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Clinical trials for Opioid-induced constipation

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    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

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    48 result(s) found for: Opioid-induced constipation. Displaying page 1 of 3.
    1  2  3  Next»
    EudraCT Number: 2013-002949-11 Sponsor Protocol Number: 1326V9235 Start Date*: 2014-02-11
    Sponsor Name:Shionogi Inc.
    Full Title: A Randomized Double-blind, Placebo-controlled, Parallel-group, Multicenter, Phase 3 Study to Evaluate the Long-term Safety of Naldemedine for the Treatment of Opioid-induced Constipation in Subje...
    Medical condition: Opioid-induced Constipation in Subjects with Non-malignant Chronic Pain Receiving Opioid Therapy
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed) SE (Completed) BE (Completed) EE (Completed) PT (Completed) HU (Completed) AT (Completed) DK (Completed) ES (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2011-001985-16 Sponsor Protocol Number: D3820C00006 Start Date*: 2011-09-09
    Sponsor Name:AstraZeneca AB
    Full Title: A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of NKTR-118 in Relieving Opioid-Induced Constipation (OIC) in Patients with Cancer-Related Pain.
    Medical condition: Scientific Terminology Opioid-Induced Constipation (OIC) Laymen Terminology Constipation after taking Opioid drugs
    Disease: Version SOC Term Classification Code Term Level
    14.0 10017947 - Gastrointestinal disorders 10071128 Opioid induced constipation LLT
    14.0 10017947 - Gastrointestinal disorders 10010774 Constipation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SK (Completed) DE (Completed) ES (Completed) BE (Completed) GB (Completed) CZ (Completed) HU (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-005935-14 Sponsor Protocol Number: 3200K1-3358-WW Start Date*: 2009-04-24
    Sponsor Name:Wyeth Research Division of Wyeth Pharmaceuticals Inc.
    Full Title: An Open-Label Study to Evaluate the Long-term Safety of Subcutaneous MOA-728 for Treatment of Opioid-Induced Constipation in Subjects With Nonmalignant Pain Estudio abierto para evaluar la segurida...
    Medical condition: Opioid-induced constipation in subjects with non-malignant pain Tratamiento del estreñimiento inducido por opiáceos en sujetos con dolor de origen no maligno
    Disease: Version SOC Term Classification Code Term Level
    9.1 10010774 Constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2013-002948-91 Sponsor Protocol Number: 1315V9232 Start Date*: Information not available in EudraCT
    Sponsor Name:Shionogi Inc.
    Full Title: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Naldemedine in the Treatment of Opioid-induced Constipation in Subjects with Non-malignant Chronic Pain Receiving Opioid Therapy
    Medical condition: Opioid-induced Constipation in Subjects with Non-malignant Chronic Pain Receiving Opioid Therapy
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed) AT (Completed) ES (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2022-000408-36 Sponsor Protocol Number: 08440012010002 Start Date*: 2022-10-25
    Sponsor Name:ZonMw
    Full Title: OMAMA-study – prevention of opioid-induced constipation in patients with advanced cancer
    Medical condition: Opioid-induced constipation in patients with advanced cancer, starting with opioids for pain
    Disease: Version SOC Term Classification Code Term Level
    24.0 10017947 - Gastrointestinal disorders 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2008-005961-77 Sponsor Protocol Number: 3200K1-3357-WW Start Date*: 2009-05-06
    Sponsor Name:Wyeth Research Division of Wyeth Pharmaceuticals Inc.
    Full Title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of Subcutaneous MOA-728 for the Treatment of Opioid-Induced Constipation Estudio multicéntrico, aleatorizado, en do...
