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Clinical trials for Loperamide

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    60 result(s) found for: Loperamide. Displaying page 1 of 3.
    1  2  3  Next»
    EudraCT Number: 2019-003172-40 Sponsor Protocol Number: N/A Start Date*: 2019-11-19
    Sponsor Name:University Hospitals Plymouth NHS Trust
    Full Title: High Dose Loperamide in Patients with Intestinal Failure (IF): Plasma Concentration and Electrocardiogram(ECG) Changes
    Medical condition: Measurement and clarification of plasma loperamide and metabolite concentrations in participants with intestinal failure
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2016-001790-33 Sponsor Protocol Number: AGO/2016/005 Start Date*: 2016-06-17
    Sponsor Name:University Hospital Ghent
    Full Title: A PHASE II, SINGLE-CENTRE, PROSPECTIVE EXPLORATORY TRIAL TO ASSESS THE EFFICACY OF LANREOTIDE AUTOGEL 120 MG IN THE SYMPTOMATIC TREATMENT OF ACUTE RADIATION INDUCED DIARRHEA
    Medical condition: radiation induced diarrhoea
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2019-001559-38 Sponsor Protocol Number: GEICAM/2018-06 Start Date*: 2022-01-20
    Sponsor Name:GEICAM (Fundación Grupo Español de Investigación en Cáncer de Mama)
    Full Title: A Randomized Phase II Study to Evaluate the Incidence of Discontinuations due to Diarrhoea at 3 Cycles in patients with Early-stage HER2-positive (HER2+), Hormone Receptor-positive (HR+) Breast Can...
    Medical condition: HER2+, HR+ Early stage Breast Cancer
    Disease: Version SOC Term Classification Code Term Level
    23.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10065430 HER2 positive breast cancer PT
    23.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10083234 Hormone receptor positive breast cancer PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing) FR (Trial now transitioned) IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2015-004374-15 Sponsor Protocol Number: PUMA-NER-6201 Start Date*: 2018-04-13
    Sponsor Name:Puma Biotechnology, Inc.
    Full Title: An Open Label Study to Characterize the Incidence and Severity of Diarrhea in Patients with Early Stage HER2+ Breast Cancer Treated with Neratinib and Intensive Loperamide Prophylaxis
    Medical condition: Early Stage HER2+ Breast Cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10065430 HER-2 positive breast cancer PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) AT (Completed)
    Trial results: View results
    EudraCT Number: 2014-004473-16 Sponsor Protocol Number: SL001-2.0 Start Date*: 2016-07-19
    Sponsor Name:Masarykův onkologický ústav
    Full Title: Prospective study investigating efficacy of lanreotide on decrease of chemotherapy induced diarrhoea (CID) in patiens with colorectal carcinoma.
    Medical condition: Chemotherapy induced diarrhoea that is resistant to common treatment including loperamide in patients with colorectal carcinoma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-004740-35 Sponsor Protocol Number: s-20140081 Start Date*: 2014-12-19
    Sponsor Name:Department of surgery, Odense University Hospital
    Full Title: Loperamide vs. Placebo's effect on ileostomy output: A clincal randomized patientblinded crossover study
    Medical condition: Patients with ileostomy because of ulcerative colitis, rectal cancer or short bowel syndrom
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004856 10012727 Diarrhea LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2016-000288-18 Sponsor Protocol Number: I3Y-MC-JPCG Start Date*: 2016-07-21
    Sponsor Name:Lilly S.A.
    Full Title: A Randomized, Open-Label, Phase 2 Study of Abemaciclib plus Tamoxifen or Abemaciclib Alone, in Women with Previously Treated Hormone Receptor-Positive, HER2-Negative, Metastatic Breast Cancer
    Medical condition: Breast cancer
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004864 10027475 Metastatic breast cancer LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: ES (Completed) AT (Completed) BE (Completed) DE (Completed) CZ (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2019-003220-21 Sponsor Protocol Number: GA19/105668 Start Date*: 2020-02-26
    Sponsor Name:University of Leeds
    Full Title: Management of diarrhoea in ulcerative colitis: multi-arm multi-stage trial of low FODMAP diet, amitriptyline, ondansetron, or loperamide: MODULATE.
    Medical condition: Diarrhoea in patients with stable ulcerative colitis.
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004856 10045365 Ulcerative colitis LLT
    20.1 100000004856 10033007 Other ulcerative colitis LLT
    20.1 100000004856 10066557 Chronic diarrhoea LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2013-003998-10 Sponsor Protocol Number: 46334 Start Date*: 2013-12-06
    Sponsor Name:Academic medical center
    Full Title: A randomized clinical trial investigating Lanreotide For output reduction in patients with high-output Enterocutaneous fistula
    Medical condition: All adult patients with a small bowel fistula with an output > 500ml/day or a an enterostomy with an output > 1500ml/day after gastro-intestinal, abdominal wall surgery. Randomization is possible i...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-000396-20 Sponsor Protocol Number: Dropizol_2020 Start Date*: 2021-01-02
    Sponsor Name:Mech-Sense, Aalborg University Hospital
    Full Title: Opium tincture against chronic diarrhea - Patients: An investigator initiated, randomized placebo-controlled, clinical trial
    Medical condition: Chronic diarrhea
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004856 10066556 Chronic diarrhea LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2014-004707-67 Sponsor Protocol Number: 2014-880 Start Date*: 2016-01-13
    Sponsor Name:Hospices Civils de Lyon
    Full Title: REDUCTION BY PASIREOTIDE OF THE EFFLUENT VOLUME IN HIGH-OUTPUT ENTEROSTOMY IN PATIENTS REFRACTORY TO USUAL MEDICAL TREATMENT: PHASE II MULTICENTRIC RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED STUDY
    Medical condition: Patients with high-output ileostomy or jejunostomy and failure of treatment with loperamide +/- codein syrup
    Disease: Version SOC Term Classification Code Term Level
    18.1 10042613 - Surgical and medical procedures 10021321 Ileostomy PT
    18.1 10042613 - Surgical and medical procedures 10023180 Jejunostomy PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-002948-28 Sponsor Protocol Number: Loop Start Date*: 2006-10-26
    Sponsor Name:MAROS Arzneimittel GmbH
    Full Title: Prospective randomized monoinstitutional study of the treatment of therapy-associated diarrhea during percutaneous radiation therapy of the small pelvis. – Comparison of loperamide and tincture of ...
