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Clinical trials for Fluid overload

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44339   clinical trials with a EudraCT protocol, of which   7369   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    55 result(s) found for: Fluid overload. Displaying page 2 of 3.
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    EudraCT Number: 2017-000584-33 Sponsor Protocol Number: 16154DMcA-AS Start Date*: 2018-02-23
    Sponsor Name:Belfast Health and Social Care Trust
    Full Title: Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST) trial: An open label dose escalation phase 1 trial followed by a randomised, double-blind, placebo-controlled ...
    Medical condition: Acute Respiratory Distress Syndrome
    Disease:
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2009-014769-16 Sponsor Protocol Number: FO001 Start Date*: 2010-06-07
    Sponsor Name:AZIENDA OSPEDALIERA OSPEDALE NIGUARDA CA` GRANDA (A.O. DI RILIEVO NAZIONALE)
    Full Title: REWORD-HF REverse WOrsening Renal function in Decompensated Heart Failure Impact of different therapeutic approaches in patients with cardiorenal syndrome in the setting of acute decompensated c...
    Medical condition: acute decompensated congestive heart failure
    Disease: Version SOC Term Classification Code Term Level
    9.1 10064652 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2018-002632-24 Sponsor Protocol Number: P160915 Start Date*: 2018-11-13
    Sponsor Name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
    Full Title: Therapeutic plasma exchange, rituximab and intravenous immunoglobulins (IVIg) for severe acute exacerbation of idiopathic pulmonary fibrosis admitted in ICU: an open, randomized, controlled trial
    Medical condition: severe acute exacerbation of idiopathic pulmonary fibrosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2023-000010-18 Sponsor Protocol Number: WATERLAND Start Date*: 2023-03-23
    Sponsor Name:Enrique de Madaria
    Full Title: Normal saline versus lactated Ringer’s solution for acute pancreatitis resuscitation, an open-label multicenter randomized controlled trial: the WATERLAND trial
    Medical condition: Acute pancreatitis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10017947 - Gastrointestinal disorders 10033647 Pancreatitis acute PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-004059-18 Sponsor Protocol Number: 17909 Start Date*: 2019-06-27
    Sponsor Name:Bayer AG
    Full Title: A Multicenter, Randomized, Parallel Group, Double Blind, Active and Placebo Controlled Study of BAY 1753011, a Dual V1a/V2 Vasopressin Receptor Antagonist, in Patients with Congestive Heart Failure...
    Medical condition: Heart failure
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10008908 Chronic heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) PT (Completed) AT (Completed) PL (Completed) GR (Completed) ES (Completed) BG (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2018-003662-14 Sponsor Protocol Number: GN17CA082 Start Date*: 2019-05-13
    Sponsor Name:NHS Greater Glasgow and Clyde [...]
    1. NHS Greater Glasgow and Clyde
    2. University of Glasgow
    Full Title: Patiromer-facilitated, dose-escalation of mineralocorticoid antagonists for the management of worsening congestion in people with heart failure and hyperkalaemia. A Phase IV, registry-based, rand...
    Medical condition: People with heart failure, worsening symptoms and signs of congestion and serum potassium >5mmol/L
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10010684 Congestive heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2009-010236-18 Sponsor Protocol Number: CSPP100A2368 Start Date*: 2009-05-28
    Sponsor Name:Novartis Farmacéutica S.A.
    Full Title: Estudio multicéntrico, aleatorizado, doble ciego, de grupos paralelos, controlado con placebo para evaluar la eficacia y seguridad a 6 meses de la terapia de aliskiren, además de la terapia estánda...
    Medical condition: Insuficiencia Cardiaca aguda descompensada
    Disease: Version SOC Term Classification Code Term Level
    9.1 10000803 Acute heart failure LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) DE (Completed) CZ (Completed) BE (Completed) IT (Completed) SK (Completed) PL (Completed) HU (Completed) SE (Completed) FI (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2014-005260-15 Sponsor Protocol Number: FPCLI002 Start Date*: 2016-02-10
    Sponsor Name:Faron Pharmaceuticals Ltd
    Full Title: A Phase III Double-blind, Randomised, Parallel Group Comparison of the Efficacy and Safety of FP-1201-lyo (Recombinant Human Interferon Beta-1a) and Placebo in the Treatment of Patients with Modera...
