- Trials with a EudraCT protocol (111)
- Paediatric studies in scope of Art45 of the Paediatric Regulation (0)
111 result(s) found for: car-t.
Displaying page 1 of 6.
EudraCT Number: 2016-004043-36 | Sponsor Protocol Number: 004:TCELL | Start Date*: 2017-04-28 |
Sponsor Name:Uppsala University | ||
Full Title: CD19-TARGETING 3RD GENERATION CAR T CELLS FOR REFRACTORY B CELL MALIGNANCY – A PHASE II TRIAL | ||
Medical condition: CD19+ B cell lymphoma or leukemia | ||
Disease: | ||
Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Children, Adolescents, Under 18, Adults, Elderly | Gender: Male, Female | |
Trial protocol: SE (Completed) | ||
Trial results: View results |
EudraCT Number: 2021-005192-39 | Sponsor Protocol Number: 202100663 | Start Date*: 2022-04-11 |
Sponsor Name:University Medical Center Groningen | ||
Full Title: Programmed death ligand 1 (PD-L1) PET imaging in patients with (Diffuse) Large B-cell lymphoma who are treated with CD19-directed CAR T-cell therapy | ||
Medical condition: Patients with relapsed/refractory large B-cell lymphoma (LBCL) after two or more lines of therapy who fulfill the eligibility criteria for CD19-directed CAR T-cell therapy according the Immune Effe... | ||
Disease: | ||
Population Age: Adults, Elderly | Gender: Male, Female | |
Trial protocol: NL (Ongoing) | ||
Trial results: (No results available) |
EudraCT Number: 2014-001673-14 | Sponsor Protocol Number: CCTL019A2205B | Start Date*: 2015-10-06 | ||||||||||||||||
Sponsor Name:Novartis Pharma Services AG | ||||||||||||||||||
Full Title: Long Term Follow-Up of Patients Exposed to Lentiviral-Based CAR T-Cell Therapy | ||||||||||||||||||
Medical condition: All patients who have been treated with chimeric antigen receptor (CAR) T-cell therapy in the context of a prior Novartis sponsored or supported study for any indication. | ||||||||||||||||||
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Population Age: Children, Under 18, Adults, Elderly | Gender: Male, Female | |||||||||||||||||
Trial protocol: AT (Ongoing) DE (Trial now transitioned) ES (Ongoing) NO (Ongoing) BE (Trial now transitioned) NL (Trial now transitioned) DK (Trial now transitioned) GB (GB - no longer in EU/EEA) SE (Trial now transitioned) FI (Trial now transitioned) IT (Ongoing) | ||||||||||||||||||
Trial results: (No results available) |
EudraCT Number: 2021-000937-15 | Sponsor Protocol Number: HO161 | Start Date*: 2022-08-25 | |||||||||||
Sponsor Name:UMCG | |||||||||||||
Full Title: A phase II non-inferiority design study comparing point-of-care produced CAR T-cell to commercial CAR T-cells in patients with relapsed/refractory Non-Hodgkin Lymphoma | |||||||||||||
Medical condition: B-Cell Non Hodgkin Lymphoma | |||||||||||||
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Population Age: Elderly | Gender: Male, Female | ||||||||||||
Trial protocol: NL (Ongoing) | |||||||||||||
Trial results: (No results available) |
EudraCT Number: 2021-003409-23 | Sponsor Protocol Number: MERMAID1 | Start Date*: 2023-12-12 | |||||||||||
Sponsor Name:Medical University of Warsaw | |||||||||||||
Full Title: Application of antiCD19 CAR T lymphocytes for the treatment of adult patients with B-cell acute lymphoblastic leukemia. Phase I/II clinical trial (MERMAID1) | |||||||||||||
Medical condition: Relapsed and refractory B-cell Acute Lymphoblastic Leukemia (B-ALL) | |||||||||||||
