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Clinical trials

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44380   clinical trials with a EudraCT protocol, of which   7392   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
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    44,380 result(s) found. Displaying page 1,998 of 2,219.
    «« First « Previous 1994  1995  1996  1997  1998  1999  2000  2001  2002  Next» Last»»
    EudraCT Number: 2014-000602-36 Sponsor Protocol Number: CRH2014 Start Date*: 2014-03-21
    Sponsor Name:KUleuven
    Full Title: The effect of corticotrophin-releasing hormone (CRH) on esophageal sensitivity in healthy volunteers: a randomized, single-blind, placebo-controlled study
    Medical condition: Changed esophageal sensitivity induced by CRH
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-004699-31 Sponsor Protocol Number: I3O-MC-JSBF Start Date*: 2016-03-23
    Sponsor Name:Eli Lilly and Company
    Full Title: Randomized, Double-Blind, Phase 2 Study of Ramucirumab or Merestinib or Placebo plus Gemcitabine and Cisplatin as First-Line Treatment in Patients with Advanced or Metastatic Biliary Tract Cancer
    Medical condition: Advanced or Metastatic Biliary Tract Cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10019815 Hepatobiliary neoplasms malignant and unspecified HLGT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed) HU (Completed) BE (Completed) GB (GB - no longer in EU/EEA) DE (Completed) SE (Completed) AT (Completed) CZ (Completed) ES (Completed) IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2011-000607-41 Sponsor Protocol Number: MMC-BCG-1 Start Date*: 2011-03-04
    Sponsor Name:Centre Hospitalier de Jolimont-Lobbes-Tubize-Nivelles
    Full Title: A phase I/II multicentric Belgian prospective novel sequential chemo-immunotherapy regimen for adjuvant treatment in non-muscle invasive bladder cancer.
    Medical condition: Patients with intermediate/high risk non-muscle invasive bladder cancer (NMIBC) • intermediate risk tumours – Ta, T1 Grade 1, Grade 2, multifocal and tumours larger than 3 cm • high risk tumours – ...
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10005003 Bladder cancer PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-000035-50 Sponsor Protocol Number: ACT16146 Start Date*: 2020-08-07
    Sponsor Name:Sanofi aventis recherche & développement
    Full Title: Randomized, open-label, Phase 2 study of SAR408701 combined with pembrolizumab and pembrolizumab alone in patients with CEACAM5 and PD-L1 positive advanced/metastatic non-squamous non–small-cell lu...
    Medical condition: Non-squamous non–small-cell lung cancer (NSQ NSCLC)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004864 10079440 Non-squamous non-small cell lung cancer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned) HU (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-005206-19 Sponsor Protocol Number: FFIS/2016/02/ST Start Date*: 2017-05-26
    Sponsor Name:Fundación para la Formación e Investigación Sanitaria (FFIS)
    Full Title: Randomised Controlled Trial with Pravastatin versus Placebo for Prevention of Preeclampsia
    Medical condition: Pre-eclampsia
    Disease: Version SOC Term Classification Code Term Level
    20.0 10036585 - Pregnancy, puerperium and perinatal conditions 10036485 Pre-eclampsia PT
    Population Age: Adults Gender: Female
    Trial protocol: GB (GB - no longer in EU/EEA) BE (Completed) ES (Completed) IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2016-000578-39 Sponsor Protocol Number: TRANSLATE-C Start Date*: 2016-07-13
