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Clinical trials for Valve replacement

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    93 result(s) found for: Valve replacement. Displaying page 1 of 5.
    1  2  3  4  5  Next»
    EudraCT Number: 2016-002291-27 Sponsor Protocol Number: RIVAR-CTP-01 Start Date*: 2016-11-07
    Sponsor Name:Aalborg University Hospital
    Full Title: Randomized trial of aspirin versus rivaroxaban after replacement of the aortic valve with a biological valve prosthesis
    Medical condition: Aortic valve stenosis
    Disease: Version SOC Term Classification Code Term Level
    19.0 10007541 - Cardiac disorders 10002918 Aortic valve stenosis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-000077-57 Sponsor Protocol Number: 2021-THORANE-Pharma-001 Start Date*: 2022-06-25
    Sponsor Name:Rigshospitalet
    Full Title: Methadone versus fentanil and oxycodone for post-operative pain reduction in patients undergoing coronary artery bypass grafting and/or valve surgery – a placebo-controlled, double-blind, randomiz...
    Medical condition: We investigate the efficacy of methadonehydrochloride for reducing optoperative opioid requirements, pain scores and improving quality of recovery in patients undergoing heart surgery (i.e. corona...
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10008937 Chronic ischemic heart disease, unspecified LLT
    20.0 10007541 - Cardiac disorders 10002911 Aortic valvular disorders HLT
    20.0 10007541 - Cardiac disorders 10061532 Mitral valve disease PT
    20.0 10042613 - Surgical and medical procedures 10062202 Mitral valve repair PT
    20.0 10042613 - Surgical and medical procedures 10027732 Mitral valve replacement PT
    20.0 10042613 - Surgical and medical procedures 10002916 Aortic valve replacement PT
    20.0 10042613 - Surgical and medical procedures 10061652 Aortic valve repair PT
    21.1 10042613 - Surgical and medical procedures 10011077 Coronary artery bypass PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2018-000017-20 Sponsor Protocol Number: ASS-Metamizol-DDI Start Date*: 2018-07-17
    Sponsor Name:Universitäts-Herzzentrum Freiburg • Bad Krozingen
    Full Title: Antiplatelet effect of acetylsalicylic acid in patients after cardiac surgery: Impact of dipyrone (metamizole)
    Medical condition: Antithrombotic therapy after surgical replacement of stenotic heart valve by a bioprosthesis or mitral valve repair
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-001777-33 Sponsor Protocol Number: EARTH-TAVR01 Start Date*: 2016-09-01
    Sponsor Name:Charité Universitätsmedizin Berlin
    Full Title: EVALUATION OF CEREBRAL THROMBOEMBOLISM AFTER TAVR
    Medical condition: Patients with severe aortic stenosis that require Transcatheter aortic valve replacement are at risk for stroke. This study is to evaluate the occurrence and extent of cerebral embolization (total...
    Disease: Version SOC Term Classification Code Term Level
    19.0 10042613 - Surgical and medical procedures 10002916 Aortic valve replacement PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2012-000632-26 Sponsor Protocol Number: TMC-BIV-11-02 Start Date*: 2013-03-22
    Sponsor Name:The Medicines Company
    Full Title: Effect of Bivalirudin on Aortic Valve Intervention Outcomes 2/3
    Medical condition: Patients undergoing transcatheter aortic valve replacement (TAVR) procedures performed via the transfemoral approach.
    Disease: Version SOC Term Classification Code Term Level
    17.0 10042613 - Surgical and medical procedures 10002916 Aortic valve replacement PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed) NL (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2015-001975-30 Sponsor Protocol Number: BAY59-7939/17938 Start Date*: 2016-01-12
    Sponsor Name:Bayer AG
    Full Title: Global multicenter, open-label, randomized, event-driven, active-controlled study comparing a rivAroxaban-based antithrombotic strategy to an antipLatelet-based strategy after transcatheter aortIc ...
    Medical condition: Patients with severe aortic stenosis that require Transcatheter aortic valve replacement are at risk of thrombus formation. Rivaroxaban (oral-anticoagulant) may reduce this risk, without increasing...
