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Clinical trials for Substance P

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    47 result(s) found for: Substance P. Displaying page 1 of 3.
    1  2  3  Next»
    EudraCT Number: 2006-000353-21 Sponsor Protocol Number: substance P Start Date*: 2006-05-29
    Sponsor Name:Cliniques Universitaire St Luc
    Full Title: Comparison of the vasoreactivity and endogenous NO production between the left and right internal mammary 6 months after bypass surgery with the injection of substance P and exogenous nitric oxide.
    Medical condition: We observe a higher FFR in the RITA then in the LIMA 6 month after CABG (Glineur D, Resistance to flow of arterial Y-grafts 6 months after coronary artery bypass surgery.Circulation. 2005 Aug 30;1...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-000333-10 Sponsor Protocol Number: GEN/231/51/BMcK/JCL Start Date*: 2004-12-15
    Sponsor Name:Research & Innovation Services, University of Dundee
    Full Title: The inhibitory effect of local anaesthetics on the G-protein-mediated vascular flare response to bradykinin and substance P
    Medical condition: Healthy volunteers
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2012-005063-28 Sponsor Protocol Number: Emend2 Start Date*: 2013-10-02
    Sponsor Name:University of Gothenburg
    Full Title: Release of substance P during peritoneal dialysis: effects of intervention. Controlled cross-over study of the neurokinin-1 receptor antagonist Aprepitant
    Medical condition: End stage renal disease under treatment with peritoneal dialysis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-005019-16 Sponsor Protocol Number: ROCKSAN Start Date*: 2009-03-19
    Sponsor Name:AMC- academisch psychiatrisch centrum
    Full Title: Randomized Olanzapine Clozapine Key study on Schizophrenia and Addiction in the Netherlands (ROCKSAN)
    Medical condition: A multi-centre prospective, randomized, double blind designed study examining the effectiveness and costs of clozapine compared to olanzapine in patients with schizophrenia or related psychotic dis...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-003141-25 Sponsor Protocol Number: 1643/2015 Start Date*: 2015-10-06
    Sponsor Name:Medical University Vienna, Department of Anesthesia, Intensive Care Medicine and Pain Management
    Full Title: Determination of the minimal alveolar concentrations of sevoflurane in patients with end stage kidney disease
    Medical condition: Renal transplantation is the curative treatment in patients with end stage kidney disease. These patients have altered intraoperative anesthetic requirements compared with patients with maintained ...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-003367-40 Sponsor Protocol Number: 2007/049/HP Start Date*: 2009-03-03
    Sponsor Name:CHU de Rouen
    Full Title: Pilot study of the effect of a substance P antagonist, aprepitant, on aldosterone and cortisol secretions in healthy volunteers
    Medical condition: The aim is to measure plasma aldosterone and cortisol concentrations in basal conditions and in response to different stimulation tests of the adrenal function
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-003683-28 Sponsor Protocol Number: SI003-001 Start Date*: 2022-07-28
    Sponsor Name:SelectImmune Pharma AB
    Full Title: Kineret for the treatment of Bladder Pain Syndrome (BPS). Randomized, double-blind, cross-over, phase II trial.
    Medical condition: Patients diagnosed with Bladder Pain Syndrome (BPS)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-001556-19 Sponsor Protocol Number: COL_SCU_2011 Start Date*: 2012-11-08
    Sponsor Name:FUNDACION IMABIS
    Full Title: A Prospective, Randomized, Doubled-masked, Single Center, Clinical Comparison of Autologous Serum, Heterologous Serum and Umbilical Cord Serum Eye Drops in the Management of Dry Eye Syndrome
    Medical condition: Ocular surface disturbances.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-000839-21 Sponsor Protocol Number: DREPADOL Start Date*: 2019-06-17
    Sponsor Name:Centre Hospitalier Intercommunal de Créteil
    Full Title: Evaluation of the efficacy and safety of aprepitant in the management of vaso-occlusive crisis in sickle cell children: randomized, single-center, randomized, phase IIb/III prospective study
    Medical condition: vaso-occlusive crisis for patients with sickle cell disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004850 10040644 Sickle cell disease LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: FR (Not Authorised)
    Trial results: (No results available)
    EudraCT Number: 2022-001900-17 Sponsor Protocol Number: 2020/0431/HP Start Date*: 2022-10-24
    Sponsor Name:DRCI - CHU de Rouen
    Full Title: PILOT STUDY OF THE EFFECT OF A SUBSTANCE P ANTAGONIST, APREPITANT, ON THE SECRETION OF ALDOSTERONE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA AND ARTERIAL HYPERTENSION SYNDROME
    Medical condition: Patients with obstructive sleep apnea syndrome with arterial hypertension
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004866 10052741 Endocrine and metabolic secondary hypertension HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2013-004333-33 Sponsor Protocol Number: 13HH1771 Start Date*: 2014-01-20
    Sponsor Name:Imperial College London
    Full Title: Phase 1 of dose escalation of extracorporeal shockwave treatment only and in combination DPP-4 inhibitor and parathyroid hormone (non-randomised, open-labelled) & Phase II of combination treatments...