    Sponsor Name:AZIENDA SANITARIA OSPEDALIERA S.CROCE E CARLE CUNEO
    Full Title: RESTORE IMMUNE COMPETENCE AGAINST CANCER CELLS IN METASTATIC COLON-RECTAL CARCINOMA RESISTANT TO STANDARD TREATMENTS TRANSLATE – Colon-rectal STUDY
    Medical condition: COLORECTAL METASTATIC CANCER
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004864 10052362 Metastatic colorectal cancer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2016-000581-31 Sponsor Protocol Number: TRANSLATE-MA Start Date*: 2016-07-13
    Sponsor Name:AZIENDA SANITARIA OSPEDALIERA S.CROCE E CARLE CUNEO
    Full Title: RESTORE IMMUNE COMPETENCE AGAINST CANCER CELLS IN BREAST CARCINOMA RESISTANT TO STANDARD TREATMENTS
    Medical condition: METASTATIC BREAST CANCER (MBC)
    Disease: Version SOC Term Classification Code Term Level
    20.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10055113 Breast cancer metastatic PT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2016-000580-17 Sponsor Protocol Number: TRANSLATE-RE Start Date*: 2016-07-13
    Sponsor Name:AZIENDA SANITARIA OSPEDALIERA S.CROCE E CARLE CUNEO
    Full Title: RESTORE IMMUNE COMPETENCE AGAINST CANCER CELLS IN RENAL CELL CARCINOMA RESISTANT TO STANDARD TREATMENTS TRANSLATE – kidney STUDY
    Medical condition: metastatic renal cell carcinoma (mRCC)
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004864 10050076 Metastatic renal carcinoma LLT
    21.1 100000004864 10015411 Esophageal squamous cell carcinoma lower third stage II LLT
    21.1 100000004864 10030193 Oesophageal squamous cell carcinoma upper third recurrent LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2016-000579-26 Sponsor Protocol Number: TRANSLATE-P Start Date*: 2016-07-13
    Sponsor Name:AZIENDA SANITARIA OSPEDALIERA S.CROCE E CARLE CUNEO
    Full Title: RESTORE IMMUNE COMPETENCE AGAINST CANCER CELLS IN PROSTATE CARCINOMA RESISTANT TO STANDARD TREATMENTS TRANSLATE – prostate STUDY
    Medical condition: metastatic castration resistant prostate carcinoma (mCRPC)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004864 10007453 Carcinoma of the prostate metastatic LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2017-000488-34 Sponsor Protocol Number: PVTRIFA2017 Start Date*: 2017-06-14
    Sponsor Name:UMBERTO I - POLICLINICO DI ROMA
    Full Title: RIFAXIMIN BLUNTED HIGHER LEVELS OF ENDOTOXIN IN CIRRHOSIS PATIENTS: A RANDOMIZED, DOUBLE BLIND, SHORT TERM INTERVENTIONAL TRIAL.
    Medical condition: PATIENTS WITH CIRRHOSIS CHILD PUGH B or C Classes
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004871 10009211 Cirrhosis liver LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-002353-38 Sponsor Protocol Number: OHIRC-20150866 Start Date*: 2017-08-31
    Sponsor Name:Ottawa Heart Institute Research Corporation (OHIRC)
    Full Title: The Optimal Anticoagulation for Enhanced Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial
    Medical condition: risk of stroke by atrial fibrillation
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10003658 Atrial fibrillation PT
    22.1 10029205 - Nervous system disorders 10014498 Embolic stroke PT
    20.0 10042613 - Surgical and medical procedures 10059864 Cardiac ablation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Trial now transitioned) BE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2013-004162-34 Sponsor Protocol Number: AB12004 Start Date*: 2015-01-02
    Sponsor Name:AB Science
    Full Title: A prospective, multicenter, randomized, double-blind, placebo-controlled, two-parallel groups, phase III clinical trial to compare the efficacy and safety of masitinib to placebo in patients with l...
