interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development
EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
Clinical Trials Information System (CTIS).
The EU Clinical Trials Register currently displays
44339
clinical trials with a EudraCT protocol, of which
7369
are clinical trials conducted with subjects less than 18 years old.
The register also displays information on
18700
older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).
Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see
Frequently Asked Questions ).
Full Title: SHERLOC: A Phase 2 Study of MM-121 in Combination with Docetaxel versus Docetaxel Alone in Patients with Heregulin Positive, Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Medical condition: Heregulin Positive, Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Disease:
Version
SOC Term
Classification Code
Term
Level
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10059515
Non-small cell lung cancer metastatic
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: A PHASE II TWO COHORT STUDY EVALUATING
THE SAFETY AND EFFICACY OF COBIMETINIB PLUS ATEZOLIZUMAB IN BRAFV600 WILD-TYPE MELANOMA WITH CENTRAL NERVOUS SYSTEM METASTASES AND COBIMETINIB PLUS ATEZOLIZU...
Full Title: A Phase 1/2a Open Label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of AFM24 in Patients with Advanced Solid Cancers
Medical condition: Advanced solid malignancies in patients whose disease has progressed after treatment with previous anticancer therapies.
Disease:
Version
SOC Term
Classification Code
Term
Level
21.0
100000004864
10048683
Advanced cancer
LLT
Population Age: Adults, Elderly
Gender: Male, Female
Trial protocol:ES(Ongoing)GB(GB - no longer in EU/EEA)DE(Completed)
Sponsor Name:Incyte Biosciences International Sàrl
Full Title: A Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies.
Medical condition: Phase 1: advanced or metastatic cervical cancer, endometrial cancer, gastric cancer, hepatocellular carcinoma, melanoma (mucosal or cutaneous), Merkel cell carcinoma, mesothelioma, MSI-H colorectal...
Disease:
Version
SOC Term
Classification Code
Term
Level
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10041067
Small cell lung cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10060121
Squamous cell carcinoma of head and neck
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10014733
Endometrial cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10027407
Mesothelioma malignant
PT
20.0
100000017553
10064467
Urothelial carcinoma
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10073071
Hepatocellular carcinoma
PT
20.0
100000018529
10027150
Melanoma malignant
LLT
20.0
100000018548
10064025
Merkel cell carcinoma
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10017758
Gastric cancer
PT
20.0
100000020977
10008229
Cervical cancer
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10061873
Non-small cell lung cancer
PT
11.0
100000005104
10038408
Renal cell carcinomas
HLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10061451
Colorectal cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10075566
Triple negative breast cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: A Phase III Randomized, Open-Label, Multicenter Study to Determine the Efficacy and Safety of Durvalumab in Combination With Tremelimumab and Enfortumab Vedotin or Durvalumab in Combination With En...
Medical condition: Cisplatin ineligible patients with histologically or cytologically documented muscle-invasive transitional cell carcinoma (TCC) of the bladder.
Disease:
Version
SOC Term
Classification Code
Term
Level
20.0
100000004864
10005004
Bladder cancer NOS
LLT
Population Age: Adults, Elderly
Gender: Male, Female
Trial protocol:FR(Trial now transitioned)DE(Trial now transitioned)ES(Ongoing)PT(Trial now transitioned)AT(Trial now transitioned)PL(Trial now transitioned)NL(Trial now transitioned)GR(Trial now transitioned)IT(Trial now transitioned)
Trial results:(No results available)
EudraCT Number: 2017-000300-26
Sponsor Protocol Number: E7080-A001-111
Start Date*: 2017-10-20
Sponsor Name:Eisai Ltd.
Full Title: A Multicenter, Open-Label Phase 1b/2 Trial of Lenvatinib (E7080) Plus Pembrolizumab in Subjects With Selected Solid Tumors
Medical condition: Non-small cell lung cancer, predominantly clear cell renal cell carcinoma, endometrial carcinoma, urothelial carcinoma, squamous cell carcinoma of the head and neck, or melanoma (excluding uveal me...
Disease:
Version
SOC Term
Classification Code
Term
Level
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10014733
Endometrial cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10060121
Squamous cell carcinoma of head and neck
PT
20.0
100000017553
10064467
Urothelial carcinoma
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10067946
Renal cell carcinoma
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10061873
Non-small cell lung cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
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• EEA CTAs: Date study was authorised to proceed • Outside EU/EEA: Date study was submitted in EudraCT