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Clinical trials for Cardiovascular diseases

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44339   clinical trials with a EudraCT protocol, of which   7369   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    2,502 result(s) found for: Cardiovascular diseases. Displaying page 8 of 126.
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    EudraCT Number: 2013-002371-17 Sponsor Protocol Number: EX1250-4080 Start Date*: 2014-01-29
    Sponsor Name:Novo Nordisk A/S
    Full Title: A trial comparing cardiovascular safety of insulin degludec versus insulin glargine in subjects with type 2 diabetes at high risk of cardiovascular events
    Medical condition: Diabetes Mellitus, Type 2
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004861 10045242 Type II diabetes mellitus LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) PL (Completed) GR (Completed) IT (Completed) ES (Completed) HR (Completed)
    Trial results: View results
    EudraCT Number: 2012-002342-21 Sponsor Protocol Number: KB055 Start Date*: 2014-07-29
    Sponsor Name:Kedrion S.P.A
    Full Title:
    Medical condition:
    Disease:
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-004749-40 Sponsor Protocol Number: PEDMet 2006-1 Start Date*: 2006-11-20
    Sponsor Name:Pediatrics
    Full Title: Glucose metabolism in patients with neurological/neuromuscular diseases.
    Medical condition: Patients with neurological/neuromuscular diseases
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-003351-12 Sponsor Protocol Number: A6141079 Start Date*: 2005-10-27
    Sponsor Name:Pfizer Ltd
    Full Title: The effect of eplerenone versus placebo on cardiovascular mortality and heart failure hospitalization in subjects with NYHA Class II Chronic Systolic Heart Failure
    Medical condition: Chronic systolic heart failure
    Disease: Version SOC Term Classification Code Term Level
    8.0 10008908 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) IE (Completed) SK (Completed) SE (Completed) GB (Completed) ES (Completed) HU (Completed) BE (Completed) PT (Completed) GR (Completed) IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-016178-33 Sponsor Protocol Number: 1245.25 Start Date*: 2010-11-12
    Sponsor Name:Boehringer Ingelheim B.V.
    Full Title: A Phase III, multicentre, international, randomised, parallel group, double blind cardiovascular safety study of BI 10773 (10 mg and 25 mg administered orally once daily) compared to usual care in ...
    Medical condition: The study will be performed in patients with type 2 diabetes mellitus and high cardiovascular risk who have insufficient glycaemic control despite diet and exercise and are either treatment naïve o...
    Disease: Version SOC Term Classification Code Term Level
    12.1 10067585 Type 2 diabetes mellitus LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) DK (Completed) ES (Completed) BE (Completed) FR (Completed) IT (Completed) HU (Completed) PT (Completed) GB (Completed) AT (Completed) GR (Completed) PL (Completed) EE (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2015-001245-89 Sponsor Protocol Number: BDR4580 Start Date*: 2015-04-13
    Sponsor Name:Sanofi-aventis
    Full Title: Relative bioavailability study between 75 mg tablet and 75 mg solution of Clopidogrel (SR25990C) after single oral administration to young healthy men. Open, crossover, randomized and monocenter study
    Medical condition: Young healthy men (intended indication cardiovascular disease)
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004865 10071110 Atherothrombosis prophylaxis LLT
    Population Age: Adults Gender: Male
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2021-001827-41 Sponsor Protocol Number: PI2020_843_0094 Start Date*: 2021-06-11
    Sponsor Name:CHU Amiens-Picardie
    Full Title: Evaluation of the early use of norepinephrine in major abdominal surgery on postoperative organ dysfunction
    Medical condition: major abdominal surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-001240-64 Sponsor Protocol Number: mz-02 Start Date*: 2013-07-09
    Sponsor Name:Bispebjerg Hospital
    Full Title: Effect of intact GLP-1 (7-36) and GLP-1 metabolite (9-36) on coronary and peripheral vascular function in adults
    Medical condition: Microvascular myocardial dysfunction
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004860 10012654 Diabetic complications cardiovascular HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-000968-30 Sponsor Protocol Number: RC31/19/0509 Start Date*: 2021-04-13
    Sponsor Name:CHU Toulouse
    Full Title: ASPirin in Immune thRombocytopenia patients with cardiovascular disEase
    Medical condition: Immune thrombocytopenia with cardiovascular disease
    Disease: Version SOC Term Classification Code Term Level
    23.0 10005329 - Blood and lymphatic system disorders 10083842 Immune thrombocytopenia PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2020-004492-40 Sponsor Protocol Number: COHERENT Start Date*: 2021-02-03
    Sponsor Name:Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev and Gentofte Hospital
    Full Title: COHERENT - The COlchicine HypERtENsion Trial
    Medical condition: Hypertension
    Disease: Version SOC Term Classification Code Term Level
    21.1 10047065 - Vascular disorders 10081425 Arterial hypertension LLT
