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Clinical trials for Degenerative disc disease

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    19 result(s) found for: Degenerative disc disease. Displaying page 1 of 1.
    EudraCT Number: 2010-023830-22 Sponsor Protocol Number: AAG-G-H-1102 Start Date*: 2012-05-23
    Sponsor Name:TETEC AG
    Full Title: NDisc Study: A Prospective Randomized Multicentre Phase I / II Clinical Trial to Evaluate Safety and Efficacy of NOVOCART® Disc plus Autologous Disc Chondrocyte Transplantation (ADCT) in the Treatm...
    Medical condition: The subject has a disc herniation with back and /or leg pain (radicular pain) and an identification for sequestrectomy according to the guidelines of DGNC and DGOOC.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10022634 Intervertebral disc disorders LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) AT (Completed)
    Trial results: View results
    EudraCT Number: 2012-004444-30 Sponsor Protocol Number: Disc_allo_MSV Start Date*: 2013-04-23
    Sponsor Name:Citospin
    Full Title: Treatment of degenerative disc disease with allogenic mesenchymal cells—MSV--
    Medical condition: Treatment of degenerative disc disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2009-012672-27 Sponsor Protocol Number: CIP0702PLF/EU Start Date*: 2009-08-17
    Sponsor Name:ApaTech Limited
    Full Title: "A prospective, randomised study comparing the use of Actifuse™ ABX synthetic bone substitute with INFUSE® in patients requiring posterolateral instrumented lumbar fusion with interbody fusion" als...
    Medical condition: Prospective trial participants will have been diagnosed with degenerative disc disease with a treatment option of decompression and Interbody Fusion with Posterolateral Intertransverse Process Fusi...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10024992 Lumbar disc disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-000860-14 Sponsor Protocol Number: GR-OG-279239-03 Start Date*: 2018-02-27
    Sponsor Name:Genera Research Ltd
    Full Title: Patient and evaluator blinded non-inferiority study on safety, tolerability and lumbar fusion efficacy of a single administration of Osteogrow (rhBMP6 in autologous blood coagulum (ABC) carrier) in...
    Medical condition: Lumbar spine single segment destabilization caused by degenerative disc disease
    Disease: Version SOC Term Classification Code Term Level
    21.1 10042613 - Surgical and medical procedures 10050505 Spinal fusion surgery PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-005766-36 Sponsor Protocol Number: Start Date*: 2006-11-17
    Sponsor Name:Sofamor - Danek
    Full Title: A Randomized Prospective Study of Instrumented Posterior Lumbar Interbody Fusion: Autologous Iliac Crest Bone Graft vs. Inductos™
    Medical condition: We will investigate if the use of Inductos in a intervertebral cage will provide us with better and or faster fusion rates.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-004480-31 Sponsor Protocol Number: ALLOB-IF1 Start Date*: 2014-05-27
    Sponsor Name:Bone Therapeutics S.A.
    Full Title: A Pilot Phase IIa, Multicentre, Open, Proof-of-concept Study on the Safety and the Efficacy of Allogeneic Osteoblastic Cells (ALLOB®) implantation in Lumbar Spinal Fusion
    Medical condition: Degenerative disc disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000018941 10070241 Degenerative disc disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-002749-40 Sponsor Protocol Number: DREAM-GR-2018-12367168 Start Date*: 2019-12-02
    Sponsor Name:UNIVERSITÀ CAMPUS BIO-MEDICO DI ROMA
    Full Title: Intervertebral Disc REgeneration mediated by Autologous Mesenchymal stem/stromal cells intradiscal injection: a phase IIB randomized clinical trial.
    Medical condition: Symptomatic chronic low back pain due to a degenerative disease of the intervertebral disc
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004859 10070241 Degenerative disc disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2010-024665-52 Sponsor Protocol Number: AMSC-DSD-001 Start Date*: 2013-07-24
    Sponsor Name:Bioinova, s.r.o.
    Full Title: Utilization of Autologous Mesenchymal Cells in Posterolateral Spinal Fusion in Degenerative Spine Disease: a Prospective, Non-randomized, Open-Label Study to Assess the Safety and the Efficacy.
    Medical condition: Spinal degenerative disease
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004859 10070241 Degenerative disc disease LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2017-002092-25 Sponsor Protocol Number: 9766 Start Date*: 2018-06-18
    Sponsor Name:University Hospital of Montpellier
    Full Title: A phase 2/3 prospective, multicentre randomized, double-blind trial, comparing intra-discal allogeneic adult BM-MSC therapy and sham-treated controls in subjects with chronic low back pain due to l...
    Medical condition: Degenerative Disc Disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing) FR (Completed) DE (Trial now transitioned) IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-021662-30 Sponsor Protocol Number: CRFB002F2301 Start Date*: 2010-11-05
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A 12 month, phase III, randomized, double-masked, multi-center, active-controlled study to evaluate the efficacy and safety of two different dosing regimens of 0.5 mg ranibizumab vs. verteporfin PD...