    Medical condition: Adult patients diagnosed with moderate or severe Acute Respiratory Distress Syndrome (ARDS)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004855 10003083 ARDS LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended) FI (Prematurely Ended) BE (Completed) ES (Prematurely Ended) CZ (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-003529-36 Sponsor Protocol Number: mRNA-3927-P101 Start Date*: 2020-12-18
    Sponsor Name:ModernaTX, Inc
    Full Title: A Global, Phase 1/2, Open-label, Dose Optimization Study to Evaluate the Safety, Pharmacodynamics, and Pharmacokinetics of mRNA-3927 in Participants with Propionic Acidemia
    Medical condition: Propionic Acidemia- Propionic acidemia is an autosomal recessive disorder caused by loss-of-function mutations in PCCA or PCCB (and in rare instances, mutations in both PCCA and PCCB), resulting in...
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004850 10080615 Propionic acidemia LLT
    Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2014-002479-28 Sponsor Protocol Number: MOL-ARDS-002 Start Date*: 2015-09-24
    Sponsor Name:Justus-Liebig University
    Full Title: GM-CSF Inhalation to improve HOst defense and Pulmonary barrier rEstoration
    Medical condition: Pneumonia associated Acute Respiratory Distress Syndrome (ARDS)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004855 10000036 A.R.D.S. LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-002112-99 Sponsor Protocol Number: F1K-MC-EVDK Start Date*: 2006-09-26
    Sponsor Name:Eli Lilly & Company Limited
    Full Title: A Phase 2 Study to Evaluate Dose and Duration of Treatment of Drotrecogin Alfa (Activated) Using Serial Measurements of Protein C in Patients with Severe Sepsis and Multiple Organ Dysfunction
    Medical condition: severe sepsis
    Disease: Version SOC Term Classification Code Term Level
    8.1 10040047 Sepsis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) BE (Completed) SE (Prematurely Ended) FR (Completed) FI (Completed) IT (Completed) GB (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2011-001264-22 Sponsor Protocol Number: SILK/Eplerenone1 Start Date*: 2012-11-08
    Sponsor Name:Region Skåne
    Full Title: Eplerenone and spironolactone in male patients with ascites due to liver cirrhosis. A Swedish prospective randomized multicenter study of efficacy and endocrinologic side effects.
    Medical condition: Ascites complicating liver cirrhosis in males
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004871 10024667 Liver cirrhosis LLT
    14.1 100000004861 10021038 Hyponatremia LLT
    14.1 10038604 - Reproductive system and breast disorders 10018800 Gynaecomastia PT
    14.1 100000004848 10003146 Arterial blood pressure decreased LLT
    14.1 100000004848 10040409 Serum testosterone LLT
    15.1 10038604 - Reproductive system and breast disorders 10025522 Male sexual dysfunction NEC LLT
    14.1 10038604 - Reproductive system and breast disorders 10025503 Male erectile disorder LLT
    14.1 100000004871 10064704 Decompensated cirrhosis LLT
    14.1 100000004857 10023422 Kidney function abnormal LLT
    14.1 100000004861 10020647 Hyperkalemia LLT
    14.1 10017947 - Gastrointestinal disorders 10003445 Ascites PT
    Population Age: Elderly Gender: Male
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-005513-41 Sponsor Protocol Number: TA799-012 Start Date*: 2021-04-19
    Sponsor Name:VectivBio AG
    Full Title: An open-label extension trial to evaluate the long-term safety of apraglutide in short bowel syndrome
    Medical condition: short bowel syndrome
    Disease: Version SOC Term Classification Code Term Level
    20.1 10017947 - Gastrointestinal disorders 10049416 Short-bowel syndrome PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Trial now transitioned) CZ (Trial now transitioned) DE (Trial now transitioned) FR (Trial now transitioned) ES (Ongoing) IT (Trial now transitioned) HU (Trial now transitioned) DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2020-002913-16 Sponsor Protocol Number: 0135-0347 Start Date*: 2020-11-26
    Sponsor Name:SCS Boehringer Ingelheim Comm. V
    Full Title: The TRISTARDS trial - ThRombolysIS Therapy for ARDS A Phase IIb/III operationally seamless, open-label, randomised, sequential, parallel-group adaptive study to evaluate the efficacy and safety of ...
