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Clinical trials for P2Y12

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44343   clinical trials with a EudraCT protocol, of which   7372   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    68 result(s) found for: P2Y12. Displaying page 1 of 4.
    1  2  3  4  Next»
    EudraCT Number: 2014-002004-24 Sponsor Protocol Number: CV185-316 Start Date*: 2017-02-08
    Sponsor Name:Bristol-Myers Squibb International Corporation
    Full Title: An Open-label, 2 x 2 Factorial, Randomized Controlled, Clinical Trial to Evaluate the Safety of Apixaban vs. Vitamin K Antagonist and Aspirin vs. Aspirin Placebo in Patients with Atrial Fibrillatio...
    Medical condition: Atrial Fibrillation and Acute Coronary Syndrome and/or Percutaneous Coronary Intervention
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10003658 Atrial fibrillation PT
    20.0 10007541 - Cardiac disorders 10051592 Acute coronary syndrome PT
    20.0 10042613 - Surgical and medical procedures 10065608 Percutaneous coronary intervention PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed) BG (Completed) AT (Completed) BE (Completed) DK (Completed) NL (Completed) PL (Completed) PT (Completed) ES (Completed) CZ (Completed) DE (Completed) SE (Completed) SK (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-005491-27 Sponsor Protocol Number: U-08-002 Start Date*: 2008-11-26
    Sponsor Name:UCR Uppsala Clinical Research Center
    Full Title: TAILORING OF PLATELET INHIBITION TO AVOID STENT THROMBOSIS TOPAS-1 A Pharmacodynamic Phase II Study of Clopidogrel P2Y12 Platelet Inhibition
    Medical condition: Previous patients in the TABR study treated with Plavix 75 mg/day and patients with stent thrombosis within 6 months or myocardial infarction within 6 month after stenting. For the control group no...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10063933 Coronary stent thrombosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2021-001418-12 Sponsor Protocol Number: NCT04483583 Start Date*: 2021-06-24
    Sponsor Name:University of Florida
    Full Title: Tailoring P2Y12 Inhibiting Therapy in Patients requiring Oral Anticoagulation after undergoing Percutaneous Coronary Intervention: The Switching Anti-Platelet and Anti-Coagulant Therapy – 2 Study
    Medical condition: Efficacy of antiplatelet therapy after percutaneous coronary intervention in patients using oral anticoagulants
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-000485-29 Sponsor Protocol Number: STH19752 Start Date*: 2017-05-23
    Sponsor Name:Dr
    Full Title: Prolonged ENoxapariN in primarY Percutaneous Coronary Intervention; a Pilot Pharmacodynamic study (PENNY PCI study)
    Medical condition: ST elevation myocardial infarction.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2023-000029-10 Sponsor Protocol Number: DESC-HBR Start Date*: 2023-03-24
    Sponsor Name:Azienda Ospedaliera Universitaria Gaetano Martino Messina
    Full Title: De-Escalation of Antiplatelet Therapy to Evaluate Platelet Reactivity and Clinical Outcomes after Coronary Stenting in Patients at High Bleeding Risk and Recent Acute Coronary Syndrome: DESC-HBR trial
    Medical condition: High bleeding risk (HBR) patients with a recent acute coronary syndrome (ACS ) who have undergone percutaneous coronary intervention (PCI) and are on double antiplatelet therapy (DAPT)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10051592 Acute coronary syndrome PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2014-004266-26 Sponsor Protocol Number: RIVAROXACS2002 Start Date*: 2015-04-13
    Sponsor Name:Janssen-Cilag International NV
    Full Title: A Randomized, Double-blind, Double-dummy, Active-controlled, Parallel-group, Multicenter Study to Compare the Safety of Rivaroxaban versus Acetylsalicylic Acid in Addition to Either Clopidogrel or ...
    Medical condition: Acute Coronary Syndrome (ACS)
    Disease: Version SOC Term Classification Code Term Level
    18.0 10007541 - Cardiac disorders 10051592 Acute coronary syndrome PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) SE (Completed) CZ (Completed) NL (Completed) HU (Completed) ES (Completed) IT (Completed) BG (Completed) DK (Completed)
    Trial results: View results
    EudraCT Number: 2014-004189-64 Sponsor Protocol Number: Hi_Tech_v1 Start Date*: 2015-08-05
    Sponsor Name:Erasmus MC
    Full Title: Hunting for the off-target properties of ticagrelor on endothelial function and other circulating biomarkers in humans
    Medical condition: Acute coronary syndrome
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) ES (Completed) IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000850-39 Sponsor Protocol Number: P141103 Start Date*: 2019-11-19
    Sponsor Name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
    Full Title: Assessment of Loading with the P2Y12 inhibitor Ticagrelor or clopidogrel to Halt ischemic Events in patients Undergoing elective coronary Stenting: the ALPHEUS study.
    Medical condition: PCI-related myocardial infarction (MI type 4) or injury (I) within 48 hours (or at hospital discharge if earlier than 48 hours) of elective PCI/stent
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10028596 Myocardial infarction PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-006695-38 Sponsor Protocol Number: 06 037 03 Start Date*: 2007-02-02
    Sponsor Name:CHU Toulouse
    Full Title: Evaluation pharmacologique des antagonistes du récepteur P2Y12 à l'ADP chez le volontaire sain
    Medical condition: Volontaires sains
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-003599-21 Sponsor Protocol Number: MEIXO-VALV-002 Start Date*: 2015-06-27
    Sponsor Name:Sociedad Española de Cardiología
    Full Title: Platelet reactivity after TAVI: A multicenter randomized clinical trial
    Medical condition: Study platelet reactivity in patients with Aortic Stenosis (AS) selected for TAVI and to assess the effectiviness of ticagrelor as antiplatelet monotherapy for the supression of high platelet react...