    Medical condition: visual impairment due to choroidal neovascularization secondary to pathologic myopia
    Disease: Version SOC Term Classification Code Term Level
    12.1 10036803 Progressive high (degenerative) myopia LLT
    12.1 10060837 Choroidal neovascularization LLT
    12.1 10047571 Visual impairment LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PT (Completed) LV (Completed) HU (Completed) LT (Completed) FR (Completed) ES (Completed) IT (Completed) AT (Completed) SK (Completed) DE (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2019-004476-19 Sponsor Protocol Number: ACTIVE-BRIC2018–ID03 Start Date*: 2020-04-28
    Sponsor Name:UNIVERSITÀ CAMPUS BIO-MEDICO DI ROMA
    Full Title: Autologous mesenchymal stem/stromal Cells for the Treatment of workers affected by chronic low back pain due to multilevel InterVErtebral disc degeneration: a phase IIB randomized clinical trial - ...
    Medical condition: Symptomatic chronic low back pain due to a degenerative disease of the intervertebral disc
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004859 10070241 Degenerative disc disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-002642-23 Sponsor Protocol Number: NVD-CLN01 Start Date*: 2016-11-28
    Sponsor Name:Novadip Biosciences
    Full Title: A prospective multi-centre, randomised, controlled study to evaluate the safety and preliminary effectiveness of NVD-001 for the treatment of low grade degenerative lumbar spondylolisthesis by inte...
    Medical condition: Patients diagnosed with symptomatic degenerative spondylolisthesis grade I or II with an indication for spinal fusion of one vertebral segment (L1-S1).
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) PL (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2015-001146-29 Sponsor Protocol Number: 1 Start Date*: 2016-01-12
    Sponsor Name:Hospital Central de la Defensa
    Full Title: Selective local anesthesia versus a combined medication injection with corticosteroids in degenerartive spine
    Medical condition: Degenerative spine pain when there are no indications for surgical treatment
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-005645-27 Sponsor Protocol Number: DBM Start Date*: 2009-06-26
    Sponsor Name:Medizinische Universität Innsbruck, vertreten durch Univ. Prof. Dr. Martin Krismer
    Full Title: Vergleich von demineralisierter Knochenmatrix (DBM) und Knochenallograft bei der anterioren lumbale Wirbelkörperfusion (ALIF) mittels Synfix LR
    Medical condition: Anteriore lumbale Wirbelkörperfusion (Anterior lumbar interbody fusion, ALIF) ist ein Standardverfahren bei der operative Behandlung von chronischem Kreuzschmerz und zur Fusion bei degenerativen ...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2004-000675-34 Sponsor Protocol Number: EU 101 Start Date*: 2004-12-21
    Sponsor Name:University Medical Center Utrecht
    Full Title: A Prospective, Randomized, Controlled, Multi-center, (Pilot) Study of Osigraft® in Instrumented Posterolateral Fusions
    Medical condition: Subjects qualifying for decompression and fusion of one spinal level (L3-S1) with the use of autograft will be recruited through the medical institutions of participating investigators. All subject...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-004269-96 Sponsor Protocol Number: IG8801CLBP201 Start Date*: 2016-02-24
    Sponsor Name:Gador S.A.
    Full Title: A 24 weeks multicentre, randomized, double-blind, placebo-controlled, parallel group, study to evaluate the efficacy, safety and tolerability of intravenous IG-8801 20 mg and 40 mg in subjects with...
    Medical condition: non-specific Chronic Low Back Pain persisting for at least 3 months
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004859 10008837 Chronic back pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-001160-38 Sponsor Protocol Number: lidocaineplif Start Date*: 2014-01-08
    Sponsor Name:ZNA Middelheim
    Full Title: Impact of intravenous lidocaine infusion on postoperative analgesia for one or two level posterior lumbar interbody fusion surgery
    Medical condition: The postoperative pain intensity after posterior interbody fusion surgery is often intense and difficult to treat with IV morphine and paracetamol alone. Besides, the use of opioids is often associ...
    Disease: Version SOC Term Classification Code Term Level
    16.0 10042613 - Surgical and medical procedures 10050505 Spinal fusion surgery PT
    16.0 10042613 - Surgical and medical procedures 10050237 Operative spinal fusion LLT
    16.0 10042613 - Surgical and medical procedures 10041575 Spinal fusion LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-005722-35 Sponsor Protocol Number: H--6-2014-070 Start Date*: 2015-06-23
    Sponsor Name:Glostrup University Hospital
    Full Title: Measures of inflammation in low back pain (LBP) and anti-TNFα for the treatment of deemed discogenic LBP - an explorative study
    Medical condition: Low back pain with and without legg-pain In the late periode 1990ies it became clear that various cytokines and other inflammatory elements played a large role for low back pain. One of the known ...
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004859 10024891 Low back pain LLT
    18.0 100000004859 10024892 Low back pain (without radiation) LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2017-000422-36 Sponsor Protocol Number: SB11-G31-AMD Start Date*: 2017-11-28
    Sponsor Name:Samsung Bioepis Co., Ltd.
    Full Title: A Phase III Randomised, Double-masked, Parallel Group, Multicentre Study to Compare the Efficacy, Safety, Pharmacokinetics and Immunogenicity between SB11 (proposed ranibizumab biosimilar) and Luce...
    Medical condition: Neovascular Age-related Macular Degeneration
    Disease: Version SOC Term Classification Code Term Level
    20.0 10015919 - Eye disorders 10071129 Neovascular age-related macular degeneration PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed) HU (Completed) GB (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
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