Flag of the European Union EU Clinical Trials Register Help

Clinical trials for Open fracture

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
    How to search [pdf]
    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
    Advanced Search: Search tools
     
    84 result(s) found for: Open fracture. Displaying page 1 of 5.
    1  2  3  4  5  Next»
    EudraCT Number: 2021-000428-36 Sponsor Protocol Number: ADJUNCT-1-2021 Start Date*: 2021-04-21
    Sponsor Name:Zealand University Hospital, Department of Anaesthesiology
    Full Title: Oral dexamethasone as an adjunct to a brachial plexus block in patients undergoing orthopaedic surgery of the forearm and hand. A randomised, blinded, placebo-controlled, parallel, triple-arm clini...
    Medical condition: Participants undergoing surgery of the bones in the hand or forearm with a lateral infraclavicular brachial plexus block as the means of providing anaesthesia and analgesia will be investigated. We...
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004863 10009924 Colles' fracture LLT
    24.0 100000004863 10017297 Fractured metacarpal LLT
    20.0 100000004863 10041223 Smith's fracture LLT
    20.1 100000004863 10017319 Fractured wrist LLT
    20.1 100000004863 10009571 Closed fracture of other bone of wrist LLT
    20.1 100000004863 10030598 Open fracture of other bone of wrist LLT
    21.1 100000004863 10030586 Open fracture of metacarpal bone(s), site unspecified LLT
    21.1 100000004863 10030531 Open fracture of base of other metacarpal bone(s) LLT
    21.1 100000004863 10030594 Open fracture of neck of metacarpal bone(s) LLT
    21.1 100000004863 10017154 Fracture of metacarpal bone(s) LLT
    20.1 100000004863 10030587 Open fracture of metacarpal bones LLT
    21.0 100000004865 10002325 Anesthesia local LLT
    24.0 100000004865 10021946 Infiltration anesthesia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2011-003142-41 Sponsor Protocol Number: 20110142 Start Date*: 2012-03-28
    Sponsor Name:AMGEN INC.
    Full Title: A Multicenter, International, Randomized, Double-blind, Alendronate-controlled Study to Determine the Efficacy and Safety of AMG 785 in the Treatment of Postmenopausal Women With Osteoporosis
    Medical condition: Postmenopausal osteoporosis
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10031285 Osteoporosis postmenopausal PT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: IT (Completed) LT (Completed) FI (Completed) PL (Completed) BE (Completed) CZ (Completed) ES (Completed) EE (Completed) GR (Completed) DE (Completed) GB (Completed) SE (Completed) AT (Completed) DK (Completed) LV (Completed) NO (Completed) NL (Completed) HU (Completed) IE (Completed) SK (Completed) BG (Completed)
    Trial results: View results
    EudraCT Number: 2011-005441-13 Sponsor Protocol Number: C11-12 Start Date*: 2013-01-03
    Sponsor Name:INSERM
    Full Title: Evaluation of efficacy and safety of autologous MSCs combined to biomaterials to enhance bone healing in patients with delayed consolidation after long bone fracture requiring graft apposition or ...
    Medical condition: Closed or open Gustilo I ans II humerus, tibial or femur diaphyseal or metaphysodiaphyseal fracture.