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Population Age: Adults | Gender: Male, Female | ||||||||||||
Trial protocol: PL (Ongoing) | |||||||||||||
Trial results: (No results available) |
EudraCT Number: 2013-001393-19 | Sponsor Protocol Number: 003:TCELL | Start Date*: 2014-04-08 |
Sponsor Name:Uppsala university | ||
Full Title: CD19-targeting 3rd generation CAR T cells for refractory B cell malignancy - a phase I/IIa trial. | ||
Medical condition: CD19+ B cell lymphoma or leukemia | ||
Disease: | ||
Population Age: Adults, Elderly | Gender: Male, Female | |
Trial protocol: SE (Completed) | ||
Trial results: View results |
EudraCT Number: 2020-004749-35 | Sponsor Protocol Number: 202000671 | Start Date*: 2021-04-08 |
Sponsor Name:University Medical Center Groningen | ||
Full Title: A phase 2 immunoPET imaging study with ZED88082A/CED88004S in patients with Large B-cell lymphoma before and after CD19-directed CAR T-cell therapy | ||
Medical condition: Patients with relapsed/refractory LBCL after 2 prior lines of therapy and qualify for CD19-directed CAR T-cell therapy. Eligibility for CAR T-cell therapy is based on the criteria posed by the Dutc... | ||
Disease: | ||
Population Age: Adults, Elderly | Gender: Male, Female | |
Trial protocol: NL (Ongoing) | ||
Trial results: (No results available) |
EudraCT Number: 2016-004867-38 | Sponsor Protocol Number: AUTO-LT1 | Start Date*: 2018-05-18 |
Sponsor Name:Autolus Limited | ||
Full Title: Long-term follow-up of patients previously treated with autologous T cells genetically modified with viral vectors. | ||
Medical condition: Potential malignancy in patients who received treatment with Autolus' CAR T cell therapy. | ||
Disease: | ||
Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults, Elderly | Gender: Male, Female | |
Trial protocol: GB (GB - no longer in EU/EEA) NL (Ongoing) | ||
Trial results: (No results available) |
EudraCT Number: 2019-001264-30 | Sponsor Protocol Number: CARAMBA-1 | Start Date*: 2020-03-11 | |||||||||||
Sponsor Name:Universitätsklinikum Würzburg | |||||||||||||
Full Title: A phase I/IIa clinical trial to assess feasibility, safety and antitumor activity of autologous SLAMF7 CAR-T cells in multiple myeloma | |||||||||||||
Medical condition: Multiple myeloma (MM) | |||||||||||||
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Population Age: Adults, Elderly | Gender: Male, Female | ||||||||||||
Trial protocol: DE (Ongoing) IT (Ongoing) ES (Ongoing) | |||||||||||||
Trial results: (No results available) |
EudraCT Number: 2022-001147-24 | Sponsor Protocol Number: ONC-2021-001 | Start Date*: 2023-04-12 | |||||||||||
Sponsor Name:IRCCS ISTITUTO CLINICO HUMANITAS | |||||||||||||
Full Title: Use of LOncastuximab Tesirine in patients with RElapsed/Refractory Diffuse Large B-Cell LYmphoma (DLBCL) or High Grade B-Cell Lymphoma (HGBCL) who have progressive disease after CAR T-cell treatmen... | |||||||||||||
Medical condition: Patients affected by relapsed/refractory DLBCL or HGBCL failing CAR T-cell therapy | |||||||||||||
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Population Age: Adults, Elderly | Gender: Male, Female | ||||||||||||
Trial protocol: IT (Ongoing) | |||||||||||||
Trial results: (No results available) |
EudraCT Number: 2019-004323-20 | Sponsor Protocol Number: BNT211-01 | Start Date*: 2020-06-30 | |||||||||||||||||||||||||||||||||||||||||
Sponsor Name:BioNTech Cell & Gene Therapies GmbH | |||||||||||||||||||||||||||||||||||||||||||
