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Clinical trials for Fibromatosis

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    17 result(s) found for: Fibromatosis. Displaying page 1 of 1.
    EudraCT Number: 2011-006037-42 Sponsor Protocol Number: IB2011-03 Start Date*: 2013-09-06
    Sponsor Name:Institut Bergonié
    Full Title:
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10059353 Desmoid tumor LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2016-005215-41 Sponsor Protocol Number: 5.5 Start Date*: 2017-05-05
    Sponsor Name:Olli Leppänen
    Full Title: DupuytrEn Treatment EffeCtiveness Trial (DETECT): a protocol for prospective, randomized, controlled, outcome assessor-blinded, three armed parallel 1:1:1, multicenter trial comparing efficacy and ...
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    19.1 10028395 - Musculoskeletal and connective tissue disorders 10013872 Dupuytren's contracture PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2006-006143-31 Sponsor Protocol Number: AUX-CC-854.01 Start Date*: 2007-10-19
    Sponsor Name:Auxilium UK Limited
    Full Title: A Phase 3, Open Label Study of Safety and Efficacy of AA4500 in the Treatment of Subjects With Dupuytren's Contracture
    Medical condition: Dupuytren's Contracture
    Disease: Version SOC Term Classification Code Term Level
    8.1 10013872 Dupuytren's contracture LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) FI (Completed) DK (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-007872-99 Sponsor Protocol Number: AUX-CC-860 Start Date*: 2010-02-01
    Sponsor Name:Auxilium UK Limited
    Full Title: Long term follow up of subjects treated with AA4500 in studies AUX-CC-854, AUX-CC-856, AUX-CC-857/AUX-CC-858 and AUX-CC-859
    Medical condition: Dupuytren's contracture
    Disease: Version SOC Term Classification Code Term Level
    14.0 10028395 - Musculoskeletal and connective tissue disorders 10013872 Dupuytren's contracture PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) DK (Completed) SE (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2020-005833-34 Sponsor Protocol Number: AL-DES-01 Start Date*: 2021-09-06
    Sponsor Name:Ayala Pharmaceuticals, Inc.
    Full Title: RINGSIDE: A Phase 2/3, Randomized, Multicenter Study to Evaluate AL102 in Patients with Progressing Desmoid Tumors
    Medical condition: Progressing desmoid tumors
    Disease: Version SOC Term Classification Code Term Level
    20.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10059352 Desmoid tumour PT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing) NL (Trial now transitioned) FR (Ongoing) PL (Trial now transitioned) DE (Trial now transitioned) IT (Trial now transitioned) BE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2018-001991-39 Sponsor Protocol Number: NIR-DT-301 Start Date*: 2019-07-26
    Sponsor Name:SpringWorks Subsidiary 2, PBC
    Full Title: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial of Nirogacestat Versus Placebo in Adult Patients with Progressing Desmoid Tumors/Aggressive Fibromatosis (DT/AF).
    Medical condition: Desmoid Tumors/Aggressive Fibromatosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA) BE (Completed) NL (Completed) DE (Completed) IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-004239-37 Sponsor Protocol Number: AUX-CC-810 Start Date*: 2015-02-26
    Sponsor Name:Auxilium UK Limited
    Full Title: Long-term safety, curvature deformity characterization, and immunogenicity over time in subjects previously treated with AA4500 for Peyronie’s disease in studies AUX-CC-802, AUX-CC-803, AUX CC 804,...
    Medical condition: Peyronie's Disease
    Disease: Version SOC Term Classification Code Term Level
    17.1 10038604 - Reproductive system and breast disorders 10034766 Peyronies disease LLT
    17.1 10038604 - Reproductive system and breast disorders 10034765 Peyronie's disease PT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: SE (Completed) GB (Completed) DK (Completed) ES (Completed) IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-005065-21 Sponsor Protocol Number: AUX-CC-862 Start Date*: 2012-03-26
    Sponsor Name:Auxilium UK Limited
    Full Title: Retreatment of recurrent contractures in joints effectively treated with AA4500 (collagenase clostridium histolyticum [XIAFLEX®/XIAPEX®]) in an Auxilium-sponsored Phase 3 Study in the United States...
    Medical condition: Dupuytren's contracture
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10013872 Dupuytren's contracture PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2016-004251-76 Sponsor Protocol Number: 87230 Start Date*: 2017-05-22
    Sponsor Name:University Hospitals of Leicester NHS Trust
    Full Title: A pragmatic multi-centre randomised controlled non-inferiority, cost effectiveness trial comparing injections of collagenase into the cord to surgical correction in the treatment of moderate Dupuyt...