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10017081 Fracture delayed union PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) ES (Completed) IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-017039-16 Sponsor Protocol Number: CL3-12911-036 Start Date*: 2010-05-05
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Effect of strontium ranelate (2g per day) in the management of long bone fractures with delayed-union or non union: an international open label study
    Medical condition: Delayed and non-united fractures
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10017088 Fracture nonunion PT
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10017081 Fracture delayed union PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) HU (Completed) FR (Completed) IT (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2011-001456-11 Sponsor Protocol Number: 20070337 Start Date*: 2012-04-17
    Sponsor Name:Amgen Inc
    Full Title: A Multicenter, International, Randomized, Double-blind, Placebo controlled, Parallel-group Study to Assess the Efficacy and Safety of Romosozumab Treatment in Postmenopausal Women With Osteoporosis
    Medical condition: Postmenopausal Osteoporosis
    Disease: Version SOC Term Classification Code Term Level
    18.0 10028395 - Musculoskeletal and connective tissue disorders 10031285 Osteoporosis postmenopausal PT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: HU (Completed) BE (Completed) DK (Completed) PL (Completed) DE (Completed) GB (Completed) EE (Completed) CZ (Completed) ES (Completed) LV (Completed) LT (Completed)
    Trial results: View results
    EudraCT Number: 2006-003688-30 Sponsor Protocol Number: CS I-040101/02 Start Date*: 2007-02-27
    Sponsor Name:Kuros Biosurgery AG
    Full Title: A phase 2 randomized, controlled, open-label (dose-blinded), multi-center, dose-finding study of the safety and efficacy of I-0401 in the treatment of patients with fractures of the tibial plateau ...
    Medical condition: Fractures of the tibial plateau requiring grafting
    Disease: Version SOC Term Classification Code Term Level
    13.1 10028395 - Musculoskeletal and connective tissue disorders 10024956 Lower limb fractures HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed) ES (Completed) IT (Completed) FR (Completed) HU (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-001054-96 Sponsor Protocol Number: 000013/BT Start Date*: 2020-03-19
    Sponsor Name:Bone Therapeutics S.A.
    Full Title: Phase IIb, Placebo-Controlled, Randomized, Double-blind, Multicenter Study to Assess the Efficacy and Safety of Allogeneic Osteoblastic Cells (ALLOB) Single Implantation in Tibial Fracture
    Medical condition: Tibial fracture considered at risk of DU/NU (based on the combination of risk factors documented to be associated with increased proportion of DU/NU).
    Disease: Version SOC Term Classification Code Term Level
    20.0 10022117 - Injury, poisoning and procedural complications 10043827 Tibia fracture PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) FR (Ongoing) DE (Prematurely Ended) HU (Prematurely Ended) PL (Prematurely Ended) ES (Ongoing) CZ (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2011-000988-28 Sponsor Protocol Number: 19403 Start Date*: 2011-08-16
    Sponsor Name:University of Edinburgh [...]
    1. University of Edinburgh
    2. NHS Lothian
    Full Title: Fractures and Bisphosphonates: A double-blind, randomised controlled trial on the effect of alendronic acid on healing and clinical outcomes of wrist fractures
    Medical condition: Fracture healing
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10017076 Fracture PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-008392-34 Sponsor Protocol Number: 20062017 Start Date*: 2009-08-27
    Sponsor Name:Amgen Inc
    Full Title: A Multi-center, Randomized, Double-blind, Placebo-controlled Study of AMG 785 in Skeletally Mature Adults with a Fresh Unilateral Tibial Diaphyseal Fracture Status Post Definitive Fracture Fixation...
    Medical condition: Acceleration of fracture healing
    Disease: Version SOC Term Classification Code Term Level
    13.1 10022117 - Injury, poisoning and procedural complications 10043827 Tibia fracture PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: LV (Completed) DK (Completed) GB (Completed) DE (Completed) FR (Completed) GR (Completed) IT (Completed) BG (Completed) HU (Completed) LT (Completed) EE (Completed) NO (Completed)
    Trial results: View results
    EudraCT Number: 2006-005093-40 Sponsor Protocol Number: CS I-040202/01 Start Date*: 2007-10-22
    Sponsor Name:Kuros Biosurgery AG
    Full Title: A phase II randomized, controlled, open-labeled (dose-blinded) dose finding study of the safety and efficacy of I-040202 in the treatment of patients with acute open tibial shaft fractures
    Medical condition: Acute open tibial shaft fractures
    Disease: Version SOC Term Classification Code Term Level
    9.1 10024956 Lower limb fractures HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) FR (Completed) HU (Completed) SI (Completed) FI (Completed) CZ (Completed) SK (Completed) IT (Completed) BG (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-001832-34 Sponsor Protocol Number: 3100N7-211-WW Start Date*: 2007-01-11
    Sponsor Name:Wyeth Pharmaceuticals Inc.
