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Clinical trials for Tolerability

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44339   clinical trials with a EudraCT protocol, of which   7369   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    14,030 result(s) found for: Tolerability. Displaying page 1 of 702.
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    EudraCT Number: 2009-014816-37 Sponsor Protocol Number: codice EUDRACT 2009-014816-37 Start Date*: 2009-10-27
    Sponsor Name:NAMED SRL
    Full Title: Open prospective, uncontrolled pilot study to assess the tolerability and efficacy of Lymdiaral injektopas (Pascoe-Named) in the treatment of pannicolopatia-edema-fibrosclerotic (PEFS) and venous...
    Medical condition: tolerability and efficacy of Lymdiaral Injektopas (Pascoe-Named)
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-006776-11 Sponsor Protocol Number: 07ct/am06perm Start Date*: 2008-02-20
    Sponsor Name:gepepharm GmbH
    Full Title: Investigation of the local tolerability of pedimitex Lösung 0.5% - a permethrin containing solution - in 100 patients with head lice infection of both gender
    Medical condition: The product is intended to be used by patients suffering from head lice infestation.
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-000718-13 Sponsor Protocol Number: BT–L-CsA–201–SCT Start Date*: 2019-12-17
    Sponsor Name:Zambon SpA
    Full Title: BOSTON-4: A Phase IIa Multi-Center, Randomized, Single-Blind Safety and Tolerability Study of inhaled Liposomal Cyclosporine A in Bronchiolitis Obliterans Syndrome Following Allogeneic Hematopoieti...
    Medical condition: Bronchiolitis Obliterans Syndrome in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) ES (Ongoing) FR (Completed)
    Trial results: View results
    EudraCT Number: 2009-012028-98 Sponsor Protocol Number: 071-007 Start Date*: Information not available in EudraCT
    Sponsor Name:GALENpharma GmbH
    Full Title: A placebo-controlled, multicentre, double-blinded, intra-individual comparison to gain evidence of the safety, tolerability and efficacy of Prednicarbat cream and ointment in patients with active a...
    Medical condition: active atopic dermatitis (according to IGA score 1 - 4)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10003639 Atopic dermatitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2011-000455-16 Sponsor Protocol Number: CYT/Heparin_01/11 Start Date*: 2011-05-05
    Sponsor Name:CYATHUS EXQUIRERE PharmaforschungsGmbH
    Full Title: Efficacy and local tolerability of topically applied heparin (Heparin 2,400 IU/ml Cutaneous Spray) on the suitability of newly constructed primary arteriovenous Fistulas in haemodialysed patients
    Medical condition: This placebo-controlled, randomized and double-blinded pilot study aims to confirm the previous study performed by Stuard et al. (2010) by proving clinically efficacy and local tolerability of topi...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2016-002092-10 Sponsor Protocol Number: EVE112-CT03-2016 Start Date*: 2016-09-10
    Sponsor Name:Evestra GmbH
    Full Title: Comparative reference-controlled investigation of bleeding pattern under treatment with a vaginal delivery system (EVE112) containing a fixed dose combination of etonogestrel and ethinylestradiol –...
    Medical condition: Safety, efficacy and tolerability investigations of a hormonal contraceptive in healthy females aged 18-40 years.
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004865 10073728 Hormonal contraception LLT
    Population Age: Adults Gender: Female
    Trial protocol: BG (Completed) PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-001177-93 Sponsor Protocol Number: SYL1001_II Start Date*: 2012-10-18
    Sponsor Name:Sylentis
    Full Title: PILOT TRIAL FOR ASSESSMENT TOLERABILITY AND EFFECT OF SYL1001 IN PATIENS WITH OCULAR PAIN
    Medical condition: PATIENTS WITH DIAGNOSIS OF OCULAR PAIN MILD TO MODERATE AND DRY EYE MILD TO MODERATE
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2006-003793-94 Sponsor Protocol Number: EFC5574 Start Date*: 2006-10-20
    Sponsor Name:sanofi-aventis recherche & développement
    Full Title: An Eight-Week, Multinational, Multicenter, Randomized, Double-blind, Placebo-controlled Study, with Escitalopram as an Active Control, to Evaluate the Efficacy, Safety and Tolerability of a Saredut...
    Medical condition: to Evaluate the Efficacy, Safety and Tolerability of a Saredutant 100 mg Dose Once Daily, in Elderly Patients with Major Depressive Disorder (MDD)
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) SE (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2005-000472-40 Sponsor Protocol Number: CN138-169 Start Date*: 2005-08-10
    Sponsor Name:Bristol-Myers Squibb International Corporation
    Full Title: A Comparative, Randomized, Open -Label, Multicenter Study on the Efficacy and Safety of Switch Treatment with Aripiprazole in Schizophrenic Out-patients who are Experiencing Insufficient Efficacy w...
    Medical condition: Schizophrenia
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed) HU (Completed) GB (Completed) AT (Completed) DE (Completed) CZ (Completed) BE (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2005-001539-31 Sponsor Protocol Number: FE999905 CS002 Start Date*: 2005-09-16
    Sponsor Name:Ferring Pharmaceuticals A/S
    Full Title: An Open-label, Multi-centre, Phase III Study of Local Tolerability of Zomacton 10 mg (Recombinant Somatropin) administered by ZomaJet Vision X
    Medical condition: Zomacton is indicated for the long term treatment of children who have growth failure due to inadequate secretion of growth hormone and for the long-term treatment of growth retardation due to Turn...