    Medical condition: Dupuytren's contracture
    Disease: Version SOC Term Classification Code Term Level
    19.1 10028395 - Musculoskeletal and connective tissue disorders 10013872 Dupuytren's contracture PT
    19.1 10042613 - Surgical and medical procedures 10013873 Dupuytren's contracture operation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2015-001780-40 Sponsor Protocol Number: 11069 Start Date*: 2015-05-21
    Sponsor Name:University of Oxford, Clinical Trials and Research Governance
    Full Title: A multi-centre, double blind, randomised, placebo-controlled, parallel group, phase II trial to determine the efficacy of intra-nodular injection of anti-TNF to control disease progression in early...
    Medical condition: Dupuytren's disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10013872 Dupuytren's contracture PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2022-000666-17 Sponsor Protocol Number: RR37_21_01 Start Date*: 2022-07-30
    Sponsor Name:Fidia Farmaceutici Spa
    Full Title: A Phase II double-blind, randomised, placebo-controlled study of efficacy and safety of Vibrio alginolyticus collagenase administered to patients with Dupuytren contracture
    Medical condition: Dupuytren contracture
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10013872 Dupuytren's contracture PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) DE (Completed) IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-000624-40 Sponsor Protocol Number: CSTI571BDE70 Start Date*: 2010-05-27
    Sponsor Name:University of Heidelberg
    Full Title: PHASE II STUDY TO EVALUATE GLIVEC (IMATINIB MESYLATE) TO INDUCE PROGRESSION ARREST IN AGGRESSIVE FIBROMATOSIS / DESMOID TUMORS NOT AMENABLE TO SURGICAL RESECTION WITH R0 INTENT OR ACCOMPANIED BY UN...
    Medical condition: AGGRESSIVE FIBROMATOSIS / DESMOID TUMORS
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-006493-23 Sponsor Protocol Number: NIMAO/2021-1/YG-01 Start Date*: 2022-04-04
    Sponsor Name:Nimes University Hospital
    Full Title: Evaluation of the patient postoperative experience of two modes of WALANT-type anesthesia (lidocaine alone or combined with ropivacaine) used in ambulatory upper-extremity surgery
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10013872 Dupuytren's contracture PT
    20.0 10029205 - Nervous system disorders 10007697 Carpal tunnel syndrome PT
    21.0 10028395 - Musculoskeletal and connective tissue disorders 10044654 Trigger finger PT
    20.0 10029205 - Nervous system disorders 10058942 Ulnar tunnel syndrome PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-002770-82 Sponsor Protocol Number: RR202200317 Start Date*: 2024-09-09
    Sponsor Name:Universitair Medisch Centrum Groningen
    Full Title: The use of FAPI-PET/CT scan and FDG-PET?CT scan in acute phase Peyronie's disease for detection of active fibroblasts and inflammation in the penis - a pilot study
    Medical condition: Peyronie's disease
    Disease: Version SOC Term Classification Code Term Level
    21.1 10038604 - Reproductive system and breast disorders 10034766 Peyronies disease LLT
    Population Age: Elderly Gender: Male
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2010-022921-13 Sponsor Protocol Number: AUX-CC-802 Start Date*: 2011-01-24
    Sponsor Name:Auxilium UK Limited
    Full Title: A PHASE 3, OPEN-LABEL STUDY OF THE SAFETY AND EFFECTIVENESS OF AA4500 ADMINISTERED TWICE PER TREATMENT CYCLE FOR UP TO FOUR TREATMENT CYCLES (2 x 4) IN MEN WITH PEYRONIE’S DISEASE
    Medical condition: Peyronie's Disease
    Disease: Version SOC Term Classification Code Term Level
    14.0 10038604 - Reproductive system and breast disorders 10034765 Peyronie's disease PT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: SE (Completed) GB (Completed) DE (Completed) DK (Completed) FR (Completed) ES (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2012-004091-19 Sponsor Protocol Number: AUX-CC-867 Start Date*: 2012-12-28
    Sponsor Name:Auxilium UK Limited
    Full Title: A Phase 3b open-label, historically-controlled study to assess the safety and efficacy of two concurrent injections of AA4500 in adult subjects with multiple Dupuytren’s contractures with palpable ...
    Medical condition: Dupuytren's contracture
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10013872 Dupuytren's contracture PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) GB (Completed) DK (Completed)
    Trial results: View results
    EudraCT Number: 2011-006205-95 Sponsor Protocol Number: 2011-006205-95 Start Date*: 2012-10-05
    Sponsor Name:ISTITUTO NAZIONALE PER LA CURA TUMORI
    Full Title: Toremifene in desmoid tumor: prospective clinical trial and identification of potential molecular targets
    Medical condition: Primary or recurrent sporadic desmoid tumor
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10028395 Musculoskeletal and connective tissue disorders SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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