    Medical condition: Opioid-induced constipation in subjects with non-malignant pain Tratamiento del estreñimiento inducido por opiáceos en sujetos con dolor de origen no maligno
    Disease: Version SOC Term Classification Code Term Level
    9.1 10010774 Constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2011-001986-41 Sponsor Protocol Number: D3820C00005 Start Date*: 2012-02-21
    Sponsor Name:AstraZeneca AB
    Full Title: A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of NKTR-118 in Patients with Non-Cancer-Related Pain and Opioid-Induced Constipation (OIC)
    Medical condition: Opioid-induced constipation (OIC)
    Disease: Version SOC Term Classification Code Term Level
    14.1 10017947 - Gastrointestinal disorders 10010774 Constipation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) HU (Completed) CZ (Completed) BE (Completed) ES (Completed) SE (Completed)
    Trial results: View results
    EudraCT Number: 2015-000419-42 Sponsor Protocol Number: Nalogexol-2014 Start Date*: 2015-05-11
    Sponsor Name:Aalborg University Hospital
    Full Title: Naloxegol and assessments of opioid induced bowel dysfunction
    Medical condition: Healthy volunteers (Opioid-induced bowel dysfunction)
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults Gender: Male
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2013-002241-11 Sponsor Protocol Number: 1314V9231 Start Date*: 2014-03-10
    Sponsor Name:Shionogi Inc.
    Full Title: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Naldemedine in the Treatment of Opioid-induced Constipation in Subjects with Non-malignant Chronic Pain Receiving Opioid Therapy
    Medical condition: Opioid-induced Constipation in Subjects with Non-malignant Chronic Pain Receiving Opioid Therapy
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) AT (Completed) CZ (Completed) GB (Completed) ES (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2011-001987-24 Sponsor Protocol Number: D3820C00004 Start Date*: 2011-08-22
    Sponsor Name:AstraZeneca AB
    Full Title: A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of NKTR-118 in Patients with Non-Cancer-Related Pain and Opioid-Induced Constipation (OIC)
    Medical condition: Opioid-induced constipation (OIC)
    Disease: Version SOC Term Classification Code Term Level
    14.1 10017947 - Gastrointestinal disorders 10010774 Constipation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) SK (Completed)
    Trial results: View results
    EudraCT Number: 2011-005061-20 Sponsor Protocol Number: ONU3705 Start Date*: 2012-06-19
    Sponsor Name:Purdue Pharma L.P.
    Full Title: A Randomized, Double-blind, Double-dummy, Placebo-controlled, Active-controlled, Parallel-group, Multicenter Trial of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess the Analgesic Eff...
    Medical condition: Opioid-induced Constipation & Moderate to Severe Chronic Low back Pain
    Disease: Version SOC Term Classification Code Term Level
    14.1 10017947 - Gastrointestinal disorders 10071128 Opioid induced constipation LLT
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10003988 Back pain PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) PL (Completed) SK (Completed) DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-003687-10 Sponsor Protocol Number: NALUGStrial Start Date*: 2022-01-26
    Sponsor Name:UZLeuven
    Full Title: Naloxegol for improving upper gastrointestinal symptoms and gastric emptying rate in patients with opioid induced constipation
    Medical condition: Opioid induced gastrointestinal dysfunction
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004856 10013225 Disorder gastrointestinal LLT
    20.1 100000004873 10079385 Opioid use disorder LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2008-005692-10 Sponsor Protocol Number: 3200K1-4006-WW Start Date*: 2009-03-25
    Sponsor Name:Wyeth Research Division of Wyeth Pharmaceuticals Inc.
    Full Title: A Randomized, Double-blind, Placebo-Controlled Trial Evaluating the Safety and Efficacy of Subcutaneous Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Subjects With Cancer-Rel...
    Medical condition: Opioid-induced constipation in subjects with cancer-related pain Estreñimiento inducido por opiáceos en pacientes con dolor de origen tumoral
    Disease: Version SOC Term Classification Code Term Level
    9.1 10010774 Constipation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2015-002310-72 Sponsor Protocol Number: 0201/DEV Start Date*: 2016-03-29
    Sponsor Name:Develco Pharma Schweiz AG
    Full Title: Open-label, uncontrolled trial to evaluate pharmacokinetics of naloxone in children from 4 to less than 18 years of age with opioid-induced constipation
    Medical condition: Opioid induced constipation
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DE (Temporarily Halted) HU (Prematurely Ended) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2014-004687-37 Sponsor Protocol Number: 14SM2335 Start Date*: 2016-06-17
    Sponsor Name:Imperial College Healthcare NHS Trust
    Full Title: Use of Methylnaltrexone for the Treatment of Opioid Induced Constipation & Gastro-Intestinal Stasis in Intensive Care Patients
    Medical condition: Opioid Induced Constipation
    Disease: Version SOC Term Classification Code Term Level
    17.1 10017947 - Gastrointestinal disorders 10010774 Constipation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-005060-26 Sponsor Protocol Number: ONU3704 Start Date*: 2012-06-19
    Sponsor Name:Purdue Pharma L.P.