    22.0 10047065 - Vascular disorders 10081902 Arterial stiffness PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2015-002667-42 Sponsor Protocol Number: ABR53999 Start Date*: 2015-09-09
    Sponsor Name:AMC
    Full Title: Sedation with propofol TCI during ERCP: Is the combination with esketamine more effective and safer than with alfentanil (SPEKA): A randomized controlled multicentre trial
    Medical condition: Patients undergoing ERCPs under propofol sedation combined with ketamine or alfentanil given by trained anesthesia nurse.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-001065-17 Sponsor Protocol Number: EXO_01 Start Date*: Information not available in EudraCT
    Sponsor Name:Fondazione IRCCS Policlinico San Matteo
    Full Title: Early treatment with evOlocumab in patients with sT-elevation myocardial Infarction undergoing primary pCi
    Medical condition: Acute myocardial infarction with persistent ST segment elevation (STEMI)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2022-003061-38 Sponsor Protocol Number: NL82555.100.22 Start Date*: 2023-05-02
    Sponsor Name:Sint Antonius Ziekenhuis
    Full Title: Genotype-gUIded cLopidogrel monoTherapY (POPular GUILTY)
    Medical condition: Non-ST elevation acute coronary syndrome (coronary artery disease)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2022-003218-36 Sponsor Protocol Number: 82646 Start Date*: 2023-06-05
    Sponsor Name:Radboudumc
    Full Title: The safety of ticagrelor monotherapy after primary percutaneous coronary intervention for ST-elevation myocardial infarction and the effect on intramyocardial haemorrhage
    Medical condition: Acute myocardial infarction
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2021-000733-14 Sponsor Protocol Number: DAPA-HD Start Date*: 2022-07-18
    Sponsor Name:Medical University of Vienna
    Full Title: SGLT2 INHIBITION (DAPAGLIFLOZIN) IN DIABETIC AND NON-DIABETIC HEMODIALYSIS PATIENTS WITH AND WITHOUT RESIDUAL URINE VOLUME: A PROSPECTIVE RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLINDED PHASE II TRIAL
    Medical condition: Cardiovascular Outcome
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2021-003889-12 Sponsor Protocol Number: 3 Start Date*: 2022-01-20
    Sponsor Name:Consorcio Centro de Investigacion Biomedica en Red, M.P. (CIBER)
    Full Title: Prospective, multicenter and open study to evaluate the efficacy of esmolol in the early identification of cardiovascular disorders induced by cirrhosis, diabetes mellitus and cardiotoxic treatments.
    Medical condition: Cardiovascular disorders induced by cirrhosis, diabetes mellitus and cardiotoxic treatments.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-003519-23 Sponsor Protocol Number: D513BC00001 Start Date*: 2014-02-05
    Sponsor Name:AstraZeneca AB
    Full Title: A Multinational, Randomised, Double-Blind, Placebo-Controlled Trial to Evaluate the Effect of Ticagrelor twice daily on the Incidence of Cardiovascular Death, Myocardial Infarction or Stroke in Pat...
    Medical condition: major cardiovascular events in type 2 diabetes mellitus patients
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004852 10042244 Stroke LLT
    19.1 10007541 - Cardiac disorders 10028596 Myocardial infarction PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) CZ (Completed) SK (Completed) SE (Completed) NL (Completed) DE (Completed) IT (Completed) GB (Completed) ES (Completed) NO (Completed) AT (Completed) DK (Completed) BE (Completed) FI (Completed) BG (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2004-000022-75 Sponsor Protocol Number: CV131-169 Start Date*: 2004-09-24
    Sponsor Name:Bristol-Myers Squibb International Corporation
    Full Title: Irbesartan Versus Placebo in Combination with Standard Cardiovascular Protection ACE-I Therapy with Ramipril for the Treatment of Albuminuria in Hypertensive Subjects at Elevated Cardiovascular Risk
    Medical condition: Albuminuria in hypertensive subjects at increased cardiovascular risk.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: LT (Completed) LV (Completed) IT (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2012-003630-16 Sponsor Protocol Number: GEIDENo.D00112 Start Date*: 2013-04-10
    Sponsor Name:German Heart Centre Munich, Department of
    Full Title: A Randomized, Parallel Group, Double-Blind Study of Ticagrelor Compared with Aspirin for Prevention of Vascular Events in Patients Undergoing Coronary Artery Bypass Graft Operation TiCAB– Ticagrelo...
    Medical condition: Ticagrelor Compared with Aspirin for Prevention of Vascular Events in Patients Undergoing Coronary Artery Bypass Graft Operation
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004866 10003601 Atherosclerosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-001674-25 Sponsor Protocol Number: 1684-H-295 Start Date*: 2012-05-25
    Sponsor Name:Francisco J. González Vílchez
    Full Title: Evaluation of the efficacy of sildenafil on the functional capacity of patients with heart failure with preserved ejection fraction. A randomized, double blind, parallel group and placebo-controlle...
    Medical condition: Heart failure with preserved ejection fraction.
    Disease: Version SOC Term Classification Code Term Level
    14.1 10007541 - Cardiac disorders 10069211 Diastolic heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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