    Medical condition: stromal gastrointestinal cancer
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004864 10062427 Gastrointestinal stromal tumor LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended) CZ (Completed) IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-003093-32 Sponsor Protocol Number: RC25/13 Start Date*: 2016-06-15
    Sponsor Name:IRCCS Burlo Garofolo
    Full Title: Randomized controlled trial to evaluate the efficacy of high flow versus low flow oxygen therapy in bronchiolitis
    Medical condition: Bronchiolitis
    Disease: Version SOC Term Classification Code Term Level
    18.1 10021881 - Infections and infestations 10006448 Bronchiolitis PT
    Population Age: Newborns, Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-004787-62 Sponsor Protocol Number: DUS Start Date*: 2014-11-26
    Sponsor Name:SOD Anestesia e Terapia Intensiva, DAI Oncologia, AOU Careggi, Firenze
    Full Title: Evaluation of muscle function recovery after deep neuromuscular blockade by acceleromyography of the adductor pollicis or diaphragmatic echography: comparison between sugammadex and neostigmine
    Medical condition: Muscle function recovery post neuromuscoular blockade
    Disease: Version SOC Term Classification Code Term Level
    19.1 10042613 - Surgical and medical procedures 10057286 Neuromuscular blockade reversal PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-003970-18 Sponsor Protocol Number: MELABLOCK Start Date*: 2016-04-14
    Sponsor Name:AZIENDA SANITARIA DI FIRENZE
    Full Title: A multicentre randomized, double-blinded and placebo-controlled clinical trial on the efficacy and safety of once daily propranolol 80 mg retard for the prevention of cutaneous malignant melanoma r...
    Medical condition: melanoma
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004864 10053571 Melanoma LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-002765-30 Sponsor Protocol Number: ABR49490 Start Date*: 2015-06-12
    Sponsor Name:EGRIS
    Full Title: European Long-acting Antipsychotics in Schizofrenia Trial EULAST
    Medical condition: Schizophrenia ICD-10 code F20
    Disease: Version SOC Term Classification Code Term Level
    19.0 10037175 - Psychiatric disorders 10039626 Schizophrenia PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Prematurely Ended) AT (Completed) IT (Completed) NO (Completed) BE (Completed) ES (Completed) DK (Completed) HU (Completed) RO (Suspended by CA) CZ (Completed) GR (Completed)
    Trial results: View results
    EudraCT Number: 2016-004118-84 Sponsor Protocol Number: ONC-2016-001 Start Date*: 2017-04-21
    Sponsor Name:IRCCS ISTITUTO CLINICO HUMANITAS
    Full Title: A multicenter, phase I-II trial of gemcitabine plus oxaliplatin and nbb-paclitaxel in subjects with advanced (unresectable or metastatic) biliary tract cancer (gallbladder cancer, cancer of the ext...
    Medical condition: Advanced (unresectable or metastatic) biliary tract cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10073073 Hepatobiliary cancer PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-004618-24 Sponsor Protocol Number: 012018CONTROL Start Date*: 2018-08-03
    Sponsor Name:IRCCS ISTITUTO CLINICO HUMANITAS
    Full Title: Evaluation of CardioprOtection by the use of betablocker Nebivolol in paTients with bReast cancer Or diffuse Large B cell lymphoma undergoing chemotherapy with anthracyclines: a randomized controll...
    Medical condition: To prevent cardiotoxicity of chemotherapeutic agents (anthracyclines)
    Disease: Version SOC Term Classification Code Term Level
    20.1 10042613 - Surgical and medical procedures 10008444 Chemotherapy cardiotoxicity attenuation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-002451-26 Sponsor Protocol Number: 538264464328 Start Date*: 2015-05-15
    Sponsor Name:Department of Psychiatry, Helsinki University Central Hospital
    Full Title: The effect of intranasal ketamine on suicidality in severely depressed and suicidal patients. Randomized, placebo-controlled study
    Medical condition: Depression
    Disease: Version SOC Term Classification Code Term Level
    17.1 10037175 - Psychiatric disorders 10012378 Depression PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2017-000658-20 Sponsor Protocol Number: 7621 Start Date*: 2017-04-24
    Sponsor Name:
    Full Title: Combinated systemic and intratympanic steroid therapy in idiopathic sudden sensorineural hearing loss
    Medical condition: Idiopathic Sudden Sensorineural Hearing Loss
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed)
    Trial results: (No results available)
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    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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