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Clinical trials for Cartilage Diseases

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44344   clinical trials with a EudraCT protocol, of which   7373   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    67 result(s) found for: Cartilage Diseases. Displaying page 1 of 4.
    1  2  3  4  Next»
    EudraCT Number: 2009-016466-82 Sponsor Protocol Number: cod16HS13 Start Date*: 2010-09-01
    Sponsor Name:CO.DON AG
    Full Title: Prospective, randomised, open label, multicentre Phase-III clinical trial to compare the efficacy and safety of the treatment with the autologous chondrocyte transplantation product co.don chondros...
    Medical condition: Cartilage defects of knee joints, osteochondral defects
    Disease: Version SOC Term Classification Code Term Level
    20.1 10022117 - Injury, poisoning and procedural complications 10007713 Cartilage tear in knee LLT
    20.0 100000004848 10007702 Cartilage biopsy LLT
    20.0 100000004859 10003423 Articular cartilage disorder LLT
    20.0 10042613 - Surgical and medical procedures 10052913 Cartilage operation PT
    20.0 10022117 - Injury, poisoning and procedural complications 10007705 Cartilage damage LLT
    20.0 100000004859 10007709 Cartilage disorders HLT
    20.0 10042613 - Surgical and medical procedures 10057104 Cartilage repair LLT
    20.1 10022117 - Injury, poisoning and procedural complications 10007710 Cartilage injury PT
    20.0 10042613 - Surgical and medical procedures 10064112 Cartilage graft PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2009-016816-20 Sponsor Protocol Number: cod16HS14 Start Date*: 2010-05-24
    Sponsor Name:co.don AG
    Full Title: Prospective, randomised, open label, multicentre Phase II clinical trial to investigate the efficacy and safety of the treatment of large defects (4-10 cm2) with 3 different doses of the autologous...
    Medical condition: Cartilage defects of knee joints, osteochondral defects
    Disease: Version SOC Term Classification Code Term Level
    18.0 10022117 - Injury, poisoning and procedural complications 10007713 Cartilage tear in knee LLT
    18.0 100000004848 10007702 Cartilage biopsy LLT
    18.0 100000004859 10003423 Articular cartilage disorder LLT
    18.0 10042613 - Surgical and medical procedures 10052913 Cartilage operation PT
    18.0 10022117 - Injury, poisoning and procedural complications 10007705 Cartilage damage LLT
    18.0 100000004859 10007709 Cartilage disorders HLT
    18.0 10042613 - Surgical and medical procedures 10057104 Cartilage repair LLT
    18.0 10022117 - Injury, poisoning and procedural complications 10007710 Cartilage injury PT
    18.0 10042613 - Surgical and medical procedures 10064112 Cartilage graft PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2012-001431-31 Sponsor Protocol Number: EMR700692-007 Start Date*: 2013-05-02
    Sponsor Name:Merck KGaA
    Full Title: A multicenter, randomized, double-blind, placebo-controlled, parallel-group, Phase II trial to investigate the efficacy and safety of 30 mcg and 100 mcg AS902330 given as one cycle of three intra-a...
    Medical condition: Knee Cartilage Injury
    Disease: Version SOC Term Classification Code Term Level
    15.1 10022117 - Injury, poisoning and procedural complications 10007710 Cartilage injury PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2009-015532-14 Sponsor Protocol Number: EMR700692-003 Start Date*: 2010-01-22
    Sponsor Name:Merck Serono S.A. - Geneva
    Full Title: A multicenter, randomized, double-blind, placebo-controlled, parallel-group phase II trial to investigate the efficacy and safety of weekly intra-articular (i.a.) injections of 10, 30, and 100 µg o...