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: View results
    EudraCT Number: 2018-004016-22 Sponsor Protocol Number: LA61-0218 Start Date*: 2018-12-27
    Sponsor Name:ApoPharma Inc.
    Full Title: Safety and acceptability of deferiprone delayed release tablets in patients with systemic iron overload
    Medical condition: Systemic iron overload
    Disease: Version SOC Term Classification Code Term Level
    20.0 10027433 - Metabolism and nutrition disorders 10065973 Iron overload PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-003257-16 Sponsor Protocol Number: CitraFleet_H-2018 Start Date*: 2018-11-07
    Sponsor Name:Goodwill Pharma Kft.
    Full Title: Efficacy, Safety and Tolerability of CitraFleet, a New Bowel Cleansing Agent – a Prospective, Single-Center, Single-Group Phase IV Study
    Medical condition: Colonoscopy bowel preparation
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004848 10017963 Gastrointestinal and abdominal imaging procedures HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed)
    Trial results: View results
    EudraCT Number: 2014-003024-46 Sponsor Protocol Number: Repha_1412 Start Date*: 2014-09-19
    Sponsor Name:Repha GmbH
    Full Title: Efficacy, safety and tolerability of Angocin Anti-Infekt N versus Placebo for MRSA eradication
    Medical condition: MRSA colonisation
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10004017 Bacterial disease carrier PT
    20.0 10021881 - Infections and infestations 10068296 MRSA colonisation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-004422-16 Sponsor Protocol Number: EA08-3-998 Start Date*: 2009-01-28
    Sponsor Name:Engelhard Arzneimittel GmbH & Co. KG
    Full Title: Investigation of local tolerability and efficacy of Muxan - a new topical treatment containing chloramine-T in 3 concentrations in comparison to Zovirax® in patients with Herpes simplex type 1
    Medical condition: Acute herpes labialis episodes caused by Herpes simplex virus-1 (HSV-1).
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-001055-50 Sponsor Protocol Number: EP-001 Start Date*: 2016-08-08
    Sponsor Name:Empros Pharma AB
    Full Title: A, single center, controlled, multiple dose, randomized study during two weeks, investigating the effect of the test formulation on efficacy, safety and markers for appetite regulation, glucose and...
    Medical condition: Obesity and diabetes, type 2.
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2019-002325-30 Sponsor Protocol Number: VMP-03/2018 Start Date*: 2019-09-18
    Sponsor Name:Dr. August Wolff GmbH & Co. KG Arzneimittel
    Full Title: Prospective, open-label, monocenter, trial to investigate the efficacy and tolerability of Vagisan® a lactic acid containing vaginal suppository, in a panel of post-menopausal women suffering from...
    Medical condition: vulvovaginal atrophy
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004872 10047782 Vulvovaginal atrophy LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2011-001849-33 Sponsor Protocol Number: SYL040012_III Start Date*: 2012-04-09
    Sponsor Name:Sylentis S.A.U.
    Full Title: DOSE FINDING CLINICAL TRIAL WITH SYL040012 TO EVALUATE THE TOLERABILITY AND EFFECT ON INTRAOCULAR PRESSURE IN SUBJECTS WITH OCULAR HYPERTENSION OR OPEN-ANGLE GLAUCOMA
    Medical condition: Ocular Hypertension or Open-Angle Glaucoma
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022891 - Investigations 10022801 Intraocular pressure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: EE (Completed) ES (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2008-002795-96 Sponsor Protocol Number: CBFH772A2201 Start Date*: 2008-12-11
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A single center, phase I, partially blinded, placebo-controlled, first-in-man study to evaluate the safety, tolerability and Proof of Mechanism (PoM) of a single administration of BFH772 in healthy...
    Medical condition: Plaque psoriasis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10037153 Psoriasis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2012-003506-27 Sponsor Protocol Number: BILA-3312/PED Start Date*: 2013-01-25
    Sponsor Name:FAES FARMA, S.A.
    Full Title: A multicenter, double-blind, randomized, placebo-controlled, parallel group study to evaluate the safety and tolerability of 10 mg once daily bilastine in children from 2 to 11 years of age with e...
    Medical condition: Allergic Rhinoconjunctivitis and Chronic Urticaria
    Disease:
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: HU (Completed) ES (Ongoing) PT (Completed) PL (Completed) HR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-003545-41 Sponsor Protocol Number: D1344C00001 Start Date*: 2014-04-14
    Sponsor Name:AstraZeneca AB
    Full Title: A Randomised, Double-Blind Study to Assess the Efficacy of Selumetinib (AZD6244, Hyd-Sulfate) in Combination with Dacarbazine Compared with Placebo in Combination with Dacarbazine as First Systemic...
    Medical condition: Metastatic uveal melanoma
    Disease: Version SOC Term Classification Code Term Level
    18.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10025654 Malignant melanoma of sites other than skin PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) GB (Completed) CZ (Completed) DE (Completed) NL (Completed) FI (Completed) ES (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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