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-005451-20 Sponsor Protocol Number: MMI_2020_35 Start Date*: 2021-06-03
    Sponsor Name:Fondation A. de Rothschild Hospital
    Full Title: REperfusion with P2Y12 inhibitors in addition to mEchanical thRombectomy for perFUsion imaging selected acute Stroke patiEnts : a multicentric randomized controlled trial
    Medical condition: patients with a clinical diagnosis of AIS consecutive to LVO between 0 and 24 hours of symptom onset and selected by perfusion imaging
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-004959-80 Sponsor Protocol Number: IIS14005 Start Date*: 2017-08-01
    Sponsor Name:Special Account For Research Funds- National and Capodistrian University of Athens
    Full Title: A randomized, pharmacodynamic comparison of ticagrelor 60mg bid vs prasugrel 5mg in patients with prior myocardial infarction
    Medical condition: In this study we aim to compare the platelet inhibition of 60mg ticagrelor bid versus 5mg prasugrel in patients with prior myocardial infarction within previous 1-3 years
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-004446-42 Sponsor Protocol Number: MB11-2018 Start Date*: 2019-06-20
    Sponsor Name:AZIENDA SANITARIA OSPEDALIERA S.CROCE E CARLE CUNEO
    Full Title: Maintenance Of aNtiplatElet Therapy in patients with coronary stenting undergoing surgery
    Medical condition: Patients a least 18 years of age on DAPT per standard of care who are planned to undergo non deferrable cardiac and non cardiac surgery which will require discontinuation of a P2Y12 inhibitor. Subj...
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10011082 Coronary artery disorders HLGT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2022-001298-30 Sponsor Protocol Number: NL81102.100.22 Start Date*: 2022-07-28
    Sponsor Name:St. Antonius Hospital
    Full Title: What is the optimal antithrombotic strategy in patients with atrial fibrillation having acute coronary syndrome or undergoing percutaneous coronary intervention?
    Medical condition: Atrial fibrillation and coronary artery disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-002586-64 Sponsor Protocol Number: ISS13616 Start Date*: 2016-10-13
    Sponsor Name:ELKE University of Athens
    Full Title: A randomized, pharmacodynamic study of cangrelor administration in STEMI patients loaded with ticagrelor
    Medical condition: In the present study, in STEMI patients undergoing primary PCI we aim therefore to compare platelet inhibition achieved in patients loaded with ticagrelor followed by cangrelor (bolus plus infusion...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-002671-26 Sponsor Protocol Number: 9113 Start Date*: 2017-12-19
    Sponsor Name:Isala
    Full Title: The effect of Opioids on P2Y12 Receptor Inhibition in patients with ST-Elevation Myocardial Infarction who are pre-treated with crushed Ticagrelor
    Medical condition: Acute Coronary syndrome
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000011652 10064346 STEMI LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-004064-29 Sponsor Protocol Number: CS747S-B-U4003 Start Date*: 2012-06-11
    Sponsor Name:Daiichi Sankyo, Inc.
    Full Title: A PHARMACODYNAMIC EVALUATION OF SWITCHING FROM TICAGRELOR TO PRASUGREL IN SUBJECTS WITH STABLE CORONARY ARTERY DISEASE: 2ND SWITCHING ANTIPLATELET AGENTS (SWAP 2)
    Medical condition: Stable Coronary Artery Disease
    Disease: Version SOC Term Classification Code Term Level
    14.1 10007541 - Cardiac disorders 10013098 Disease coronary artery LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2016-003721-41 Sponsor Protocol Number: SKS-CANTI2016 Start Date*: 2018-03-01
    Sponsor Name:Department of Cardiology, Aarhus University Hospital, Skejby
    Full Title: Cangrelor versus Ticagrelor for Early Platelet Inhibition in ST-Elevation Myocardial Infarction. (The CanTi study)
    Medical condition: ST-elevation Myocardial Infarction
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10064345 ST segment elevation myocardial infarction LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2008-008298-77 Sponsor Protocol Number: CV185-068 Start Date*: 2009-04-14
    Sponsor Name:Bristol-Myers Squibb International Corporation
    Full Title: Apixaban for Prevention of Acute Ischemic Events - 2 A Phase 3, Randomized, Double-Blind, Evaluation of the Safety and Efficacy of Apixaban In Subjects with a Recent Acute Coronary Syndrome
    Medical condition: Subjects with a recent acute coronary syndrome (ACS) and at least 2 additional risk factors for recurrent ischemic events.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10051592 Acute coronary syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) AT (Prematurely Ended) NL (Prematurely Ended) SE (Prematurely Ended) NO (Completed) ES (Prematurely Ended) FI (Prematurely Ended) GB (Prematurely Ended) IT (Prematurely Ended) DK (Completed) CZ (Prematurely Ended) BE (Completed) HU (Prematurely Ended) DE (Completed) BG (Prematurely Ended) SK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2021-000823-11 Sponsor Protocol Number: TIMO Start Date*: 2023-03-09
    Sponsor Name:Sahlgrenska University Hospital Gothenburg
    Full Title: Ticagrelor monotherapy after coronary stenting in patients with acute myocardial infarction. A prospective single-centre, single-arm phase II study
    Medical condition: Antiplatelet therapy in patients who undergo coronary artery stenting due to coronary artery disease (CAD) or acute coronary syndrome (ACS). The present study will examine whether ticagrelor, as mo...
    Disease: Version SOC Term Classification Code Term Level
    22.1 100000004849 10048560 Coronary artery disease aggravated LLT
    20.0 100000004849 10071111 Non ST segment elevation acute coronary syndrome LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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