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Clinical trials for NMDA receptor

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    22 result(s) found for: NMDA receptor. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2022-003279-41 Sponsor Protocol Number: PSY-NIL-0013 Start Date*: 2023-03-31
    Sponsor Name:Medical University of Vienna, University Department of Psychiatry and Psychotherapy
    Full Title: Investigating N-methyl-d-aspartate (NMDA) receptor alterations in major depressive disorder by brain PET
    Medical condition: Major Depression
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2022-003266-21 Sponsor Protocol Number: PSY-NIL-0012 Start Date*: 2023-03-31
    Sponsor Name:Medical University of Vienna
    Full Title: Acute effects of ketamine on the glutamatergic NMDA receptor quantified by PET and the radioligand (R)-[11C]-Me-NB1
    Medical condition: Acute effects of ketamine
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2018-002637-37 Sponsor Protocol Number: NL66693.058.18 Start Date*: 2020-06-29
    Sponsor Name:Leiden University
    Full Title: Manipulating NMDA-dependent learning to alter nocebo effects: A pharmacological fMRI study on pain and itch.
    Medical condition: Nocebo effects on pain and itch
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-000986-40 Sponsor Protocol Number: EVT 101/1002 Start Date*: 2007-08-07
    Sponsor Name:Evotec NeurosciencesGmbH
    Full Title: A double blind, placebo controlled study to investigate the role of NMDA receptor NR2B subunit selective antagonism on cognitive functions and neurophysiology in healthy subjects as measured with MRI
    Medical condition: Investigation of cognitive function and neurophysiology.
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2005-004498-31 Sponsor Protocol Number: SC05-02 Start Date*: 2005-10-05
    Sponsor Name:FONDAZIONE SANTA LUCIA
    Full Title: Behaviour and cognition in Alzheimer s disease patients treated with the NMDA receptor antagonist memantine collelation with the apoptotic mechanisms.
    Medical condition: Treatment of patients with Alzheimer s Disease
    Disease: Version SOC Term Classification Code Term Level
    6.1 10009843 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-012658-19 Sponsor Protocol Number: Protocol_KET-MET_2009 Start Date*: 2009-08-27
    Sponsor Name:Leiden University Medical Center
    Full Title:
    Medical condition: Acute pain to be tested in healthy volunteers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-005239-15 Sponsor Protocol Number: MISO Start Date*: 2016-08-12
    Sponsor Name:Charité - Universitätsmedizin Berlin
    Full Title: Effects of mineralocorticoid receptor stimulation on cognitive bias and social cognition in patients with major depression and healthy controls: what’s the role of NMDA receptors?
    Medical condition: depressed patients and healthy control subjects
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2010-024543-33 Sponsor Protocol Number: P64 Start Date*: 2011-04-14
    Sponsor Name:Maastricht University
    Full Title: Can memantine prevent memory impairment induced by MDMA in humans
    Medical condition: none
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-005538-59 Sponsor Protocol Number: 22-09-2008 Start Date*: 2009-02-18
    Sponsor Name:ZonMw
    Full Title: Impulsivity, a risk factor in relapse to substance use disorder: investigating neural substrates before and after pharmacological challenges
    Medical condition: Alcohol dependence Cocaine dependence
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-001541-24 Sponsor Protocol Number: NeuroIPT-1 Start Date*: 2016-03-07
    Sponsor Name:University Medical Center Freiburg
    Full Title: Neuroenhancement of Interpersonal Psychotherapy in Major Depression
    Medical condition: Major Depression (ICD-10; F32.2/F33.2)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-002667-42 Sponsor Protocol Number: ABR53999 Start Date*: 2015-09-09
    Sponsor Name:AMC
    Full Title: Sedation with propofol TCI during ERCP: Is the combination with esketamine more effective and safer than with alfentanil (SPEKA): A randomized controlled multicentre trial
    Medical condition: Patients undergoing ERCPs under propofol sedation combined with ketamine or alfentanil given by trained anesthesia nurse.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-001496-21 Sponsor Protocol Number: LOC-2013 Start Date*: 2013-06-18
    Sponsor Name:Harry Scheinin
    Full Title: The Neural Mechanisms of Anesthesia and Human Consciousness
    Medical condition: No medical condition or disease involved. The study subjects are healthy volunteers.