    Full Title: A Phase 2, Multicenter, Single-Blind, Randomized, Stratified, Standard-of-Care Controlled, Feasibility and Safety Study of rhBMP-2/CPM as an Adjuvant Therapy for Fractures of the Proximal Femur
    Medical condition: Closed fracture of the proximal femur
    Disease: Version SOC Term Classification Code Term Level
    8.1 10020100 Hip fracture LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) FI (Completed) HU (Completed) FR (Completed) SE (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2009-013935-39 Sponsor Protocol Number: CL3-06911-002 Start Date*: 2009-12-28
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: The efficacy and safety of a daily oral administration of S06911 (strontium ranelate 2g/vitamin D3 1000 IU fixed combination) on vitamin D insufficiency in the treatment of osteoporotic postmenopau...
    Medical condition: Osteoporotic men and postmenauposal women
    Disease: Version SOC Term Classification Code Term Level
    12.0 10031283 Osteoporosis fracture LLT
    12.0 10031285 Osteoporosis postmenopausal LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed) ES (Completed) FR (Completed) BE (Completed) GB (Completed) CZ (Completed) DE (Completed) DK (Prematurely Ended) AT (Completed) HU (Completed) PL (Completed) SK (Completed)
    Trial results: View results
    EudraCT Number: 2011-003697-93 Sponsor Protocol Number: OXITIB2011 Start Date*: 2011-12-15
    Sponsor Name:Hospital Universitario de Canarias
    Full Title: Effectiveness of hyperbaric oxygen therapy in the treatment of the open tibial fractures. Open clinical trial, randomized, prospective and controlled.
    Medical condition: Open tibial fractures
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10030647 Open fracture of unspecified part of tibia LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-003813-24 Sponsor Protocol Number: SIFU17 Start Date*: 2019-11-28
    Sponsor Name:Charité-Universitätsmedizin Berlin
    Full Title: A phase I/IIa, prospective, mono-center, randomized, open labeled, controlled study to assess the safety and efficacy of applying Iloprost locally in the fracture site to promote bone healing in pa...
    Medical condition: Proximal humeral fracture
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-014270-18 Sponsor Protocol Number: CL3-06911-003 Start Date*: 2010-01-13
    Sponsor Name:Laboratorios Servier S.L.
    Full Title: "Eficacia y seguridad de una administración oral diaria de S06911 (combinación fija de ranelato de estroncio 2g / vitamina D3 1000UI) en la deficiencia de vitamina D para el tratamiento de la osteo...
    Medical condition: Osteoporosis en hombres y mujeres postmenopáusicas
    Disease: Version SOC Term Classification Code Term Level
    9 10031283 Osteoporosis fracture LLT
    9 10031285 Osteoporosis postmenopausal LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) BE (Completed) DK (Prematurely Ended) SK (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2015-000650-38 Sponsor Protocol Number: ALLOB-MF1 Start Date*: 2015-07-01
    Sponsor Name:Bone Therapeutics S.A.
    Full Title: A Phase IIA, multicentre, open study on the safety and efficacy of allogeneic osteoblastic cells (ALLOB®) implantation in multiple non-infected delayed-union (DU) fractures
    Medical condition: Multiple non-infected delayed-union fractures
    Disease: Version SOC Term Classification Code Term Level
    17.1 10028395 - Musculoskeletal and connective tissue disorders 10017081 Fracture delayed union PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-005101-21 Sponsor Protocol Number: GR-OG-279239-01 Start Date*: 2014-12-22
    Sponsor Name:Genera Research Ltd
    Full Title: Safety, tolerability, systemic pharmacokinetics and efficacy of a single dose of Osteogrow (rhBMP6 in autologous Whole Blood Coagulum Derived [WBCD] carrier) delivered locally to the fracture site ...