    Medical condition: Therapy-associated diarrhea during radiaton therapy of small pelvis (including enteritis as a result of radiation therapy and enteritis as a result of radiation- and chemotherapy).
    Disease: Version SOC Term Classification Code Term Level
    8.1 10012735 Diarrhoea LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-005642-37 Sponsor Protocol Number: sandopouch-01 Start Date*: 2007-04-10
    Sponsor Name:University of Leuven, Division of Gastroenterology
    Full Title: Sandostatin® in the treatment of diarrhea in patients with ileal pouch anal anastomosis.
    Medical condition: IPAA Pouchitis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2010-023347-14 Sponsor Protocol Number: 2010-10 Start Date*: 2011-03-02
    Sponsor Name:Gastroenterology CHC Liege
    Full Title: Treatment of Crohn’s disease-associated refractory diarrhoea with octreotide LAR An open pilot study
    Medical condition: Crohn Disease refractory diarrhoea
    Disease: Version SOC Term Classification Code Term Level
    12.1 10066533 Diarrhea recurrent LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-000533-31 Sponsor Protocol Number: 17GA001 Start Date*: 2017-11-07
    Sponsor Name:Nottingham University Hospitals NHS Trust
    Full Title: TReatment of Irritable bowel syndrome using Titrated ONdansetron Trial
    Medical condition: Irritable Bowel Syndrome with Diarrhoea
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004856 10060845 Diarrhea predominant irritable bowel syndrome LLT
    21.1 100000004856 10060849 Diarrhoea predominant irritable bowel syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-004419-32 Sponsor Protocol Number: PMS-2018-002 Start Date*: 2019-10-03
    Sponsor Name:Pharmascience Inc.
    Full Title: A Phase IIa, Proof of Concept, Randomized, Double-Blind, Dose-Finding, Cross-Over Study of the Efficacy, Safety and Tolerability of a New Enteric-Coated Cholestyramine Capsule in Adult Short Bowel ...
    Medical condition: Bile-acid induced diarrhea in adult patients with Short Bowel Syndrome (SBS)
    Disease: Version SOC Term Classification Code Term Level
    20.1 10017947 - Gastrointestinal disorders 10049416 Short-bowel syndrome PT
    20.1 10017947 - Gastrointestinal disorders 10080049 Bile acid diarrhea LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: View results
    EudraCT Number: 2014-005486-75 Sponsor Protocol Number: I3Y-MC-JPBY Start Date*: 2015-07-24
    Sponsor Name:Lilly S.A.
    Full Title: neoMONARCH: A Phase 2 Neoadjuvant Trial Comparing the Biological Effects of 2 Weeks of Abemaciclib (LY2835219) in Combination with Anastrozole to those of Abemaciclib Monotherapy and Anastrozole Mo...
    Medical condition: Postmenopausal Women with Hormone Receptor Postive, HER2 Negative Breast Cancer
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004864 10007050 Cancer LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: ES (Completed) AT (Completed) DE (Completed) NL (Completed) BE (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2015-000868-34 Sponsor Protocol Number: ZKES-EcNO-2015 Start Date*: 2015-05-29
    Sponsor Name:ZKES GmbH
    Full Title: Randomized, placebo controlled phase III trial of a microbiological concomitant therapy/prevention of chemotherapeutical induced diarrhea (caused by inflammation and an impaired intestinal barrier)...
    Medical condition: Gastric or colorectal cancers, where a treatment with 5-Fluoruracil and one further chemotherapeutic remedy (either irinotecan or a platinum based chemotherapeutic remedy) is planned.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-003777-28 Sponsor Protocol Number: OBADIAH1 Start Date*: 2012-04-26
    Sponsor Name:Imperial College London and Imperial College Healthcare NHS Trust
    Full Title: Obeticholic acid treatment in patients with bile acid diarrhoea: an open-label, pilot study of mechanisms, safety and symptom response.
    Medical condition: Bile acid diarrhoea (also known as bile acid malabsorption)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2017-002679-25 Sponsor Protocol Number: S60420 Start Date*: 2017-09-12
    Sponsor Name:KU Leuven
    Full Title: Characterization of colonic motility patterns in different functional bowel disorders compared to health and their role in moving content
    Medical condition: Functional bowel disorders; irritable bowel syndrome (constipation, diarrhea and mixed), chronic constipation, and chronic diarrhea.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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