    Full Title: A Randomized, Double-blind, Double-dummy, Placebo-controlled, Active-controlled, Parallel-group, Multicenter Trial of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess the Analgesic Eff...
    Medical condition: Opioid-induced Constipation & Moderate to Severe Chronic Low back Pain
    Disease: Version SOC Term Classification Code Term Level
    17.0 10028395 - Musculoskeletal and connective tissue disorders 10003988 Back pain PT
    17.0 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) PL (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2007-000854-30 Sponsor Protocol Number: 3200K1-4000-WW(B2541005) Start Date*: 2009-02-27
    Sponsor Name:Salix Pharmaceuticals Inc.
    Full Title: A Randomized, Double-Blind, Placebo-Controlled Study of a Fixed Dose of Subcutaneous Methylnaltrexone in Adults With Advanced Illness and Opioid-Induced Constipation: Efficacy, Safety, and Addition...
    Medical condition: Opioid-induced constipation in subjects with advanced illness
    Disease: Version SOC Term Classification Code Term Level
    14.1 10017947 - Gastrointestinal disorders 10010774 Constipation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) ES (Prematurely Ended) FR (Completed) FI (Prematurely Ended) DK (Prematurely Ended) PT (Completed) SE (Prematurely Ended) DE (Prematurely Ended) BE (Prematurely Ended) IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2017-000657-39 Sponsor Protocol Number: 0217/DEV Start Date*: 2017-08-15
    Sponsor Name:Develco Pharma Schweiz AG
    Full Title: Randomised, double-blind, placebo-controlled, parallel-group, multi-centre, phase III trial to investigate the efficacy, safety and tolerability of Naloxone HCl PR Tablets in patients with opioid i...
    Medical condition: Opioid induced constipation
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed) SK (Completed) ES (Completed) BG (Completed) PT (Completed) GB (Completed) HU (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2013-000180-81 Sponsor Protocol Number: SLT4501 Start Date*: 2013-09-20
    Sponsor Name:Mundipharma Research GmbH & Co. KG
    Full Title: A single-arm, open-label, multicentre, non-randomised, study to assess the effect and tolerability of standardised laxative therapy (SLT) for the reversal of opioid-induced constipation (OIC) in s...
    Medical condition: Assess the effect and tolerability of standardised laxative therapy (SLT) for the reversal of opioid-induced constipation (OIC) in subjects suffering from malignant or non-malignant pain that requi...
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004856 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) SE (Completed)
    Trial results: View results
    EudraCT Number: 2009-015652-20 Sponsor Protocol Number: M0001-C301/SPD555-301 Start Date*: 2010-05-10
    Sponsor Name:Shire-Movetis NV
    Full Title: A 12-week, randomised, double-blind, placebo-controlled trial to evaluate the efficacy and safety of prucalopride in subjects with chronic non-cancer pain suffering from opioid induced constipation
    Medical condition: opioid induced constipation in subjects with chronic non-cancer pain
    Disease: Version SOC Term Classification Code Term Level
    14.1 10017947 - Gastrointestinal disorders 10010774 Constipation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Prematurely Ended) PL (Prematurely Ended) DE (Prematurely Ended) CZ (Completed) FR (Completed) NL (Prematurely Ended) BG (Prematurely Ended) GB (Prematurely Ended) ES (Prematurely Ended) HU (Prematurely Ended)
    Trial results: View results
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