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Clinical trials for HLA-B27

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44346   clinical trials with a EudraCT protocol, of which   7374   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    18 result(s) found for: HLA-B27. Displaying page 1 of 1.
    EudraCT Number: 2011-000311-34 Sponsor Protocol Number: P07642 Start Date*: 2011-11-29
    Sponsor Name:Schering-Plough Research Institute, a Division of Schering Corporation
    Full Title: A Multicenter, Randomized, Double-blind, Placebo-controlled Study of the Effect of Golimumab Administered Subcutaneously in Subjects with Active Axial Spondyloarthritis (Phase 3b, Protocol No. P0...
    Medical condition: Active Axial Spondyloarthritis (SpA)
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004859 10041672 Spondylitis ankylosing LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) ES (Completed) FI (Completed) IT (Completed) GR (Completed)
    Trial results: View results
    EudraCT Number: 2009-010643-14 Sponsor Protocol Number: M10-791 Start Date*: 2009-07-22
    Sponsor Name:Abbott GmbH & Co. KG
    Full Title: A Multicenter Study of the Efficacy and Safety of the Human Anti-TNF Monoclonal Antibody Adalimumab in Subjects with Axial Spondyloarthritis
    Medical condition: Active axial spondyloarthritis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10051265 Spondyloarthropathy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) DE (Completed) GB (Prematurely Ended) CZ (Completed) ES (Completed) BE (Completed) NL (Completed)
    Trial results: View results
    EudraCT Number: 2015-000541-24 Sponsor Protocol Number: B1801381 Start Date*: 2016-01-12
    Sponsor Name:Pfizer Inc., 235 East 42nd Street, New York, NY 10017
    Full Title: A Multicenter Open-Label Study of Etanercept Withdrawal and Retreatment in Subjects with Non-Radiographic Axial Spondyloarthritis who Achieved Adequate 24 Week Response
    Medical condition: Spondyloarthritis (SpA)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10071400 Axial spondyloarthritis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) FI (Completed) BE (Completed) PL (Completed) HU (Completed) SE (Completed) ES (Completed) NL (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2005-001202-60 Sponsor Protocol Number: 09/05 Start Date*: 2005-05-26
    Sponsor Name:Organisation name was not entered
    Full Title: Metotreksaatti aksiaalisen spondyloartropatian hoidossa
    Medical condition: Aksiaalinen spondyloartropatia (varhainen selkärankareuma)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-015515-40 Sponsor Protocol Number: vumc-09-206 Start Date*: 2009-11-20
    Sponsor Name:Wyeth Pharmaceuticals B.V.
    Full Title: PREVENTION OF THE PROGRESSION OF VERY EARLY SYMPTOMS INTO ANKYLOSING SPONDYLITIS: A PLACEBO CONTROLLED TRIAL WITH ETANERCEPT
    Medical condition: The diagnosis of Ankylosing Spondylitis (AS) requires radiographically proven sacroiliitis.Inflammation on MRI is a prognostic factor for the development of AS. The aim is the decrease of inflammat...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-001728-23 Sponsor Protocol Number: AGO/2017/004 Start Date*: 2017-06-27
    Sponsor Name:Ghent University
    Full Title: Efficacy of golimumab in early axial spondyloarthritis (axSpA) in relation to gut inflammation, an early remission induction study (GO GUT).
    Medical condition: early axial spondyloarthritis (axSpA) in relation to gut inflammation
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2015-003938-27 Sponsor Protocol Number: I1F-MC-RHBX Start Date*: 2016-06-06
    Sponsor Name:Eli Lilly and Company
    Full Title: A 52 Week Multicenter, Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ixekizumab (LY2439821) in bDMARD Naive Patients with Nonradiographic Axial Spondyloa...
