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Clinical trials for Internal anal sphincter

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    12 result(s) found for: Internal anal sphincter. Displaying page 1 of 1.
    EudraCT Number: 2007-004114-13 Sponsor Protocol Number: 956 Start Date*: 2008-01-07
    Sponsor Name:POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI
    Full Title: TOPIC LEVETIRACETAM IN ANAL FISSURE. A PILOT STUDY ABOUT EFFECTIVENESS AND TOLERABLENESS
    Medical condition: Anal fissure
    Disease: Version SOC Term Classification Code Term Level
    9.1 10002153 Anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2005-002335-27 Sponsor Protocol Number: IGG-VIJA-001 Start Date*: 2005-09-01
    Sponsor Name:ISTITUTO GIANNINA GASLINI
    Full Title: Botulin Toxin injection for the treatment of Internal Anal Sphincter Achalasia
    Medical condition: Treatment of internal anal sphincter achalasia
    Disease: Version SOC Term Classification Code Term Level
    6.1 10042613 SOC
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-000853-30 Sponsor Protocol Number: DRGT119C01 Start Date*: 2019-05-31
    Sponsor Name:Druggability Technologies Holdings Ltd
    Full Title: A Randomized, Double-Blind, Adaptive Trial with an Open-Label Treatment Extension to Determine the Efficacy and Safety of Topical DRGT-119 0.1% and 0.2% Gels in Patients with Chronic Anal Fissure
    Medical condition: chronic anal fissure
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10071195 Chronic anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2017-001216-11 Sponsor Protocol Number: FISAN-BOT-2017-01 Start Date*: 2017-04-25
    Sponsor Name:Dra. A. Teresa Calderón Duque
    Full Title: Usefulness of botulinum toxin type A in the treatment of chronic anal fissure
    Medical condition: Chronic anal fissure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-002819-60 Sponsor Protocol Number: FAC-BOTOX Start Date*: 2021-08-19
    Sponsor Name:Hospital Universitario de Burgos
    Full Title: Treatment of chronic anal fissure with ultrasound-guided intersphincteric infiltration of botulinum toxin A.
    Medical condition: Chronic anal fissure
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-002882-19 Sponsor Protocol Number: MCHT001 Start Date*: 2004-12-10
    Sponsor Name:Mid Cheshire Hospitals NHS Trust
    Full Title: A controlled trial into the benefit of topical perianal glyceryl trinitrate (GTN) as a sphincter relaxant, pre-insertion of ultrasound probe for trans rectal ultrasound (TRUS) guided biopsy of the ...
    Medical condition: Prostate Cancer Diagnosis – Pain relief during biopsy
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-003351-65 Sponsor Protocol Number: RDD110 Start Date*: 2016-03-16
    Sponsor Name:RDD Pharma Ltd.
    Full Title: The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients with Anal Fissure
    Medical condition: Anal Fissure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BG (Completed) PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-003627-54 Sponsor Protocol Number: 150601 Start Date*: 2016-05-11
    Sponsor Name:Tecnimede, Sociedade Técnico-Medicinal, S.A.
    Full Title: Randomized, multicenter, placebo-controlled, double blind study to assess the efficacy and tolerability of 2% diltiazem hydrochloride in the treatment of chronic anal fissure and a 24 week follow-u...
    Medical condition: Cronic Anal fissure (CAF) The underlying pathogenesis of chronic anal fissure involves initial local trauma (generally caused by hard stools), resulting in a wound, internal anal sphincter spasm an...
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000016260 10071195 Chronic anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2005-005675-15 Sponsor Protocol Number: DIL-UBI-DEX-CLOII/2003/003/PT Start Date*: 2008-10-08
    Sponsor Name:Tecnimede, Sociedade Técnico-Medicinal S.A.
    Full Title: Randomized, multicenter, placebo-controlled, single blind study to assess the efficacy and tolerability of a combination of a cream containing ubidecarenone, dexpanthenol and chlorohexidine and a p...
    Medical condition: Cronic Anal fissure (CAF) The underlying pathogenesis of chronic anal fissure involves initial local trauma (generally caused by hard stools), resulting in a wound, internal anal sphincter spasm an...
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004856 10071195 Chronic anal fissure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PT (Completed) CZ (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2011-003206-25 Sponsor Protocol Number: NRL001-01/2011(SEFI) Start Date*: 2012-01-25
    Sponsor Name:Norgine Ltd
    Full Title: A multi-centre, phase II, double-blind, randomised, placebo-controlled, parallel group, dose-ranging study in patients with faecal incontinence; to evaluate the efficacy, safety and tolerability of...
    Medical condition: Faecal incontinence
    Disease: Version SOC Term Classification Code Term Level
    14.1 10017947 - Gastrointestinal disorders 10016092 Faecal incontinence PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) CZ (Completed) DE (Completed) ES (Completed) GB (Completed) IT (Completed) HU (Completed)
    Trial results: Removed from public view
    EudraCT Number: 2010-021659-17 Sponsor Protocol Number: CMMAd/InFe/2011 Start Date*: 2013-08-14
    Sponsor Name:Fundación Pública Andaluza Progreso y Salud
    Full Title: Phase I / II, multicenter, double blind, randomized, comparison of two groups and two doses, to evaluate the safety and efficacy of autologous ASCs in the treatment of fecal incontinence.
    Medical condition: Patients with incontinence faecal
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004856 10056118 Incontinence faecal LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2021-002331-34 Sponsor Protocol Number: ALOFEC-2019 Start Date*: 2022-11-08
    Sponsor Name:FIMABIS
    Full Title: A multicenter, randomized, double-blind Phase IIb study to evaluate the safety and efficacy of the intralesional administration of two doses of expanded allogeneic adipose tissue adult stem mesench...
    Medical condition: Fecal incontinence
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10016296 Fecal incontinence LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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