (Completed) ES (Completed) NL (Completed) GR (Completed) HR (Completed)
    Trial results: View results
    EudraCT Number: 2011-006171-19 Sponsor Protocol Number: 2011 Start Date*: 2011-10-27
    Sponsor Name:AZIENDA OSPEDALIERA MEYER
    Full Title: randomized multicentric clinical trial upon efficacy of two different drugs combination to eradication of early p.aeruginosa infection in cystic fibrosis patients over 5 years old.
    Medical condition: Cystic fibrosis patients with early P.aeruginosa infection.
    Disease: Version SOC Term Classification Code Term Level
    14.1 10038738 - Respiratory, thoracic and mediastinal disorders 10038738 Respiratory, thoracic and mediastinal disorders SOC
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-006182-18 Sponsor Protocol Number: 15.12.12 Start Date*: 2012-02-23
    Sponsor Name:Danish Headache Center
    Full Title:
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029205 - Nervous system disorders 10020397 Horton's headache LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2012-005830-12 Sponsor Protocol Number: RF-2010-2321799 Start Date*: 2012-10-30
    Sponsor Name:ISTITUTO AUXOLOGICO ITALIANO
    Full Title: Parenteral iron supplementation, chemoreflex response, quality of life and exercise capacity in patients with chronic heart failure
    Medical condition: Chronic heart failure
    Disease: Version SOC Term Classification Code Term Level
    14.1 10007541 - Cardiac disorders 10007541 Cardiac disorders SOC
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-003051-19 Sponsor Protocol Number: Z7190M01 Start Date*: 2012-02-14
    Sponsor Name:ZAMBON S.p.A.
    Full Title: Evaluation of the speed of action of Ibuprofen Arginine in comparison to Ibuprofen in the acute pain relief after mini invasive orthopaedic arthroscopic knee surgery in adults.
    Medical condition: Postoperative acute pain.
    Disease: Version SOC Term Classification Code Term Level
    14.1 10042613 - Surgical and medical procedures 10027289 Meniscectomy (knee) LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2013-004977-28 Sponsor Protocol Number: 701079.01.013 Start Date*: 2014-02-06
    Sponsor Name:Dr. Willmar Schwabe GmbH & Co. KG
    Full Title: Safety and intake effect of EPs®7630 (an extract from the roots of Pelargonium sidoides)
    Medical condition: common cold
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004862 10010106 Common cold LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-005024-42 Sponsor Protocol Number: TCP-102 Start Date*: 2014-06-18
    Sponsor Name:Menlo Therapeutics, Inc.
    Full Title: A Randomized, Double-Blind, Placebo-Controlled, Study of the Neurokinin-1 Receptor Antagonist VPD-737 in Subjects with Prurigo Nodularis
    Medical condition: Pruritus nodularis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) IE (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2013-004103-40 Sponsor Protocol Number: ALDOXORUBICIN-P3-STS-01 Start Date*: 2014-03-20
    Sponsor Name:CytRx Corporation
    Full Title: A Multicenter, Randomized, Open-Label Phase 3 Study to Investigate the Efficacy and Safety of Aldoxorubicin Compared to Investigator’s Choice in Subjects with Metastatic, Locally Advanced, or Unres...
    Medical condition: Metastatic, Locally Advanced, or Unresectable Soft Tissue Sarcoma
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004864 10041298 Soft tissue sarcomas histology unspecified HLT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) ES (Prematurely Ended) FR (Prematurely Ended) IT (Prematurely Ended) NL (Prematurely Ended) PL (Prematurely Ended) DK (Prematurely Ended) BG (Prematurely Ended) GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2013-004117-40 Sponsor Protocol Number: Q03.13.01 Start Date*: 2013-12-19
    Sponsor Name:Fidia Farmaceutici SpA
    Full Title: Randomized, controlled, double-blinded clinical trial, with open-label extension on the efficacy of ultrasound guided injection of hyaluronic acid (500-730 KDa) (HYALGAN®) versus saline solution in...
    Medical condition: Achilles tendinopathy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2013-003660-31 Sponsor Protocol Number: ALV003-1221 Start Date*: 2013-11-27
    Sponsor Name:Alvine Pharmaceuticals, Inc.
    Full Title: A Phase 2b, Randomized, Double-Blind, PLacebo-Controlled Dose-Ranging Study of the Efficacy and Safety of ALV003 Treatment in Symptomatic Celiac Disease Patients Maintained on a Gluten-Free Diet
    Medical condition: Celiac Disease
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004856 10007864 Celiac disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) GB (Completed) IE (Completed) NO (Completed)
    Trial results: View results
    EudraCT Number: 2013-003733-15 Sponsor Protocol Number: B-003 Start Date*: 2013-11-13
    Sponsor Name:VU University medical center
    Full Title: The Dutch CSF and PET Biomarker Concordance of Alzheimer’s Disease pathology study
    Medical condition: Patients visiting the VUmc Alzheimer Center with objective cognitive complaints or diagnosed with Alzheimer's Disease.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-004831-47 Sponsor Protocol Number: TWO2-001 Start Date*: 2007-11-30
    Sponsor Name:Linde Gas Therapeutics
    Full Title: Topical Wound Oxygen vs. Compression Therapy in the Management of Refractory, Non-Healing Venous Leg Ulcers; A prospective Randomised Controlled Trial
    Medical condition: Chronic, refarctory, non-healing venous ulcers with a duration of more than two years.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10047260 Venous ulceration LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-000446-30 Sponsor Protocol Number: 02-2014 Start Date*: 2014-07-23
    Sponsor Name:Maasstad Ziekenhuis
    Full Title: Metformin vs Control to prevent gestational diabetes mellitus (GDM) in women with a high risk for GDM, an open label randomized controlled trial. The Medico-GDM trial.
    Medical condition: Pregnant women with a high risk of gestational diabetes mellitus (GDM)
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
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    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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