    Medical condition: bDMARD Naive Patients with Nonradiographic Axial Spondyloarthritis
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10076297 Non-radiographic axial spondyloarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) RO (Completed) FI (Completed) CZ (Completed) AT (Completed) PL (Completed) NL (Completed)
    Trial results: View results
    EudraCT Number: 2008-004862-24 Sponsor Protocol Number: ESBA105CRD04 Start Date*: 2009-01-02
    Sponsor Name:ESBATech, an Alcon Biomedical Research Unit LLC
    Full Title: An open-label exploratory study to assess the safety, tolerability and clinical activity of topically applied ESBA105 in patients with acute anterior uveitis
    Medical condition: Acute, unilateral anterior uveitis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10002709 Anterior uveitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-004020-65 Sponsor Protocol Number: MK-8259-038 Start Date*: 2017-07-20
    Sponsor Name:Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
    Full Title: A Phase-IV, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial to Evaluate the Efficacy and Safety of Golimumab (MK-8259 [SCH 900259]) After Treatment Withdrawal, Compared With Cont...
    Medical condition: Treatment of non-radiographic axial spondyloarthritis (nr-axSpA)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10076297 Non-radiographic axial spondyloarthritis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed) ES (Completed) NL (Completed) PL (Completed) RO (Completed)
    Trial results: View results
    EudraCT Number: 2015-000752-20 Sponsor Protocol Number: PETSPA Start Date*: 2015-06-29
    Sponsor Name:University of Helsinki
    Full Title: The efficacy of adalimumab and conventional antirheumatic drugs in alleviating axial and aortic inflammation detected in PET/CT in patients with axial spondyloarthritis
    Medical condition: Axial and aortic inflammation detected in PET/CT imaging in patients with axial spondyloarthritis
    Disease: Version SOC Term Classification Code Term Level
    18.0 10028395 - Musculoskeletal and connective tissue disorders 10071400 Axial spondyloarthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-000982-51 Sponsor Protocol Number: P05336 Start Date*: 2009-07-01
    Sponsor Name:Schering-Plough Research Institute, a Division of Schering Corporation
    Full Title: Infliximab as First Line Therapy in Patients with Early Active Axial Spondyloarthritis Trial
    Medical condition: Moderate-to-severe active axial spondyloarthritis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10058338 Spondylarthritis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed) AT (Completed) BE (Completed) DE (Completed) HU (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2005-002320-34 Sponsor Protocol Number: M01 Start Date*: 2005-10-12
    Sponsor Name:Charité Universitätsmedizin Berlin
    Full Title: Randomized controlled 12 months trial with etanercept (enbrel ®) vs. sulfasalazine followed by an open-label extension with etanercept up to week 540 in early axial spondyloarthritis with focus on ...
    Medical condition: The proposed study is designed to get first data on efficacy and safety of etanercept in the treatment of patients with moderate to severe early axial Spondyloarthritis (SpA) with disease duration...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2009-014567-39 Sponsor Protocol Number: M10-883 Start Date*: 2010-02-19
    Sponsor Name:AbbVie Deutschland GmbH & Co. KG
    Full Title: A Multicenter Study of the Efficacy and Safety of the Human Anti-TNF Monoclonal Antibody Adalimumab in Subjects with Peripheral Spondyloarthritis
    Medical condition: Peripheral Spondyloarthritis
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004859 10052775 Spondyloarthropathies HLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) FR (Completed) BE (Completed) IE (Completed) HU (Completed) ES (Completed) CZ (Completed) GR (Completed)
    Trial results: View results
    EudraCT Number: 2021-001256-34 Sponsor Protocol Number: CAIN457X12301 Start Date*: 2022-02-07
    Sponsor Name:Novartis Pharma AG
    Full Title: A randomized, parallel-group, double-blind, placebo-controlled, multicenter phase III study to investigate the efficacy and safety of secukinumab (Cosentyx) 300 mg administered subcutaneously in pa...