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-004982-10 Sponsor Protocol Number: LOC-2016 Start Date*: 2015-12-15
    Sponsor Name:Harry Scheinin
    Full Title: The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)
    Medical condition: No medical condition or disease involved. The study subjects are healthy volunteers.
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-000317-14 Sponsor Protocol Number: RAD-GRIN-101 Start Date*: 2022-11-28
    Sponsor Name:GRIN Therapeutics, Inc.
    Full Title: A Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms of Multiple Individually Titrated Doses of Radiprodil in Children with GRIN-...
    Medical condition: gain of function (GoF) variants in the GRIN2B gene
    Disease: Version SOC Term Classification Code Term Level
    21.1 10037175 - Psychiatric disorders 10064062 Neurodevelopmental disorder PT
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: ES (Ongoing) NL (Trial now transitioned) DE (Trial now transitioned) IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-004835-19 Sponsor Protocol Number: 38RC16.015 Start Date*: 2017-07-20
    Sponsor Name:University Hospital Grenoble
    Full Title: Dexamethasone in Herpes Simplex Virus Encephalitis Open label Randomized Controlled Trial with an Observer-blinded evaluation at 6 months
    Medical condition: HSV encephalitis
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000013665 10014590 Encephalitis herpes LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2018-002669-20 Sponsor Protocol Number: 03KET2018 Start Date*: 2018-09-18
    Sponsor Name:Celon Pharma SA
    Full Title: A multicentre, double-blind, randomised, placebo - controlled phase II study to assess efficacy, safety and pharmacokinetics of inhaled Esketamine in subjects with treatment-resistant bipolar depre...
    Medical condition: Eketamine, ketamine’s enantiomer, is designed for use in tretment resistant depression, both unipolar and bipolar. Many publications have demonstrated the effect of ketamine/esketamine (mainly admi...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-001963-22 Sponsor Protocol Number: 02KET2018 Start Date*: 2018-08-29
    Sponsor Name:Celon Pharma SA
    Full Title: A multicentre, double-blind, randomised, placebo - controlled phase II study to assess efficacy, safety and pharmacokinetics of inhaled Esketamine in subject with treatment-resistant depression in ...
    Medical condition: Eketamine, ketamine’s enantiomer, is designed for use in tretment resistant depression, both unipolar and bipolar. Many publications have demonstrated the effect of ketamine/esketamine (mainly admi...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-000870-20 Sponsor Protocol Number: IMU-AD-001 Start Date*: 2015-05-27
    Sponsor Name:Immungenetics AG
    Full Title: An open-label, multicenter, controlled pharmaco-dynamic clinical trial to explore the Amyloid beta draining effect of Thiethylperazine (TEP) in subjects with early-to-mild dementia due to Alzheimer...
    Medical condition: Newly diagnosed early-to-mild dementia due to Alzheimer's Disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029205 - Nervous system disorders 10012271 Dementia Alzheimer's type PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2015-005263-16 Sponsor Protocol Number: NSC15001 Start Date*: 2016-07-11
    Sponsor Name:Pharmatrophix Inc
    Full Title: A 6-months prospective, multi-center, double-blind, placebo-controlled, randomized, adaptive-trial-design study to evaluate safety, tolerability and exploratory endpoints of either placebo or two d...
    Medical condition: Mild to moderate Alzheimer's disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004852 10001896 Alzheimer's disease LLT
    20.0 100000004852 10066571 Progression of Alzheimer's disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) CZ (Completed) DE (Completed) SE (Completed) ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-001846-42 Sponsor Protocol Number: CAQW051A2104 Start Date*: 2007-10-05
    Sponsor Name:Novartis Pharma AG
    Full Title: A 4-week, parallel-group, randomized, double-blind, placebo-controlled, adaptive proof of concept study of AQW051 at up to three dose levels for the treatment of patients with findings consistent w...
    Medical condition: Mild Alzheimer’s disease (AD) and amnestic mild cognitive impairment (amnestic MCI)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10001896 Alzheimer's disease LLT
    9.1 10009846 Cognitive impairment LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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