Full Title: Phase 1/2a, first-in-human, open-label, dose escalation trial with expansion cohorts to evaluate safety and preliminary efficacy of CLDN6 CAR-T with or without CLDN6 RNA-LPX in patients with CLDN6-... | |||||||||||||||||||||||||||||||||||||||||||
Medical condition: CLDN6-positive relapsed or refractory advanced solid tumors | |||||||||||||||||||||||||||||||||||||||||||
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Population Age: Adults, Elderly | Gender: Male, Female | ||||||||||||||||||||||||||||||||||||||||||
Trial protocol: DE (Ongoing) NL (Ongoing) SE (Ongoing) | |||||||||||||||||||||||||||||||||||||||||||
Trial results: (No results available) |
EudraCT Number: 2020-005515-51 | Sponsor Protocol Number: 202000814 | Start Date*: 2021-06-28 |
Sponsor Name:Medical University Medical Center Groningen | ||
Full Title: An explorative and feasibility study of Venetoclax combined with Tamoxifen in patients with relapsed/refractory Diffuse Large B-cell Lymphoma | ||
Medical condition: relapsed/refractory Diffuse Large B-cell Lymphoma | ||
Disease: | ||
Population Age: Adults, Elderly | Gender: Male, Female | |
Trial protocol: NL (Ongoing) | ||
Trial results: (No results available) |
EudraCT Number: 2021-003445-37 | Sponsor Protocol Number: ELPIDA-ALLOCART-01 | Start Date*: 2021-09-30 | |||||||||||
Sponsor Name:Aghia Sophia Children’s Hospital | |||||||||||||
Full Title: A Phase 2 Study of the Efficacy and Safety of a Dose of Donor-Derived CD19-targeted CAR T cells for children and young adults (up to 39 years old) with recurrent or persistent CD19 (+) Acute Leukem... | |||||||||||||
Medical condition: Relapsed b Acute Lymphoblastic Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation | |||||||||||||
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Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults | Gender: Male, Female | ||||||||||||
Trial protocol: GR (Ongoing) | |||||||||||||
Trial results: (No results available) |
EudraCT Number: 2016-004808-60 | Sponsor Protocol Number: HD-CAR-1/V04 | Start Date*: 2018-04-12 | ||||||||||||||||
Sponsor Name:University Hospital Heidelberg | ||||||||||||||||||
Full Title: Treatment of patients with relapsed or refractory CD19+ lymphoid disease with T lymphocytes transduced by RV-SFG.CD19.CD28.4-1BBzeta retroviral vector - A unicenter Phase I /II clinical trial | ||||||||||||||||||
Medical condition: Relapsed and/or refractory CD19+ leukemia and lymphoma | ||||||||||||||||||
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Population Age: Children, Adolescents, Under 18, Adults, Elderly | Gender: Male, Female | |||||||||||||||||
Trial protocol: DE (Ongoing) | ||||||||||||||||||
Trial results: (No results available) |
EudraCT Number: 2022-000186-40 | Sponsor Protocol Number: B1931036 | Start Date*: 2022-10-07 | |||||||||||
Sponsor Name:Pfizer Inc. | |||||||||||||
Full Title: A PROSPECTIVE, RANDOMIZED, OPEN-LABEL PHASE 2 STUDY TO EVALUATE THE SUPERIORITY OF INOTUZUMAB OZOGAMICIN MONOTHERAPY VERSUS ALLR3 FOR INDUCTION TREATMENT OF CHILDHOOD HIGH RISK FIRST RELAPSE B-CELL... | |||||||||||||
Medical condition: Acute Lymphoblastic Leukemia (ALL) | |||||||||||||
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Population Age: Infants and toddlers, Children, Adolescents, Under 18 | Gender: Male, Female | ||||||||||||