    Disease: Version SOC Term Classification Code Term Level
    19.0 10042613 - Surgical and medical procedures 10002916 Aortic valve replacement PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) ES (Prematurely Ended) BE (Prematurely Ended) NO (Prematurely Ended) AT (Prematurely Ended) DK (Prematurely Ended) SE (Prematurely Ended) NL (Prematurely Ended) GB (Prematurely Ended) FR (Prematurely Ended) CZ (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2008-001672-70 Sponsor Protocol Number: 17.3.2008 Start Date*: 2008-05-30
    Sponsor Name:Heli Leppikangas
    Full Title: The effects of levosimendan on haemodynamics in patients undergoing elective aortic valve replacement (AVR) together with coronary artery bypass grafting (CABG) surgry
    Medical condition: Aortic valve dysfunction and coronary artery disease
    Disease: Version SOC Term Classification Code Term Level
    9.1 10011078 Coronary artery disease LLT
    9.1 10002916 Aortic valve replacement LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: View results
    EudraCT Number: 2005-001930-34 Sponsor Protocol Number: 170674-3479 Start Date*: 2005-11-25
    Sponsor Name:Department of Cardiology, Odense University Hospital
    Full Title: Left ventricular reverse remodelling after aortic valve replacement in severe valvular aortic stenosis - effect of blockade of the angiotensin-II receptor
    Medical condition: Patients with severe aortic valve stenosis treated with Aortic Valve Replacement (AVR)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-000608-40 Sponsor Protocol Number: No-DAPT-TAVI Start Date*: 2018-07-06
    Sponsor Name:AOU DI BOLOGNA POLICLINICO S.ORSOLA-MALPIGHI
    Full Title: Aspirin versus Aspirin plus Clopidogrel in Patients Undergoing Transcatheter Aortic Valve Replacement: a Randomized Multicenter Study
    Medical condition: valvular aortic stenosis submitted to TAVI
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10002918 Aortic valve stenosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-005630-21 Sponsor Protocol Number: D5130C00173 Start Date*: 2016-06-30
    Sponsor Name:National and Kapodistrian University of Athens
    Full Title: A Prospective, Multicentre, Randomized, Open Label, Blinded Endpoint, Phase 3 Trial to Assess the Safety and Efficacy of Prophylactic TicagrelOr with Acetylsalicylic Acid versus CLopidogrel with Ac...
    Medical condition: Preventing cerebrovascular embolic events during the TAVI procedure
    Disease: Version SOC Term Classification Code Term Level
    19.0 10007541 - Cardiac disorders 10002918 Aortic valve stenosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-002799-18 Sponsor Protocol Number: ICICOR-2017-01 Start Date*: 2017-12-27
    Sponsor Name:José Alberto San Román Calvar
    Full Title: Renin-angiotensin System Blockade Benefits in Clinical Evolution and Ventricular Remodeling After Transcatheter Aortic Valve Implantation (RASTAVI)
    Medical condition: Severe aortic stenosis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10047065 - Vascular disorders 10002906 Aortic stenosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-001425-26 Sponsor Protocol Number: REDOX19032019 Start Date*: 2019-07-04
    Sponsor Name:Thoraxcentrum Erasmus MC
    Full Title: Rotterdam Edoxaban Leaflet Evaluation in Patients after Transcatheter Aortic Valve Implantation
    Medical condition: aortic stenosis
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-005296-18 Sponsor Protocol Number: BI8021_5101 Start Date*: 2007-08-27
    Sponsor Name:Heinrich-Heine-Universität Duesseldorf
    Full Title: Einsatz von Haemateâ HS bei Patienten mit schweren Blutungskomplikationen bei Herzklappenersatz wegen Aortenstenose HAVAS-Studie (Haemate HS in patients with severe bleeding undergoing valve repl...
