interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development
EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
Clinical Trials Information System (CTIS).
The EU Clinical Trials Register currently displays
44341
clinical trials with a EudraCT protocol, of which
7370
are clinical trials conducted with subjects less than 18 years old.
The register also displays information on
18700
older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).
Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see
Frequently Asked Questions ).
Full Title: A randomized, double-blind, multi-centre, placebo controlled phase II clinical study to evaluate the efficacy, tolerance and safety of an aqueous gel containing 2% (w/w) of cidofovir, directly appl...
Medical condition: High Grade of Cervical Intraepithelial Neoplasia (CIN).
Disease:
Version
SOC Term
Classification Code
Term
Level
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: A single arm, multicenter, international trial of tisotumab vedotin (HuMax®-TF-ADC) in previously treated, recurrent or metastatic cervical cancer
Medical condition: recurrent or metastatic cervical cancer
Disease:
Version
SOC Term
Classification Code
Term
Level
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: A Phase 1b/2 Open-Label Trial of Tisotumab Vedotin (HuMax®-TF-ADC) Monotherapy and in Combination with Other Agents in Subjects with Recurrent or Stage IVB Cervical Cancer
Medical condition: recurrent or stage IVB cervical cancer
Disease:
Version
SOC Term
Classification Code
Term
Level
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10008342
Cervix carcinoma
PT
Population Age: Adults, Elderly
Gender: Female
Trial protocol:DK(Completed)NL(Trial now transitioned)GB(GB - no longer in EU/EEA)CZ(Trial now transitioned)BE(Trial now transitioned)IT(Trial now transitioned)ES(Ongoing)
Trial results:(No results available)
EudraCT Number: 2019-001655-39
Sponsor Protocol Number: GCT1015-07
Start Date*: 2021-08-17
Sponsor Name:Genmab A/S
Full Title: A Randomized, Open-Label, Phase 3 Trial of Tisotumab Vedotin Versus Investigator’s Choice Chemotherapy in Second- or Third-Line Recurrent or Metastatic Cervical Cancer
Medical condition: Second- or Third-Line Recurrent or Metastatic Cervical Cancer
Disease:
Version
SOC Term
Classification Code
Term
Level
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10008342
Cervix carcinoma
PT
Population Age: Adults
Gender: Male, Female
Trial protocol:ES(Ongoing)NO(Trial now transitioned)SE(Trial now transitioned)FI(Trial now transitioned)BE(Trial now transitioned)AT(Trial now transitioned)DK(Completed)NL(Trial now transitioned)PL(Trial now transitioned)IT(Trial now transitioned)DE(Trial now transitioned)
Trial results:(No results available)
EudraCT Number: 2006-000236-27
Sponsor Protocol Number: VEG105281
Start Date*: 2006-12-15
Sponsor Name:GlaxoSmithKline Research & Development Limited
Full Title: A Phase II, Open-Label, Randomized, Multicenter Trial of Pazopanib (GW786034) in Combination with Lapatinib (GW572016) Compared to Pazopanib Montherapy and Lapatinib Monotherapy in Subjects with FI...
Medical condition: Patients with FIGO Stage IVB or recurrent or persistent cervical cancer with zero or one prior chemotherapy regimen for advanced/recurrent disease
Sponsor Name:FONDAZIONE IRCCS "ISTITUTO NAZIONALE DEI TUMORI"
Full Title: Phase II Study of Neoadjuvant Chemotherapy With Dose-Dense Paclitaxel In Association With Carboplatin followed by Radical Surgery for Locally Advanced Cervical Cancer (FIGO stage IB2- IIIA) Patients.
Medical condition: Locally Advanced Cervical Cancer
Disease:
Version
SOC Term
Classification Code
Term
Level
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: An international randomised trial of radical surgery followed by adjuvant (chemo)radiation versus no further treatment in patients with early-stage, intermediate-risk cervical cancer patients
Medical condition: early-stage, intermediate-risk cervical cancer patients
Disease:
Version
SOC Term
Classification Code
Term
Level
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
1. NHS Greater Glasgow and Clyde 2. University of Glasgow
Full Title: CIRCCa(Cediranib In Recurrent Cervical Cancer)
A Randomised Double Blind Phase II trial of carboplatin-paclitaxel plus cediranib versus carboplatin-paclitaxel plus placebo in metastatic/recurrent c...
Medical condition: Metastatic/ Recurrent carinoma of cervix
Disease:
Version
SOC Term
Classification Code
Term
Level
13.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10041848
Squamous cell carcinoma of the cervix
PT
13.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: A Phase IIIb observer-blind, randomized, multicentre primary immunization study to evaluate the immunogenicity and safety of GSK Biologicals’ HPV-16/18 L1 VLP AS04 vaccine and Merck's Quadrivalent ...
Medical condition: Cervarix is indicated in females from 10 years of age onwards for the prevention of persistent infection, premalignant cervical lesions and cervical cancer (squamous-cell carcinoma and adenocarcino...
Disease:
Version
SOC Term
Classification Code
Term
Level
14.0
10021881 - Infections and infestations
10033723
Papilloma viral infection NOS
LLT
14.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10008229
Cervical cancer
LLT
14.0
10038604 - Reproductive system and breast disorders
Full Title: BGOG-OV5:Phase II study of weekly Paclitaxel/Carboplatin in combination with prophylactic G-CSF in the treatment of gynaecological cancers.