    Medical condition: Acute respiratory distress syndrome caused by Covid-19
    Disease: Version SOC Term Classification Code Term Level
    21.1 10038738 - Respiratory, thoracic and mediastinal disorders 10001052 Acute respiratory distress syndrome PT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed) DE (Prematurely Ended) AT (Ongoing) PT (Completed) NL (Completed) FR (Completed) DK (Prematurely Ended) IT (Prematurely Ended) PL (Completed) RO (Ongoing) ES (Completed)
    Trial results: View results
    EudraCT Number: 2018-004572-35 Sponsor Protocol Number: CR845-CLIN3105 Start Date*: 2019-06-17
    Sponsor Name:Cara Therapeutics, Inc.
    Full Title: An Open-Label, Multicenter Study to Evaluate the Safety and Effectiveness of Intravenous CR845 in Hemodialysis Patients with Moderate-to-Severe Pruritus
    Medical condition: Moderate-to-Severe Pruritus in Hemodialysis Patients
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) CZ (Completed) PL (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2019-004670-25 Sponsor Protocol Number: CQ-001-19 Start Date*: 2022-11-16
    Sponsor Name:Corequest sagl
    Full Title: Peritoneal Ultrafiltration in cardio Renal syndrome to prevent heart failure Exacerbation: The PURE Study
    Medical condition: Congestive Heart Failure
    Disease: Version SOC Term Classification Code Term Level
    20.1 10007541 - Cardiac disorders 10007559 Cardiac failure congestive PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2021-006644-27 Sponsor Protocol Number: CARR-ARDS-2021 Start Date*: 2023-02-28
    Sponsor Name:AZIENDA OSPEDALIERO-UNIVERSITARIA UDINE
    Full Title: Efficacy and safety of anakinra in non-COVID-19 related ARDS. ESKA study.
    Medical condition: Acute respiratory distress syndrome (ARDS)
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004855 10003083 ARDS LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-003763-35 Sponsor Protocol Number: 2016_76 Start Date*: 2018-05-17
    Sponsor Name:centre hospitalier universitaire de Lille
    Full Title: Conservative Iron Chelation by Deferiprone as a disease-modifying Strategy for Amyotrophic Lateral Sclerosis using a Multicentre Parallel group, placebo controlled, Randomized clinical trial
    Medical condition: De novo Amyotrophic Lateral Sclerosis patients
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-001930-17 Sponsor Protocol Number: CR845-CLIN3103 Start Date*: 2018-09-20
    Sponsor Name:Cara Therapeutics INC
    Full Title: A MULTICENTER, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY TO EVALUATE THE SAFETY AND EFFICACY OF INTRAVENOUS CR845 IN HEMODIALYSIS PATIENTS WITH MODERATE-TO-SEVERE PRURITUS, WITH A 52...
    Medical condition: PRURITUS,
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: HU (Completed) CZ (Completed) GB (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2015-004825-14 Sponsor Protocol Number: D1680C00016 Start Date*: 2016-05-04
    Sponsor Name:AstraZeneca AB
    Full Title: A 24-Week, Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled Study to Investigate the Effects of Saxagliptin, Saxagliptin Combined with Dapagliflozin, and Sitagliptin in Pat...
    Medical condition: Patients with type 2 diabetes mellitus and heart failure
    Disease: Version SOC Term Classification Code Term Level
    18.1 10007541 - Cardiac disorders 10011078 Coronary artery disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended) HU (Completed) BG (Completed) RO (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
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