Trial protocol: HU (Ongoing) DE (Ongoing) AT (Ongoing) BE (Ongoing) SE (Ongoing) FR (Ongoing) SK (Ongoing) IT (Ongoing) ES (Ongoing) PL (Ongoing) GR (Ongoing) CZ (Ongoing) NL (Ongoing) FI (Ongoing) DK (Ongoing) | |||||||||||||
Trial results: (No results available) |
EudraCT Number: 2017-001541-26 | Sponsor Protocol Number: M16-106 | Start Date*: 2021-05-04 |
Sponsor Name:AbbVie Inc | ||
Full Title: A Study of Venetoclax in Combination With Navitoclax and Chemotherapy in Subjects With Relapsed/Refractory Acute Lymphoblastic Leukemia or Relapsed/Refractory Lymphoblastic Lymphoma | ||
Medical condition: Acute Lymphoblastic Leukemia (ALL) Lymphoblastic Lymphoma | ||
Disease: | ||
Population Age: Children, Adolescents, Under 18, Adults, Elderly | Gender: Male, Female | |
Trial protocol: Outside EU/EEA | ||
Trial results: View results |
EudraCT Number: 2021-003815-25 | Sponsor Protocol Number: CP0101-CLL | Start Date*: 2022-02-21 |
Sponsor Name:CellPoint B.V. | ||
Full Title: A Phase I/II study to evaluate the feasibility, safety and preliminary efficacy of point-of-care manufactured anti-CD19 CAR T in subjects with relapsed or refractory Chronic Lymphocytic Leukemia (C... | ||
Medical condition: relapsed / refractory Chronic Lymphocytic Leukemia relapsed / refractory Small Lymphocytic Lymphoma | ||
Disease: | ||
Population Age: Adults, Elderly | Gender: Male, Female | |
Trial protocol: ES (Trial now transitioned) | ||
Trial results: (No results available) |
EudraCT Number: 2019-004310-33 | Sponsor Protocol Number: CAR4SAR | Start Date*: 2022-02-21 |
Sponsor Name:Dr. Antonio Pérez Martínez | ||
Full Title: A Phase I Trial of Memory T Cells Expressing an ANTI-NKG2D Chimeric Antigen Receptor in Children, Adolescents and Young Adults with Advanced Sarcoma | ||
Medical condition: Advanced Sarcoma | ||
Disease: | ||
Population Age: Children, Adolescents, Under 18, Adults | Gender: Male, Female | |
Trial protocol: ES (Ongoing) | ||
Trial results: (No results available) |
EudraCT Number: 2017-002849-30 | Sponsor Protocol Number: CCTL019B2101J/CHP-959 | Start Date*: 2017-11-16 | |||||||||||||||||||||
Sponsor Name:University of Pennsylvania | |||||||||||||||||||||||
Full Title: A Phase I/IIA Study of Redirected Autologous T Cells Engineered to Contain Anti-CD19 Attached to TCRzeta and 4-1BB Signaling Domains in Patients With Chemotherapy Resistant Or Refractory CD19+ Leuk... | |||||||||||||||||||||||
Medical condition: Chemotherapy resistant or refractory CD19+ B-cell Leukemia and Lymphoma. | |||||||||||||||||||||||
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Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults | Gender: Male, Female | ||||||||||||||||||||||
Trial protocol: Outside EU/EEA | |||||||||||||||||||||||
Trial results: View results |
EudraCT Number: 2021-003712-27 | Sponsor Protocol Number: P1605-SUR-D23 | Start Date*: 2022-07-27 | |||||||||||
Sponsor Name:IMV Inc. | |||||||||||||
Full Title: A Phase 2b, Open-label, Multicenter, Randomized Parallel-Group, Two-Stage, Study of an Immunotherapeutic Treatment DPX-Survivac and Pembrolizumab, with and without Intermittent LowDose Cyclophospha... | |||||||||||||
Medical condition: Relapsed/Refractory Diffuse Large B-Cell Lymphoma | |||||||||||||
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Population Age: Adults, Elderly | Gender: Male, Female | ||||||||||||
Trial protocol: ES (Ongoing) FR (Ongoing) PL (Completed) HU (Ongoing) | |||||||||||||
Trial results: (No results available) |
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