    Medical condition: Knee Cartilage Injury
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10007710 Cartilage injury PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) HU (Completed) SI (Completed) BG (Prematurely Ended) AT (Completed)
    Trial results: View results
    EudraCT Number: 2016-000784-16 Sponsor Protocol Number: NCPACI Start Date*: 2016-04-15
    Sponsor Name:Akershus University Hospital
    Full Title: Focal cartilage defects in the knee – A randomized controlled trial comparing Autologous Chondrocyte Implantation with arthroscopic debridement
    Medical condition: Symptomatic focal cartilage defects in the knee
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-003594-28 Sponsor Protocol Number: BCCT2011 Start Date*: 2013-11-07
    Sponsor Name:BioTissue Technologies GmbH
    Full Title: A Comparative Observational Prospective Randomized Open-Label Study on Efficacy of BioSeed®-C and chondrotissue® Treatment of Local Femoral Cartilage Defects in the Knee.
    Medical condition: focal femoral cartilage defects in the knee joint
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004863 10007705 Cartilage damage LLT
    16.1 100000004865 10057104 Cartilage repair LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000592-27 Sponsor Protocol Number: 13102014 Start Date*: 2015-06-18
    Sponsor Name:Helsinki University Central Hospital
    Full Title: Immunodeficiency in cartilage-hair hypoplasia: sub-project on safety of vaccination against chickenpox
    Medical condition: Cartilage-hair hypoplasia patients.
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-003418-28 Sponsor Protocol Number: CLNA043X2201 Start Date*: 2017-04-18
    Sponsor Name:Novartis Pharma AG
    Full Title: A randomized, placebo-controlled, patient and investigator blinded, single dose, Proof of Concept study investigating the safety, tolerability and preliminary efficacy of intra-articular LNA043 in ...
    Medical condition: Acute cartilage injuries
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-003584-11 Sponsor Protocol Number: MACT-IBK-2015 Start Date*: 2015-12-11
    Sponsor Name:Medical University Innsbruck
    Full Title: Matrix-associated autologous chrondrocyte transplantation for grade four cartilage lesions of the knee joint - clinical and radiological outcome in correlation to the initial cell count of the cho...
    Medical condition: Cartilage lesion
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004859 10072638 Articular cartilage defect LLT
    18.0 100000004865 10064113 Cartilage allograft LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2017-004143-21 Sponsor Protocol Number: OA-orMSCp-01 Start Date*: Information not available in EudraCT
    Sponsor Name:Bioinova, a.s.
    Full Title: Efficacy of autologous bone marrow-derived mesenchymal stem cells seeded on a 3D scaffold in treatment of knee cartilage defects. A randomized, controlled, open-label, multi-centre clinical trial.
    Medical condition: Knee Cartilage Defect
    Disease: Version SOC Term Classification Code Term Level
    27.0 10022117 - Injury, poisoning and procedural complications 10007710 Cartilage injury PT
    21.1 10022117 - Injury, poisoning and procedural complications 10007705 Cartilage damage LLT
    20.0 10042613 - Surgical and medical procedures 10057104 Cartilage repair LLT
    21.0 10028395 - Musculoskeletal and connective tissue disorders 10072638 Articular cartilage defect LLT
    20.0 10042613 - Surgical and medical procedures 10052913 Cartilage operation PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2018-004067-31 Sponsor Protocol Number: OA-orMSCp-02 Start Date*: 2018-12-21
    Sponsor Name:Bioinova, s.r.o.
    Full Title: Autologous bone marrow-derived mesenchymal stem cells seeded on a 3D scaffold in treatment of knee cartilage defects. Prospective open-label study to assess safety and feasibility.
    Medical condition: Knee Cartilage Defect
    Disease: Version SOC Term Classification Code Term Level
    20.1 10022117 - Injury, poisoning and procedural complications 10007710 Cartilage injury PT
    20.0 10042613 - Surgical and medical procedures 10052913 Cartilage operation PT
    20.0 10042613 - Surgical and medical procedures 10057104 Cartilage repair LLT
    21.0 100000004859 10072638 Articular cartilage defect LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-004052-30 Sponsor Protocol Number: CLNA043X2202 Start Date*: 2017-04-28
    Sponsor Name:Novartis Pharma AG
    Full Title: A randomized, placebo-controlled, patient and investigator blinded, Proof of Concept study investigating the safety, tolerability and preliminary efficacy of multiple intra-articular LNA043 injecti...