    Medical condition: ischaemic cardiomyopathy
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10077980 Chronic systolic heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2020-001431-27 Sponsor Protocol Number: CovidVal01 Start Date*: 2020-06-05
    Sponsor Name:Klinikum St. Georg gGmbH
    Full Title: Treatment of Sars-CoV2 infections (Covid-19) in patients without or with chronic kidney disease (CKD) with valsartan vs placebo, a three-armed randomized, partly blinded trial
    Medical condition: Sars-Cov2 infection
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-001088-11 Sponsor Protocol Number: s56489 Start Date*: 2014-07-29
    Sponsor Name:MEDA
    Full Title: Academic study on the effects of MP 29-02 nasal spray on inflammatory mediators in allergic rhinitis
    Medical condition: Allergic rhinitis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-000001-23 Sponsor Protocol Number: DroSpas-1 Start Date*: 2018-10-25
    Sponsor Name:Bionorica SE
    Full Title: A phase III, multi-centre, randomised, double-blind, placebo-controlled, parallel-group clinical trial to investigate the efficacy and safety of BX-1 for the symptomatic relief of spasticity in pat...
    Medical condition: Symptomatic relief of spasticity in patients with multiple sclerosis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029205 - Nervous system disorders 10029205 Nervous system disorders SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) CZ (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2007-004438-18 Sponsor Protocol Number: MeIn/06/NEB-DIA/001 Start Date*: 2008-04-08
    Sponsor Name:A. Menarini Farmaceutica Internazionale s.r.l.
    Full Title: Comparative effects of Nebivolol and Carvedilol on orthostatic hypotension in hypertensive patients with type 2 diabetes mellitus (DIANECA)
    Medical condition: Orthostatic hypotension in hypertensive patients with type 2 diabetes mellitus
    Disease: Version SOC Term Classification Code Term Level
    9.1 10031127 Orthostatic hypotension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) IE (Prematurely Ended) LV (Prematurely Ended) AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-000971-18 Sponsor Protocol Number: SynAct-CS003 Start Date*: 2020-05-28
    Sponsor Name:SynAct Pharma ApS
    Full Title: An exploratory, randomized, double-blind, multicenter, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, and efficacy of AP1189 daily doses versus placebo administered ...
    Medical condition: Idiopathic membranous nephropathy and severe proteinuria
    Disease: Version SOC Term Classification Code Term Level
    21.1 10038359 - Renal and urinary disorders 10027170 Membranous nephropathy LLT
    21.1 10038359 - Renal and urinary disorders 10029164 Nephrotic syndrome PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned) NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-004504-35 Sponsor Protocol Number: RF-2010-2311148 Start Date*: 2013-02-26
    Sponsor Name:IRCCS CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI
    Full Title: The use of Oxytocin as adjunctive therapy for the treatment of schizophrenia: a randomized, double blind trial
    Medical condition: Schizophrenia
    Disease: Version SOC Term Classification Code Term Level
    14.1 10037175 - Psychiatric disorders 10039628 Schizophrenia and other psychotic disorders HLGT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-010188-18 Sponsor Protocol Number: 26859 Start Date*: 2010-07-01
    Sponsor Name:Eli Lilly Nederland
    Full Title: Effectiveness of Transmural Collaborative care and Duloxetine for major depressive disorder and (sub)chronic pain: a randomized placebo-controlled Multi-Centre trial.
    Medical condition: Major depressive disorder (episode or recurrent), as principal DSM-IV diagnosis combined with (sub)chronic pain symptoms as defined bij score of >3 on BPI painlist for at least six weeks.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-000410-38 Sponsor Protocol Number: LP0066-1019 Start Date*: 2013-10-25
    Sponsor Name:LEO Pharma A/S
    Full Title: Topical Aprepitant in Prurigo Patients (iTAPP) An exploratory phase IIa trial with topically applied aprepitant in patients with prurigo
    Medical condition: Prurigo can present either with hyperkeratotic nodules as prurigo nodularis or without nodules as Prurigo simplex. The disease is characterised by intensely pruritic, lichenified, or excoriated pap...
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004858 10037084 Prurigo nodularis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2005-005638-10 Sponsor Protocol Number: SST-Pr-2-2005 Start Date*: 2007-02-12
    Sponsor Name:University of Münster
    Full Title: Evaluation of the antipruritic effect of Elidel (pimecrolimus) in non-atopic pruritic disease
    Medical condition: Prurigo nodularis
    Disease: Version SOC Term Classification Code Term Level
    8.1 10037084 Prurigo nodularis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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