    Medical condition: Peripheral Spondyloarthritis
    Disease: Version SOC Term Classification Code Term Level
    24.1 10028395 - Musculoskeletal and connective tissue disorders 10085753 Peripheral spondyloarthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SK (Prematurely Ended) IT (Prematurely Ended) HU (Prematurely Ended) ES (Prematurely Ended) DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2021-005178-25 Sponsor Protocol Number: 216152 Start Date*: 2022-08-22
    Sponsor Name:GlaxoSmithKline Biologicals SA
    Full Title: A Phase 1/2a, observer-blind, randomized, controlled, two-stage, multi-country study to evaluate the safety, reactogenicity, and immune response of the trivalent vaccine against invasive nontyphoid...
    Medical condition: Healthy volunteers (prevention of invasive nontyphoidal Salmonella disease and typhoid fever)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2023-000945-18 Sponsor Protocol Number: 219449 Start Date*: 2024-10-28
    Sponsor Name:GlaxoSmithKline Biologicals
    Full Title: A Phase 2 single-blind, randomized, controlled, single center study to assess the immunogenicity and safety of a 2-dose schedule with GVGH altSonflex1-2-3 vaccine in African infants (H06_02TP)
    Medical condition: Prophylaxis for Shigellosis induced by Shigella sonnei, Shigella flexneri 1b, Shigella flexneri 2a and Shigella flexneri 3a.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10040550 Shigella infections HLT
    27.1 10021881 - Infections and infestations 10054178 Shigella infection PT
    20.0 10021881 - Infections and infestations 10040542 Shigella LLT
    20.0 10021881 - Infections and infestations 10040547 Shigella flexneri LLT
    20.0 10021881 - Infections and infestations 10040551 Shigella sonnei LLT
    20.1 10021881 - Infections and infestations 10004016 Bacterial diarrhoea PT
    20.0 10017947 - Gastrointestinal disorders 10012735 Diarrhoea PT
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: (No results available)
    EudraCT Number: 2021-000891-12 Sponsor Protocol Number: 212149 Start Date*: 2021-10-05
    Sponsor Name:GlaxoSmithKline Biologicals
    Full Title: A staged Phase I/II observer-blind, randomised, controlled, multi-country study to evaluate the safety, reactogenicity, and immune responses to the GVGH altSonflex1-2-3 vaccine against S. sonnei an...
    Medical condition: Prophylaxis for Shigellosis induced by Shigella sonnei, Shigella flexneri 1b, Shigella flexneri 2a and Shigella flexneri 3a.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10040550 Shigella infections HLT
    20.0 10021881 - Infections and infestations 10054178 Shigella infection PT
    20.0 10021881 - Infections and infestations 10040542 Shigella LLT
    20.0 10021881 - Infections and infestations 10040547 Shigella flexneri LLT
    20.0 10021881 - Infections and infestations 10040551 Shigella sonnei LLT
    20.1 10021881 - Infections and infestations 10004016 Bacterial diarrhoea PT
    20.0 10017947 - Gastrointestinal disorders 10012735 Diarrhoea PT
    Population Age: Infants and toddlers, Children, Under 18, Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-000401-21 Sponsor Protocol Number: CAIN457H3301 Start Date*: 2017-05-16
    Sponsor Name:Novartis Farmacéutica, S.A.
    Full Title: SKIPPAIN (Speed of onset of SecuKinumab-Induced relief from Pain in Patients with Axial SpoNdyloarthritis) A 24-week, randomized, double-blind, placebo-controlled, multicenter study to evaluate the...
    Medical condition: Axial Spondyloarthritis
    Disease: Version SOC Term Classification Code Term Level
    19.1 10028395 - Musculoskeletal and connective tissue disorders 10071400 Axial spondyloarthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) CZ (Completed) FI (Completed) GB (Completed) LV (Completed) LT (Completed) GR (Completed) BE (Completed) SE (Completed) BG (Completed) PL (Completed) HR (Completed) IT (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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