    Medical condition: Acute cartilage injuries
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed) CZ (Completed) DK (Completed)
    Trial results: View results
    EudraCT Number: 2012-001570-29 Sponsor Protocol Number: NL4014200012 Start Date*: 2012-08-28
    Sponsor Name:University Medical Center Utrecht
    Full Title: Instant MSC Product accompanying Autologous Chondron Transplantation (IMPACT) for focal articular cartilage lesions of the knee; feasibility and safety
    Medical condition: Articular cartilage defects of the femural condyl and trochlea of the knee
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2019-002963-92 Sponsor Protocol Number: CLRX712A12201 Start Date*: 2020-02-05
    Sponsor Name:Novartis Pharma AG
    Full Title: A randomized, placebo-controlled, subject and investigator blinded study investigating the safety, tolerability and preliminary efficacy of 8-week treatment with intra-articular LRX712 to regenerat...
    Medical condition: Cartilage injuries
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-004581-10 Sponsor Protocol Number: CL2-201086-002 Start Date*: 2018-09-04
    Sponsor Name:Institut de Recherches Internationales Servier
    Full Title: Efficacy and safety of 3 doses of S201086/GLPG1972 administered orally once daily in patients with knee osteoarthritis. A 52-week international, multi-regional, multi-center, randomized, double-bli...
    Medical condition: Osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) HU (Completed) DK (Completed) PL (Completed) BG (Completed)
    Trial results: View results
    EudraCT Number: 2016-004755-75 Sponsor Protocol Number: MICROPREP Start Date*: 2017-09-28
    Sponsor Name:Clinique Juge
    Full Title: Intra articular injection of microfat and platelet-rich plasma in the treatment of knee osteoarthritis : a pilot study
    Medical condition: knee osteoarthritis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-005681-37 Sponsor Protocol Number: CL/BIO/15-005 Start Date*: 2016-04-18
    Sponsor Name:BIOIBERICA S.A.
    Full Title: Evaluation of the evolution of imaging markers of cartilage degradation in patients with knee osteoarthritis receiving DROGLICAN®: a Pilot Study
    Medical condition: Knee Osteoarthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2011-003059-20 Sponsor Protocol Number: EMR700692_006 Start Date*: 2013-07-31
    Sponsor Name:Merck KGaA
    Full Title: A multicenter, randomized, double-blind, placebo-controlled, parallel-group trial to investigate the efficacy and safety of different intra-articular (i.a.) dosages of sprifermin in subjects with p...
    Medical condition: Primary osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) EE (Completed) DK (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2020-003631-21 Sponsor Protocol Number: CLNA043A12203 Start Date*: 2021-06-28
    Sponsor Name:Novartis Pharma AG
    Full Title: A randomized, four-arm, canakinumab placebo-controlled, participant, investigator and sponsor-blinded study investigating the safety, tolerability and efficacy of intra-articular canakinumab follow...
    Medical condition: osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    21.1 10028395 - Musculoskeletal and connective tissue disorders 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) CZ (Prematurely Ended) HU (Prematurely Ended) EE (Completed) LT (Completed) LV (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-005000-17 Sponsor Protocol Number: JU-BioMiStem-01 Start Date*: 2021-09-20
    Sponsor Name:Jagiellonian University
    Full Title: A Randomized, Double Blind, Two Arms, Controlled Phase I/II Safety and Efficacy Study on MesoCellA-Ortho Tissue Engineered Product Intraarticularly Administrated in Adult Patients with Osteoarthrosis
    Medical condition: articular knee diseases
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: (No results available)
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