Medical condition: recurrence of ovarian, fallopian tube or peritoneal carcinoma, cervical carcinoma or endometrial carcinoma
Disease:
Version
SOC Term
Classification Code
Term
Level
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10008231
Cervical cancer recurrent
LLT
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10014736
Endometrial cancer recurrent
PT
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: A Phase 2, Multicenter Study to Evaluate the Efficacy and Safety Using Autologous Tumor Infiltrating Lymphocytes (LN-145) in Patients with Recurrent, Metastatic or Persistent Cervical Carcinoma
Medical condition: Recurrent, metastatic, or persistent Cervical Carcinoma
Disease:
Version
SOC Term
Classification Code
Term
Level
21.1
100000004864
10008229
Cervical cancer
LLT
Population Age: Adults, Elderly
Gender: Female
Trial protocol:GB(GB - no longer in EU/EEA)DE(Completed)NL(Prematurely Ended)ES(Ongoing)FR(Trial now transitioned)IT(Trial now transitioned)
Trial results:(No results available)
EudraCT Number: 2021-000179-36
Sponsor Protocol Number: MS200647_0054
Start Date*: 2021-10-15
Sponsor Name:Merck KGaA
Full Title: An Open-label, Multicenter Follow-up Study to Collect Long-term Data on Participants from Multiple Bintrafusp alfa (M7824) Clinical Studies
Medical condition: Non-small cell lung cancer (NSCLC), biliary tract cancer (BTC), cervical cancer, and triple-negative breast cancer (TNBC)
Disease:
Version
SOC Term
Classification Code
Term
Level
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10061873
Non-small cell lung cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10073077
Intrahepatic cholangiocarcinoma
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10074879
Extrahepatic cholangiocarcinoma
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10017614
Gallbladder cancer
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10008229
Cervical cancer
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: A phase I/IIa open label study to assess the safety, tolerability, immunogenicity and clinical activity of EI-201 mRNA immunotherapy given intravenously in subjects with recurrent or metastatic HPV...
Medical condition: Incurable recurrent or metastatic (R/M) HPV16-positive (HPV16+) tumors (e.g. oropharyngeal cancer, cervical, vulvar, vaginal, anal, penile cancer, etc.)
Disease:
Version
SOC Term
Classification Code
Term
Level
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10067821
Head and neck cancer
PT
21.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10008229
Cervical cancer
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10047777
Vulvar cancer
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10061424
Anal cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10046885
Vaginal cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: Phase II and Pharmacological Study with Wee-1 Inhibitor AZD1775 Combined with Carboplatin in Patients with p53 Mutated Epithelial Ovarian Cancer
that Show Early Relapse (< 3 months) or Progressio...
Medical condition: p53 mutated epithelial ovarian cancer (after first line standard therapy), non-small cell lung cancer, small cell lung cancer, cervical and endometrial cancer
Disease:
Version
SOC Term
Classification Code
Term
Level
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10014733
Endometrial cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10041067
Small cell lung cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10061873
Non-small cell lung cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10055094
Cervix cancer metastatic
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Full Title: A multi-center, open-label trial investigating the efficacy and safety of continued treatment with tisotumab vedotin in patients with solid tumors known to express tissue factor
Medical condition: Cancer of the ovary, cervix, endometrium, bladder, prostate (castrationresistant prostate cancer [CRPC]), esophagus, lung (non-small cell lung cancer [NSCLC]), and Squamous cell carcinoma of the he...
Disease:
Version
SOC Term
Classification Code
Term
Level
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10060862
Prostate cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10014742
Endometrial neoplasms malignant
HLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10008342
Cervix carcinoma
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10023774
Large cell lung cancer
PT
20.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10062878
Gastrooesophageal cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10005003
Bladder cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10029104
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
SOC
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10067821
Head and neck cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Sponsor Name:Bristol-Myers Squibb International Corporation
Full Title: Non-Comparative, Open-Label, Multiple Cohort, Phase 1/2 Study of Nivolumab and Nivolumab plus Ipilimumab in Subjects with Virus-Positive and Virus-Negative Solid Tumors
Medical condition: Virus-associated tumors
Disease:
Version
SOC Term
Classification Code
Term
Level
20.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10017758
Gastric cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10060121
Squamous cell carcinoma of head and neck
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10008229
Cervical cancer
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10046885
Vaginal cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10061306
Nasopharyngeal cancer
PT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10047777
Vulvar cancer
LLT
20.0
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10064025
Merkel cell carcinoma
LLT
Population Age: Adults, Elderly
Gender: Male, Female
Trial protocol:NL(Completed)DE(Completed)BE(Completed)GB(GB - no longer in EU/EEA)ES(Completed)
Full Title: Prospektive Studie zur potentiellen Protektion der Ovarfunktion von Frauen mit gynäkologischen Malignomen unter Chemotherapie mittels GnRH-Analoga-Applikation
Medical condition: Primärdiagnose eines histologisch gesicherten gynäkologischen Malignoms: Zervixkarzinom, rezeptornegatives Mammakarzinom, Ovarialkarzinom, Vaginalkarzinom, Vulvakarzinom mit Ovarerhalt und fehlende...
Disease:
Version
SOC Term
Classification Code
Term
Level
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10008342
Cervix carcinoma
PT
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10046885
Vaginal cancer
PT
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10047777
Vulvar cancer
LLT
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
10006187
Breast cancer
PT
14.1
10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
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