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Clinical trials for Daptomycin

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    36 result(s) found for: Daptomycin. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2015-000125-36 Sponsor Protocol Number: Dapto Start Date*: 2016-08-02
    Sponsor Name:University Hospital Tübingen
    Full Title: Daptomycin concentration in drainage fluid and blood samples of ICU patients
    Medical condition: Intensive Care Patients after Surgery treated with Daptomycin and wound draingae
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2013-000586-37 Sponsor Protocol Number: BACSARM Start Date*: 2013-09-23
    Sponsor Name:Miquel Pujol Rojo (Infectious Diseases Service-Hospital Universitari de Bellvitge-IDIBELL)
    Full Title: Randomized multicenter study to assess efficacy of Daptomycin plus Fosfomycin versus Daptomycin monotherapy for treatment of methicillin resistant Staphylococcus aureus bacteremia in hospitalized p...
    Medical condition: Methicillin resistant Staphylococcus aureus bacteremia, complicated or uncomplicated
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-002781-23 Sponsor Protocol Number: DAP-PEDS-07-02 Start Date*: 2015-06-29
    Sponsor Name:Cubist Pharmaceuticals, Inc
    Full Title: An Evaluation of the Pharmacokinetic Profile and Safety of a Single Dose of Daptomycin in Pediatric Subjects Aged Two to Six Years Who are Concurrently Receiving Standard Antibiotic Therapy for Pro...
    Medical condition: Gram-positive Infection
    Disease:
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2007-007640-10 Sponsor Protocol Number: J&P002/2007 Start Date*: 2009-01-28
    Sponsor Name:PD Dr. med. K-H. Konz
    Full Title: Tissue pharmacokinetics of daptomycin measured by in vivo microdialysis in patients with diabetic foot infection
    Medical condition: A group of adult male or female patients with documented diabetes and bacterial soft tissue infection of the foot who must be subjected to undergo intravenous antimicrobial therapy with broad-spect...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-006949-75 Sponsor Protocol Number: J&P005/2008 Start Date*: 2009-08-13
    Sponsor Name:Medical University Graz, Department for Plastic Surgery
    Full Title: Tissue pharmacokinetics of daptomycin measured by in vivo microdialysis in patients with diabetic foot infection
    Medical condition: A group of adult male or female patients with documented diabetes and bacterial soft tissue infection of the foot who must be subjected to undergo intravenous antimicrobial therapy with broad spect...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2009-016092-30 Sponsor Protocol Number: V1.0 Start Date*: 2010-01-21
    Sponsor Name:Medizinische Universität Wien, Univ.Klinik f.Innere Medizin I,Abt. f. Infektionen u.Tropenmedizin
    Full Title: THE PHARMACOKINETICS OF DAPTOMYCIN DURING CONTINUOUS VENOVENOUS HEMOFILTRATION
    Medical condition: pharmacokinetics of Daptomycin during CVVHF(intensive care patients continuous venovenous haemodiafiltration) in critically ill patients.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2007-005399-15 Sponsor Protocol Number: CEFFOS7 Start Date*: 2010-03-10
    Sponsor Name:Medizinische Universität Graz - Abteilung für Thorax- und Hyperbare Chirurgie
    Full Title: Penetration of Cubicin® and Fosfomycin® into skeletal muscle and subcutaneous adipose tissue of necrotizing soft tissue infections, measured by in-vivo microdialysis
    Medical condition: A group of adult male or female patients with documented necrotizing soft tissue infection who must be subjected to undergo intravenous antimicrobial therapy with broad spectrum antibiotics.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-001349-40 Sponsor Protocol Number: DAP002 Start Date*: 2005-07-31
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A Multicentre, Randomised, Assessor-Blind Study to Evaluate Efficacy and Safety of Daptomycin versus Vancomycin or Teicoplanin for Treatment of Complicated Skin and Soft Tissue Infections (cSSTI)
    Medical condition: Complicated Skin and Soft Tissue Infections (cSSTI)
    Disease: Version SOC Term Classification Code Term Level
    8.1 10040786 Skin structures and soft tissue infections HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) ES (Completed) DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2017-002888-18 Sponsor Protocol Number: CHAVANET-PHRC-2016 Start Date*: 2018-01-16
    Sponsor Name:CHU Dijon Bourgogne
    Full Title: Adjunction of daptomycin for the treatment of pneumococcal meningitis AddaMAP study
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10027253 Meningitis pneumococcal PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-002779-64 Sponsor Protocol Number: DAP-PEDS-09-01 Start Date*: 2015-06-29
    Sponsor Name:Cubist Pharmaceuticals, Inc.
    Full Title: An Evaluation of the Pharmacokinetic Profile and Safety of a Single Dose of Daptomycin in Pediatric Subjects Aged 3 Months to Twenty-Four Months Who Are Concurrently Receiving Standard Antibiotic T...
    Medical condition: Gram Positive Bacterial Infection
    Disease:
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2020-001576-15 Sponsor Protocol Number: MK-3009-029 Start Date*: 2020-05-28
    Sponsor Name:Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
    Full Title: A Phase II Open-Label, Single-arm Clinical Trial to Study the Safety, Efficacy and Pharmacokinetics of MK-3009 (Daptomycin) in Japanese Pediatric Participants Aged 1 to 17 Years with Complicated Sk...
