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Clinical trials for Intervertebral Disc Degeneration

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44394   clinical trials with a EudraCT protocol, of which   7406   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    8 result(s) found for: Intervertebral Disc Degeneration. Displaying page 1 of 1.
    EudraCT Number: 2014-001449-26 Sponsor Protocol Number: 6603/1132 Start Date*: 2015-01-22
    Sponsor Name:Seikagaku Corporation
    Full Title: A Multicenter, Open-label Study of SI-6603 in Patients with Lumbar Disc Herniation (Phase III)
    Medical condition: Lumbar disc herniation
    Disease: Version SOC Term Classification Code Term Level
    17.1 10028395 - Musculoskeletal and connective tissue disorders 10050296 Intervertebral disc protrusion PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2012-001816-42 Sponsor Protocol Number: 24-02-2012 Start Date*: 2012-06-12
    Sponsor Name:Kuopion yliopistollinen sairaala
    Full Title:
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10012151 Degeneration of cervical intervertebral disc LLT
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10012153 Degeneration of lumbar or lumbosacral intervertebral disc LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-018335-17 Sponsor Protocol Number: CSM/Fusión/2009 Start Date*: 2010-07-20
    Sponsor Name:Fundación de la Universidad de Salamanca
    Full Title: Ensayo clínico en fase I/II prospectivo, abierto, no aleatorizado para el tratamiento de la discopatía degenerativa intervertebral lumbar mediante artrodesis posterolateral instrumentada y células ...
    Medical condition: Discopatía degenerativa intervertebral lumbar
    Disease: Version SOC Term Classification Code Term Level
    9 10012153 Degeneration of lumbar or lumbosacral intervertebral disc LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-003160-44 Sponsor Protocol Number: 191177 Start Date*: 2013-04-30
    Sponsor Name:Orthopaedic Research Laboratory, Århus University Hospital
    Full Title: Treatment of moderate intervertebral disc degeneration with autologous bonemarrow derived mesenchymal stem cells (bMSC):
    Medical condition: Moderate intervertebral disc degeneration without radiculopathy
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004859 10025020 Lumbosacral spondylosis without myelopathy LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-023830-22 Sponsor Protocol Number: AAG-G-H-1102 Start Date*: 2012-05-23
    Sponsor Name:TETEC AG
    Full Title: NDisc Study: A Prospective Randomized Multicentre Phase I / II Clinical Trial to Evaluate Safety and Efficacy of NOVOCART® Disc plus Autologous Disc Chondrocyte Transplantation (ADCT) in the Treatm...
    Medical condition: The subject has a disc herniation with back and /or leg pain (radicular pain) and an identification for sequestrectomy according to the guidelines of DGNC and DGOOC.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10022634 Intervertebral disc disorders LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) AT (Completed)
    Trial results: View results
    EudraCT Number: 2019-002749-40 Sponsor Protocol Number: DREAM-GR-2018-12367168 Start Date*: 2019-12-02
    Sponsor Name:UNIVERSITÀ CAMPUS BIO-MEDICO DI ROMA
    Full Title: Intervertebral Disc REgeneration mediated by Autologous Mesenchymal stem/stromal cells intradiscal injection: a phase IIB randomized clinical trial.
    Medical condition: Symptomatic chronic low back pain due to a degenerative disease of the intervertebral disc
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004859 10070241 Degenerative disc disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2019-004476-19 Sponsor Protocol Number: ACTIVE-BRIC2018–ID03 Start Date*: 2020-04-28
    Sponsor Name:UNIVERSITÀ CAMPUS BIO-MEDICO DI ROMA
    Full Title: Autologous mesenchymal stem/stromal Cells for the Treatment of workers affected by chronic low back pain due to multilevel InterVErtebral disc degeneration: a phase IIB randomized clinical trial - ...
    Medical condition: Symptomatic chronic low back pain due to a degenerative disease of the intervertebral disc
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004859 10070241 Degenerative disc disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-002092-25 Sponsor Protocol Number: 9766 Start Date*: 2018-06-18
    Sponsor Name:University Hospital of Montpellier
    Full Title: A phase 2/3 prospective, multicentre randomized, double-blind trial, comparing intra-discal allogeneic adult BM-MSC therapy and sham-treated controls in subjects with chronic low back pain due to l...
    Medical condition: Degenerative Disc Disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing) FR (Completed) DE (Trial now transitioned) IT (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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