    Medical condition: Distal radius fracture.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10022117 - Injury, poisoning and procedural complications 10048049 Wrist fracture PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HR (Completed)
    Trial results: View results
    EudraCT Number: 2022-000680-49 Sponsor Protocol Number: MATRIx1.0 Start Date*: 2022-12-13
    Sponsor Name:AZIENDA SOCIO SANITARIA TERRITORIALE MONZA (ASST-MONZA)
    Full Title: Mesenchymal stromal cells for traumatic brain injury. A multicenter, double blind, randomized, placebo-controlled phase II trial
    Medical condition: Severe traumatic brain injury
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004863 10032349 Other open skull fracture with intracranial injury LLT
    20.0 100000004863 10032350 Other open skull fracture with intracranial injury of other and unspecified nature LLT
    20.0 100000004863 10009630 Closed fracture of vault of skull with intercranial injury of other and unspecified nature LLT
    20.0 100000004863 10009631 Closed fracture of vault of skull with intracranial injury LLT
    20.0 100000004863 10009648 Closed skull fracture with intracranial injury of other and unspecified nature LLT
    20.0 100000004863 10009512 Closed fracture of base of skull with intracranial injury LLT
    20.0 100000004863 10031756 Other closed skull fracture with intracranial injury LLT
    20.0 100000004863 10030657 Open fracture of vault of skull with intracranial injury LLT
    20.0 100000004863 10030658 Open fracture of vault of skull with intracranial injury of other and unspecified nature LLT
    20.0 100000004863 10030666 Open fractures involving skull or face with other bones, with intracranial injury LLT
    20.0 100000004863 10017263 Fracture of vault of skull, closed with intracranial injury LLT
    20.0 100000004863 10031757 Other closed skull fracture with intracranial injury of other and unspecified nature LLT
    20.0 100000004863 10009636 Closed fractures involving skull or face with other bones, with intracranial injury LLT
    20.0 100000004852 10042327 Subarachnoid, subdural, and extradural haemorrhage, following injury LLT
    20.0 100000004852 10031590 Other and unspecified intracranial hemorrhage following injury LLT
    20.0 100000004852 10031587 Other and unspecified intracranial haemorrhage following injury LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2015-001820-51 Sponsor Protocol Number: BMC2012-PhaseII Start Date*: 2016-06-27
    Sponsor Name:Dekan der medizinischen Fakultät, Universitätsklinikum Frankfurt, Goethe-Universität
    Full Title: BMC2012, Cell based therapy by implanted bone marrow-derived mononuclear cells (BMC) for bone augmentation of plate-stabilized proximal humeral fractures - a randomized, open, multicentric study - ...
    Medical condition: Investigation of cell based therapy by implanted bone marrow-derived mononuclear cells for bone augmentation on osteosynthesis of proximal humeral fractures
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2015-000431-32 Sponsor Protocol Number: ORTHOUNION Start Date*: 2017-05-25
    Sponsor Name:Universidad Autónoma de Madrid (U.A.M.)
    Full Title: A MULTI-CENTRE, OPEN-LABEL, RANDOMIZED, COMPARATIVE CLINICAL TRIAL OF TWO DIFFERENT DOSES OF BONE MARROW AUTOLOGOUS HUMAN MESENCHYMAL STEM CELLS PLUS BIOMATERIAL VERSUS ILIAC CREST AUTOLOGOUS GRAFT...
    Medical condition: Diaphyseal and/or metaphysodiaphyseal fractures (femur, tibia, humerus) with status of non-union
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10028395 Musculoskeletal and connective tissue disorders SOC
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10017085 Fracture malunion PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing) DE (Completed) FR (Ongoing) IT (Completed)
    Trial results: (No results available)
    Download Options:
    Number of Trials to download:
    Download Content:
    Download Format:
    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
    1  2  3  4  5  Next»
    Query did not match any studies.
    For support, Contact us.
    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

    European Medicines Agency © 1995-Sat May 10 04:25:16 CEST 2025 | Domenico Scarlattilaan 6, 1083 HS Amsterdam, The Netherlands
    EMA HMA