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Clinical trials for Placebo AND Saline injection

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44352   clinical trials with a EudraCT protocol, of which   7380   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    71 result(s) found for: Placebo AND Saline injection. Displaying page 1 of 4.
    1  2  3  4  Next»
    EudraCT Number: 2008-005120-86 Sponsor Protocol Number: 112077 Start Date*: 2009-01-08
    Sponsor Name:GlaxoSmithKline Biologicals
    Full Title: A phase II, observer-blind, randomised, placebo-controlled, adjuvant-dose selection, multicenter prophylactic vaccination study to evaluate the immunogenicity and safety of GSK Biologicals’ herpes ...
    Medical condition: Primary immunisation of subjects aged 50 years or older against herpes zoster (HZ). The study population includes healthy volunteer males and females in the age ranges: 50-59 years of age (YOA), 6...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: View results
    EudraCT Number: 2005-005519-12 Sponsor Protocol Number: V59P11 Start Date*: 2006-03-13
    Sponsor Name:CHIRON
    Full Title: A Phase 3, Multi-Center, Observer Blind, Controlled, Randomized Study to Compare the Immunogenicity and Safety of the Concomitant Administration of a Combined Tetanus, Reduced Diphtheria, and Acell...
    Medical condition: Active profilaxys against Neisseria Mengitidis type A, C, W, Y
    Disease: Version SOC Term Classification Code Term Level
    6.1 10027249 PT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2014-001155-22 Sponsor Protocol Number: Lap2014NMB Start Date*: 2014-05-22
    Sponsor Name:Mona Ring Gätke
    Full Title: Muscle relaxation during open upper abdominal surgery -can the surgical conditions be optimized? (The laparotomy study)
    Medical condition: The aim of the study is to investigate if intense NMB improves surgical conditions during operation in patients scheduled for elective open upper abdominal surgery.
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004865 10023697 Laparotomy & drainage LLT
    17.0 100000004865 10051777 Staging laparotomy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2006-004252-20 Sponsor Protocol Number: VITRIS.at Start Date*: 2010-09-03
    Sponsor Name:Medizinische Universität Innsbruck - Univ.-Klinik für Anästhesie und Allgemeine Intensivmedizin
    Full Title: A Multicenter, Randomized, Controlled Trial Assessing Arginine Vasopressin vs. Saline Placebo in Refractory Traumatic Hemorrhagic Shock Patients (VITRIS.at-Study)
    Medical condition: The purpose of the trial is to assess effects of arginine vasopressin vs. saline placebo on hospital admission rate and hospital discharge rate in presumed traumatic hemorrhagic shock patients afte...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10044541 Traumatic shock LLT
    9.1 10044541 Traumatic shock PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-001668-13 Sponsor Protocol Number: GE-012-106 Start Date*: 2017-10-25
    Sponsor Name:GE Healthcare Ltd. and its Affiliates
    Full Title: Parallel-Group, Placebo-Controlled Randomized Study Investigating the Effect of Intravenous Iso-osmolar Iodinated Contrast Material Iodixanol (Visipaque™ Injection 320 mgI/mL) on Renal Function in ...
    Medical condition: Chronic Kidney Disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000070575 10076410 Chronic kidney disease stage 3 LLT
    20.0 100000070575 10076411 Chronic kidney disease stage 4 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended) GB (Prematurely Ended) BE (Prematurely Ended) HU (Completed) PL (Prematurely Ended) NL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-003509-18 Sponsor Protocol Number: NAC0606 Start Date*: 2007-08-13
    Sponsor Name:University of Edinburgh [...]
    1. University of Edinburgh
    2. NHS Lothian Health Board
    Full Title: Mechanisms for the effect of acetylcysteine on renal function after exposure to radiographic contrast material
    Medical condition: Radiocontrast-induced nephropathy
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-001636-19 Sponsor Protocol Number: HTX-011-302 Start Date*: 2017-09-15
    Sponsor Name:Heron Therapeutics, Inc.
    Full Title: A Phase 3, Randomized, Double-Blind, Saline Placebo- and Active-Controlled, Multicenter Study of HTX-011 via Local Administration for Postoperative Analgesia and Decreased Opioid Use Following Unil...
    Medical condition: Postoperative Analgesia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2021-002784-21 Sponsor Protocol Number: 20210516 Start Date*: 2022-04-01
    Sponsor Name:Västra Götalandsregionen
    Full Title: Botulinum toxin type A as treatment for chronic myogenous orofacial pain - a radomized controlled, double-blind clinical trial
    Medical condition: Chronic myalgia (>6months) in the facial region.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2020-004034-38 Sponsor Protocol Number: MK-7684A-002 Start Date*: 2021-04-19
    Sponsor Name:Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc
    Full Title: A Phase 2, Multicenter, Randomized Study to Compare the Efficacy and Safety of MK-7684A or MK-7684A Plus Docetaxel Versus Docetaxel Monotherapy in the Treatment of Participants With Metastatic Non-...
    Medical condition: Non Small Cell Lung cancer
    Disease: Version SOC Term Classification Code Term Level
    21.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10059515 Non-small cell lung cancer metastatic PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Trial now transitioned) DK (Trial now transitioned) DE (Trial now transitioned) BE (Trial now transitioned) AT (Trial now transitioned) PL (Trial now transitioned) FR (Trial now transitioned) IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2015-005757-12 Sponsor Protocol Number: FAIR-HFpEF Start Date*: 2017-06-06
    Sponsor Name:Charité – Universitätsmedizin Berlin
    Full Title: Effect of IV iron (ferric carboxymaltose, Ferinject) on exercise tolerance, symptoms and quality of life in patients with heart failure with preserved ejection fraction (HFpEF) and iron deficiency ...