    Medical condition: Intraoperative Blutungsneigung während des Aortenklappenersatzes bei Patienten mit isolierter valvulärer Aortenstenose oder kombiniertem Aortenvitium mit führender Stenose Klassifikationscode ICD1...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10009730 Coagulation defects, other and unspecified LLT
    9.1 10002918 Aortic valve stenosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-005784-24 Sponsor Protocol Number: MEIXO-VALV-001 Start Date*: 2012-06-14
    Sponsor Name:Andres Iñiguez Romo
    Full Title: Dual antiplatelet therapy versus oral anticoagulation for a short time to prevent cerebral embolism after percutaneous aortic valve implantation. Multicenter randomized clinical trial.
    Medical condition: Evaluate the efficacy of dual antiplatelet therapy versus oral anticoagulation for primary prevention of cerebral thromboembolism at three months after percutaneous aortic valve implantation (TAVI).
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-003125-28 Sponsor Protocol Number: POPTAV001 Start Date*: 2013-12-24
    Sponsor Name:St. Antonius Hospital
    Full Title: Antiplatelet therapy for patients undergoing transcatheter aortic valve implantation
    Medical condition: Aortic stenosis for which a transcatheter aortic valve implantation (TAVI) is performed.
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: NL (Completed) BE (Completed) GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2021-004271-14 Sponsor Protocol Number: DAPAS Start Date*: 2021-12-06
    Sponsor Name:Aarhus University Hospital, department of Cardiology
    Full Title: Effect of Dapagliflozin on myocardial and renal function following aortic valve stenosis intervention
    Medical condition: Patients with aortic stenosis undergoing trans catheter aortic valve replacement.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10058186 Aortic valve stenosis and insufficiency LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2007-001685-33 Sponsor Protocol Number: 07-002 Start Date*: 2007-12-28
    Sponsor Name:RWTH Aachen University
    Full Title: Prospective Comparison of Phenpocoumon (Marcumar) and Acetylsalicylic Acid (ASS) as to Progression of the Valvular and Coronary Calcification.
    Medical condition: Treatment with oral anti-coagulants prevents thromboembolic complications e.g at atrial fibrillation or artificial heart valves. Primary objective of the study is the prospective comparison of the ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-006324-62 Sponsor Protocol Number: NN1810-3540 Start Date*: 2009-04-16
    Sponsor Name:Novo Nordisk A/S
    Full Title: A Multi-Centre, Randomised, Double-Blind, Placebo Controlled Trial on Efficacy and Safety of FXIII Replenishment with two different Doses of Recombinant Factor XIII following Cardiopulmonary Bypass...
    Medical condition: Aquired FXIII deficiency following cardiopulmonary bypass surgery (CABG (coronary atery bypass grafting) or CABG plus single heart valve replacement/repairs or planned replacement/repair of a singl...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10063919 Bypass surgery LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Prematurely Ended) DK (Completed) ES (Completed) GB (Completed) IT (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2010-023788-16 Sponsor Protocol Number: P-Monofer-CABG-01 Start Date*: 2011-03-22
    Sponsor Name:Pharmacosmos A/S
    Full Title: A Randomized, Prospective, Double-Blind, Comparative Placebo-Controlled Study of Intravenous Iron Isomaltoside 1000 (Monofer®) Administered by Infusions to Non-anemic Patients Undergoing Elective o...
    Medical condition: Non-anemic Patients Undergoing Elective or Sub-Acute CABG, Valve Replacement or a Combination thereof
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004863 10054312 Anemia postoperative LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2005-000464-95 Sponsor Protocol Number: IPC-05-2004 Start Date*: 2005-10-14
    Sponsor Name:Inotek Pharmaceuticals Corporation
    Full Title: A phase II randomized, double-blind, placebo-controlled, multi-center study to evaluate tolerability, safety pharmacokinetics and efficacy of intravenous INO-1001 in high-risk subjects undergoing c...
    Medical condition: INO-1001 is being developed for the treatment of high-risk subjects undergoing cardiopulmonary bypass (CPB) for coronary revascularization and/or valve surgery.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Prematurely Ended)
    Trial results: (No results available)
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