    Medical condition: Complicated Skin and Soft Tissue Infections or Bacteremia caused by Gram-positive cocci
    Disease: Version SOC Term Classification Code Term Level
    20.1 10021881 - Infections and infestations 10060945 Bacterial infection PT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2013-000864-28 Sponsor Protocol Number: DAP-PEDOST-11-03 Start Date*: 2014-01-02
    Sponsor Name:Cubist Pharmaceuticals, LLC
    Full Title: A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogeno...
    Medical condition: Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004862 10009081 Chronic osteomyelitis LLT
    19.1 100000004862 10046076 Unspecified osteomyelitis LLT
    19.1 100000004862 10009091 Chronic osteomyelitis, site unspecified LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DE (Completed) HU (Completed) IT (Completed) ES (Completed) GR (Completed) LV (Completed) GB (Completed) EE (Completed) BG (Completed) FR (Completed) SI (Completed) Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2012-003447-29 Sponsor Protocol Number: DAP-PEDBAC-11-02 Start Date*: 2013-06-11
    Sponsor Name:Cubist Pharmaceuticals, Inc.
    Full Title: A COMPARATIVE EVALUATION OF THE SAFETY AND EFFICACY OF DAPTOMYCIN VERSUS STANDARD OF CARE IN PEDIATRIC SUBJECTS TWO - SEVENTEEN YEARS OF AGE WITH BACTEREMIA CAUSED BY STAPHYLOCOCCUS AUREUS.
    Medical condition: Bacteremia caused by Staphylococcus Aureus.
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004862 10054637 Staphylococcal bacteremia LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IT (Completed) ES (Completed) HU (Completed) GR (Completed) Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2006-005453-30 Sponsor Protocol Number: DAP-OST-06-02 Start Date*: 2007-09-11
    Sponsor Name:Cubist Pharmaceuticals, Inc.
    Full Title: A Phase 2 Randomized Study Investigating the Safety, Efficacy and Pharmacokinetics of Daptomycin 6 mg/kg and 8 mg/kg Versus Comparator in the Treatment of Subjects Undergoing Surgical Standard of ...
    Medical condition: Treatment of subjects undergoing surgical standard of care for osteomyelitis associated with an infected prosthetic hip or knee joint caused by methicillin-resistant Staphylococcus Aureus and/or co...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10064250 Staphylococcal osteomyelitis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-017704-86 Sponsor Protocol Number: Dapto-Spondi-09 Start Date*: 2010-03-15
    Sponsor Name:OSPEDALE POLICLINICO S. MATTEO
    Full Title: Phase II clinical trial for the Staph. Aureus spondylodiscitis treatmen with daptomycin
    Medical condition: S. Aureus spondylodiscitis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10062691 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-022348-18 Sponsor Protocol Number: MCBC134ADE02T Start Date*: 2010-11-08
    Sponsor Name:Heart- and Diabetescenter NRW
    Full Title: Application of Daptomycin in MRSA infected diabetic foot in comparison to vancomycin treatment
    Medical condition: Patients eligible for this study suffer from diabetic foot infections.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-004990-24 Sponsor Protocol Number: ZKS000529 Start Date*: 2008-05-05
    Sponsor Name:University Medical Center Freiburg
    Full Title: Comparison of the concentrations of the antibiotic compound Daptomycin in serum, cartilage-, muscle and subcutaneous tissue after a preoperative intravenous administration (Klinische Studie zum ...
    Medical condition: Elective orthopedic surgery
    Disease: Version SOC Term Classification Code Term Level
    9.1 10042609 Surgery PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-001699-43 Sponsor Protocol Number: BPR-CS-009 Start Date*: 2018-12-13
    Sponsor Name:Basilea Pharmaceutica International Ltd
    Full Title: A randomized, double-blind, multi-center study to establish the efficacy and safety of ceftobiprole medocaril compared to daptomycin in the treatment of Staphylococcus aureus bacteremia, including ...
    Medical condition: Complicated staphylococcus aureus bacteremia (cSAB)
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004862 10058887 Staphylococcus aureus bacteremia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) HU (Completed) BG (Completed) ES (Completed) IT (Completed) GR (Completed) PT (Completed)
    Trial results: View results
    EudraCT Number: 2009-014391-22 Sponsor Protocol Number: CCBC134A2404 Start Date*: Information not available in EudraCT
    Sponsor Name:Novartis Pharma AG
    Full Title: An open label, multi-center, randomized, comparative Phase IIIb study to compare efficacy and safety of intravenous (i.v.) daptomycin with that of Semi-synthetic Penicillins (SSPs) or vancomycin in...
    Medical condition: complicated skin and soft tissue infections.
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: DE (Completed) IT (Completed) ES (Completed) AT (Completed)
    Trial results: View results
    EudraCT Number: 2015-002778-19 Sponsor Protocol Number: DAP-PEDS-07-03 Start Date*: 2015-06-29
    Sponsor Name:Cubist Pharmaceuticals, Inc.
    Full Title: An Evaluation of the Safety, Efficacy and Pharmacokinetics of Daptomycin in Pediatric Subjects Aged One to Seventeen Years With Complicated Skin and Skin Structure Infections Caused by Gram-Positiv...
    Medical condition: Complicated skin and skin structure infections (cSSSI) caused by Gram-positive pathogens
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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