    Medical condition: Patients with heart failure with preserved ejection fraction (HFpEF) and iron deficiency (ID) with and without anaemia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2017-004188-11 Sponsor Protocol Number: MK-3475-789 Start Date*: 2018-05-09
    Sponsor Name:Merck Sharp & Dohme LLC
    Full Title: A Randomized, Double-Blind, Phase 3 Study of Pemetrexed + Platinum Chemotherapy with or without Pembrolizumab (MK-3475) in TKI-resistant EGFR-mutated Tumors in Metastatic Non-squamous Non-small Cel...
    Medical condition: Metastatic Non-squamous Non-small Cell Lung Cancer
    Disease: Version SOC Term Classification Code Term Level
    21.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10029522 Non-small cell lung cancer stage IV PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) ES (Completed) FR (Completed) DE (Completed) GB (GB - no longer in EU/EEA) IT (Completed)
    Trial results: View results
    EudraCT Number: 2019-002124-32 Sponsor Protocol Number: CUSA-081-HEM-01 Start Date*: 2020-01-02
    Sponsor Name:Chiesi Farmaceutici S.p.A.
    Full Title: READY 1: A Phase 3, Randomized, Double-Blind, Active and Placebo-Controlled Study on the use of CUSA-081 for Dysfunctional Central Venous Access Devices (CVADs)
    Medical condition: Catheter Occlusion Thrombosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) BE (Completed) ES (Prematurely Ended) RO (Ongoing)
    Trial results: View results
    EudraCT Number: 2020-005547-23 Sponsor Protocol Number: 12217 Start Date*: 2021-07-22
    Sponsor Name:AZ Delta vzw
    Full Title: Management of Popeye sign with botulinum toxin after tenotomy of the long head of the biceps tendon: a double-blinded randomized controlled trial
    Medical condition: Popeye sign or cramping pain after shoulder artroscopy with biceps tenotomy
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-004565-33 Sponsor Protocol Number: EASI Start Date*: 2006-11-16
    Sponsor Name:Chemische Fabrik Kreussler & Co.GmbH
    Full Title: Efficacy and safety of Aethoxysklerol compared to Sodium Tetradecyl Sulfate and Isotonic Saline (placebo) for the treatment of reticular veins and spider veins including subgroup to investigate the...
    Medical condition: Patients suffering from varicose veins (spider veins or reticular veins in the legs) should be treated with a sclerosing agent.
    Disease: Version SOC Term Classification Code Term Level
    8.1 10047001 Varicose veins LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2016-003939-38 Sponsor Protocol Number: P160404J Start Date*: 2017-12-19
    Sponsor Name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
    Full Title: Short-term efficacy of a single ultrasound-guided intra-articular injection of botulinum toxin A associated with splinting for base-of-thumb osteoarthritis on pain at 3 months: A randomized placebo...
    Medical condition: Patients referred to our Physical Medicine Rehabilitation Department of a tertiary care center in Paris, France, for the management of Base-of-thumb osteoarthritis (BTOA)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10062893 Rhizarthrosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2014-004343-12 Sponsor Protocol Number: ICARISTrialProtocol Start Date*: 2015-10-07
    Sponsor Name:Mater Research Institute University of Queensland
    Full Title: Impact on Caesarean Section Rates Following Injections of Sterile Water
    Medical condition: Back pain in labour and childbirth
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-003694-15 Sponsor Protocol Number: MK-3475-189 Start Date*: 2016-03-04
    Sponsor Name:Merck Sharp & Dohme LLC
    Full Title: A Randomized, Double-Blind, Phase III Study of Platinum+Pemetrexed Chemotherapy with or without Pembrolizumab (MK-3475) in First Line Metastatic Non-squamous Non-small Cell Lung Cancer Subjects (KE...
    Medical condition: non-squamous non-small cell lung cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004864 10079440 Non-squamous non-small cell lung cancer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed) DE (Completed) GB (GB - no longer in EU/EEA) AT (Completed) BE (Completed) ES (Completed) NL (Completed) FI (Completed) DK (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2009-011219-20 Sponsor Protocol Number: 2009/04 Start Date*: 2009-05-18
    Sponsor Name:Hopital Foch
    Full Title: Comparison between two methods of post-operative analgesia after thoracotomy: epidural administration of sufentanil and levobupivacaine and epidural administration of levobupivacaine associated wit...
    Medical condition: postoperative epidural analgesia
    Disease: Version SOC Term Classification Code Term Level
    9.1 10054891 Epidural analgesia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2022-002717-41 Sponsor Protocol Number: TRAPEZIUS Start Date*: 2023-06-27
    Sponsor Name:HOSPITAL CLINIC DE BARCELONA
    Full Title: EFFICACY AND SAFETY OF LOCAL TREATMENT OF TRAPEZIUS MYOFASCIAL SYNDROME IN PATIENTS WITH FIBROMYALGIA THROUGH ULTRASOUND-GUIDED INTERFASCIAL BLOCK OF THE TRAPEZIUS MUSCLE
    Medical condition: TRAPEZIUS MYOFASCIAL SYNDROME IN FIBROMYALGIA PATIENTS
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-002044-26 Sponsor Protocol Number: 104438 Start Date*: 2005-07-28
    Sponsor Name:GlaxoSmithKline Biologicals
    Full Title: A randomized, double-blind, placebo-controlled, post-marketing phase III Study to evaluate the efficacy of GSK Biologicals’ influenza vaccine (Fluarix™) administered intramuscularly in adults
    Medical condition: Immunization against influenza in male and female subjects aged 18 to 64 years
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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